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Author = Sills, Eric Scott;
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Displaying Results 1 - 17 of 17 on page 1 of 1
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Bivariate analysis of basal serum anti-Müllerian hormone measurements and human blastocyst development after IVF.
(2011)
Sills, Eric Scott; Collins, Gary S; Brady, Adam C; Walsh, David J; Marron, Kevin D; Pec...
Bivariate analysis of basal serum anti-Müllerian hormone measurements and human blastocyst development after IVF.
(2011)
Sills, Eric Scott; Collins, Gary S; Brady, Adam C; Walsh, David J; Marron, Kevin D; Peck, Alison C; Walsh, Anthony PH; Salem, Rifaat D
Abstract:
<p>This article is also available at <a href="http://www.rbej.com/content/9/1/153">http://www.rbej.com/content/9/1/153</a></p>
<p>BACKGROUND: To report on relationships among baseline serum anti-Müllerian hormone (AMH) measurements, blastocyst development and other selected embryology parameters observed in non-donor oocyte IVF cycles.</p> <p>METHODS: Pre-treatment AMH was measured in patients undergoing IVF (n = 79) and retrospectively correlated to in vitro embryo development noted during culture.</p> <p>RESULTS: Mean (+/- SD) age for study patients in this study group was 36.3 ± 4.0 (range = 28-45) yrs, and mean (+/- SD) terminal serum estradiol during IVF was 5929 +/- 4056 pmol/l. A moderate positive correlation (0.49; 95% CI 0.31 to 0.65) was noted between basal serum AMH and number of MII oocytes retrieved. Similarly, a moderate positive correlation (0.44) was observed between serum AMH and number of early cle...
https://epubs.rcsi.ie/obsgynart/8
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Clinical Presentation and Conservative Management of Tympanic Membrane Perforation during Intrapartum Valsalva Maneuver.
(2010)
Baum, Jonathan D; Rattigan, Meghan I; Sills, Eric Scott; Walsh, Anthony PH
Clinical Presentation and Conservative Management of Tympanic Membrane Perforation during Intrapartum Valsalva Maneuver.
(2010)
Baum, Jonathan D; Rattigan, Meghan I; Sills, Eric Scott; Walsh, Anthony PH
Abstract:
<p>This article is also available at <a href="http://www.hindawi.com/">www.hindawi.com</a></p>
<p>Background. Tympanic membrane perforation may occur when ear pressures are excessive, including valsalva maneuver associated with active labor and vaginal delivery. A pressure differential across the eardrum of about 5 psi can cause rupture; the increased intraabdominal pressure spikes repeatedly manifested by "pushing" during second-stage labor easily approach (and may exceed) this level. Material and Method. We describe a healthy 21-year old nulliparous patient admitted in active labor at 39-weeks' gestational age. Results. Blood appeared asymptomatically in the left ear canal at delivery during active, closed-glottis pushing. Otoscopic examination confirmed perforation of the left tympanic membrane. Complete resolution of the eardrum rupture was noted at postpartum check-up six weeks later. Conclusion. While the precise incid...
https://epubs.rcsi.ie/obsgynart/15
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Determining the status of non-transferred embryos in Ireland: a conspectus of case law and implications for clinical IVF practice.
(2009)
Sills, Eric Scott; Murphy, Sarah Ellen
Determining the status of non-transferred embryos in Ireland: a conspectus of case law and implications for clinical IVF practice.
(2009)
Sills, Eric Scott; Murphy, Sarah Ellen
Abstract:
<p>This article is also available from http://www.biomedcentral.com/</p>
<p>The development of in vitro fertilisation (IVF) as a treatment for human infertilty was among the most controversial medical achievements of the modern era. In Ireland, the fate and status of supranumary (non-transferred) embryos derived from IVF brings challenges both for clinical practice and public health policy because there is no judicial or legislative framework in place to address the medical, scientific, or ethical uncertainties. Complex legal issues exist regarding informed consent and ownership of embryos, particularly the use of non-transferred embryos if a couple separates or divorces. But since case law is only beginning to emerge from outside Ireland and because legislation on IVF and human embryo status is entirely absent here, this matter is poised to raise contractual, constitutional and property law issues at the highest level. Our analysis examines this medico-legal c...
https://epubs.rcsi.ie/obsgynart/5
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First Irish delivery following sequential, two-stage embryo and blastocyst transfer.
(2012)
Hayrinen, L H; Sills, Eric Scott; Fogarty, Alicia O; Walsh, David J; Lutsyk, Alexander ...
First Irish delivery following sequential, two-stage embryo and blastocyst transfer.
