Institutions
|
About Us
|
Help
|
Gaeilge
0
1000
Home
Browse
Advanced Search
Search History
Marked List
Statistics
A
A
A
Author(s)
Institution
Publication types
Funder
Year
Limited By:
Author = Commins, Sean;
48 items found
Sort by
Title
Author
Item type
Date
Institution
Peer review status
Language
Order
Ascending
Descending
25
50
100
per page
1
2
Bibtex
CSV
EndNote
RefWorks
RIS
XML
Displaying Results 1 - 25 of 48 on page 1 of 2
Marked
Mark
A Possible Role for Protein Synthesis, Extracellular Signal-Regulated Kinase, and Brain-Derived Neurotrophic Factor in Long-Term Spatial Memory Retention in the Water Maze
(2008)
McGauran, Anne-Marie T.; Moore, J. Bernadette; Madsen, Declan; Barry, Daniel; O'De...
A Possible Role for Protein Synthesis, Extracellular Signal-Regulated Kinase, and Brain-Derived Neurotrophic Factor in Long-Term Spatial Memory Retention in the Water Maze
(2008)
McGauran, Anne-Marie T.; Moore, J. Bernadette; Madsen, Declan; Barry, Daniel; O'Dea, Shirley; Mahon, Bernard P.; Commins, Sean
Abstract:
Hippocampal protein synthesis is dependent upon a number of different molecular and cellular mechanisms that act together to make previously labile memories more stable and resistant to disruption. Both brain-derived neurotrophic factor (BDNF) and extracellular signal-Regulated kinase (ERK) are known to play an important role in protein synthesis-dependent memory consolidation, via the mitogen-activated protein-kinase (MAP-K) signaling pathway during the transcription phase of protein synthesis. The current study investigates the influence of protein synthesis inhibition (PSI) by cycloheximide on spatial learning and memory. In an initial experiment, the authors utilized two doses of cycloheximide (0.5 mg/kg and 1.0 mg/kg, intraperitoneally) to determine the dose at which long-term (>24 hours) memories are impaired. A second experiment was designed to investigate the effect of PSI on the formation of cue-platform associations in the watermaze, and on BDNF and ERK expression in th...
http://mural.maynoothuniversity.ie/7159/
Marked
Mark
An exploration of EEG features during recovery following stroke – implications for BCI-mediated neurorehabilitation therapy
(2014)
Leamy, Darren J.; Kocijan, Jus; Domijan, Katarina; Duffin, Joseph; Roche, Richard; Comm...
An exploration of EEG features during recovery following stroke – implications for BCI-mediated neurorehabilitation therapy
(2014)
Leamy, Darren J.; Kocijan, Jus; Domijan, Katarina; Duffin, Joseph; Roche, Richard; Commins, Sean; Collins, Ronan; Ward, Tomas E.
Abstract:
Background: Brain-Computer Interfaces (BCI) can potentially be used to aid in the recovery of lost motor control in a limb following stroke. BCIs are typically used by subjects with no damage to the brain therefore relatively little is known about the technical requirements for the design of a rehabilitative BCI for stroke. Methods: 32-channel electroencephalogram (EEG) was recorded during a finger-tapping task from 10 healthy subjects for one session and 5 stroke patients for two sessions approximately 6 months apart. An off-line BCI design based on Filter Bank Common Spatial Patterns (FBCSP) was implemented to test and compare the efficacy and accuracy of training a rehabilitative BCI with both stroke-affected and healthy data. Results: Stroke-affected EEG datasets have lower 10-fold cross validation results than healthy EEG datasets. When training a BCI with healthy EEG, average classification accuracy of stroke-affected EEG is lower than the average for healthy EEG. Classificati...
http://mural.maynoothuniversity.ie/6074/
Marked
Mark
An exploration of EEG features during recovery following stroke - implications for BCI-mediated neurorehabilitation therapy
(2014)
Leamy, Darren J; Kocijan, Juš; Domijan, Katarina; Duffin, Joseph; Roche, Richard AP; Co...
