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A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males. (2015)

BOKDE, ARUN

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Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation (2019)

Whelan, Robert; Bokde, Arun; Hongtao, Ruan; Zhou, Yunyi; Qiang, Luo; Robert, Gabriel H....

Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation (2019)

Whelan, Robert; Bokde, Arun; Hongtao, Ruan; Zhou, Yunyi; Qiang, Luo; Robert, Gabriel H.; Desrivieres, Sylvane; Burke Quinlan, Erin; Liu, ZhaoWen; Banaschewski, Tobias; Bromberg, Uli; B?chel, Christian; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Itterman, Bernd; Martinot, Jean-Luc; Paill?re Martinot, Marie-Laure

Abstract:

Adolescent binge drinking has been associated with higher risks for the development of many health problems throughout the lifespan. Adolescents undergo multiple changes that involve the co-development processes of brain, personality and behavior; therefore, certain behavior, such as alcohol consumption, can have disruptive effects on both brain development and personality maturation. However, these effects remain unclear due to the scarcity of longitudinal studies. In the current study, we used multivariate approaches to explore discriminative features in brain functional architecture, personality traits, and genetic variants in 19-year-old individuals (n?=?212). Taking advantage of a longitudinal design, we selected features that were more drastically altered in drinkers with an earlier onset of binge drinking. With the selected features, we trained a hierarchical model of support vector machines using a training sample (n?=?139). Using an independent sample (n?=?73), we tested th...

http://hdl.handle.net/2262/89523

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Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment. (2010)

BOKDE, ARUN; HAMPEL, HARALD

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Amygdalar reactivity is associated with prefrontal cortical thickness in a large population-based sample of adolescents (2019)

Whelan, Robert; Bokde, Arun

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Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis. (2015)

BOKDE, ARUN

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Basal forebrain volume, but not hippocampal volume, is a predictor of global cognitive decline in patients with alzheimer's disease treated with cholinesterase inhibitors (2018)

Bokde, Arun; Teipel, Stefan J.; Cavedo, Enrica; Hampel, Harald; Gothe, Michel J.

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Brain A? load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD (2019)

Bokde, Arun; Vergallo, Andrea; Houot, Marion; Cavedo, Enrica; Lemercier, Pablo; Vanmech...

Brain A? load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD (2019)

Bokde, Arun; Vergallo, Andrea; Houot, Marion; Cavedo, Enrica; Lemercier, Pablo; Vanmechelen, Eugeen; De Vos, Ann; Habert, Marie-Odile; Potier, Marie-Claude; Dubois, Bruno; Lista, Simone; Hampel, Harald; the INSIGHT-preAD study group; the Alzheimer Precision Medicine Intitiative (APMI)

Abstract:

Introduction: Successful development of effective ?-site amyloid precursor protein cleaving enzyme 1 (BACE1)?targeted therapies for early stages of Alzheimer's disease requires biomarker-guided intervention strategies. Methods: We investigated whether key biological factors such as sex, apolipoprotein E (APOE ?4) allele, and age affect longitudinal plasma BACE1 concentrations in a large monocenter cohort of individuals at risk for Alzheimer's disease. We explored the relationship between plasma BACE1 concentrations and levels of brain amyloid-? (A?) deposition, using positron emission tomography global standard uptake value ratios. Results: Baseline and longitudinal mean concentrations of plasma BACE1 were significantly higher in women than men. We also found a positive significant impact of plasma BACE1 on baseline A??positron emission tomography global standard uptake value ratios. Discussion: Our results suggest a sexual dimorphism in BACE1-related upstream mechanis...

http://hdl.handle.net/2262/91324

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Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus (2014)

BOKDE, ARUN

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Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior (2017)

BOKDE, ARUN; WHELAN, ROBERT

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Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat (2015)

BOKDE, ARUN; WHELAN, ROBERT

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Changes in resting connectivity with age: A simultaneous electroencephalogram and functional magnetic resonance imaging investigation. (2013)

O'CONNELL, REDMOND; ROBERTSON, IAN; BOKDE, ARUN; NOLAN, HUGH

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Current Practice in the Referral of Individuals with Suspected Dementia for Neuroimaging by General Practitioners in Ireland and Wales (2016)

CIBLIS, AURELIA; BOKDE, ARUN

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Diagnostic power of default mode network resting state fMRI in the detection of Alzheimer's disease. (2012)

BOKDE, ARUN; HAMPEL, HARALD

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Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease (2019)

Bokde, Arun; Chiesa, Patrizia A.; Cavedo, Enrica; Vergallo, Andrea; Lista, Simone; Poti...

Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease (2019)

Bokde, Arun; Chiesa, Patrizia A.; Cavedo, Enrica; Vergallo, Andrea; Lista, Simone; Potier, Marie-Claude; Habert, Marie-Odile; Dubois, Bruno; Thiebaut de Schotten, Michel; Hampel, Harald; the INSIGHT-preAD study group; the Alzheimer Precision Medicine Intitiative (APMI)

Abstract:

Introduction: The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods: In a large-scale monocentric cohort of 224 amyloid stratified individuals at risk for Alzheimer's disease, default mode network (DMN) resting state functional connectivity (FC) was investigated between two serial time points across 2 years. Results: Widespread DMN FC changes were shown in frontal and posterior areas, as well as in the right hippocampus. There were no cross-sectional differences, however, apolipoprotein E ?4 (APOE ?4) carriers demonstrated slower increase in FC in frontal lobes. There was no impact of individual brain amyloid load status. Discussion: For the first time, we demonstrated that the pleiotropic biological effect of the APOE ?4 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may become useful surrogate outcomes...

http://hdl.handle.net/2262/91325

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Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample. (2014)

BOKDE, ARUN

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Disrupted Thalamus White Matter Anatomy and Posterior Default Mode Network Effective Connectivity in Amnestic Mild Cognitive Impairment. (2017)

Bokde, Arun; Kenny, Rose; Lyons, Declan

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Do ADHD-impulsivity and BMI have shared polygenic and neural correlates? (2019)

Whelan, Robert; Bokde, Arun

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Donepezil Impairs Memory in Healthy Older Subjects: Behavioural, EEG and Simultaneous EEG/fMRI Biomarkers (2011)

FAGAN, ANDREW; ROBERTSON, IAN; BALSTERS, JOSHUA; O'CONNELL, REDMOND; CASSIDY, SARA...

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DRD2/ANKK1 polymorphism modulates the effect of ventral striatal activation on working memory performance (2014)

Bokde, Arun; Lalor, Edmund

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EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction. (2017)

BOKDE, ARUN

Mark

Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? (2018)

Bokde, Arun; Whelan, Robert; Kaminski, Jakob A.; Schlagenhauf, Florian; Rapp, Michael; ...

Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability? (2018)

Bokde, Arun; Whelan, Robert; Kaminski, Jakob A.; Schlagenhauf, Florian; Rapp, Michael; Awasthi, Swapnil; Ruggeri, Barbara; Deserno, Lorenz; Banaschewski, Tobias; Bromberg, Uli; B?chel, Christian; Burke Quinlan, Erin; Desrivieres, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Ittermann, Bernd; Martinot, Jean-Luc; Paill?re Martinot, Marie-Laure

Abstract:

Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to be explained by genetic changes. One possible explanation for the strong malleability of cognitive performance measure is that environmental factors modify gene expression via epigenetic mechanisms. Epigenetic factors may help to understand the recent observations of an association between dopamine-dependent encoding of reward prediction errors and cognitive capacity, which was modulated by adverse life events. The possible manifestation of malleable biomarkers contributing to variance in cognitive test performance, and thus possibly contributing to the ? missing heritability ? between estimates from twin studies and variance explained by genetic markers, is still unclear. Here we show in 1475 healthy adolescents from the IMaging and GENetics (IMAGEN) sample that ge...

http://hdl.handle.net/2262/90793

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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group (2019)

Bokde, Arun; Jia, Tianye; Chu, Congying; van Dongen, Jenny; Papastergios, Evangelos; Ar...

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group (2019)

Bokde, Arun; Jia, Tianye; Chu, Congying; van Dongen, Jenny; Papastergios, Evangelos; Armstrong, Nicola J.; Bastin, Mark E.; Carrillo-Roa, Tania; den Braber, Anouk; Harris, Mathew; Jansen, Rick; Liu, Jingyu; Luciano, Michelle; Ori, Anil P.S.; Roiz Santia?ez, Roberto; Ruggeri, Barbara; Sarkisyan, Daniil; Shin, Jean; Sungeun, Kim; Tordesillas Guti?rrez, Diana

Abstract:

DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)?three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant as...

http://hdl.handle.net/2262/91323

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Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project (2019)

Bokde, Arun; Whelan, Robert; Brislin, Sarah J.; Patrick, Christopher J.; Flor, Herta; N...

Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project (2019)

Bokde, Arun; Whelan, Robert; Brislin, Sarah J.; Patrick, Christopher J.; Flor, Herta; Nees, Frauke; Heinrich, Angela; Drislane, Laura E.; Yancey, James R.; Banaschewski, Tobias; Bromberg, Uli; B?chel, Christian; Burke Quinlan, Erin; Desrivieres, Sylvane; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc

Abstract:

Trait disinhibition, a clinical-liability construct, has well-established correlates in the diagnostic, self-rating, task-behavioral, and brain potential response domains. Recently, studies have begun to test for neuroimaging correlates of this liability factor, but more work of this type using larger data sets is needed to clarify its brain bases. The current study details the development and validation of a scale measure of trait disinhibition composed of questionnaire items available in the IMAGEN project, a large-scale longitudinal study of factors contributing to substance abuse that includes clinical interview, self-report personality, task-behavioral, neuroimaging, and genomic measures. Using a construct-rating and psychometric refinement approach, a scale was developed that evidenced: (a) positive relations with interview-assessed psychopathology in the IMAGEN sample, both concurrently and prospectively and (b) positive associations with scale measures of disinhibition and r...

http://hdl.handle.net/2262/91684