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Author = Hill, Arnold DK;
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Displaying Results 1 - 25 of 32 on page 1 of 2
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A comparison of performances of consultant surgeons, NCHDs and medical students in a modified HPAT examination.
(2010)
Quinn, Alison; Corrigan, Mark A; Broderick, J; McEntee, G; Hill, Arnold DK
A comparison of performances of consultant surgeons, NCHDs and medical students in a modified HPAT examination.
(2010)
Quinn, Alison; Corrigan, Mark A; Broderick, J; McEntee, G; Hill, Arnold DK
Abstract:
<p>The original article is avaliable at <a href="http://www.imj.ie">www.imj.ie</a></p>
<p>Following the implementation of the Fottrell report, entry to medical school in Ireland has undergone significant change. Medical school studentship is now awarded based on a combination of points obtained from the final examination of Irish secondary schools (the leaving certificate) combined with HPAT scores (Health Professions Admissions Test). The HPAT is designed to test a candidate's knowledge in several different fields including problem solving skills, logical and non verbal reasoning. A sample HPAT was administered to a test group composed of consultant surgeons, non consultant hospital doctors, and medical students. Statistical analysis was performed and no significant difference was found between the performances of the groups. This is surprising as it was expected that groups with greater experience at medical problem solving would ha...
https://epubs.rcsi.ie/surgart/18
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A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44
(2014)
Babina, Irina S; McSherry, Elaine A; Donatello, Simona; Hill, Arnold DK; Hopkins, Ann M
A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44
(2014)
Babina, Irina S; McSherry, Elaine A; Donatello, Simona; Hill, Arnold DK; Hopkins, Ann M
Abstract:
Abstract Introduction Most breast cancer-related deaths result from metastasis, a process involving dynamic regulation of tumour cell adhesion and migration. The adhesion protein CD44, a key regulator of cell migration, is enriched in cholesterol-enriched membrane microdomains termed lipid rafts. We recently reported that raft affiliation of CD44 negatively regulates interactions with its migratory binding partner ezrin. Since raft affiliation is regulated by post-translational modifications including palmitoylation, we sought to establish the contribution of CD44 palmitoylation and lipid raft affiliation to cell migration. Methods Recovery of CD44 and its binding partners from raft versus non-raft membrane microdomains was profiled in non-migrating and migrating breast cancer cell lines. Site-directed mutagenesis was used to introduce single or double point mutations into both CD44 palmitoylation sites (Cys286 and Cys295), where...
http://dx.doi.org/10.1186/bcr3614
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A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44.
(2014)
Babina, Irina S; McSherry, Elaine A; Donatello, Simona; Hill, Arnold DK; Hopkins, Ann M
A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44.
(2014)
Babina, Irina S; McSherry, Elaine A; Donatello, Simona; Hill, Arnold DK; Hopkins, Ann M
Abstract:
<p>The original article is available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>INTRODUCTION: Most breast cancer-related deaths result from metastasis, a process involving dynamic regulation of tumour cell adhesion and migration. The adhesion protein CD44, a key regulator of cell migration, is enriched in cholesterol-enriched membrane microdomains termed lipid rafts. We recently reported that raft affiliation of CD44 negatively regulates interactions with its migratory binding partner ezrin. Since raft affiliation is regulated by post-translational modifications including palmitoylation, we sought to establish the contribution of CD44 palmitoylation and lipid raft affiliation to cell migration.</p> <p>METHODS: Recovery of CD44 and its binding partners from raft versus non-raft membrane microdomains was profiled in non-migrating and migrating breast cancer cell lines. Site-directed mutagenesis was...
https://epubs.rcsi.ie/surgart/21
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A targeted e-learning program for surgical trainees to enhance patient safety in preventing surgical infection.
(2010)
McHugh, Seamus M; Corrigan, Mark; Dimitrov, Borislav D; Cowman, Seamus; Tierney, Sean; ...
A targeted e-learning program for surgical trainees to enhance patient safety in preventing surgical infection.
