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Displaying Results 1 - 25 of 984 on page 1 of 40
Marked
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-ing words in RBMT: multilingual evaluation and exploration of pre- and post-processing solutions
(2010)
Aranberri Monasterio, Nora
-ing words in RBMT: multilingual evaluation and exploration of pre- and post-processing solutions
(2010)
Aranberri Monasterio, Nora
Abstract:
This PhD dissertation falls within the domain of machine translation and it specifically focuses on the machine translation of IT-domain -ing words into four target languages: French, German, Japanese and Spanish. Claimed to be problematic due to their linguistic flexibility, i.e. -ing words can function as nouns, adjectives and verbs, this dissertation investigates how problematic -ing words are and explores possible solutions for improvement of their MT output. A corpus-based approach for a better representation of the domain-specific structures where -ing words occur is used. After selecting a significant sample, the -ing words are classified following a functional categorisation presented by Izquierdo (2006). The sample is machine-translated using a customised RBMT system. A feature-based human evaluation is then performed in order to obtain information about the specific feature under study. The results showed that 73% of the -ing words were correctly translated in terms of gra...
http://doras.dcu.ie/15093/
Marked
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‘Can biomimetic principles coupled with advanced fabrication technologies and stimuli-responsive materials drive revolutionary advances in wearable and implantable biochemical sensors?’
(2016)
Diamond, Dermot; Florea, Larisa; Dunne, Aishling; Tudor, Alexandru; Ben Azouz, Aymen; C...
‘Can biomimetic principles coupled with advanced fabrication technologies and stimuli-responsive materials drive revolutionary advances in wearable and implantable biochemical sensors?’
(2016)
Diamond, Dermot; Florea, Larisa; Dunne, Aishling; Tudor, Alexandru; Ben Azouz, Aymen; Coleman, Simon
Abstract:
Since the initial breakthroughs in the 1960’s and 70’s that led to the development of the glucose biosensor, the oxygen electrode, ion-selective electrodes, and electrochemical/optochemical diagnostic devices, the vision of very reliable, affordable chemical sensors and bio-sensors capable of functioning autonomously for long periods of time (years), and providing access to continuous streams of real-time data remains unrealized. This is despite massive investment in research and the publication of many thousands of papers in the literature. It is over 40 years since the first papers proposing the concept of the artificial pancreas, by combining the glucose electrode with an insulin pump. Yet even now, there is no chemical sensor/biosensor that can function reliably inside the body for more than a few days, and such is the gap in what can be delivered (days), and what is required (minimum 10 years) for implantable devices, it is not surprising that in health diagnostics, the overw...
http://doras.dcu.ie/21064/
Marked
Mark
‘SWEATCH’ – A platform for real-time monitoring of sweat electrolyte composition
(2016)
Glennon, Tom; O'Quigley, Conor; McCaul, Margaret; Coyle, Shirley; Matzeu, Giusy; C...
‘SWEATCH’ – A platform for real-time monitoring of sweat electrolyte composition
(2016)
Glennon, Tom; O'Quigley, Conor; McCaul, Margaret; Coyle, Shirley; Matzeu, Giusy; Coleman, Simon; Ben Azouz, Aymen; Beirne, Stephen; Wallace, Gordon; White, Paddy; O'Mahoney, Niamh; Diamond, Dermot
Abstract:
Since the initial breakthroughs in the 1960’s and 70’s that led to the development of the glucose biosensor, the oxygen electrode, ion-selective electrodes, and electrochemical/optochemical diagnostic devices, the vision of very reliable, affordable chemical sensors and bio-sensors capable of functioning autonomously for long periods of time (years), and providing access to continuous streams of real-time data remains unrealized. This is despite massive investment in research and the publication of many thousands of papers in the literature. It is over 40 years since the first papers proposing the concept of the artificial pancreas, by combining the glucose electrode with an insulin pump. Yet even now, there is no chemical sensor/biosensor that can function reliably inside the body for more than a few days, and such is the gap in what can be delivered (days), and what is required (minimum 10 years) for implantable devices, it is not surprising that in health diagnostics, the overw...
http://doras.dcu.ie/21115/
Marked
Mark
“Calixarenes as ionophores in ion- selective electrodes: The Past and The Future of Chemical Sensing”
(2014)
Diamond, Dermot
“Calixarenes as ionophores in ion- selective electrodes: The Past and The Future of Chemical Sensing”
(2014)
Diamond, Dermot
Abstract:
This paper focuses on the context of early research into the use of calixarenes as ionophores in ion-selective electrodes and explains the basis for their exquisite selectivity in terms of the 3D arrangement of polar binding sites [1]. However, in order to make chemical sensors with long effective lifetimes, this polar cavity must be associated with an overall non-polar molecular character, in order to ensure that that the binding sites do not leach rapidly into aqueous sample media. Furthermore, while selectivity demands a significant binding constant (at least for the primary target ion), this cannot be too large, or binding becomes irreversible, leading to device failure. I will also review the trend towards solid-state sensor configurations compatible with printing technologies and low-cost mass production. To achieve this goal, the electrode internal-filling solution must be replaced with a solid material capable of emulating the mixed conductance behaviour that (in convent...
http://doras.dcu.ie/20249/
Marked
Mark
#hardtoparse: POS tagging and parsing the twitterverse
(2011)
Foster, Jennifer; Cetinoglu, Ozlem; Wagner, Joachim; Le Roux, Joseph; Hogan, Stephen; N...