(2012)
Hayrinen, L H; Sills, Eric Scott; Fogarty, Alicia O; Walsh, David J; Lutsyk, Alexander D; Walsh, Anthony PH
Abstract:
<p>This article is also available from <a href="http://www.ijms.ie">www.ijms.ie</a></p>
<p>BACKGROUND: The timing of embryo transfer (ET) after in vitro fertilisation (IVF) remains controversial, and there are no reliable guidelines available to prospectively identify which patients would benefit from either day-3 or blastocyst transfer. While blastocyst transfer is generally favoured over day-3 transfers, very few IVF patients get both in the same treatment cycle.</p> <p>CASE DESCRIPTION: We report on a 35.5-year-old female with tubal factor infertility who underwent IVF, which included transfer of a fresh day-3 embryo and a thawed blastocyst frozen at day 6. Transfer occurred on two separate days (days 3 and 6) in a two-stage/dual catheter fashion and resulted in a healthy term singleton livebirth.</p> <p>CONCLUSIONS: While combined day-3 and day-5 ET has been available elsewhere for several years, this is the fir...
https://epubs.rcsi.ie/obsgynart/18
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Follow-up analysis of federal process of care data reported from three acute care hospitals in rural Appalachia
(2013)
Sills, Eric Scott; Chiriac, Liubomir; Vaughan, Denis; Jones, Christopher A; Salem, Shala A
Follow-up analysis of federal process of care data reported from three acute care hospitals in rural Appalachia
(2013)
Sills, Eric Scott; Chiriac, Liubomir; Vaughan, Denis; Jones, Christopher A; Salem, Shala A
Abstract:
<p>This article is also available at <a href="http://www.dovepress.com">www.dovepress.com</a></p>
<p><strong>Background: </strong>This investigation evaluated standardized process of care data collected on selected hospitals serving a remote rural section of westernmost North Carolina.</p> <p><strong>Methods: </strong>Centers for Medicare and Medicaid Services data were analyzed retrospectively for multiple clinical parameters at Fannin Regional Hospital, Murphy Medical Center, and Union General Hospital. Data were analyzed by paired <em>t</em>-test for individual comparisons among the three study hospitals to compare the three facilities with each other, as well as with state and national average for each parameter.</p> <p><strong>Results: </strong>Centers for Medicare and Medicaid Services “Hospital Compare” data from 2011 showed Fannin Regional Hospital to have sign...
https://epubs.rcsi.ie/obsgynart/11
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Irish public opinion on assisted human reproduction services: Contemporary assessments from a national sample
(2013)
Walsh, David J; Sills, Eric Scott; Collins, Gary S; Hawrylyshyn, Christine A; Sokol, Pi...
Irish public opinion on assisted human reproduction services: Contemporary assessments from a national sample
(2013)
Walsh, David J; Sills, Eric Scott; Collins, Gary S; Hawrylyshyn, Christine A; Sokol, Piotr; Walsh, Anthony PH
Abstract:
<p>The original article is available at <a href="http://ecerm.org">http://ecerm.org</a></p>
<p><strong>Objective: </strong>To measure Irish opinion on a range of assisted human reproduction (AHR) treatments.</p> <p><strong>Methods: </strong>A nationally representative sample of Irish adults (n=1,003) were anonymously sampled by telephone survey.</p> <p><strong>Results: </strong>Most participants (77%) agreed that any fertility services offered internationally should also be available in Ireland, although only a small minority of the general Irish population had personal familiarity with AHR or infertility. This sample finds substantial agreement (63%) that the Government of Ireland should introduce legislation covering AHR. The range of support for gamete donation in Ireland ranged from 53% to 83%, depending on how donor privacy and disclosure policies are presented. For example, ...
https://epubs.rcsi.ie/obsgynart/20
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IVF for premature ovarian failure: first reported births using oocytes donated from a twin sister.
(2010)
Sills, Eric Scott; Brady, Adam C; Omar, Ahmed B; Walsh, David J; Salma, Umme; Walsh, An...
IVF for premature ovarian failure: first reported births using oocytes donated from a twin sister.
