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Author = Kelly, Daniel;
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Displaying Results 76 - 100 of 124 on page 4 of 5
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Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects
(2005)
KELLY, DANIEL; PRENDERGAST, PATRICK JOHN
Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects
(2005)
KELLY, DANIEL; PRENDERGAST, PATRICK JOHN
Abstract:
peer-reviewed
Cartilage defects that penetrate the subchondral bone can undergo spontaneous repair through the formation of a fibrous or cartilaginous tissue mediated primarily by mesenchymal stem cells from the bone marrow. This tissue is biomechanically inferior to normal articular cartilage, and is often observed to degrade over time. The factors that control the type and quality of the repair tissue, and its subsequent degradation, have yet to be elucidated. In this paper, we hypothesise a relationship between the mechanical environment of mesenchymal stem cells and their subsequent dispersal, proliferation, differentiation and death. The mechano-regulation stimulus is hypothesised to be a function of strain and fluid flow; these quantities are calculated using a finite element model of the tissue. A finite element model of an osteochondral defect in the knee was created, and used to simulate the spontaneous repair process. The model predicts bone formation through both endo...
http://hdl.handle.net/2262/29006
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Mechanobiological models of Skeletal Tissue Differentiation
(2005)
KELLY, DANIEL
Mechanobiological models of Skeletal Tissue Differentiation
(2005)
KELLY, DANIEL
Abstract:
peer-reviewed
Mechanical forces may act within tissues at the cellular level to regulate biological processes, a field of study that has been termed mechanobiology. The aim of computational mechanobiology is to derive sets of equations that describe the changes in cell expression, and hence the composition, structure and phenotype of tissues, as a function of the applied mechanical stimuli. This chapter will attempt to review the different mechanobiological models that have been developed to relate mechanical stimuli to tissue differentiation. The majority of these models have been used to simulate tissue differentiation during fracture healing or osteochondral defect repair. Based on this review, a number of recommendations will be made by the author for the future development of computational models of tissue differentiation.
http://hdl.handle.net/2262/29046
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Microclimate moderates plant responses to macroclimate warming.
(2013)
KELLY, DANIEL
Microclimate moderates plant responses to macroclimate warming.
(2013)
KELLY, DANIEL
Abstract:
Recent global warming is acting across marine, freshwater, and terrestrial ecosystems to favor species adapted to warmer conditions and/or reduce the abundance of cold-adapted organisms (i.e., ?thermophilization? of communities). Lack of community responses to increased temperature, however, has also been reported for several taxa and regions, suggesting that ?climatic lags? may be frequent. Here we show that microclimatic effects brought about by forest canopy closure can buffer biotic responses to macroclimate warming, thus explaining an apparent climatic lag. Using data from 1,409 vegetation plots in European and North American temperate forests, each surveyed at least twice over an interval of 12?67 y, we document significant thermophilization of ground-layer plant communities. These changes reflect concurrent declines in species adapted to cooler conditions and increases in species adapted to warmer conditions. However, thermophilization, particularly the increase of warm-adapt...
http://hdl.handle.net/2262/72444
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Microwave bone imaging: experimental evaluation of calcaneus bone phantom and imaging prototype
(2021)
Amin, Bilal; Sheridan, Colin; Kelly, Daniel; O'Halloran, Martin; Elahi, Muhammad A...
Microwave bone imaging: experimental evaluation of calcaneus bone phantom and imaging prototype
(2021)
Amin, Bilal; Sheridan, Colin; Kelly, Daniel; O'Halloran, Martin; Elahi, Muhammad Adnan
Abstract:
Microwave imaging (MWI) can be used as an alternate imaging modality for monitoring bone health. Evaluation and characterization of MWI prototype is a precursor step before in vivo investigation of bone dielectric properties. This paper presents experimental evaluation of a novel two layered simplified cylindrical shaped 3D printed human calcaneus bone phantom along with corresponding MWI prototype designed to image the bone phantom. The shape of the calcaneus bone was approximated with a cylinder. The external and internal layers represent cortical bone and trabecular bone respectively. Each layer of the phantom was filled with respective liquid tissue mimicking mixture (TMM). A MWI prototype was designed having six microstrip antennas in order to hold calcaneus bone phantom. The bone phantom was placed in the imaging prototype and scattered signals were measured at each antenna. Moreover, the performance of the system was explored by examining microwave measurement sensitivity. Ba...