#hardtoparse: POS tagging and parsing the twitterverse
(2011)
Foster, Jennifer; Cetinoglu, Ozlem; Wagner, Joachim; Le Roux, Joseph; Hogan, Stephen; Nivre, Joakim; Hogan, Deirdre; van Genabith, Josef
Abstract:
We evaluate the statistical dependency parser, Malt, on a new dataset of sentences taken from tweets. We use a version of Malt which is trained on gold standard phrase structure Wall Street Journal (WSJ) trees converted to Stanford labelled dependencies. We observe a drastic drop in performance moving from our in-domain WSJ test set to the new Twitter dataset, much of which has to do with the propagation of part-of-speech tagging errors. Retraining Malt on dependency trees produced by a state-of-the-art phrase structure parser, which has itself been self-trained on Twitter material, results in a significant improvement. We analyse this improvement by examining in detail the effect of the retraining on individual dependency types.
http://doras.dcu.ie/16484/
Marked
Mark
2D distinct element modeling of the structure and growth of normal faults in multilayer sequences : 2. Impact of confining pressure and strength contrast on fault zone growth and geometry
(2007)
Schöpfer, Martin P. J.; Childs, Conrad; Walsh, John J.
2D distinct element modeling of the structure and growth of normal faults in multilayer sequences : 2. Impact of confining pressure and strength contrast on fault zone growth and geometry
(2007)
Schöpfer, Martin P. J.; Childs, Conrad; Walsh, John J.
Abstract:
The growth of normal faults in periodically layered sequences with varying strength contrast and at varying confining pressure is modeled using the Distinct Element Method. The normal faulting models are comprised of strong layers (bonded particles) and weak layers (non-bonded particles) that are deformed using a predefined fault at the base of the sequence. The model results suggest that faults in sequences with high strength contrast at low confining pressure are highly segmented due to different types of failure (extension vs. shear failure) in the different layers. The degree of segmentation decreases as the strength contrast decreases and confining pressure increases. Faults at low confining pressure localize as extension (Mode I) fractures within the strong layers and are later linked via shallow dipping faults in the weak ones. This leads to initial staircase geometries that, with increasing displacement, cause space problems that are later resolved by splaying and segmentati...
http://hdl.handle.net/10197/3034
Marked
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An investigation into Bridgman furnace solidification of titanium alloys
(2013)
MOONEY, ROBIN; MCFADDEN, SHAUN
An investigation into Bridgman furnace solidification of titanium alloys
(2013)
MOONEY, ROBIN; MCFADDEN, SHAUN
http://hdl.handle.net/2262/75677
Marked
Mark
7B7: a novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells
(2014)
O'Sullivan, Dermot; Henry, Michael; Joyce, Helena; Walsh, Naomi; Mc Auley, Edel; D...
7B7: a novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells
(2014)
O'Sullivan, Dermot; Henry, Michael; Joyce, Helena; Walsh, Naomi; Mc Auley, Edel; Dowling, Paul; Swan, Niall; Moriarty, Michael; Barnham, Paul; Clynes, Martin; Larkin, Annemarie
Abstract:
Development of more effective therapeutic strategies for cancers of high unmet need requires the continued discovery of disease-specific protein targets for therapeutic antibody targeting. In order to identify novel proteins associated with cancer cell invasion/metastasis, we present here an alternative to antibody targeting of cell surface proteins with an established role in invasion; our functional antibody screening approach involves the isolation and selection of MAbs that are primarily screened for their ability to inhibit tumour invasion. A clonal population of the Mia PaCa-2, a pancreatic ductal adenocarcinoma (PDAC) cell line, which displays a highly invasive phenotype, was used to generate MAbs with the objective of identifying membrane targets directly involved in cancer invasion. Selected MAb 7B7 can significantly reduce invasion in a dose-responsive manner in Mia PaCa-2 clone 3 and DLKP-M squamous lung carcinoma cells. Using immunoprecipitation and liquid chromatography...
http://eprints.maynoothuniversity.ie/6927/
Marked
Mark
A 100dB SFDR 0.5V pk-pk band-pass DAC implemented on a low voltage CMOS process
(2012)
Mullane, Brendan; O'Brien, Vincent
A 100dB SFDR 0.5V pk-pk band-pass DAC implemented on a low voltage CMOS process
(2012)
Mullane, Brendan; O'Brien, Vincent
Abstract:
Direct Digital Synthesis (DDS) systems generate fine frequency resolution signals over a broad spectrum that are used in a wide variety of applications such as multi-mode RF, communications, measurements and test. A high performance DDS band-pass Digital to Analog Converter (DAC) architecture and implementation is presented that delivers high spectral purity over a narrow-band response. The low power D/A Converter is portable to standard CMOS processes and designed to achieve over 100dB narrow-band SFDR performance using Sigma-Delta (ΣΔ) modulation and multi-bit current steering techniques. A 3rd order digital ΣΔ modulator is combined with a 4th order digital Dynamic Element Matching (DEM) block to shape the noise while calibrating for process mismatch variations. A low silicon area output stage is used to deliver a high performance specification.