(2010)
McHugh, Seamus M; Corrigan, Mark; Dimitrov, Borislav D; Cowman, Seamus; Tierney, Sean; Humphreys, Hilary; Hill, Arnold DK
Abstract:
<p>This article is also available from <a href="http://onlinelibrary.wiley.com/">http://onlinelibrary.wiley.com</a></p>
<p>INTRODUCTION: Surgical site infection accounts for 20% of all health care-associated infections (HCAIs); however, a program incorporating the education of surgeons has yet to be established across the specialty.</p> <p>METHODS: An audit of surgical practice in infection prevention was carried out in Beaumont Hospital from July to November 2009. An educational Web site was developed targeting deficiencies highlighted in the audit. Interactive clinical cases were constructed using PHP coding, an HTML-embedded language, and then linked to a MySQL relational database. PowerPoint tutorials were produced as online Flash audiovisual movies. An online repository of streaming videos demonstrating best practice was made available, and weekly podcasts were made available on the iTunes© store for free download. Usage o...
https://epubs.rcsi.ie/gpart/23
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An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models.
(2011)
Donatello, Simona; Hudson, Lance; Cottell, David C; Blanco, Alfonso; Aurrekoetxea, Igor...
An imbalance in progenitor cell populations reflects tumour progression in breast cancer primary culture models.
(2011)
Donatello, Simona; Hudson, Lance; Cottell, David C; Blanco, Alfonso; Aurrekoetxea, Igor; Shelly, Martin J; Dervan, Peter A; Kell, Malcolm R; Stokes, Maurice; Hill, Arnold DK; Hopkins, Ann M
Abstract:
<p>This article is also available from <a href="http://www.jeccr.com/content/pdf/1756-9966-30-45.pdf?bcsi_scan_A676AEF22227A21F=Kf3iE/S/sY/o/F74L1n9XdBnJTABAAAAnQ8GAA==&bcsi_scan_filename=1756-9966-30-45.pdf">http://www.jeccr.com/content/pdf/1756-9966-30-45</a></p>
<p>ABSTRACT: BACKGROUND: Many factors influence breast cancer progression, including the ability of progenitor cells to sustain or increase net tumour cell numbers. Our aim was to define whether alterations in putative progenitor populations could predict clinicopathological factors of prognostic importance for cancer progression. METHODS: Primary cultures were established from human breast tumour and adjacent non-tumour tissue. Putative progenitor cell populations were isolated based on co-expression or concomitant absence of the epithelial and myoepithelial markers EPCAM and CALLA respectively. RESULTS: Significant reductions in cellular senescence were observed in tumour ...
https://epubs.rcsi.ie/surgart/6
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Assessing the functional performance of post-call hospital doctors using a Nintendo Wii.
(2011)
Clancy, K; Brady, P; McHugh, Seamus M; Corrigan, Mark A; Sheikh, Athar S; Lehane, Elain...
Assessing the functional performance of post-call hospital doctors using a Nintendo Wii.
(2011)
Clancy, K; Brady, P; McHugh, Seamus M; Corrigan, Mark A; Sheikh, Athar S; Lehane, Elaine; Hill, Arnold DK
Abstract:
<p>The original article is available at <a href="http://www.imj.ie">www.imj.ie</a></p>
<p>Sleep deprivation is an established part of the working life for Non-Consultant Hospital Doctors (NCHDs) in Ireland. Concern exists about the effect of extended NCHD work hours. We utilised a Nintendo Wii to evaluate motor function of NCHDs both prior to their on-call shift and the day afterwards. Data was exported to SPSS ver. 15 for statistical analysis with p < 0.05 considered significant. A total of 72 NCHDs were invited to participate in this study. There was a 62.5% (45) rate of follow-up. Overall 27 (60%) NCHDs were on medical call, with 18 (40%) on surgical call. There was no statistically significant difference between NCHDs pre-and post-call motor assessment scores. The majority of study participants (75.5%, n = 34) had four or more hours sleep. On-call duty allows for a greater than anticipated amount of sleep per on-call shift and there...
https://epubs.rcsi.ie/surgart/16
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Bare Below the Elbows: A comparative study of a tertiary and district general hospital.
