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Limited By:	Author = Peterson, Veronica L.;

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Comparative compositional analysis of the gut microbiome in animal models of addiction and stress (2018)

Peterson, Veronica L.

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Drunk bugs: chronic vapour alcohol exposure induces marked changes in the gut microbiome in mice (2017)

Peterson, Veronica L.; Jury, Nicholas J.; Cabrera-Rubio, Raul; Draper, Lorraine A.; Cri...

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Host microbiota regulates central nervous system serotonin receptor 2C editing in rodents (2019)

van de Wouw, Marcel; Stilling, Roman M.; Peterson, Veronica L.; Ryan, Feargal J.; Hoban...

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Golubeva, Anna V.; Joyce, Susan A.; Moloney, Gerard M.; Burokas, Aurelijus; Sherwin, Eo...

Golubeva, Anna V.; Joyce, Susan A.; Moloney, Gerard M.; Burokas, Aurelijus; Sherwin, Eoin; Arboleya, Silvia; Flynn, Ian; Khochanskiy, Dmitry; Moya-Pérez, Angela; Peterson, Veronica L.; Rea, Kieran; Murphy, Kiera; Makarova, Olga; Buravkov, Sergey; Hyland, Niall P.; Stanton, Catherine; Clarke, Gerard; Gahan, Cormac G.; Dinan, Timothy G.; Cryan, John F.

Abstract:

Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental conditions worldwide. There is growing awareness that ASD is highly comorbid with gastrointestinal distress and altered intestinal microbiome, and that host-microbiome interactions may contribute to the disease symptoms. However, the paucity of knowledge on gut-brain axis signaling in autism constitutes an obstacle to the development of precision microbiota-based therapeutics in ASD. To this end, we explored the interactions between intestinal microbiota, gut physiology and social behavior in a BTBR T+ Itpr3tf/J mouse model of ASD. Here we show that a reduction in the relative abundance of very particular bacterial taxa in the BTBR gut – namely, bile-metabolizing Bifidobacterium and Blautia species, - is associated with deficient bile acid and tryptophan metabolism in the intestine, marked gastrointestinal dysfunction, as well as impaired social interactions in BTBR mice. Together these data support the c...

http://hdl.handle.net/10468/5135

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Recombinant incretin-secreting microbe improves metabolic dysfunction in high-fat diet fed rodents (2017)

Ryan, Paul M.; Patterson, Elaine; Kent, Robert M.; Stack, Helena; O'Connor, Paula ...

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Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents (2020)

Ryan, Paul M; Patterson, Elaine; Kent, Robert M.; Stack, Helena; O’Connor, Paula M.; Mu...

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Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse (2017)

Scott, Karen A.; Ida, Masayuki; Peterson, Veronica L.; Prenderville, Jack A.; Moloney, ...

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Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice (2017)

Burokas, Aurelijus; Arboleya, Silvia; Moloney, Rachel D.; Peterson, Veronica L.; Murphy...

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The enduring effects of early life stress on the microbiota-gut-brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend (2019)

O'Mahony, Siobhain M.; McVey Neufeld, Karen-Anne; Waworuntu, Rosaline V.; Pusceddu...

The enduring effects of early life stress on the microbiota-gut-brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend (2019)

O'Mahony, Siobhain M.; McVey Neufeld, Karen-Anne; Waworuntu, Rosaline V.; Pusceddu, Matteo M.; Manurung, Sarmauli; Murphy, Kiera; Strain, Conall; Laguna, Mamen C.; Peterson, Veronica L.; Stanton, Catherine; Berg, Brian M.; Dinan, Timothy G.; Cryan, John F.

Abstract:

Nutritional interventions targeting the microbiota-gut-brain axis are proposed to modulate stress-induced dysfunction of physiological processes and brain development. Maternal separation (MS) in rats induces long-term alterations to behavior, pain responses, gut microbiome and brain neurochemistry. In this study, the effects of dietary interventions (milk fat globule membrane (MFGM) and a polydextrose/galactooligosaccharide prebiotic blend (PDX/GOS)) were evaluated. Diets were provided from postnatal day 21 to both non-separated (NS) and MS offspring. Spatial memory, visceral sensitivity and stress reactivity were assessed in adulthood. Gene transcripts associated with cognition and stress and the caecal microbiota composition were analysed. MS-induced visceral hypersensitivity was ameliorated by MFGM and to greater extent with the combination of MFGM and prebiotic blend. Furthermore, spatial learning and memory were improved by prebiotics and MFGM alone and with the combination. T...

http://hdl.handle.net/10468/8474