An exploration of EEG features during recovery following stroke - implications for BCI-mediated neurorehabilitation therapy
(2014)
Leamy, Darren J; Kocijan, Juš; Domijan, Katarina; Duffin, Joseph; Roche, Richard AP; Commins, Sean; Collins R; Ward, Tomas E
Abstract:
Abstract Background Brain-Computer Interfaces (BCI) can potentially be used to aid in the recovery of lost motor control in a limb following stroke. BCIs are typically used by subjects with no damage to the brain therefore relatively little is known about the technical requirements for the design of a rehabilitative BCI for stroke. Methods 32-channel electroencephalogram (EEG) was recorded during a finger-tapping task from 10 healthy subjects for one session and 5 stroke patients for two sessions approximately 6 months apart. An off-line BCI design based on Filter Bank Common Spatial Patterns (FBCSP) was implemented to test and compare the efficacy and accuracy of training a rehabilitative BCI with both stroke-affected and healthy data. Results Stroke-affected EEG datasets have lower 10-fold cross validation results than healthy EEG datasets. When training a BCI with healthy EEG, average classification ...
http://dx.doi.org/10.1186/1743-0003-11-9
Marked
Mark
An exploratory study of the role played by sustained attention along a rural Irish route using a video-playback system
(2014)
Daly, Noel; Brogan, Michael; Kaneswaran, David; Deegan, Catherine; Markham, Charles; Co...
An exploratory study of the role played by sustained attention along a rural Irish route using a video-playback system
(2014)
Daly, Noel; Brogan, Michael; Kaneswaran, David; Deegan, Catherine; Markham, Charles; Commins, Sean
Abstract:
Inattention and distractibility are major causes of driver accidents. Using a video playback system with a video sequence taken from a rural Irish road, we compared the speed of those considered as having either high or low levels of sustained attention along the route, as well as, at targeted sections of the road. In addition, we manipulated the video sequence by adding a speed limit sign (augmented sequence) or by removal of the middle white line (redacted sequence) to determine how each group would react. Results revealed that those with high sustained attention showed generally lower speeds compared to those with low sustained attention with a significant difference between the groups at bends. Further, although no difference in reaction was found for any particular manipulated sequence, the high sustained attention group was found to be significantly slower at these locations. In addition, some gender differences were observed, females showed significantly lower speeds on strai...
http://mural.maynoothuniversity.ie/10712/
Marked
Mark
Antagonism of glutamate receptors in the CA1 to perirhinal cortex projection prevents long-term potentiation and attenuates levels of brain-derived neurotrophic factor
(2009)
Kealy, John; Commins, Sean
Antagonism of glutamate receptors in the CA1 to perirhinal cortex projection prevents long-term potentiation and attenuates levels of brain-derived neurotrophic factor
(2009)
Kealy, John; Commins, Sean
Abstract:
The CA1 to perirhinal cortex projection is one of multiple hippocampal–neocortical projections considered to be involved in memory consolidation. This projection has been shown to sustain long-term potentiation (LTP) following stimulation of CA1. Here we examined the pharmacological properties underpinning the plasticity observed in this projection. A stimulating electrode was inserted into the area CA1 and a recording electrode was inserted into the perirhinal cortex of urethane-anaesthetised Wistar rats. Rats (n=6 in each drug group) were administered with either saline (0.09%), MK-801 (NMDA antagonist; 0.1 mg/kg) or CNQX (AMPA/kainate antagonist; 1.5 mg/kg). Baseline recordings were made for 10 min by stimulating area CA1 (0.05 Hz stimulation protocol). High-frequency stimulation (HFS; 250 Hz) was performed and post-HFS fEPSP recordings were made for 1 h (0.05 Hz, as above). Baseline and post-HFS paired-pulse facilitation (PPF) recordings were performed across six different inter...
http://mural.maynoothuniversity.ie/5547/
Marked
Mark
Autobiographical memory, the ageing brain and mechanisms of psychological interventions
(2018)
Allen, Andrew P; Doyle, Caoilainn; Commins, Sean; Roche, Richard A.P.
