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Mark

Assessing methods to specify the target difference for a randomised controlled trial: delta (difference elicitation in trials) review (2018)

Cook, Jonathan; Hislop, Jennifer; Adewuyi, Temitope; Harrild, Kirsten; Altman, Douglas;...

Mark

Long-term effects of statin treatment in elderly people: extended follow-up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) (2013)

Lloyd, Suzanne M.; Stott, David J.; de Craen, Anton J. M.; Kearney, Patricia M.; Sattar...

Long-term effects of statin treatment in elderly people: extended follow-up of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) (2013)

Lloyd, Suzanne M.; Stott, David J.; de Craen, Anton J. M.; Kearney, Patricia M.; Sattar, Naveed; Perry, Ivan J.; Packard, Christopher J.; Briggs, Andrew; Marchbank, Laura; Comber, Harry; Jukema, J. Wouter; Westendorp, Rudi G. J.; Trompet, Stella; Buckley, Brendan M.; Ford, Ian

Abstract:

Background The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), a placebo-controlled trial of pravastatin, demonstrated a 19% reduction in coronary outcomes (p = 0.006) after a mean of 3.2 years, with no impact on stroke outcomes or all-cause mortality. However, there was a suggestion of increased cancer risk. Our aim is to determine the long-term benefits and safety of pravastatin treatment in older people using post-trial follow-up of the PROSPER participants. Methods: 5,804 (2,520 Scottish) men and women aged 70–82 years with either pre-existing vascular disease or increased risk of such disease because of smoking, hypertension or diabetes, were randomised to 40 mg pravastatin or matching placebo. Using record linkage to routinely collected health records, all participants (full cohort) were linked to death and cancer registries, and the Scottish cohort additionally to hospital admissions, to provide composite fatal/non-fatal cardiovascular outcomes (total mean ...

http://hdl.handle.net/10468/1508

Mark

PATHway I: Design and rationale for the investigation of the feasibility, clinical effectiveness and cost-effectiveness of a technology enabled cardiac rehabilitation platform. (2017)

Claes, Jomme; Buys, Roselien; Woods, Catherine B.; Briggs, Andrew; Geue, Claudia; Aitke...

PATHway I: Design and rationale for the investigation of the feasibility, clinical effectiveness and cost-effectiveness of a technology enabled cardiac rehabilitation platform. (2017)

Claes, Jomme; Buys, Roselien; Woods, Catherine B.; Briggs, Andrew; Geue, Claudia; Aitken, Moira; Moyna, Niall M.; Moran, Kieran A.; McCaffery, Noel; Chouvarda, Ioanna; Walsh, Deirdre M.J.; Budts, Werner; Filos, Dimitris; Triantafyllidis, Andreas; Maglaveras, Nicos; Cornelissen, Veronique A.

Abstract:

Introduction Exercise-based cardiac rehabilitation (CR) independently alters the clinical course of cardiovascular diseases resulting in a significant reduction in all-cause and cardiac mortality. However, only 15%–30% of all eligible patients participate in a phase 2 ambulatory programme. The uptake rate of community-based programmes following phase 2 CR and adherence to long-term exercise is extremely poor. Newer care models, involving telerehabilitation programmes that are delivered remotely, show considerable promise for increasing adherence. In this view, the PATHway (Physical Activity Towards Health) platform was developed and now needs to be evaluated in terms of its feasibility and clinical efficacy. Methods and analysis In a multicentre randomised controlled pilot trial, 120 participants (m/f, age 40– 80 years) completing a phase 2 ambulatory CR programme will be randomised on a 1:1 basis to PATHway or usual care. PATHway involves a comprehensive, internetenabled, sensor-ba...

http://hdl.handle.net/10344/5884

Mark

PATHway I: design and rationale for the investigation of the feasibility, clinical effectiveness and cost-effectiveness of a technology-enabled cardiac rehabilitation platform (2017)

Claes, Jomme; Buys, Roselien; Woods, Catherine; Briggs, Andrew; Geue, Claudia; Aitken, ...

