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Limited By:	Author = Wilson, James F;

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Displaying Results 1 - 4 of 4 on page 1 of 1

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Genomic insights into the population structure and history of the Irish Travellers. (2017)

Gilbert, Edmund; Carmi, Shai; Ennis, Sean; Wilson, James F; Cavalleri, Gianpiero L

Genomic insights into the population structure and history of the Irish Travellers. (2017)

Gilbert, Edmund; Carmi, Shai; Ennis, Sean; Wilson, James F; Cavalleri, Gianpiero L

Abstract:

The original article is available at www.nature.com
The Irish Travellers are a population with a history of nomadism; consanguineous unions are common and they are socially isolated from the surrounding, 'settled' Irish people. Low-resolution genetic analysis suggests a common Irish origin between the settled and the Traveller populations. What is not known, however, is the extent of population structure within the Irish Travellers, the time of divergence from the general Irish population, or the extent of autozygosity. Using a sample of 50 Irish Travellers, 143 European Roma, 2232 settled Irish, 2039 British and 6255 European or world-wide individuals, we demonstrate evidence for population substructure within the Irish Traveller population, and estimate a time of divergence before the Great Famine of 1845-1852. We quantify the high levels of autozygosity, which are comparable to levels previously described in Orcadian 1(st)/2(nd) cousin of...

https://epubs.rcsi.ie/mctart/85

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Sequencing and analysis of an Irish human genome (2010)

Tong, Pin; Prendergast, James FD; Lohan, Amanda J; Farrington, Susan M; Cronin, Simon; ...

Sequencing and analysis of an Irish human genome (2010)

Tong, Pin; Prendergast, James FD; Lohan, Amanda J; Farrington, Susan M; Cronin, Simon; Friel, Nial; Bradley, Dan G; Hardiman, Orla; Evans, Alex; Wilson, James F; Loftus, Brendan

Abstract:

The original publication is available at http://www.biomedcentral.com
BACKGROUND: Recent studies generating complete human sequences from Asian, African and European subgroups have revealed population-specific variation and disease susceptibility loci. Here, choosing a DNA sample from a population of interest due to its relative geographical isolation and genetic impact on further populations, we extend the above studies through the generation of 11-fold coverage of the first Irish human genome sequence. RESULTS: Using sequence data from a branch of the European ancestral tree as yet unsequenced, we identify variants that may be specific to this population. Through comparisons with HapMap and previous genetic association studies, we identified novel disease-associated variants, including a novel nonsense variant putatively associated with inflammatory bowel disease. We describe a novel method for improving SNP calling accuracy at low genome coverage u...

https://epubs.rcsi.ie/clinneursciart/1

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The genetic landscape of Scotland and the Isles. (2019)

Gilbert, Edmund; O'Reilly, Seamus; Merrigan, Michael; McGettigan, Darren; Vitart, ...

The genetic landscape of Scotland and the Isles. (2019)

Gilbert, Edmund; O'Reilly, Seamus; Merrigan, Michael; McGettigan, Darren; Vitart, Veronique; Joshi, Peter K; Clark, David W; Campbell, Harry; Hayward, Caroline; Ring, Susan M; Golding, Jean; Goodfellow, Stephanie; Navarro, Pau; Kerr, Shona M; Amador, Carmen; Campbell, Archie; Haley, Chris S; Porteous, David J; Cavalleri, Gianpiero L; Wilson, James F

Abstract:

The original article is available at <a href="https://www.pnas.org/">https://www.pnas.org</a>
Britain and Ireland are known to show population genetic structure; however, large swathes of Scotland, in particular, have yet to be described. Delineating the structure and ancestry of these populations will allow variant discovery efforts to focus efficiently on areas not represented in existing cohorts. Thus, we assembled genotype data for 2,554 individuals from across the entire archipelago with geographically restricted ancestry, and performed population structure analyses and comparisons to ancient DNA. Extensive geographic structuring is revealed, from broad scales such as a NE to SW divide in mainland Scotland, through to the finest scale observed to date: across 3 km in the Northern Isles. Many genetic boundaries are consistent with Dark Age kingdoms of Gaels, Picts, Britons, and Norse. Populations in the Hebrides, the Highland...

https://epubs.rcsi.ie/spharmart/60

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The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland (2017)

Gilbert, Edmund; O'Reilly, Seamus; Merrigan, Michael; McGettigan, Darren; Molloy, ...

The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland (2017)

Gilbert, Edmund; O'Reilly, Seamus; Merrigan, Michael; McGettigan, Darren; Molloy, Anne M; Brody, Lawrence C; Bodmer, Walter; Hutnik, Katarzyna; Ennis, Sean; Lawson, Daniel J; Wilson, James F; Cavalleri, Gianpiero L

Abstract:

This article is also available at <a href="https://www.nature.com/articles/s41598-017-17124-4?WT.feed_name=subjects_population-genetics">https://www.nature.com/articles/s41598-017-17124-4?WT.feed_name=subjects_population-genetics</a>
The extent of population structure within Ireland is largely unknown, as is the impact of historical migrations. Here we illustrate fine-scale genetic structure across Ireland that follows geographic boundaries and present evidence of admixture events into Ireland. Utilising the ‘Irish DNA Atlas’, a cohort (n = 194) of Irish individuals with four generations of ancestry linked to specific regions in Ireland, in combination with 2,039 individuals from the Peoples of the British Isles dataset, we show that the Irish population can be divided in 10 distinct geographically stratified genetic clusters; seven of ‘Gaelic’ Irish ancestry, and three of shared Irish-British ancestry. In addition we observe a m...

https://epubs.rcsi.ie/mctart/89

Displaying Results 1 - 4 of 4 on page 1 of 1

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