Autobiographical memory, the ageing brain and mechanisms of psychological interventions
(2018)
Allen, Andrew P; Doyle, Caoilainn; Commins, Sean; Roche, Richard A.P.
Abstract:
Elucidating the impact of healthy cognitive ageing and dementia on autobiographical memory (AM) may help deepen our theoretical understanding of memory and underlying neural changes. The distinction between episodic and semantic autobiographical memory is particularly informative in this regard. Psychological interventions, particularly those involving reminiscence or music, have led to differential effects on episodic and semantic autobiographical memory. We propose that executive function is a key mediator of psychological therapies on autobiographical memory. We also highlight that interventions that alleviate stress and improve mood, including in major depression, can enhance autobiographical memory. Future research employing more longitudinal approaches and examining moderating factors such as gender and education level will deepen our understanding of changes in AM in later life, enhance our theoretical understanding of the neuroscience of AM and ageing, and help to develop be...
http://mural.maynoothuniversity.ie/13148/
Marked
Mark
Chronic fluoxetine treatment attenuates post-septic affective changes in the mouse
(2016)
Anderson, Sean T.; Commins, Sean; Moynagh, Paul N.; Coogan, Andrew
Chronic fluoxetine treatment attenuates post-septic affective changes in the mouse
(2016)
Anderson, Sean T.; Commins, Sean; Moynagh, Paul N.; Coogan, Andrew
Abstract:
It has been previously demonstrated that the induction of sepsis in rodents results in persistent impairments in affective and cognitive domains. In this study we have examined the impact of chronic treatment with the antidepressant fluoxetine on affective behaviours and hippocampal neuroinflammation and stem cell proliferation in animals that have previously undergone sepsis induced by peripheral treatment with lipopolysaccharide. We find that fluoxetine significantly attenuates post-septic increases in behavioural despair and motivated exploration, whilst also reversing the effects of previous sepsis on activated microglia and stem cell proliferation. These results indicate that conventional antidepressants may be effective in the management of mood disorders in survivors of sepsis.
http://mural.maynoothuniversity.ie/10718/
Marked
Mark
Comparable walking gait performance during executive and non-executive cognitive dual-tasks in chronic stroke: A pilot study
(2019)
Walshe, Elizabeth; Roche, Richard; Ward, Christina; Patterson, Matt; O'Neill, Desm...
Comparable walking gait performance during executive and non-executive cognitive dual-tasks in chronic stroke: A pilot study
(2019)
Walshe, Elizabeth; Roche, Richard; Ward, Christina; Patterson, Matt; O'Neill, Desmond; Collins, Ronan; Commins, Sean
Abstract:
Background: Falls are a serious problem among stroke survivors due to subsequent injuries, recovery setbacks, dependence, and mortality. A growing body of dual-task (DT) studies suggests a role of executive functions in gait control and falls, particularly in subacute stroke. However, few studies have compared distinct executive and non-executive tasks, nor their effects on chronic stroke gait. Research question: The purpose of this crosssectional study was to compare the effects of distinct working memory (2-back) and inhibition (Stroop) tasks on walking gait performance in chronic stroke survivors. Methods: A pilot sample of chronic stroke survivors (n = 11, 8 males, mean age = 70.91, 6-12months poststroke event) and age-matched healthy controls (n = 13, 4 male; mean age = 68.46) were tested. Gait performance (speed, stride time, stride time variability, stride length and stride length variability) was measured using 2 wireless inertial measurement sensors under 4 walking conditio...
http://mural.maynoothuniversity.ie/13879/
Marked
Mark
Concurrent task performance enhances low-level visuomotor learning
(2007)
Roche, Richard; Commins, Sean; Agnew, Francis; Cassidy, Sarah; Corapi, Kristin; Leibbra...
