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Limited By:	Author = O'Sullivan, Finbarr;

Displaying Results 1 - 14 of 14 on page 1 of 1

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A simple evaluation of the benefit of combined kinetic analysis of multiple injection dynamic PET scans (2019)

Gu, Fengyun; O'Sullivan, Finbarr; Muzi, Mark; Mankoff, David A.

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Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kBp50 (2013)

Canavan, Mary; McCarthy, Ciara; Ben Larbi, Nadia; Dowling, Jennifer; Collins, Laura; O&...

Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-kBp50 (2013)

Canavan, Mary; McCarthy, Ciara; Ben Larbi, Nadia; Dowling, Jennifer; Collins, Laura; O'Sullivan, Finbarr; Hurley, Grainne; Murphy, Carola; Quinlan, Aoife; Moloney, Gerry; Darby, Trevor; MacSharry, John; Kagechika, Hiroyuki; Moynagh, Paul N.; Melgar, Silvia; Loscher, Christine E.

Abstract:

There is now convincing evidence that liver X receptor (LXR) is an important modulator of the inflammatory response; however, its mechanism of action remains unclear. This study aimed to examine the effect of LXR on the IL-12 family of cytokines and examined the mechanism by which LXR exerted this effect. We first demonstrated that activation of murine-derived dendritic cells (DC) with a specific agonist to LXR enhanced expression of LXR following activation with LPS, suggesting a role in inflammation. Furthermore, we showed LXR expression to be increased in vivo in dextrane sulphate sodium-induced colitis. LXR activation also suppressed production of IL-12p40, IL-12p70, IL-27 and IL-23 in murine-derived DC following stimulation with LPS, and specifically targeted the p35, p40 and EBI3 subunits of the IL-12 cytokine family, which are under the control of the NF-kB subunit p50 (NF-kBp50). Finally, we demonstrated that LXR can associate with NF-kBp50 in DC and that LXR activation prev...

http://mural.maynoothuniversity.ie/4953/

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An exploration of the prognostic utility of shortened dynamic imaging protocols for PET-FDG scans (2019)

Wu, Qi; O'Sullivan, Finbarr; Muzi, Mark; Mankoff, David

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An illustration of the use of model-based bootstrapping for evaluation of uncertainty in kinetic information derived from dynamic PET (2019)

Gu, Fengyun; Wu, Qi; O'Sullivan, Finbarr; Huang, Jian; Muzi, Mark; Mankoff, David A.

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Assessment of a statistical AIF extraction method for dynamic PET studies with 15O water and 18F fluorodeoxyglucose in locally advanced breast cancer patients (2018)

O'Sullivan, Finbarr; O'Sullivan, Janet N.; Huang, Jian; Doot, Robert; Muzi, M...

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Assessment of the prognostic value of radiomic features in 18F-FMISO PET imaging of hypoxia in postsurgery brain cancer patients: secondary analysis of imaging data from a single-center study and the multicenter ACRIN 6684 trial (2020)

Muzi, Mark; Wolsztynski, Eric; Fink, James R.; O'Sullivan, Janet N.; O'Sulliv...

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Demodex-Associated Bacillus Proteins Induce an Aberrant Wound Healing Response in a Corneal Epithelial Cell Line: Possible Implications for Corneal Ulcer Formation in Ocular Rosacea (2012)

O'Reilly, Niamh; Gallagher, Clair; Reddy Katikireddy, Kishore; Clynes, Martin; O&#...

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Exposure of a Corneal Epithelial Cell Line (hTCEpi) to Demodex-Associated Bacillus Proteins Results in an Inflammatory Response (2014)

McMahon, Frederick W.; Gallagher, Clair; O'Reilly, Niamh; Clynes, Martin; O'S...

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Positron emission tomography-based assessment of metabolic gradient and other prognostic features in sarcoma (2018)

Wolsztynski, Eric; O'Sullivan, Finbarr; Keyes, Eimear; O'Sullivan, Janet; Ear...

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Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress (2006)

Dowling, Paul; O'Driscoll, Lorraine; O'Sullivan, Finbarr; Dowd, Andrew; Henry...

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Statistical assessment of treatment response in a cancer patient based on pre-therapy and post-therapy FDG-PET scans (2016)

Wolsztynski, Eric; O'Sullivan, Finbarr; O'Sullivan, Janet; Eary, Janet F.

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The Gamma characteristic of reconstructed PET images: Implications for ROI analysis (2017)

Mou, Tian; Huang, Jian; O'Sullivan, Finbarr

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The impact of arterial input function determination variations on prostate dynamic contrast-enhanced magnetic resonance imaging pharmacokinetic modeling: a multicenter data analysis challenge, part II (2019)

Huang, Wei; Chen, Yiyi; Fedorov, Andriy; Li, Xia; Jajamovich, Guido H.; Malyarenko, Dar...

Huang, Wei; Chen, Yiyi; Fedorov, Andriy; Li, Xia; Jajamovich, Guido H.; Malyarenko, Dariya I.; Aryal, Madhava P.; LaViolette, Peter S.; Oborski, Matthew J.; O'Sullivan, Finbarr; Abramson, Richard G.; Jafari-Khouzani, Kourosh; Afzal, Aneela; Tudorica, Alina; Moloney, Brendan; Gupta, Sandeep N.; Besa, Cecilia; Kalpathy-Cramer, Jayashree; Mountz, James M.; Laymon, Charles M.

Abstract:

This multicenter study evaluated the effect of variations in arterial input function (AIF) determination on pharmacokinetic (PK) analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data using the shutter-speed model (SSM). Data acquired from eleven prostate cancer patients were shared among nine centers. Each center used a site-specific method to measure the individual AIF from each data set and submitted the results to the managing center. These AIFs, their reference tissue-adjusted variants, and a literature population-averaged AIF, were used by the managing center to perform SSM PK analysis to estimate Ktrans (volume transfer rate constant), ve (extravascular, extracellular volume fraction), kep (efflux rate constant), and τi (mean intracellular water lifetime). All other variables, including the definition of the tumor region of interest and precontrast T1 values, were kept the same to evaluate parameter variations caused by variations in only the AIF. Con...

http://hdl.handle.net/10468/8592