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Mark

?? T cells and NK cells ? Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity. (2015)

MILLS, KINGSTON

Mark

A crucial role for IL-1 in the induction of IL-17 producing T cells that mediate autoimmune encephalomyelitis (2006)

LAVELLE, EDWARD; MILLS, KINGSTON

Mark

A murine model in which protection correlates with pertussis vaccine efficacy in children demonstrates complementary roles for humoral and cell mediated immunity in protection against Bordetella pertussis (1998)

MILLS, KINGSTON

Mark

A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection against Bordetella pertussis, including Pertactin Deficient Strains (2019)

Mills, Kingston

Mark

A population of proinflammatory T cells coexpresses ?? and ?? T cell receptors in mice and humans (2020)

Mills, Kingston; Moran, Barry

Mark

A regulatory role for IL-4 in differential inflammatory responses in the lung following infection of mice primed with Th1- or Th2-inducing pertussis vaccines (2000)

MILLS, KINGSTON

Mark

Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells (2010)

MILLS, KINGSTON; MCQUILLAN, KEITH; LYNCH, MARINA

Mark

Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus (2003)

Lynch, Marina; Kelly, Aine; Mills, Kingston

Mark

Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction. (2011)

LYNCH, MARINA; MILLS, KINGSTON

Mark

Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells (2008)

MILLS, KINGSTON

Mark

Adenylate cyclase toxin from Bordetella pertussis synergises with lipopolysaccharide to promote innate IL-10 production and enhance the induction of Th2 and regulatory T cells (2004)

LAVELLE, EDWARD; MILLS, KINGSTON

Mark

Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential. (2015)

MILLS, KINGSTON; CREAGH, EMMA

Mark

Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells. (2013)

MILLS, KINGSTON; KEANE, JOSEPH; RUANE, DARREN; COLEMAN, MICHELLE; MORAN, BARRY

Mark

Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics (2008)

CONROY, HELEN; FLETCHER, JEAN; LAVELLE, EDWARD; MILLS, KINGSTON

Mark

Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in IFN- ? receptor or immunoglobulin Y chain genes (1997)

MILLS, KINGSTON

Mark

Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in Interferon- Receptor or Immunoglobulin ? Chain Genes (1997)

MILLS, KINGSTON

Mark

Autophagy and inflammatory diseases. (2013)

MILLS, KINGSTON

Mark

Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells (2013)

GALVIN, KAREN; HIGGINS, SARAH; MILLS, KINGSTON; STEFANSKA, ANNA; MORAN, BARRY; DUNGAN, ...

Mark

Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE against pertussis toxin but not against common allergens (2000)

MILLS, KINGSTON

Mark

Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells. (2014)

MILLS, KINGSTON

Mark

Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death (2005)

LAVELLE, EDWARD; MILLS, KINGSTON

Mark

Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses. (2008)

MILLS, KINGSTON; ROSS, PADRAIG JOHN

Irish Research Council for Science Engineering and Technology

Mark

Caspase-11 promotes allergic airway inflammation (2020)

Creagh, Emma; Lavelle, Edward; O'Neill, Luke; Mills, Kingston; Zas?ona, Zbigniew; ...

Caspase-11 promotes allergic airway inflammation (2020)

Creagh, Emma; Lavelle, Edward; O'Neill, Luke; Mills, Kingston; Zas?ona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M.; Carroll, Richard G.; Palsson-McDermott, Eva M.; Hughes, Mark M.; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G.; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd

Abstract:

Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 suppreses caspase-11 expression in murine and human macrophages and in the airways of mice with allergic inflammation. Remarkably, caspase-11-deficient mice are strongly resistant to developing experimental allergic airway inflammation, where PGE2 is known to be protective. Expression of caspase-11 is elevated in the lung of wild type mice with allergic airway inflammation. Blocking PGE2 production with indomethacin enhances, whereas the prostaglandin E1 analog misoprostol inhibits lung caspase-11 expression. Finally, alveolar macrophages from asthma patients exhibit increased expression of caspase-4, a human homologue of caspase-11. Our findings identify PGE2 as a negative regulator of caspase-11-driven pyroptosis and implicate caspase-4/11 as a critical contributor ...