http://hdl.handle.net/10379/16711
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Microwave calcaneus phantom for bone imaging applications
(2021)
Amin, Bilal; Kelly, Daniel; Shahzad, Atif; O'Halloran, Martin; Elahi, Muhammad Adnan
Microwave calcaneus phantom for bone imaging applications
(2021)
Amin, Bilal; Kelly, Daniel; Shahzad, Atif; O'Halloran, Martin; Elahi, Muhammad Adnan
Abstract:
Microwave imaging can be used as an alternate modality for monitoring bone health. Dielectrically accurate, anthropomorphic phantoms play vital role in testing of imaging prototype prior to clinical applications. However, no study to date has proposed cortical and trabecular hone phantoms. This paper presents a multilayered 3D-printed human calcaneus structure. Further, we have proposed liquid based tissue phantoms that mimic the dielectric properties of skin, muscle, cortical bone and trabecular bone. Tissue phantoms are composed of Trition X-100, water and salt. The dielectric properties were measured across 0.5-8.5 GHz. Each layer of the 3D-printed structure was filled with corresponding tissue phantom. The combined average percentage difference between dielectric properties of reference data and proposed tissue phantoms was found to be 2.9% for trabecular bone, 7.3% for cortical hone, 7.1% for muscle, and 8.7% for skin over the full measured frequency band. These tissue phantoms...
http://hdl.handle.net/10379/16627
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Modelling Hurricane Exposure and Wind Speed on a Mesoclimate Scale: A Case Study from Cusuco NP, Honduras.
(2014)
KELLY, DANIEL
Modelling Hurricane Exposure and Wind Speed on a Mesoclimate Scale: A Case Study from Cusuco NP, Honduras.
(2014)
KELLY, DANIEL
Abstract:
High energy weather events are often expected to play a substantial role in biotic community dynamics and large scale diversity patterns but their contribution is hard to prove. Currently, observations are limited to the documentation of accidental records after the passing of such events. A more comprehensive approach is synthesising weather events in a location over a long time period, ideally at a high spatial resolution and on a large geographic scale. We provide a detailed overview on how to generate hurricane exposure data at a meso-climate level for a specific region. As a case study we modelled landscape hurricane exposure in Cusuco National Park (CNP), Honduras with a resolution of 50 m?50 m patches. We calculated actual hurricane exposure vulnerability site scores (EVVS) through the combination of a wind pressure model, an exposure model that can incorporate simple wind dynamics within a 3-dimensional landscape and the integration of historical hurricanes data. The EVSS wa...
http://hdl.handle.net/2262/75177
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Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner
(2020)
MAHON, OLWYN; Kelly, Daniel; Mills, Kingston; Dunne, Aisling; Nicolosi, Valeria
Nano-particle mediated M2 macrophage polarization enhances bone formation and MSC osteogenesis in an IL-10 dependent manner
(2020)
MAHON, OLWYN; Kelly, Daniel; Mills, Kingston; Dunne, Aisling; Nicolosi, Valeria
Abstract:
Engineering a pro-regenerative immune response following scaffold implantation is integral to functional tissue regeneration. The immune response to implanted biomaterials is determined by multiple factors, including biophysical cues such as material stiffness, topography and particle size. In this study we developed an immune modulating scaffold for bone defect healing containing bone mimetic nano hydroxyapatite particles (BMnP). We first demonstrate that, in contrast to commercially available micron-sized hydroxyapatite particles, in-house generated BMnP preferentially polarize human macrophages towards an M2 phenotype, activate the transcription factor cMaf and specifically enhance production of the anti-inflammatory cytokine, IL-10. Furthermore, nano-particle treated macrophages enhance mesenchymal stem cell (MSC) osteogenesis in vitro and this occurs in an IL-10 dependent manner, demonstrating a direct pro-osteogenic role for this cytokine. BMnPs were also capable of driving pr...