Concurrent task performance enhances low-level visuomotor learning
(2007)
Roche, Richard; Commins, Sean; Agnew, Francis; Cassidy, Sarah; Corapi, Kristin; Leibbrand, Sandra; Lipson, Zoë; Rickard, Jonathan; Sorohan, Jean; Wynne, Ciara; O'Mara, Shane
Abstract:
Visuomotor association learning involves learning to make a motor response to an arbitrary visual stimulus. This learning is essential for visual search and discrimination performance and is reliant upon a well-defined neural circuit in the brain that includes the prefrontal cortex and the hippocampal formation. In the present study, we investigated the possible role of attentional processes during such learning using dual-task interference. A motor, verbal, or perceptual concurrent task was performed during the learning/training block of a simple visual discrimination task. Contrary to expectation, the dual-task groups showed improved learning and learning-dependent performance compared with untrained control and non-dual-task trained groups. A second experiment revealed that this effect did not appear to be due to increased arousal level; the inclusion of alerting tones during learning did not result in facilitation. These findings suggest that the engagement of attention, but not...
http://mural.maynoothuniversity.ie/10694/
Marked
Mark
Cyclooxygenase inhibition attenuates endotoxin-induced spatial learning deficits, but not an endotoxin-induced blockade of long-term potentiation
(2005)
Shawa, Kendra N.; Commins, Sean; O'Mara, Shane
Cyclooxygenase inhibition attenuates endotoxin-induced spatial learning deficits, but not an endotoxin-induced blockade of long-term potentiation
(2005)
Shawa, Kendra N.; Commins, Sean; O'Mara, Shane
Abstract:
Peripheral administration of lipopolysaccharide (LPS), a potent bacterial endotoxin, can cause a variety of central effects, including production of cytokines and cyclooxygenases in the brain, as well as peripheral increases in corticosterone. These, in turn, may contribute to neuroimmune-induced neurocognitive deficits. We show here LPS causes deficits in hippocampal-dependent spatial learning in the water maze but that treatment with ibuprofen, a broad-spectrum cyclooxygenase inhibitor, reverses the deficits induced in spatial learning by LPS. We also show that LPS causes an impairment in the induction of long-term potentiation in the dentate gyrus in vivo, a major contemporary model of learning and memory. No differences were found in corticosterone levels in trunk blood but we find a decrease in brain-derived neurotrophic factor (BDNF) expression in LPS group compared to saline controls. Paradoxically compared to the behavioral findings treatment with ibuprofen does not attenuat...
http://mural.maynoothuniversity.ie/10716/
Marked
Mark
Derived stimulus relations, semantic priming, and event-related potentials: testing a behavioral theory of semantic networks
(2018)
Barnes-Holmes, Dermot; Staunton, Carmel; Whelan, Robert; Barnes-Holmes, Yvonne; Commins...
Derived stimulus relations, semantic priming, and event-related potentials: testing a behavioral theory of semantic networks
(2018)
Barnes-Holmes, Dermot; Staunton, Carmel; Whelan, Robert; Barnes-Holmes, Yvonne; Commins, Sean; Walsh, Derek; Stewart, Ian; Smeets, Paul M; Dymond, Simon
Abstract:
Derived equivalence relations, it has been argued, provide a behavioral model of semantic or symbolic meaning in natural language, and thus equivalence relations should possess properties that are typically associated with semantic relations. The present study sought to test this basic postulate using semantic priming. Across three experiments, participants were trained and tested in two 4-member equivalence relations using word-like nonsense words. Participants also were exposed to a single- or two-word lexical decision task, and both direct (Experiment 1) and mediated (Experiments 2 and 3) priming effects for reaction times and event-related potentials were observed within but not across equivalence relations. The findings support the argument that derived equivalence relations provides a useful preliminary model of semantic relations.
http://hdl.handle.net/10379/8852
Marked
Mark
Derived Stimulus Relations, Semantic Priming, and Event-Related Potentials: Testing a Behavioral Theory of Semantic Networks
(2005)
Barnes-Holmes, Dermot; Staunton, Carmel; Whelan, Robert; Barnes-Holmes, Yvonne; Commins...
