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Limited By:	Author = Almohammed, Sawsan;

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3D-Printed Peptide-Hydrogel Nanoparticle Composites for Surface-Enhanced Raman Spectroscopy Sensing (2019)

Almohammed, Sawsan; Alruwaili, Maha; Reynaud, Emmanuel G.; Redmond, Gareth; Rice, James...

3D-Printed Peptide-Hydrogel Nanoparticle Composites for Surface-Enhanced Raman Spectroscopy Sensing (2019)

Almohammed, Sawsan; Alruwaili, Maha; Reynaud, Emmanuel G.; Redmond, Gareth; Rice, James H.; Rodriguez, Brian J.

Abstract:

Precise control over the arrangement of plasmonic nanomaterials is critical for label-free single-molecule surface-enhanced Raman spectroscopy (SERS)-based sensing applications. SERS templates should provide high sensitivity and reproducibility and be cost-effective and easy to prepare. Additive manufacturing by extrusion-based three-dimensional (3D) printing is an emerging technique for the spatial arrangement of nanomaterials and is a method that may satisfy these SERS template requirements. In this work, we use 3D printing to produce sensitive and reproducible SERS templates using a fluorenylmethyloxycarbonyl diphenylalanine (Fmoc-FF) hydrogel loaded with silver or gold nanoparticles. The Fmoc-FF template allows the detection of low Raman cross-section molecules such as adenine at concentrations as low as 100 pM.
Enterprise Ireland
European Commission Horizon 2020
Science Foundation Ireland
The Ministry of Higher Education of Saudi Arabia under the King Abdullah S...

http://hdl.handle.net/10197/10962

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Nucleobase sensing using highly-sensitive surface-enhanced Raman spectroscopy templates comprising organic semiconductor peptide nanotubes and metal nanoparticles (2019)

Almohammed, Sawsan; Rodriguez, Brian J.; Rice, James H.

Nucleobase sensing using highly-sensitive surface-enhanced Raman spectroscopy templates comprising organic semiconductor peptide nanotubes and metal nanoparticles (2019)

Almohammed, Sawsan; Rodriguez, Brian J.; Rice, James H.

Abstract:

Templates formed from aligned diphenylalanine nanotubes with plasmon-active metal nanoparticles are a promising nanocomposite for large-scale, rapid, stable, and cost-effective surface-enhanced Raman spectroscopy (SERS) substrates. The high sensitivity of such templates arises from an arrangement of densely packed plasmon-active silver nanoparticles that enhance the localized electromagnetic field and allow the detection of the nucleobases adenine, cytosine, thymine, uracil, and guanine at concentrations in the range 10−5 to 10−9 M. Blinking of the SERS signal is observed, indicating sensitivity down to the single or few molecule limit. Such blinking could result from charge transfer process. These results demonstrate the potential for using aligned diphenylalanine nanotube-metal nanoparticle templates for practical monitoring of biomolecules and are promising initial steps toward the use of peptide nanotube-based in diagnostic sensing applications.
European Commission Horizon 2...

http://hdl.handle.net/10197/10587

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Wettability gradient-induced alignment of peptide nanotubes as templates for biosensing applications (2016)

Almohammed, Sawsan; Oladapo, Sarah O.; Ryan, Kate; Kholkin, Andrei L.; Rice, James H.; ...

Wettability gradient-induced alignment of peptide nanotubes as templates for biosensing applications (2016)

Almohammed, Sawsan; Oladapo, Sarah O.; Ryan, Kate; Kholkin, Andrei L.; Rice, James H.; Rodriguez, Brian J.

Abstract:

Self-assembled diphenylalanine (FF) peptide nanotubes (PNTs) have attracted significant attention due to their well-ordered supramolecular structure and wide range of functional capabilities that may enable potential nanobiotechnology applications. However, self-assembled PNTs are generally inhomogeneous at the macroscale, which has limited their potential use. Reproducibly controlling the assembly and alignment of PNTs is therefore critical to enable the widespread use of PNTs, e.g., in sensing applications. In this study, a surface patterning technique based on UV/ozone exposure through a mask is used to align PNTs. Exposed regions become hydrophilic, leading to directed spreading of the FF solution and alignment of the PNTs that improves as the difference in wettability between adjacent regions increases. Alignment was further found to depend on the concentration- and temperature-dependent diameter of the PNTs formed and the size of the hydrophilic area. Finally, aligned PNTs dec...

http://hdl.handle.net/10197/7642

Displaying Results 1 - 3 of 3 on page 1 of 1

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