http://hdl.handle.net/2262/93507
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Organic farming and landscape structure: Effects on insect-pollinated plant diversity in intensively managed grasslands
(2012)
POWER, EILEEN; STOUT, JANE; KELLY, DANIEL; KELLY, DANIEL LUCIUS; STOUT, JANE CATHERINE
Organic farming and landscape structure: Effects on insect-pollinated plant diversity in intensively managed grasslands
(2012)
POWER, EILEEN; STOUT, JANE; KELLY, DANIEL; KELLY, DANIEL LUCIUS; STOUT, JANE CATHERINE
Abstract:
12 Hide Figures Abstract Introduction Methods Results Discussion Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Figures Abstract Parallel declines in insect-pollinated plants and their pollinators have been reported as a result of agricultural intensification. Intensive arable plant communities have previously been shown to contain higher proportions of self-pollinated plants compared to natural or semi-natural plant communities. Though intensive grasslands are widespread, it is not known whether they show similar patterns to arable systems nor whether local and/or landscape factors are influential. We investigated plant community composition in 10 pairs of organic and conventional dairy farms across Ireland in relation to the local and landscape context. Relationships between plant groups and local factors (farming system, position in field and soil parameters) and landscape factors (e.g. la...
http://hdl.handle.net/2262/66677
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Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism
(2020)
Kelly, Daniel; Mahon, Olwyn; McCarthy, Geraldine M.; Dunne, Aisling
Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism
(2020)
Kelly, Daniel; Mahon, Olwyn; McCarthy, Geraldine M.; Dunne, Aisling
Abstract:
A number of studies have demonstrated that molecules called ?alarmins? or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprogramming of immune cells, including macrophages, is emerging as a prominent player in determining immune cell phenotype and function. The aim of this study was to investigate if basic calcium phosphate (BCP) crystals which are OA-associated DAMPs, impact on macrophage phenotype and metabolism.
http://hdl.handle.net/2262/93506
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Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization
(2019)
Kelly, Daniel; Mahon, Olwyn R.; McCarthy, Geraldine M.; Dunne, Aisling
Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization
(2019)
Kelly, Daniel; Mahon, Olwyn R.; McCarthy, Geraldine M.; Dunne, Aisling
Abstract:
Objective: A number of studies have demonstrated that molecules called ?alarmins? or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprog-ramming of immune cells, including macrophages, is emerging as a prominent player in determiningimmune cell phenotype and function. The aim of this study was to investigate if basic calcium phosphate(BCP) crystals which are OA-associated DAMPs, impact on macrophage phenotype and metabolism.Methods:Human monocyte derived macrophages were treated with BCP crystals and expression of M1(CXCL9, CXCL10) and M2 (MRC1, CCL13)-associated markers was assessed by real-time PCR while surfacematuration marker (CD40, CD80&CD86) expression was assessed byflow cytometry. BCP inducedmetabolic changes were assessed by Seahorse analysis and glycolytic marker expression (hexokinase2(HK2), Glut1 and HIF1a) was examined using real-time PCR and immunoblotting.Results:Treatment with BCP crystals upregula...
http://hdl.handle.net/2262/91316
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Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes.
(2010)
Kelly, Daniel; Buckley, Conor
Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes.