Derived Stimulus Relations, Semantic Priming, and Event-Related Potentials: Testing a Behavioral Theory of Semantic Networks
(2005)
Barnes-Holmes, Dermot; Staunton, Carmel; Whelan, Robert; Barnes-Holmes, Yvonne; Commins, Sean; Walsh, Derek; Stewart, Ian; Smeets, Paul M.; Dymond, Simon
Abstract:
Derived equivalence relations, it has been argued, provide a behavioral model of semantic or symbolic meaning in natural language, and thus equivalence relations should possess properties that are typically associated with semantic relations. The present study sought to test this basic postulate using semantic priming. Across three experiments, participants were trained and tested in two 4-member equivalence relations using word-like nonsense words. Participants also were exposed to a single- or two-word lexical decision task, and both direct (Experiment 1) and mediated (Experiments 2 and 3) priming effects for reaction times and event-related potentials were observed within but not across equivalence relations. The findings support the argument that derived equivalence relations provides a useful preliminary model of semantic relations.
http://mural.maynoothuniversity.ie/10703/
Marked
Mark
Differences in cue-dependent spatial navigation may be revealed by in-depth swimming analysis
(2009)
Harvey, Deirdre; Brant, Lesley; Commins, Sean
Differences in cue-dependent spatial navigation may be revealed by in-depth swimming analysis
(2009)
Harvey, Deirdre; Brant, Lesley; Commins, Sean
Abstract:
Several factors can influence allocentric navigation in the Morris water maze (MWM), including the number of available distal visual cues. Using in-depth analytical measures investigating platform-based and swimming behaviour, we examine and compare animals exposed to either one or three distal visual cues during MWM acquisition. We demonstrate that, although animals exposed to one cue can acquire the task as well as those in a multiple cue condition, several subtle differences between the groups’ swimming behaviours are noted. Both groups actively use cues to guide them to the platform, but changing the number of cues alters the animals’ patterns of behaviour, wherein exposure to a single cue leads to a simpler strategy in which the cue appears to act as a beacon for navigation.
http://mural.maynoothuniversity.ie/10697/
Marked
Mark
Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism
(2016)
Commins, Sean; Farina, Francesca
Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism
(2016)
Commins, Sean; Farina, Francesca
Abstract:
The objective of this study was to examine the effects of NMDAR and AMPAR antagonism on the expression of Zif268 and c-Fos in the hippocampus and medial prefrontal cortex during spatial memory encoding in rats trained in the Morris water maze. NMDAR inhibition impaired navigation and significantly attenuated expression of Zif268, but not c-Fos, in area CA1. AMPAR channel blockade had little effect on learning or IEG expression. Overall, Zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with Zif268 being more closely linked to spatial learning.
http://mural.maynoothuniversity.ie/10693/
Marked
Mark
Does prior sepsis alter subsequent circadian and sickness behaviour response to lipopolysaccharide treatment in mice?
(2015)
Anderson, Sean T.; O'Callaghan, Emma; Commins, Sean; Coogan, Andrew
Does prior sepsis alter subsequent circadian and sickness behaviour response to lipopolysaccharide treatment in mice?
(2015)
Anderson, Sean T.; O'Callaghan, Emma; Commins, Sean; Coogan, Andrew
Abstract:
Previous data has shown that prior history of immune challenge may affect central and behavioural responses to subsequent immune challenge, either leading to exaggerated responses via priming mechanisms or lessened responses via endotoxin tolerance. In this set of experiments we have examined how previously lipopolysaccharide (LPS)-induced sepsis shapes the response to subsequent treatment with lower dose LPS. After treatment with LPS (5 mg/kg) or saline mice were allowed to recover for 3–4 months before being challenged with a lower dose of LPS (100 μg/kg) for assessment of sickness behaviours. Performance on the open field test and the tail suspension test was assessed, and no evidence was found that prior sepsis altered sickness or depressive-like behaviour following LPS treatment. We then examined the responsiveness of the circadian system of mice to LPS. We found that in control animals, LPS induced a significant phase delay of the behavioural rhythm and that this was not the c...