PATHway I: design and rationale for the investigation of the feasibility, clinical effectiveness and cost-effectiveness of a technology-enabled cardiac rehabilitation platform (2017)

Claes, Jomme; Buys, Roselien; Woods, Catherine; Briggs, Andrew; Geue, Claudia; Aitken, Moira; Moyna, Niall; Moran, Kieran; McCaffrey, Noel; Walsh, Deirdre; Chouvarda, Ioanna; Budts, Werner; Filos, Dimitris; Triantafyllidis, Andreas; Maglaveras, Nicos; Cornelissen, Véronique

Abstract:

Introduction. Exercise-based cardiac rehabilitation (CR) independently alters the clinical course of cardiovascular diseases resulting in a signi cant reduction in all-cause and cardiac mortality. However, only 15%–30% of all eligible patients participate in a phase 2 ambulatory programme. The uptake rate of community-based programmes following phase 2 CR and adherence to long-term exercise is extremely poor. Newer care models, involving telerehabilitation programmes that are delivered remotely, show considerable promise for increasing adherence. In this view, the PATHway (Physical Activity Towards Health) platform was developed and now needs to be evaluated in terms of its feasibility and clinical efficacy. Methods and analysis. In a multicentre randomised controlled pilot trial, 120 participants (m/f, age 40–80 years) completing a phase 2 ambulatory CR programme will be randomised on a 1:1 basis to PATHway or usual care. PATHway involves a comprehensive, internet- enabled, sensor...

http://doras.dcu.ie/21924/

Mark

Technology-enabled cardiac rehabilitation through PATHway. Design and rationale for the investigation of its feasibility, clinical effectiveness and cost-effectiveness (2016)

Cornelissen, Véronique; Moyna, Niall; Claes, Jomme; Briggs, Andrew; McDermott, Clare M....

Technology-enabled cardiac rehabilitation through PATHway. Design and rationale for the investigation of its feasibility, clinical effectiveness and cost-effectiveness (2016)

Cornelissen, Véronique; Moyna, Niall; Claes, Jomme; Briggs, Andrew; McDermott, Clare M.; Chouvarda, Ioanna; Filos, Dimitris; Finlay, Dewar D.; Daras, Petros; Walsh, Deirdre; Budts, Werner; Woods, Catherine; Moran, Kieran; Buys, Roselien

Abstract:

Background Exercise-based cardiac rehabilitation (CR) favorable and independently alters the clinical course of cardiovascular diseases resulting in a significant reduction in all-cause and cardiac mortality. However, only 15-30% of all eligible patients participate in a phase 2 ambulatory program. Uptake rates of community based programs following phase 2 CR are even lower and adherence to long-term CR is extremely poor. Newer care models, involving programs that are delivered remotely such as telehealth programs, show considerable promise for increasing adherence. In this view, PATHway (Physical Activity Towards Health) is being developed and needs to be evaluated on feasibility and potential clinical benefit. Methods In a multicentre randomized controlled pilot trial, 120 patients (m/f, age 40-80yrs) completing a phase 2 ambulatory CR program will be randomized on a 1:1 basis to PATHway or usual care. PATHway involves a complex comprehensive, internet-enabled, sensor-based home ...

http://doras.dcu.ie/21308/

Mark

Technology-enabled cardiac rehabilitation through PATHway. Design and rationale for the investigation of its feasibility, clinical effectiveness and cost-effectiveness (2016)

Cornelissen, Véronique; Moyna, Niall; Claes, Jomme; Briggs, Andrew; McDermott, Clare M....

Technology-enabled cardiac rehabilitation through PATHway. Design and rationale for the investigation of its feasibility, clinical effectiveness and cost-effectiveness (2016)

Abstract:

Background. Exercise-based cardiac rehabilitation (CR) favorable and independently alters the clinical course of cardiovascular diseases resulting in a significant reduction in all-cause and cardiac mortality. However, only 15-30% of all eligible patients participate in a phase 2 ambulatory program. Uptake rates of community based programs following phase 2 CR are even lower and adherence to long-term CR is extremely poor. Newer care models, involving programs that are delivered remotely such as telehealth programs, show considerable promise for increasing adherence. In this view, PATHway (Physical Activity Towards Health) is being developed and needs to be evaluated on feasibility and potential clinical benefit. Methods. In a multicentre randomized controlled pilot trial, 120 patients (m/f, age 40-80yrs) completing a phase 2 ambulatory CR program will be randomized on a 1:1 basis to PATHway or usual care. PATHway involves a complex comprehensive, internet-enabled, sensor-based hom...

http://doras.dcu.ie/21927/

Displaying Results 1 - 6 of 6 on page 1 of 1