(2010)
Kelly, Daniel; Buckley, Conor
Abstract:
Background For current tissue engineering or regenerative medicine strategies, chondrocyte (CC)- or mesenchymal stem cell (MSC)-seeded constructs are typically cultured in normoxic conditions (20% oxygen). However, within the knee joint capsule a lower oxygen tension exists. Objective The objective of this study was to investigate how CCs and infrapatellar fad pad derived MSCs will respond to a low oxygen (5%) environment in 3D agarose culture. Our hypothesis was that culture in a low oxygen environment (5%) will enhance the functional properties of cartilaginous tissues engineered using both cell sources. Experimental design Cell-encapsulated agarose hydrogel constructs (seeded with CCs or infrapatellar fat pad (IFP) derived MSCs) were prepared and cultured in a chemically defined serum-free medium in the presence (CCs and MSCs) or absence (CCs only) of transforming growth factor-beta3 (TGF-?3) in normoxic (20%) or low oxygen (5%) conditions for 42 days. Constructs were assessed ...
http://hdl.handle.net/2262/41081
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Pervasive Sound Sensing: A Weakly Supervised Training Approach
(2015)
Kelly, Daniel; Caulfield, Brian
Pervasive Sound Sensing: A Weakly Supervised Training Approach
(2015)
Kelly, Daniel; Caulfield, Brian
Abstract:
Modern smartphones present an ideal device for pervasive sensing of human behaviour. Microphones have the potential to reveal key information about a persons behaviour.However, they have been utilized to a significantly lesser extent than other smartphone sensors in the context of human behaviour sensing. We postulate that, in order for microphones to be useful in behaviour sensing applications, the analysis tecniques must be flexible and allow easy modification of the types of sounds to be sensed. A simplification of the training data collection process could allow a more flexible sound classification framework. We hypothesize that detailed training, a prerequisite for the majority of sound sensing techniques, is not necessary and that a significantly less detailed and time consuming data collection process can be carried out, allow-ng even a non expert to conduct the collection, labeling, and training process. To test this hypothesis, we implement a diverse density-based multiple ...
http://hdl.handle.net/10197/6853
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Phylogenetic classification of the world's tropical forests
(2018)
Kelly, Daniel
Phylogenetic classification of the world's tropical forests
(2018)
Kelly, Daniel
Abstract:
Identifying and explaining regional differences in tropical forest dynamics, structure, diversity, and composition are critical for anticipating region-specific responses to global environmental change. Floristic classifications are of fundamental importance for these efforts. Here we provide a global tropical forest classification that is explicitly based on community evolutionary similarity, resulting in identification of five major tropical forest regions and their relationships: (i) Indo-Pacific, (ii) Subtropical, (iii) African, (iv) American, and (v) Dry forests. African and American forests are grouped, reflecting their former western Gondwanan connection, while Indo-Pacific forests range from eastern Africa and Madagascar to Australia and the Pacific. The connection between northern-hemisphere Asian and American forests is confirmed, while Dry forests are identified as a single tropical biome.
http://hdl.handle.net/2262/89576
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Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues
(2019)
Nicolosi, Valeria; Kelly, Daniel
Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues
(2019)
Nicolosi, Valeria; Kelly, Daniel
Abstract:
The regeneration of complex tissues and organs remains a major clinical challenge. With a view towards bioprinting such tissues, we developed a new class of pore-forming bioink to spatially and temporally control the presentation of therapeutic genes within bioprinted tissues. By blending sacrificial and stable hydrogels, we were able to produce bioinks whose porosity increased with time following printing. When combined with amphipathic peptide-based plasmid DNA delivery, these bioinks supported enhanced non-viral gene transfer to stem cells in vitro. By modulating the porosity of these bioinks, it was possible to direct either rapid and transient (pore-forming bioinks), or slower and more sustained (solid bioinks) transfection of host or transplanted cells in vivo. To demonstrate the utility of these bioinks for the bioprinting of spatially complex tissues, they were next used to zonally position stem cells and plasmids encoding for either osteogenic (BMP2) or chondrogenic (combin...