(2013)
Collins, Anne M; Connaughton, James; Hill, Arnold DK; Ridgway, Paul F
Bare Below the Elbows: A comparative study of a tertiary and district general hospital.
(2013)
Collins, Anne M; Connaughton, James; Hill, Arnold DK; Ridgway, Paul F
Abstract:
<p>The original article is available at www.imj.ie</p>
<p>A 'Bare Below the Elbows' (BBTE) dress code policy has been introduced by the majority of NHS trusts in the UK. The aim of this Irish study was to evaluate the impact of an educational intervention on perception of medical attire. The study was carried out in two centres: a tertiary referral centre (Beaumont Hospital) and a district hospital (MRH, Portlaoise). Two questionnaires, incorporating photographic evaluation of appropriate attire for consultants and junior doctors, were completed pre and post BBTE education. One hundred and five patients participated. Analysis pre BBTE education indicated patients considered formal attire and white coats most appropriate for consultants and junior doctors respectively. Post-intervention analysis revealed a significant reduction in the popularity of both (p</p>
https://epubs.rcsi.ie/surgart/37
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Breaking Barriers to Successful Implementation of Day Case Laparoscopic Cholecystectomy.
(2015)
Reynolds, Ian; Bolger, Jarlath; Al-Hilli, Z; Hill, Arnold DK
Breaking Barriers to Successful Implementation of Day Case Laparoscopic Cholecystectomy.
(2015)
Reynolds, Ian; Bolger, Jarlath; Al-Hilli, Z; Hill, Arnold DK
Abstract:
<p>The original article is available at www.imj.ie</p>
<p>Laparoscopic cholecystectomy is a common procedure performed in both emergency and elective settings. Our aim was to analyse the trends in laparoscopic surgery in Ireland in the public and private healthcare systems. In particular we studied the trend in day case laparoscopic cholecystectomy. National HIPE data for the years 2010-2012 was obtained. Similar datasets were obtained from the three main health insurers. 19,214 laparoscopic cholecystectomies were carried out in Ireland over the 3-year period. More procedures were performed in the public system than the private system from 2010-2012. There was a steady increase in surgeries performed in the public sector, while the private sector remained static. Although the ALOS was significantly higher in the public sector, there was an increase in the rate of day case procedures from 416 (13%) to 762 (21.9%). The day case rates in private hospitals increase...
https://epubs.rcsi.ie/surgart/36
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Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase.
(2011)
McSherry, Elaine A; Brennan, Kieran; Hudson, Lance; Hill, Arnold DK; Hopkins, Ann M
Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase.
(2011)
McSherry, Elaine A; Brennan, Kieran; Hudson, Lance; Hill, Arnold DK; Hopkins, Ann M
Abstract:
<p>This article is also available from <a href="http://breast-cancer-research.com/content/pdf/bcr2853.pdf">http://breast-cancer-research.com/content/pdf/bcr2853.pdf</a></p>
<p>ABSTRACT: INTRODUCTION: The adhesion protein junctional adhesion molecule-A (JAM-A) regulates epithelial cell morphology and migration, and its over-expression has recently been linked with increased risk of metastasis in breast cancer patients. As cell migration is an early requirement for tumor metastasis, we sought to identify the JAM-A signalling events regulating migration in breast cancer cells. METHODS: MCF7 breast cancer cells (which express high endogenous levels of JAM-A) and primary cultures from breast cancer patients were used for this study. JAM-A was knocked down in MCF7 cells using siRNA to determine the consequences for cell adhesion, cell migration and the protein expression of various integrin subunits. As we had previously demonstrated a link betw...
https://epubs.rcsi.ie/surgart/5
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CA 15-3 is predictive of response and disease recurrence following treatment in locally advanced breast cancer.
(2006)
Al-azawi, Dhafir; Kelly, Gabrielle; Myers, Eddie; McDermott, Enda W; Hill, Arnold DK; D...
CA 15-3 is predictive of response and disease recurrence following treatment in locally advanced breast cancer.