(2010)
Sills, Eric Scott; Brady, Adam C; Omar, Ahmed B; Walsh, David J; Salma, Umme; Walsh, Anthony PH
Abstract:
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p><strong>BACKGROUND:</strong> Premature ovarian failure (POF) remains a clinically challenging entity because in vitro fertilisation (IVF) with donor oocytes is currently the only treatment known to be effective.</p> <p><strong>METHODS: </strong>A 33 year-old nulligravid patient with a normal karyotype was diagnosed with POF; she had a history of failed fertility treatments and had an elevated serum FSH (42 mIU/ml). Oocytes donated by her dizygotic twin sister were used for IVF. The donor had already completed a successful pregnancy herself and subsequently produced a total of 10 oocytes after a combined FSH/LH superovulation regime. These eggs were fertilised with sperm from the recipient's husband via intracytoplasmic injection and two fresh embryos were transferred to the recipient on day...
https://epubs.rcsi.ie/obsgynart/2
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Medical Student Experiences in Clinical Reproductive Medicine: Dual-Cohort Assessment of a New Learning Module at the Royal College of Surgeons in Ireland
(2013)
Walsh, Anthony PH; Collins, Gary S; Walsh, David J; Shkrobot, Lyuda V; Malone, Fergal D...
Medical Student Experiences in Clinical Reproductive Medicine: Dual-Cohort Assessment of a New Learning Module at the Royal College of Surgeons in Ireland
(2013)
Walsh, Anthony PH; Collins, Gary S; Walsh, David J; Shkrobot, Lyuda V; Malone, Fergal D; Sills, Eric Scott
Abstract:
<p>This article is also available from <a href="http://www.journaljammr.com/index.php/JAMMR/article/view/12398">journaljammr.com</a></p> <p>British Journal of Medicine and Medical Research is continued by <a href="http://www.journaljammr.com/index.php/JAMMR">Journal of Advances in Medicine and Medical Research</a></p>
<p><strong>Aims: </strong>Exposure to a structured curriculum in reproductive medicine during medical school is helpful given the high frequency of fertility and pregnancy-related issues that future physicians will encounter. This study sought to evaluate a new reproductive medicine module for medical students.<br /><strong></strong></p> <p><strong>Study Design: </strong>Prospective cohort study.<br /><strong></strong></p> <p><strong>Place and Duration of Study:</strong> Dublin, Ireland; 2008-2010...
https://epubs.rcsi.ie/obsgynart/12
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Ovarian dysgenesis associated with an unbalanced X;6 translocation: first characterisation of reproductive anatomy and cytogenetic evaluation in partial trisomy 6 with breakpoints at Xq22 and 6p23.
(2012)
Sills, Eric Scott; Cotter, Philip D; Marron, Kevin D; Shkrobot, Lyuda V; Walsh, Harriet...
Ovarian dysgenesis associated with an unbalanced X;6 translocation: first characterisation of reproductive anatomy and cytogenetic evaluation in partial trisomy 6 with breakpoints at Xq22 and 6p23.
(2012)
Sills, Eric Scott; Cotter, Philip D; Marron, Kevin D; Shkrobot, Lyuda V; Walsh, Harriet MA; Salem, Rifaat D
Abstract:
<p>This article is also available at http://www.spandidos-publications.com/mmr/5/1/29</p>
<p>The aim of this study was to describe the clinical and laboratory findings associated with a previously unreported unbalanced X;6 translocation. Physical examination, reproductive history and cytogenetic techniques were used to characterise a novel chromosomal anomaly associated with gonadal dysgenesis. A healthy non-dysmorphic 23 year-old phenotypic female with primary amenorrhea and infertility presented for reproductive endocrinology evaluation. No discrete ovarian tissue was identified on transvaginal ultrasound, although the uterus appeared essentially normal. BMI was 19 kg/m2. Serum FSH and oestradiol were 111 mIU/ml and 15 pmol/l, respectively. TSH, prolactin and all infectious serologies were all normal. The karyotype of 46,X,der(X)t(X;6)(q22;p23) was determined following cytogenetic analysis of peripheral blood lymphocytes via fluorescence in situ hybridisation...
https://epubs.rcsi.ie/obsgynart/9
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Ovarian hyperstimulation syndrome: current views on pathophysiology, risk factors, prevention, and management.
(2009)
Alper, Michael M; Smith, Laura P; Sills, Eric Scott
Ovarian hyperstimulation syndrome: current views on pathophysiology, risk factors, prevention, and management.