http://hdl.handle.net/2262/95623
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Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing
(2015)
KELLY, DANIEL; VINARDELL, TATIANA; CUNNIFFE, GR?INNE; O'BRIEN, FERGAL
Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing
(2015)
KELLY, DANIEL; VINARDELL, TATIANA; CUNNIFFE, GR?INNE; O'BRIEN, FERGAL
Abstract:
Clinical translation of tissue engineered therapeutics is hampered by the significant logistical and regulatory challenges associated with such products, prompting increased interest in the use of decellularized extracellular matrix (ECM) to enhance endogenous regeneration. Most bones develop and heal by endochondral ossification, the replacement of a hypertrophic cartilaginous intermediary with bone. The hypothesis of this study is that a porous scaffold derived from decellularized tissue engineered hypertrophic cartilage will retain the necessary signals to instruct host cells to accelerate endogenous bone regeneration. Cartilage tissue (CT) and hypertrophic cartilage tissue (HT) were engineered using human bone marrow derived mesenchymal stem cells, decellularized and the remaining ECM was freeze-dried to generate porous scaffolds. When implanted subcutaneously in nude mice, only the decellularized HT-derived scaffolds were found to induce vascularization and de novo mineral accu...
http://hdl.handle.net/2262/75178
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Postnatal changes to the mechanical properties of articular cartilage are driven by the evolution of its collagen network
(2015)
KELLY, DANIEL; NAGEL, THOMAS; GANNON, ALANNA
Postnatal changes to the mechanical properties of articular cartilage are driven by the evolution of its collagen network
(2015)
KELLY, DANIEL; NAGEL, THOMAS; GANNON, ALANNA
Abstract:
While it is well established that the composition and organisation of articular cartilage dramatically change during skeletal maturation, relatively little is known about how this impacts the mechanical properties of the tissue. In this study, digital image correlation was first used to quantify spatial deformation within mechanically compressed skeletally immature (4 and 8 week old) and mature (1 and 3 year old) porcine articular cartilage. The compressive modulus of the immature tissue was relatively homogeneous, while the stiffness of mature articular cartilage dramatically increased with depth from the articular surface. Other, well documented, biomechanical characteristics of the tissue also emerged with skeletal maturity, such as strain-softening and a depth-dependent Poisson?s ratio. The most significant changes that occurred with age were in the deep zone of the tissue, where an order of magnitude increase in compressive modulus (from 0.97 MPa to 9.4 MPa for low applied stra...
http://hdl.handle.net/2262/75180
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Prediction of optimal mechanical properties for a scaffold used in osteochondral defect repair
(2006)
KELLY, DANIEL; PRENDERGAST, PATRICK JOHN
Prediction of optimal mechanical properties for a scaffold used in osteochondral defect repair
(2006)
KELLY, DANIEL; PRENDERGAST, PATRICK JOHN
Abstract:
peer-reviewed
The optimal mechanical properties of a scaffold to promote cartilage generation in osteochondral defects in vivo are not known. During normal daily activities cartilage is subjected to large cyclic loads that not only facilitate nutrient transport and waste removal through the dense tissue but also act as a stimulus to the chondrocytes. In contrast, cartilage tissue is commonly engineered in vitro in a static culture and hence, in many cases, the properties of scaffolds have been tailored to suit this in vitro environment. In this study, a mechano-regulation algorithm for tissue differentiation has been used to determine the influence scaffold material properties on chondrogenesis in a finite element model of an osteochondral defect. It is predicted that increasing the stiffness of the scaffold increases the amount of cartilage formation and reduces the amount of fibrous tissue formation in the defect, but this only holds true up to a certain threshold stiffness ab...
http://hdl.handle.net/2262/29149
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Recapitulating Aspects of the Oxygen and Substrate Environment of the Damaged Joint Milieu for Stem Cell-Based Cartilage Tissue Engineering.
(2013)
Kelly, Daniel; Buckley, Conor
Recapitulating Aspects of the Oxygen and Substrate Environment of the Damaged Joint Milieu for Stem Cell-Based Cartilage Tissue Engineering.