(2006)
Al-azawi, Dhafir; Kelly, Gabrielle; Myers, Eddie; McDermott, Enda W; Hill, Arnold DK; Duffy, Michael J; Higgins, Niall O
Abstract:
<p>This article is also available from www.biomedcentral.com</p>
<p>BACKGROUND: Primary chemotherapy (PC) is used for down-staging locally advanced breast cancer (LABC). CA 15-3 measures the protein product of the MUC1 gene and is the most widely used serum marker in breast cancer.</p> <p>METHODS: We retrospectively investigated the role of CA 15-3 in conjunction with other clinico-pathological variables as a predictor of response and time to disease recurrence following treatment in LABC. Pre and post primary chemotherapy serum concentrations of CA 15-3 together with other variables were reviewed and related to four outcomes following primary chemotherapy (clinical response, pathological response, time to recurrence and time to progression). Persistently elevated CA 15-3 after PC was considered as consecutively high levels above the cut off point during and after PC.</p> <p>RESULTS: 73 patients were included in this study. Patients rece...
https://epubs.rcsi.ie/surgart/9
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Chlorhexidine-alcohol versus povidone-iodine for pre-operative skin preparation: A systematic review and meta-analysis.
(2015)
Ayoub, Firas; Quirke, Michael; Conroy, Ronan; Hill, Arnold DK
Chlorhexidine-alcohol versus povidone-iodine for pre-operative skin preparation: A systematic review and meta-analysis.
(2015)
Ayoub, Firas; Quirke, Michael; Conroy, Ronan; Hill, Arnold DK
Abstract:
<p>The original article is available at http://www.sciencedirect.com</p>
<p><strong>Background:</strong> Surgical site infection (SSI) is a dreaded postoperative complication. Although preoperative skin cleansing in order to prevent surgical site infection (SSI) is standard surgical practice, there is clinical equipoise concerning whether povidone iodine (PI) or chlorhexidine alcohol (CHA) is the antiseptic agent of choice.</p> <p><strong>Objectives:</strong> To determine whether CHA or PI is the preferred preoperative skin preparation for reducing SSI in clean, clean-contaminated and contaminated surgery.</p> <p><strong>Search methods:</strong> PubMed, Embase, and gray literature sources were searched for randomized controlled trials (RCTs) comparing both CHA and PI between 1980 and 2014. Comparative RCTs of preoperative CHA versus PI studying SSI in clean, clean-contaminated and contaminated surgery ...
https://epubs.rcsi.ie/surgart/43
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Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings.
(2018)
Leech, Astrid O; Vellanki, Sri HariKrishna; Rutherford, Emily J; Keogh, Aoife; Jahns, H...
Cleavage of the extracellular domain of junctional adhesion molecule-A is associated with resistance to anti-HER2 therapies in breast cancer settings.
(2018)
Leech, Astrid O; Vellanki, Sri HariKrishna; Rutherford, Emily J; Keogh, Aoife; Jahns, Hanne; Hudson, Lance; O'Donovan, Norma; Sabri, Siham; Abdulkarim, Bassam; Sheehan, Katherine M; Kay, Elaine W; Young, Leonie S; Hill, Arnold DK; Smith, Yvonne E; Hopkins, Ann M
Abstract:
<p>The original article is available at <a href="https://www.biomedcentral.com/">www.biomedcentral.com</a></p>
<p><strong>BACKGROUND:</strong> Junctional adhesion molecule-A (JAM-A) is an adhesion molecule whose overexpression on breast tumor tissue has been associated with aggressive cancer phenotypes, including human epidermal growth factor receptor-2 (HER2)-positive disease. Since JAM-A has been described to regulate HER2 expression in breast cancer cells, we hypothesized that JAM-dependent stabilization of HER2 could participate in resistance to HER2-targeted therapies.</p> <p><strong>METHODS:</strong> Using breast cancer cell line models resistant to anti-HER2 drugs, we investigated JAM-A expression and the effect of JAM-A silencing on biochemical/functional parameters. We also tested whether altered JAM-A expression/processing underpinned differences between drug-sensitive and -resistant cells and ...
https://epubs.rcsi.ie/surgart/50
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Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours.
(2011)
Caiazza, Francesco; McCarthy, Nina S; Young, Leonie; Hill, Arnold DK; Harvey, Brian J; ...
Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours.
(2011)
Caiazza, Francesco; McCarthy, Nina S; Young, Leonie; Hill, Arnold DK; Harvey, Brian J; Thomas, Warren
Abstract:
<p>This article is also available at <a href="http://www.nature.com">http://www.nature.com</a></p>
<p>BACKGROUND: The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression correlated with EGFR/HER2 over-expression in a small number of breast cancer cell lines.</p> <p>METHODS: The importance of differential cPLA(2)α activity in clinical breast cancer was established by relating the expression of cPLA(2)α in tissue samples from breast cancer patients, and two microarray-based gene expression datasets to different clinicopathological and therapeutic parameters.</p> <p>RESULTS: High cPLA(2)α mRNA expression correlated with clinical parameters of poor prognosis, which are charac...
https://epubs.rcsi.ie/molmedart/9
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Development and validation of a clinical prediction rule to identify suspected breast cancer: a prospective cohort study.
(2014)
Galvin, Rose; Joyce, Doireann; Downey, Eithne; Boland, Fiona; Fahey, Tom; Hill, Arnold DK
Development and validation of a clinical prediction rule to identify suspected breast cancer: a prospective cohort study.
(2014)
Galvin, Rose; Joyce, Doireann; Downey, Eithne; Boland, Fiona; Fahey, Tom; Hill, Arnold DK
Abstract:
<p>The original article is available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND: The number of primary care referrals of women with breast symptoms to symptomatic breast units (SBUs) has increased exponentially in the past decade in Ireland. The aim of this study is to develop and validate a clinical prediction rule (CPR) to identify women with breast cancer so that a more evidence based approach to referral from primary care to these SBUs can be developed.</p> <p>METHODS: We analysed routine data from a prospective cohort of consecutive women reviewed at a SBU with breast symptoms. The dataset was split into a derivation and validation cohort. Regression analysis was used to derive a CPR from the patient's history and clinical findings. Validation of the CPR consisted of estimating the number of breast cancers predicted to occur compared with the actual number of observed breast ...
https://epubs.rcsi.ie/gpart/53
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Evaluation of medical student retention of clinical skills following simulation training.
(2019)
Offiah, Gozie; Ekpotu, Lenin P; Murphy, Siobhan; Kane, Daniel; Gordon, Alison; O'S...
Evaluation of medical student retention of clinical skills following simulation training.
(2019)
Offiah, Gozie; Ekpotu, Lenin P; Murphy, Siobhan; Kane, Daniel; Gordon, Alison; O'Sullivan, Muireann; Sharifuddin, Sue Faye; Hill, Arnold DK; Condron, Claire M
Abstract:
<p>The original article is available at <a href="https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-019-1663-2">www.biomedcentral.com</a></p>
<p><strong>BACKGROUND:</strong> Adequate clinical skills training is a challenge for present day medical education. Simulation Based Education (SBE) is playing an increasingly important role in healthcare education worldwide to teach invasive procedures. The impact of this teaching on students along with retention of what is taught is not fully understood. The purpose of this study was to evaluate the retention levels of practical skills taught and assessed by SBE and to explore the degree of re-training required to restore decayed performance. In exploring this aim, the study further investigates how skilled performance decays over time and which dimensions of clinical skills were more likely to decay.</p> <p><strong>METHODS:</strong> Study participants ...
https://epubs.rcsi.ie/surgart/54
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Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies.
(2017)
Toomey, Sinead; Eustace, Alex J; Fay, Joanna; Sheehan, Katherine M; Carr, Aoife; Milews...
Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies.