http://mural.maynoothuniversity.ie/10710/
Marked
Mark
Dual-task and electrophysiological markers of executive cognitive processing in older adult gait and fall-risk
(2015)
Walshe, Elizabeth; Patterson, Matthew R.; Commins, Sean; Roche, Richard
Dual-task and electrophysiological markers of executive cognitive processing in older adult gait and fall-risk
(2015)
Walshe, Elizabeth; Patterson, Matthew R.; Commins, Sean; Roche, Richard
Abstract:
The role of cognition is becoming increasingly central to our understanding of the complexity of walking gait. In particular, higher-level executive functions are suggested to play a key role in gait and fall-risk, but the specific underlying neurocognitive processes remain unclear. Here, we report two experiments which investigated the cognitive and neural processes underlying older adult gait and falls. Experiment 1 employed a dual-task (DT) paradigm in young and older adults, to assess the relative effects of higher-level executive function tasks (n-Back, Serial Subtraction and visuo-spatial Clock task) in comparison to non-executive distracter tasks (motor response task and alphabet recitation) on gait. All DTs elicited changes in gait for both young and older adults, relative to baseline walking. Significantly greater DT costs were observed for the executive tasks in the older adult group. Experiment 2 compared normal walking gait, seated cognitive performances and concurrent e...
http://mural.maynoothuniversity.ie/10709/
Marked
Mark
Emergence of an egocentric cue guiding and allocentric inferring strategy that mirrors hippocampal brain-derived neurotrophic factor (BDNF) expression in the Morris water maze
(2008)
Harvey, Deirdre; McGauran, Anne-Marie T.; Murphy, Jonathan; Burns, Lauren; McMonagle, E...
Emergence of an egocentric cue guiding and allocentric inferring strategy that mirrors hippocampal brain-derived neurotrophic factor (BDNF) expression in the Morris water maze
(2008)
Harvey, Deirdre; McGauran, Anne-Marie T.; Murphy, Jonathan; Burns, Lauren; McMonagle, Eoghan; Commins, Sean
Abstract:
From insects to humans, successful navigation relies on retained representations of spatial relations. These representations are thought to depend on the hippocampal formation, particularly those that are independent of the navigator (allocentric representations). The Morris water maze is a simple and popular task often used to assess spatial navigation. But how animals navigate toward and retain information regarding the location of the goal in this task remains unclear. We provide a comprehensive account of how the water maze is accomplished behaviourally. Our findings suggest that animals solve the task using distal cues via an initial view-matching strategy that is supported by egocentric guidance. Through increased training, however, an emergence of an egocentric-guiding strategy combined with the animal’s greater ability to infer the hidden platform’s location (via allocentric extrapolation) emerges. We also demonstrate that behavioural changes, towards a more allocentric stra...
http://mural.maynoothuniversity.ie/10698/
Marked
Mark
Feedback control strategies for spatial navigation revealed by dynamic modelling of learning in the Morris water maze
(2011)
Fey, Dirk; Commins, Sean; Bullinger, Eric
Feedback control strategies for spatial navigation revealed by dynamic modelling of learning in the Morris water maze
(2011)
Fey, Dirk; Commins, Sean; Bullinger, Eric
Abstract:
The Morris water maze is an experimental procedure in which animals learn to escape swimming in a pool using environmental cues. Despite its success in neuroscience and psychology for studying spatial learning and memory, the exact mnemonic and navigational demands of the task are not well understood. Here, we provide a mathematical model of rat swimming dynamics on a behavioural level. The model consists of a random walk, a heading change and a feedback control component in which learning is reflected in parameter changes of the feedback mechanism. The simplicity of the model renders it accessible and useful for analysis of experiments in which swimming paths are recorded. Here, we used the model to analyse an experiment in which rats were trained to find the platform with either three or one extramaze cue. Results indicate that the 3-cues group employs stronger feedback relying only on the actual visual input, whereas the 1-cue group employs weaker feedback relying to some extent ...