(2009)
Alper, Michael M; Smith, Laura P; Sills, Eric Scott
Abstract:
<p>This article is also available from <a href="http://www.jexpclinassistreprod.com">www.jexpclinassistreprod.com</a></p>
<p>OBJECTIVE: To summarize current views on the pathophysiology, risk factors, prevention, clinical features, and management of Ovarian Hyperstimulation Syndrome (OHSS).</p> <p>DESIGN: Literature review</p> <p>RESULTS: OHSS is a condition characterized by increased capillary permeability, and experimental evidence has identified a provocative link to pathologic vasoactive cytokine actions. Although the ultimate physiologic mechanism of OHSS is not yet known, there are well-known risk factors that must be considered during the administration of medications to treat infertility. Clinical features are consequences of third-spaced intravascular fluid, and OHSS may become life-threatening secondary to thromboembolism or compromised pulmonary or cardiovascular function. Cornerstones of prevention have ...
https://epubs.rcsi.ie/obsgynart/17
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Ovarian serous adenocarcinoma identified during IVF: diagnostic approach, surgical management, and reproductive outcome.
(2009)
Walsh, David J; Sills, Eric Scott; Shkrobot, Lyuda V; Gleeson, Noreen C; Sheppard, Mary...
Ovarian serous adenocarcinoma identified during IVF: diagnostic approach, surgical management, and reproductive outcome.
(2009)
Walsh, David J; Sills, Eric Scott; Shkrobot, Lyuda V; Gleeson, Noreen C; Sheppard, Mary N; Walsh, Anthony PH
Abstract:
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND: To present a diagnostic evaluation and treatment strategy for serous adenocarcinoma of the ovary discovered during an in vitro fertilisation (IVF) sequence, and report on reproductive outcome after tumour resection and embryo transfer.</p> <p>CASE PRESENTATION: Cycle monitoring in IVF identified an abnormal ovarian lesion which was subjected to ultrasound-guided needle aspiration. Cytology suggested malignancy, and unilateral oophorectomy was performed after formal staging. After surgery, the patient underwent an anonymous donor oocyte IVF cycle which established a viable twin intrauterine pregnancy. No recurrence of cancer has been detected in the >72 month follow-up interval; mother and twin daughters continue to do well.</p> <p>CONCLUSION: Suspicious adnexal structures noted during control...
https://epubs.rcsi.ie/obsgynart/6
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Prospective randomized trial of iliohypogastric-ilioinguinal nerve block on post-operative morphine use after inpatient surgery of the female reproductive tract.
(2008)
Wehbe, Salim A; Ghulmiyyah, Labib M; Dominique, El-Khawand H; Hosford, Sarah L; Ehleben...
Prospective randomized trial of iliohypogastric-ilioinguinal nerve block on post-operative morphine use after inpatient surgery of the female reproductive tract.
(2008)
Wehbe, Salim A; Ghulmiyyah, Labib M; Dominique, El-Khawand H; Hosford, Sarah L; Ehleben, Carole M; Saltzman, Steven L; Sills, Eric Scott
Abstract:
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>OBJECTIVE: To determine the impact of pre-operative and intra-operative ilioinguinal and iliohypogastric nerve block on post-operative analgesic utilization and length of stay (LOS).</p> <p>METHODS: We conducted a prospective randomized double-blind placebo controlled trial to assess effectiveness of ilioinguinal-iliohypogastric nerve block (IINB) on post-operative morphine consumption in female study patients (n = 60). Patients undergoing laparotomy via Pfannenstiel incision received injection of either 0.5% bupivacaine + 5 mcg/ml epinephrine for IINB (Group I, n = 28) or saline of equivalent volume given to the same site (Group II, n = 32). All injections were placed before the skin incision and after closure of rectus fascia via direct infiltration. Measured outcomes were post-operative morphine consumption (and ass...
https://epubs.rcsi.ie/obsgynart/7
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Recipient screening in IVF: First data from women undergoing anonymous oocyte donation in Dublin.
(2011)
Walsh, Anthony PH; Omar, Ahmed B; Marron, Kevin D; Walsh, David J; Salma, Umme; Sills, ...
Recipient screening in IVF: First data from women undergoing anonymous oocyte donation in Dublin.
(2011)
Walsh, Anthony PH; Omar, Ahmed B; Marron, Kevin D; Walsh, David J; Salma, Umme; Sills, Eric Scott
Abstract:
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND: Guidelines for safe gamete donation have emphasised donor screening, although none exist specifically for testing oocyte recipients. Pre-treatment assessment of anonymous donor oocyte IVF treatment in Ireland must comply with the European Union Tissues and Cells Directive (Directive 2004/23/EC). To determine the effectiveness of this Directive when applied to anonymous oocyte recipients in IVF, we reviewed data derived from selected screening tests performed in this clinical setting.</p> <p>METHODS: Data from tests conducted at baseline for all women enrolling as recipients (n = 225) in the anonymous oocyte donor IVF programme at an urban IVF referral centre during a 24-month period were analysed. Patient age at programme entry and clinical pregnancy rate were also tabulated. All recipients had at least one...
https://epubs.rcsi.ie/obsgynart/4
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The evolution of health policy guidelines for assisted reproduction in the Republic of Ireland, 2004-2009.