(2017)
Toomey, Sinead; Eustace, Alex J; Fay, Joanna; Sheehan, Katherine M; Carr, Aoife; Milewska, Malgorzata; Madden, Stephen F; Teiserskiene, Ausra; Kay, Elaine W; O'Donovan, Norma; Gallagher, William; Grogan, Liam; Breathnach, Oscar; Walshe, Janice; Kelly, Catherine; Moulton, Brian; Kennedy, M John; Gullo, Guiseppe; Hill, Arnold DK; Power, Colm
Abstract:
<p>The original article is available at www.biomedcentral.com</p>
<p>BACKGROUND: The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations (ERBB family mutations) occur alone or co-occur with somatic mutations in the gene encoding the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) in 19% of human epidermal growth factor receptor 2 (HER2)-positive breast cancers. Because ERBB family mutations can activate the PI3K/AKT pathway and likely have similar canonical signalling effects to PI3K pathway mutations, we investigated their combined impact on response to neoadjuvant HER2-targeted therapies.</p> <p>METHODS: Baseline tumour biopsies were available from 74 patients with HER2-positive breast cancer who were enrolled in the phase II TCHL neoadjuvant study (ICORG 10-05) assessing TCH (...
https://epubs.rcsi.ie/molmedart/35
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Introducing the physician associate role in Ireland: Evaluation of a hospital based pilot project
(2019)
Joyce, Pauline; Hooker, Roderick S; Woodmansee, Denni; Hill, Arnold DK
Introducing the physician associate role in Ireland: Evaluation of a hospital based pilot project
(2019)
Joyce, Pauline; Hooker, Roderick S; Woodmansee, Denni; Hill, Arnold DK
Abstract:
<p>The original article is available at <a href="http://www.sciedu.ca/journal/index.php/jha/article/view/14753">www.sciedu.ca</a></p>
<p><strong>Objective:</strong> Ireland has medical workforce challenges and a growing demand for services. One strategy is to include Physician Associates (PAs) in healthcare settings. A pilot study was undertaken with PAs recruited from North America and the United Kingdom to work in a large Dublin teaching hospital.</p> <p><strong>Methods:</strong> Four PAs were deployed on surgical services. Communication with the hospital staff preceded their employment. A series of interviews were undertaken at the beginning [2015] and end [2017] of the project. Data collection included surveys and interviews with staff and PAs.</p> <p><strong>Results:</strong> Despite a series of communications about the employment of PAs a lack of awareness among hospital sta...
https://epubs.rcsi.ie/smedart/13
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Junctional adhesion molecule-A is co-expressed with HER2 in breast tumors and acts as a novel regulator of HER2 protein degradation and signaling.
(2012)
Brennan, Kieran; McSherry, Elaine A; Hudson, Lance; Kay, Elaine W; Hill, Arnold DK; You...
Junctional adhesion molecule-A is co-expressed with HER2 in breast tumors and acts as a novel regulator of HER2 protein degradation and signaling.
(2012)
Brennan, Kieran; McSherry, Elaine A; Hudson, Lance; Kay, Elaine W; Hill, Arnold DK; Young, Leonie S; Hopkins, Ann M
Abstract:
<p>This article is also available at <a href="http://www.ncbi.nlm.nih.gov/pubmed/22751120">http://www.ncbi.nlm.nih.gov/pubmed/22751120</a> or <a href="http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2012276a.html">http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2012276a.html</a></p>
<p>Junctional adhesion molecule-A (JAM-A) is a membranous cell-cell adhesion protein involved in tight-junction formation in epithelial and endothelial cells. Its overexpression in breast tumors has recently been linked with increased risk of metastasis. We sought to identify if JAM-A overexpression was associated with specific subtypes of breast cancer as defined by the expression of human epidermal growth factor receptor-2 (HER2), estrogen receptor (ER) and progesterone receptor. To this end, JAM-A immunohistochemistry was performed in two breast cancer tissue microarrays. In parallel, cross-talk between JAM-A, HER2 and E...
https://epubs.rcsi.ie/surgart/13
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Lipid Raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.
(2012)
Donatello, Simona; Babina, Irina S; Hazelwood, Lee D; Hill, Arnold DK; Nabi, Ivan R; Ho...
Lipid Raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.