http://mural.maynoothuniversity.ie/10713/
Marked
Mark
Frequency-dependent changes in synaptic plasticity and brain-derived neurotrophic factor (BDNF) expression in the CA1 to perirhinal cortex projection
(2010)
Kealy, John; Commins, Sean
Frequency-dependent changes in synaptic plasticity and brain-derived neurotrophic factor (BDNF) expression in the CA1 to perirhinal cortex projection
(2010)
Kealy, John; Commins, Sean
Abstract:
The ability of a synapse to be modulated both positively and negatively may be considered as a plausible model for the formation of learning and memory. The CA1 to perirhinal cortex projection is one of the multiple hippocampal–neocortical projections considered to be crucially involved in memory consolidation. We and others have previously demonstrated the ability of this projection to undergo long-term potentiation (LTP), however it is currently unknown whether the CA1-perirhinal projection can also be modified negatively (i.e. demonstrate long-term depression (LTD)). Here we investigate whether the CA1 to perirhinal projection in vivo in the anaesthetised animal shows a frequency-dependent pattern of synaptic plasticity that is coupled with brain-derived neurotrophic factor (BDNF) expression. Five groups of animals were used and each group underwent one of five different stimulation protocols (1 Hz, 5 Hz, 10 Hz, 50 Hz or 100 Hz) followed by poststimulation recordings at baseline ...
http://mural.maynoothuniversity.ie/5617/
Marked
Mark
High-density event-related potentials: Current theories and practice
(2006)
Roche, Richard; Scanlon, P.; Commins, Sean
High-density event-related potentials: Current theories and practice
(2006)
Roche, Richard; Scanlon, P.; Commins, Sean
Abstract:
Event-Related Potentials (ERPs) are changes in the ongoing electrical activity of the brain (Electroencephalograms, or EEGs) which are caused by the specific occurrence of a cognitive, motor or perceptual event. Any changes in EEG due to the demands of the task are amplified, averaged and extracted as ERP waveforms (see Figure 1). These wave-forms are measured as the difference between the electrical activity of a baseline reference electrode attached to an electrically inactive site, such as the mastoid bone below the ear or the naison on the nose, and the electrical activity of the areas of the brain covered by the electrodes. These changes allow neuroscientists to determine what areas of brain are being stimulated at a given time (and therefore which brain areas are involved in a given process), precisely when these areas become activated and what happens in these areas when people make an error.
http://mural.maynoothuniversity.ie/1019/
Marked
Mark
High-resolution ERP mapping of cortical activation related to implicit object-location memory
(2009)
Murphy, Johathan S.; Wynne, Ciara; O'Rourke, Edel M.; Commins, Sean; Roche, Richard
High-resolution ERP mapping of cortical activation related to implicit object-location memory
(2009)
Murphy, Johathan S.; Wynne, Ciara; O'Rourke, Edel M.; Commins, Sean; Roche, Richard
Abstract:
High-density event-related potentials (ERPs) were recorded during an object recognition task which involved task-irrelevant changes in the location of studied objects. Participants categorised objects as studied or novel while data were analysed to ascertain the effect of the location changes on performance and waveform topography. Our results indicate that humans can classify objects faster and more accurately when using implicit spatial memory. Individual differences observed in object recognition proficiency were absent if objects were presented in their ‘correct’ location. In a second experiment we replicated the behavioural findings while manipulating viewpoint to discount scene recognition as an underlying factor. We propose a model which includes activation of the right medial temporal lobe prior to P300 elicitation to account for the prophylactic effect of implicit processing on object recognition. Hemispheric differences in parietal componentry dependant on sex of participa...
http://mural.maynoothuniversity.ie/10695/
Marked
Mark
Hippocampal contribution to vector model hypothesis during cue-dependent navigation
(2013)
Diviney, Mairead; Fey, Dirk; Commins, Sean
Hippocampal contribution to vector model hypothesis during cue-dependent navigation
(2013)
Diviney, Mairead; Fey, Dirk; Commins, Sean
Abstract:
Learning to navigate toward a goal is an essential skill. Place learning is thought to rely on the ability of animals to associate the location of a goal with surrounding environmental cues. Using the Morris water maze, a task popularly used to examine place learning, we demonstrate that distal cues provide animals with distance and directional information. We show how animals use the cues in a visually dependent guidance manner to find the goal. Further, we demonstrate how hippocampal lesions disrupt this learning mechanism. Our results can be explained through the vector model of navigation built on associative learning principles rather than evoking a cognitive map.
