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Limited By:	Author = Hill, Arnold DK;

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A comparison of performances of consultant surgeons, NCHDs and medical students in a modified HPAT examination. (2010)

Quinn, Alison; Corrigan, Mark A; Broderick, J; McEntee, G; Hill, Arnold DK

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A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44 (2014)

Babina, Irina S; McSherry, Elaine A; Donatello, Simona; Hill, Arnold DK; Hopkins, Ann M

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A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44. (2014)

Babina, Irina S; McSherry, Elaine A; Donatello, Simona; Hill, Arnold DK; Hopkins, Ann M

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A targeted e-learning program for surgical trainees to enhance patient safety in preventing surgical infection. (2010)

McHugh, Seamus M; Corrigan, Mark; Dimitrov, Borislav D; Cowman, Seamus; Tierney, Sean; ...

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An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models. (2011)

Donatello, Simona; Hudson, Lance; Cottell, David C; Blanco, Alfonso; Aurrekoetxea, Igor...

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Assessing the functional performance of post-call hospital doctors using a Nintendo Wii. (2011)

Clancy, K; Brady, P; McHugh, Seamus M; Corrigan, Mark A; Sheikh, Athar S; Lehane, Elain...

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Bare Below the Elbows: A comparative study of a tertiary and district general hospital. (2013)

Collins, Anne M; Connaughton, James; Hill, Arnold DK; Ridgway, Paul F

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Breaking Barriers to Successful Implementation of Day Case Laparoscopic Cholecystectomy. (2015)

Reynolds, Ian; Bolger, Jarlath; Al-Hilli, Z; Hill, Arnold DK

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Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase. (2011)

McSherry, Elaine A; Brennan, Kieran; Hudson, Lance; Hill, Arnold DK; Hopkins, Ann M

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CA 15-3 is predictive of response and disease recurrence following treatment in locally advanced breast cancer. (2006)

Al-azawi, Dhafir; Kelly, Gabrielle; Myers, Eddie; McDermott, Enda W; Hill, Arnold DK; D...

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Chlorhexidine-alcohol versus povidone-iodine for pre-operative skin preparation: A systematic review and meta-analysis. (2015)

Ayoub, Firas; Quirke, Michael; Conroy, Ronan; Hill, Arnold DK

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Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings. (2018)

Leech, Astrid O; Vellanki, Sri HariKrishna; Rutherford, Emily J; Keogh, Aoife; Jahns, H...

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Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours. (2011)

Caiazza, Francesco; McCarthy, Nina S; Young, Leonie; Hill, Arnold DK; Harvey, Brian J; ...

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Development and validation of a clinical prediction rule to identify suspected breast cancer: a prospective cohort study. (2014)

Galvin, Rose; Joyce, Doireann; Downey, Eithne; Boland, Fiona; Fahey, Tom; Hill, Arnold DK

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Evaluation of medical student retention of clinical skills following simulation training. (2019)

Offiah, Gozie; Ekpotu, Lenin P; Murphy, Siobhan; Kane, Daniel; Gordon, Alison; O'S...

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Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies. (2017)

Toomey, Sinead; Eustace, Alex J; Fay, Joanna; Sheehan, Katherine M; Carr, Aoife; Milews...

Toomey, Sinead; Eustace, Alex J; Fay, Joanna; Sheehan, Katherine M; Carr, Aoife; Milewska, Malgorzata; Madden, Stephen F; Teiserskiene, Ausra; Kay, Elaine W; O'Donovan, Norma; Gallagher, William; Grogan, Liam; Breathnach, Oscar; Walshe, Janice; Kelly, Catherine; Moulton, Brian; Kennedy, M John; Gullo, Guiseppe; Hill, Arnold DK; Power, Colm

Abstract:

The original article is available at www.biomedcentral.com
BACKGROUND: The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations (ERBB family mutations) occur alone or co-occur with somatic mutations in the gene encoding the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) in 19% of human epidermal growth factor receptor 2 (HER2)-positive breast cancers. Because ERBB family mutations can activate the PI3K/AKT pathway and likely have similar canonical signalling effects to PI3K pathway mutations, we investigated their combined impact on response to neoadjuvant HER2-targeted therapies. METHODS: Baseline tumour biopsies were available from 74 patients with HER2-positive breast cancer who were enrolled in the phase II TCHL neoadjuvant study (ICORG 10-05) assessing TCH (...