(2011)
Walsh, David J; Ma, Mary L; Sills, Eric Scott
The evolution of health policy guidelines for assisted reproduction in the Republic of Ireland, 2004-2009.
(2011)
Walsh, David J; Ma, Mary L; Sills, Eric Scott
Abstract:
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>ABSTRACT: This analysis reports on Irish regulatory policies for in vitro fertilisation (IVF) from 2004-2009, in the context of membership changes within the Medical Council of Ireland. To achieve this, the current (2009) edition of the Guide to Professional Conduct & Ethics was compared with the immediately preceding version (2004). The statutory composition of the Medical Council from 2004-2009 was also studied. Content analysis of the two editions identified the following differences: 1) The 2004 guide states that IVF "should only be used after thorough investigation has failed to reveal a treatable cause of the infertility", while the 2009 guide indicates IVF "should only be used after thorough investigation has shown that no other treatment is likely to be effective"; 2) The 2004 stipulation stating th...
https://epubs.rcsi.ie/obsgynart/3
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The long path to pregnancy: early experience with dual anonymous gamete donation in a European in vitro fertilisation referral centre.
(2010)
Sills, Eric Scott; Mykhaylyshyn, Lyubov O; Dorofeyeva, Ulyana S; Walsh, David J; Salma,...
The long path to pregnancy: early experience with dual anonymous gamete donation in a European in vitro fertilisation referral centre.
(2010)
Sills, Eric Scott; Mykhaylyshyn, Lyubov O; Dorofeyeva, Ulyana S; Walsh, David J; Salma, Umme; Omar, Ahmed B; Coull, Graham D; David, Ileana A; Brickell, Kathy M; Tsar, Olga M; Walsh, Anthony PH
Abstract:
<p>This article is also available from <a href="http://www.reproductive-health-journal.com">http://www.reproductive-health-journal.com</a></p>
<p>BACKGROUND: This investigation describes features of patients undergoing in vitro fertilisation (IVF) and embryo transfer (ET) where both gametes were obtained from anonymous donors.</p> <p>METHODS: Gamete unsuitability or loss was confirmed in both members of seven otherwise healthy couples presenting for reproductive endocrinology consultation over a 12-month interval in Ireland. IVF was undertaken with fresh oocytes provided by anonymous donors in Ukraine; frozen sperm (anonymous donor) was obtained from a licensed tissue establishment. For recipients, saline-enhanced sonography was used to assess intrauterine contour with endometrial preparation via transdermal estrogen.</p> <p>RESULTS: Among commissioning couples, mean+/-SD female and male age was 41.9 +/- 3.7 and 44....
https://epubs.rcsi.ie/obsgynart/1
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Transvaginal ultrasound imaging for assessment of early pregnancy.
(2010)
Sills, Eric Scott; Walsh, David J; Walsh, Anthony PH
Transvaginal ultrasound imaging for assessment of early pregnancy.
(2010)
Sills, Eric Scott; Walsh, David J; Walsh, Anthony PH
Abstract:
<p>This article is also available at <a href="http://www.imj.ie">www.imj.ie</a></p>
https://epubs.rcsi.ie/obsgynart/13
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Who abandons embryos after IVF?
(2010)
Walsh, Anthony PH; Tsar, Olga M; Walsh, David J; Baldwin, P M; Shkrobot, Lyuda V; Sills...
Who abandons embryos after IVF?
(2010)
Walsh, Anthony PH; Tsar, Olga M; Walsh, David J; Baldwin, P M; Shkrobot, Lyuda V; Sills, Eric Scott
Abstract:
<p>This article is also available at <a href="http://www.imj.ie">www.imj.ie</a></p>
<p>This investigation describes features of in vitro fertilisation (IVF) patients who never returned to claim their embryos following cryopreservation. Frozen embryo data were reviewed to establish communication patterns between patient and clinic; embryos were considered abandoned when 1) an IVF patient with frozen embryo/s stored at our facility failed to make contact with our clinic for > 2 yrs and 2) the patient could not be located after a multi-modal outreach effort was undertaken. For these patients, telephone numbers had been disconnected and no forwarding address was available. Patient, spouse and emergency family contact/s all escaped detection efforts despite an exhaustive public database search including death records and Internet directory portals. From 3244 IVF cycles completed from 2000 to 2008, > or = 1 embryo was frozen in 1159 cases ...
https://epubs.rcsi.ie/obsgynart/14
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