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A differential interplay between the expression of Th1/Th2/Treg related cytokine genes in Teladorsagia circumcincta infected DRB1*1101 carrier lambs (2012)

Hassan, Musa; Hanrahan, James P; Good, Barbara; Mulcahy, Grace; Sweeney, Torres

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A differential interplay between the expression of th1/th2/treg related cytokine genes in teladorsagia circumcincta infected drb1*1101 carrier lambs (2018)

Hassan, Musa; Hanrahan, James P; Good, Barbara; Mulcahy, Grace; Sweeney, Torres

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Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken (2004)

Lynn, David J.; Higgs, Rowan; Gaines, Susan; Tierney, Joanna; James, Tharappel; Lloyd, ...

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Comparison of diagnostic techniques for the detection of Cryptosporidium oocysts in animal samples (2016)

Mirhashemi, Marzieh Ezzaty; Zintl, Annetta; Grant, Tim; Lucy, Frances E.; Mulcahy, Grac...

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Determining the Prevalence and Seasonality of Fasciola hepatica in Pasture-based Dairy herds in Ireland using a Bulk Tank Milk ELISA (2015)

Bloemhoff, Yris; Forbes, Andrew; Danaher, Martin; Good, Barbara; Morgan, Eric; Mulcahy,...

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Determining the prevalence and seasonality of fasciola hepatica in pasture-based dairy herds in ireland using a bulk tank milk elisa (2018)

Bloemhoff, Yris; Forbes, Andrew; Danaher, Martin; Good, Barbara; Morgan, Eric; Mulcahy,...

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Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines (2003)

Dalton, John P.; O'Neill, Sandra M.; Stack, Colin M.; Collins, Peter R.; Walshe, A...

Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines (2003)

Dalton, John P.; O'Neill, Sandra M.; Stack, Colin M.; Collins, Peter R.; Walshe, Alan; Sekiya, Mary; Doyle, Sean; Mulcahy, Grace; Hoyle, Deborah; Khaznadji, Eric; Moire, Nathalie; Brennan, Gerard; Mousley, Angela; Kreshchenko, Natalia; Maule, Aaron G.; Donnelly, Sheila M.

Abstract:

Fasciola hepatica secretes cathepsin L proteases that facilitate the penetration of the parasite through the tissues of its host, and also participate in functions such as feeding and immune evasion. The major proteases, cathepsin L1 (FheCL1) and cathepsin L2 (FheCL2) are members of a lineage that gave rise to the human cathepsin Ls, Ks and Ss, but while they exhibit similarities in their substrate specificities to these enzymes they differ in having a wider pH range for activity and an enhanced stability at neutral pH. There are presently 13 Fasciola cathepsin L cDNAs deposited in the public databases representing a gene family of at least seven distinct members, although the temporal and spatial expression of each of these members in the developmental stage of F. hepatica remains unclear. Immunolocalisation and in situ hybridisation studies, using antibody and DNA probes, respectively, show that the vast majority of cathepsin L gene expression is carried out in the epithelial cell...