(2012)
Donatello, Simona; Babina, Irina S; Hazelwood, Lee D; Hill, Arnold DK; Nabi, Ivan R; Hopkins, Ann M
Abstract:
<p>This article is also available at <a href="http://www.sciencedirect.com/science/article/pii/S0002944012006670">http://www.sciencedirect.com/science/article/pii/S0002944012006670</a> or <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502863/">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502863/</a></p>
<p>Cancer cell migration is an early event in metastasis, the main cause of breast cancer-related deaths. Cholesterol-enriched membrane domains called lipid rafts influence the function of many molecules, including the raft-associated protein CD44. We describe a novel mechanism whereby rafts regulate interactions between CD44 and its binding partner ezrin in migrating breast cancer cells. Specifically, in nonmigrating cells, CD44 and ezrin localized to different membranous compartments: CD44 predominantly in rafts, and ezrin in nonraft compartments. After the induction of migration (either nonspecific or CD44-dr...
https://epubs.rcsi.ie/surgart/12
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Patient Willingness to be Seen by a Physician Associate in Ireland
(2018)
Joyce, Pauline; Arnett, Richard; Hill, Arnold DK; Hooker, Roderick S
Patient Willingness to be Seen by a Physician Associate in Ireland
(2018)
Joyce, Pauline; Arnett, Richard; Hill, Arnold DK; Hooker, Roderick S
Abstract:
<p>The original article is available at <a href="http://www.sciedupress.com">http://www.sciedupress.com</a></p>
<p><strong>Background: </strong>The physician associate (PA) role was piloted in Dublin, Ireland between 2015 and 2017. However, the concept of a PA and the acceptance of their role in Ireland had not been previously explored.</p> <p><strong>Objective:</strong> To investigate the willingness of Irish citizens to be seen by a PA based on medical scenarios in a typical clinical setting.</p> <p><strong>Design:</strong> A mixed methods study was undertaken. A preference survey, with three medical scenarios, gave participants a choice to be treated by a PA or a doctor, with two time trade-off options offered. Responses were supported with qualitative text. Four hundred people were invited to participate as surrogate patients.</p> <p><strong>Setting and parti...
https://epubs.rcsi.ie/smedart/10
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Preparing students to be doctors: introduction of a sub-internship program.
(2009)
Robb, William B; Falk, Gavin A; Khan, W H; Hill, Arnold DK
Preparing students to be doctors: introduction of a sub-internship program.
(2009)
Robb, William B; Falk, Gavin A; Khan, W H; Hill, Arnold DK
Abstract:
<p>The origingal article is available at <a href="http://www.imj.ie">www.imj.ie</a></p>
<p>Preparing graduates for the transformation from medical student to doctor provides medical schools with a real challenge. Medical educators advocate a process of graduated delegation of responsibility in the clinical years of medical school. This is best exemplified in the North American system of sub-internship programmes; an educational approach which European medical schools have been slow to adopt. This study reports on the introduction of an intensive two-week surgical sub-internship for final medical year students. "Sub-interns" were asked to complete pre and post sub-internship online questionnaires assessing their readiness to perform clinical and practical skills, attitudes towards the program, and how well it prepared students for internship. Forty-nine students completed a questionnaire pre sub-internship and 47 completed the pos...
https://epubs.rcsi.ie/surgart/17
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Prevalence and predictors of initial oral antibiotic treatment failure in adult emergency department patients with cellulitis: a pilot study.
(2015)
Quirke, Michael; Boland, Fiona; Fahey, Tom; O'Sullivan, Ronan; Hill, Arnold DK; St...
Prevalence and predictors of initial oral antibiotic treatment failure in adult emergency department patients with cellulitis: a pilot study.
(2015)
Quirke, Michael; Boland, Fiona; Fahey, Tom; O'Sullivan, Ronan; Hill, Arnold DK; Stiell, Ian; Wakai, Abel
Abstract:
<p>The original article is available at http://bmjopen.bmj.com</p>
<p>INTRODUCTION: Assessment of cellulitis severity in the emergency department (ED) setting is problematic. Given the lack of research performed to describe the epidemiology and management of cellulitis, it is unsurprising that heterogeneous antibiotic prescribing and poor adherence to guidelines is common. It has been shown that up to 20.5% of ED patients with cellulitis require either a change in route or dose of the initially prescribed antibiotic regimen. The current treatment failure rate for empirically prescribed oral antibiotic therapy in Irish EDs is unknown. The association of patient risk factors with treatment failure has not been described in our setting. Lower prevalence of community-acquired methicillin-resistant Staphylococcus aureus-associated infection, differing antibiotic prescribing preferences and varying availability of outpatient intravenous therapy programmes may result ...
https://epubs.rcsi.ie/surgart/41
Marked
Mark
Preventing healthcare-associated infection through education: have surgeons been overlooked?