(2013)
Kelly, Daniel; Buckley, Conor
Abstract:
Human infrapatellar fat pad contains a source of mesenchymal stem cells (FPSCs) that potentially offer a novel population for the treatment of damaged or diseased articular cartilage. Existing cartilage repair strategies such as microfracture harness the presence of a low-oxygen microenvironment, fibrin clot formation at sites of microfracture, and elevations in growth factors in the damaged joint milieu. Bearing this in mind, the objective of this study was to determine the chondrogenic potential of diseased human FPSCs in a model system that recapitulates some of these features. In the first phase of the study, the role of transforming growth factor beta-3 (TGF-?3) and fibroblast growth factor-2 (FGF-2), in addition to an altered oxygen-tension environment, on the colony-forming unit-fibroblast (CFU-F) capacity and growth kinetics of human FPSCs during monolayer expansion was evaluated. The subsequent chondrogenic capacity of these cells was quantified in both normoxic (20%) and l...
http://hdl.handle.net/2262/67197
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Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration
(2019)
Kelly, Daniel
Recapitulating bone development through engineered mesenchymal condensations and mechanical cues for tissue regeneration
(2019)
Kelly, Daniel
Abstract:
Large bone defects cannot form a callus and exhibit high complication rates even with the best treatment strategies available. Tissue engineering approaches often use scaffolds designed to match the properties of mature bone. However, natural fracture healing is most efficient when it recapitulates development, forming bone via a cartilage intermediate (endochondral ossification). Because mechanical forces are critical for proper endochondral bone development and fracture repair, we hypothesized that recapitulating developmental mechanical forces would be essential for large bone defect regeneration in rats. Here, we engineered mesenchymal condensations that mimic the cellular organization and lineage progression of the early limb bud in response to local transforming growth factor-?1 presentation from incorporated gelatin microspheres. We then controlled mechanical loading in vivo by dynamically tuning fixator compliance. Mechanical loading enhanced mesenchymal condensation-induced...
http://hdl.handle.net/2262/94797
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Recognizing Spatiotemporal Gestures and Movement Epenthesis in Sign Language
(2009)
Kelly, Daniel; McDonald, John; Markham, Charles
Recognizing Spatiotemporal Gestures and Movement Epenthesis in Sign Language
(2009)
Kelly, Daniel; McDonald, John; Markham, Charles
Abstract:
A novel system for the recognition of spatiotemporal hand gestures used in sign language is presented. While recognition of valid sign sequences is an important task in the overall goal of machine recognition of sign language, recognition of movement epenthesis is an important step towards continuous recognition of natural sign language. We propose a framework for recognizing valid sign segments and identifying movement epenthesis. Experiments show our proposed system performs well when classifying eight different signs and identifying 100 different types of movement epenthesis. A ROC analysis of the systems classifications performance showed an area under the curve measurement of 0.949.
http://mural.maynoothuniversity.ie/8334/
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Regeneration of osteochondral defects using developmentally inspired cartilaginous templates
(2018)
Kelly, Daniel
Regeneration of osteochondral defects using developmentally inspired cartilaginous templates
(2018)
Kelly, Daniel
http://hdl.handle.net/2262/85145
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Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites
(2020)
Kelly, Daniel
Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites
(2020)
Kelly, Daniel
Abstract:
Engineering constructs that mimic the complex structure, composition and biomechanics of the articular cartilage represents a promising route to joint regeneration. Such tissue engineering strategies require the development of biomaterials that mimic the mechanical properties of articular cartilage whilst simultaneously providing an environment supportive of chondrogenesis. Here three-dimensional (3D) bioprinting is used to develop polycaprolactone (PCL) fibre networks to mechanically reinforce interpenetrating network (IPN) hydrogels consisting of alginate and gelatin methacryloyl (GelMA). Inspired by the significant tension-compression nonlinearity of the collagen network in articular cartilage, we printed reinforcing PCL networks with different ratios of tensile to compressive modulus. Synergistic increases in compressive modulus were observed when IPN hydrogels were reinforced with PCL networks that were relatively soft in compression and stiff in tension. The resulting composit...
http://hdl.handle.net/2262/93558
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Remote rehabilitation: a solution to overloaded & scarce health care systems
(2018)
Esquivel, Karla Munoz; Nevala, Elina; Alamaki, Antti; Condell, Joan; Kelly, Daniel; Dav...