http://mural.maynoothuniversity.ie/4436/
Marked
Mark
Hippocampal contributions to neurocognitive mapping in humans: A new model
(2006)
Roche, Richard; Mangaoang, Maeve A.; Commins, Sean; O'Mara, Shane
Hippocampal contributions to neurocognitive mapping in humans: A new model
(2006)
Roche, Richard; Mangaoang, Maeve A.; Commins, Sean; O'Mara, Shane
Abstract:
The ability of an organism to develop, maintain, and act upon an abstracted internal representation of spatially extensive environments can provide an increased chance in ensuring that organism's survival. Here, we propose a neurocognitive model of spatial representation describing how several different processes interact and segregate the differing types of information used to produce a unified cognitive map. This model proposes that view‐based egocentric and vestibulomotor translational information are functionally and anatomically separate, and that these parallel systems result in independent, but interacting, models within a neurocognitive map of space. In this context, we selectively review relevant portions of the large literature, addressing the establishment and operation of such spatial constructs in humans and the brain systems that underpin them, with particular reference to the hippocampal formation (HF). We present a reinterpretation of the types of knowledge used...
http://mural.maynoothuniversity.ie/10696/
Marked
Mark
Human locomotion of a route assists in subsequent blind navigation
(2006)
Roche, Richard; Murphy, J.; O'Riordan, K.; Glad, K.; Commins, Sean; Mangaoang, Mae...
Human locomotion of a route assists in subsequent blind navigation
(2006)
Roche, Richard; Murphy, J.; O'Riordan, K.; Glad, K.; Commins, Sean; Mangaoang, Maeve A.; O'Mara, S.M.
Abstract:
Human spatial navigation requires the establishment of a sophisticated internal representation of the environment, termed the cognitive map. Non-visual navigation requires individuals to rely on their stored model of the world in order to avoid obstacles and navigate successfully.
http://mural.maynoothuniversity.ie/1013/
Marked
Mark
Interaction between paired-pulse facilitation and long-term potentiation in the projection from hippocampal area CA1 to the entorhinal cortex
(2005)
Craig, Sarah; Commins, Sean
Interaction between paired-pulse facilitation and long-term potentiation in the projection from hippocampal area CA1 to the entorhinal cortex
(2005)
Craig, Sarah; Commins, Sean
Abstract:
The hippocampus communicates with the neocortex via the entorhinal cortex and is thought to be critically involved in the consolidation of memories. This paper contains in vivo evidence of a projection from the hippocampal area CA1 to the entorhinal cortex. Current theories of memory formation suggest that the backprojections from the hippocampus to the neocortex should undergo some form of plastic change in order that memories become consolidated. Paired-pulse facilitation (PPF) and long-term potentiation (LTP) are forms of short- and long-term plasticity, respectively. We show that the CA1 to entorhinal cortex projection is capable of sustaining PPF over a wide range of stimulus intervals. In addition we demonstrate that following high frequency stimulation of this pathway the evoked response in the entorhinal cortex remains potentiated for at least 30 min. Finally, we demonstrate that PPF changes following LTP depending on the initial ratio of PPF, suggesting that LTP expression ...
http://mural.maynoothuniversity.ie/10700/
Displaying Results 1 - 25 of 48 on page 1 of 2
1
2
Bibtex
CSV
EndNote
RefWorks
RIS
XML
Institution
Lenus (1)
Maynooth University (45)
NUI Galway (2)
Item Type
Journal article (47)
Other (1)
Peer Review Status
Peer-reviewed (45)
Unknown (3)
Year
2020 (1)
2019 (1)
2018 (3)
2017 (2)
2016 (3)
2015 (4)
2014 (3)
2013 (2)
2012 (1)
2011 (2)
2010 (1)
2009 (3)
2008 (3)
2007 (2)
2006 (7)
2005 (6)
2004 (2)
2003 (1)
2002 (1)
built by Enovation Solutions