(2010)
McHugh, Seamus M; Hill, Arnold DK; Humphreys, Hilary
Preventing healthcare-associated infection through education: have surgeons been overlooked?
(2010)
McHugh, Seamus M; Hill, Arnold DK; Humphreys, Hilary
Abstract:
<p>BACKGROUND/AIMS: Some 20-30% of HCAI are considered to be preventable through an extensive infection prevention and control programme. Through an extensive literature review we aim to critically appraise studies which have utilised education initiatives to decrease HCAI.</p> <p>METHODS: An extensive review of the literature was carried out in both online medical journals and through the Royal College of Surgeons in Ireland library.</p> <p>FINDINGS: Many studies over the last 10 years have demonstrated success in educating nursing staff, critical care healthcare workers as well as medical students and junior doctors in the infection prevention and control of infection. Comparatively few have focussed on surgical trainees. A blended learning approach, with particular focus on the small group format is important. Interventions involving web-based learning in combination with established education formats are proving successful in changing behaviour.<...
https://epubs.rcsi.ie/clinmicart/13
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Mark
Preventing infection in general surgery: improvements through education of surgeons by surgeons.
(2011)
McHugh, Seamus M; Corrigan, Mark A; Dimitrov, Borislav D; Cowman, Seamus; Tierney, Sean...
Preventing infection in general surgery: improvements through education of surgeons by surgeons.
(2011)
McHugh, Seamus M; Corrigan, Mark A; Dimitrov, Borislav D; Cowman, Seamus; Tierney, Sean; Hill, Arnold DK; Humphreys, Hilary
Abstract:
<p>This article is also available at http://www.sciencedirect.com/science/article/pii/S0195670111001708</p>
<p>Surgical patients are at particular risk of healthcare-associated infection (HCAI) due to the presence of a surgical site leading to surgical site infection (SSI), and because of the need for intravascular access resulting in catheter-related bloodstream infection (CRBSI). A two-year initiative commenced with an initial audit of surgical practice; this was used to inform the development of a targeted educational initiative by surgeons specifically for surgical trainees. Parameters assessed during the initial audit and a further audit after the educational initiative were related to intra- and postoperative aspects of the prevention of SSIs, as well as care of peripheral venous catheters (PVCs) in surgical patients. The proportion of prophylactic antibiotics administered prior to incision across 360 operations increased from 30.0% to 59.1% (P72h (10.6% ...
https://epubs.rcsi.ie/gpart/27
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Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer.
(2015)
Ali, Azlena; Creevey, Laura; Hao, Yuan; McCartan, Damian; O'Gaora, Peadar; Hill, A...
Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer.
(2015)
Ali, Azlena; Creevey, Laura; Hao, Yuan; McCartan, Damian; O'Gaora, Peadar; Hill, Arnold DK; Young, Leonie; McIlroy, Marie
Abstract:
<p>The original article is available at www.biomedcentral.com</p>
<p>INTRODUCTION: HOX genes play vital roles in growth and development, however, atypical redeployment of these genes is often associated with steroidal adaptability in endocrine cancers. We previously identified HOXC11 to be an indicator of poor response to hormonal therapy in breast cancer. In this study we aimed to elucidate genes regulated by HOXC11 in the endocrine resistant setting.</p> <p>METHODS: RNA-sequencing paired with transcription factor motif-mapping was utilised to identify putative HOXC11 target genes in endocrine resistant breast cancer. Validation and functional evaluation of the target gene, prosaposin (PSAP), was performed in a panel of endocrine sensitive and resistant breast cancer cell lines. The clinical significance of this finding was explored in clinical cohorts at both mRNA and protein level.</p> <p>RESULTS: PSAP was shown to be regulated by HOX...
https://epubs.rcsi.ie/surgart/31
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