Remote rehabilitation: a solution to overloaded & scarce health care systems
(2018)
Esquivel, Karla Munoz; Nevala, Elina; Alamaki, Antti; Condell, Joan; Kelly, Daniel; Davies, Richard; Heaney, David; Nordstrom, Anna; Larsson, Markus Akerlund; Nilsson, Daniel; Barton, John; Tedesco, Salvatore
Abstract:
The population across Northern Europe is aging. Coupled with socio-economic challenges, health care systems are at risk of overloading and incurring unsustainable high costs. Rehabilitation services are used disproportionately by older people. One solution pertinent to rural areas is to change the model of rehabilitation to incorporate new technologies. This has the potential to free resources and reduce costs. However, implementation is challenging. In the Northern Periphery and Artic Programme (NPA), the Smart sensor Devices for rehabilitation and Connected health (SENDoc) project [1] is focused on introducing wearable sensor systems among elderly communities to support their rehabilitation. It is important to understand the context into which change is introduced. Therefore, an overview of the current state of health care systems in the four partner countries is presented, defining the concept of rehabilitation and how remote rehabilitation is currently delivered. Advantages (e.g...
http://hdl.handle.net/10468/7271
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SENDoc – to implement wearable sensors in rehabilitation practice for the elderly
(2019)
Nevala, Elina; Alamäki, Antti; Jalovaara, Juha; Muñoz Esquivel, Karla; Condell, Joan; H...
SENDoc – to implement wearable sensors in rehabilitation practice for the elderly
(2019)
Nevala, Elina; Alamäki, Antti; Jalovaara, Juha; Muñoz Esquivel, Karla; Condell, Joan; Heaney, David; Barton, John; Tedesco, Salvatore; Kelly, Daniel; Davies, Richard; Nordström, Anna; Åkerlund Larsson, Markus
Abstract:
Wearable sensors are the most promising technology for the automatic, continuous and long-term evaluation in areas of functional capacity. In the SENDoc project, we test different kinds of wearable sensors and implement them into rehabilitation practice for the elderly. Wearable sensors can be integrated into both acute and chronic situations and may provide the necessary information for managing health disorders and rehabilitation, to both patients and healthcare personnel (Appelboom et al., 2014)
http://hdl.handle.net/10468/10389
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Solid-State Phase Transformation and Self-Assembly of Amorphous Nanoparticles into Higher-Order Mineral Structures
(2020)
Kelly, Daniel
Solid-State Phase Transformation and Self-Assembly of Amorphous Nanoparticles into Higher-Order Mineral Structures
(2020)
Kelly, Daniel
Abstract:
Materials science has been informed by nonclassical pathways to crystallization, based on biological processes, about the fabrication of damage-tolerant composite materials. Various biomineralizing taxa, such as stony corals, deposit metastable, magnesium-rich, amorphous calcium carbonate nanoparticles that further assemble and transform into higher-order mineral structures. Here, we examine a similar process in abiogenic conditions using synthetic, amorphous calcium magnesium carbonate nanoparticles. Applying a combination of high-resolution imaging and in situ solid-state nuclear magnetic resonance spectroscopy, we reveal the underlying mechanism of the solid-state phase transformation of these amorphous nanoparticles into crystals under aqueous conditions. These amorphous nanoparticles are covered by a hydration shell of bound water molecules. Fast chemical exchanges occur: the hydrogens present within the nanoparticles exchange with the hydrogens from the surface-bound H2O molec...
http://hdl.handle.net/2262/94798
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