ACCEPTED
Peer reviewed
http://hdl.handle.net/10344/5652
Marked
Mark
A Bayesian approach to comparing theoretic models to observational data: A case study from solar flare physics
(2011)
GALLAGHER, PETER THOMAS
A Bayesian approach to comparing theoretic models to observational data: A case study from solar flare physics
(2011)
GALLAGHER, PETER THOMAS
Abstract:
Solar flares are large-scale releases of energy in the solar atmosphere, which are characterized by rapid changes in the hydrodynamic properties of plasma from the photosphere to the corona. Solar physicists have typically attempted to understand these complex events using a combination of theoretical models and observational data. From a statistical perspective, there are many challenges associated with making accurate and statistically significant comparisons between theory and observations, due primarily to the large number of free parameters associated with physical models. This class of ill-posed statistical problem is ideally suited to Baysian methods. In this paper, the solar flare studied by Raftery et al. (2008) is reanalysed using a Baysian framework. This enables us to study the evolution of the flare's temperature, emission measure and energy loss in a statistically self-consistent manner. The Baysian-based techniques confirm that both conductive and non-thermal bea...
http://hdl.handle.net/2262/59497
Marked
Mark
A bioactive metallurgical grade porous silicon-polytetrafluoroethylene sheet for guided bone regeneration applications
(2014)
Chadwick, Edward G; Clarkin, O.M; Raghavendra, R; Tanner, David A
A bioactive metallurgical grade porous silicon-polytetrafluoroethylene sheet for guided bone regeneration applications
(2014)
Chadwick, Edward G; Clarkin, O.M; Raghavendra, R; Tanner, David A
Abstract:
The properties of porous silicon make it a promising material for a host of applications including drug delivery, molecular and cell-based biosensing, and tissue engineering. Porous Silicon has previously shown its potential for the controlled release of pharmacological agents and in assisting bone healing. Hydroxyapatite, the principle constituent of bone, allows osteointegration in vivo, due to its chemical and physical similarities to bone. Synthetic hydroxyapatite is currently applied as a surface coating to medical devices and prosthetics, encouraging bone in-growth at their surface & improving osseointegration. This paper examines the potential for the use of an economically produced porous silicon particulate-polytetrafluoroethylene sheet for use as a guided bone regeneration device in periodontal and orthopaedic applications. The particulate sheet is comprised of a series of microparticles in a polytetrafluoroethylene matrix and is shown to produce a stable hydroxyapatit...
http://hdl.handle.net/10344/3976
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A Bridgman Furnace Front Tracking Model
(2015)
Mooney, Robin Patrick
A Bridgman Furnace Front Tracking Model
(2015)
Mooney, Robin Patrick
Abstract:
The Bridgman furnace is widely used in industry and research, mainly because it provides a means to directionally solidify materials in a controlled manner, so that the resulting microstructure, and hence material properties, can be manipulated. This thesis details, firstly, the development and verification of a numerical Front Tracking Model (FTM) to track the position of, and growth conditions at, the columnar front during transient directional solidification in a Bridgman furnace; and, secondly, its application to experiments investigating Columnar to Equiaxed Transition (CET) in a gamma TiAl multicomponent hypoperitectic alloy. Previous FTMs have been applied in fixed grid numerical domains where the solidifying material - normally of hypoeutectic composition - is contained within that domain throughout simulations; the model demonstrated here accounts for movement of material through the domain and is adapted for hypoperitectic solidification. The model is applied, firstly, to ...
http://hdl.handle.net/2262/74991
Marked
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A combined audio-visual contribution to event detection in field sports broadcast video. Case study: Gaelic football
(2003)
Sadlier, David A.; O'Connor, Noel E.; Marlow, Seán; Murphy, Noel
A combined audio-visual contribution to event detection in field sports broadcast video. Case study: Gaelic football
(2003)
Sadlier, David A.; O'Connor, Noel E.; Marlow, Seán; Murphy, Noel
Abstract:
In this paper we propose novel, audio-visual analysis techniques for event detection in broadcast TV sports video content. The scope of the design is constrained to the specialized domain of 'field sport', and specifically, Gaelic Football is presented as an experimental case study. We show that a combination of speech-band energy tracking in the audio domain, coupled with colour dominance pattern recognition in the video domain, provides a useful contribution to event detection for broadcast Gaelic Football matches. It is projected that, any conclusions made therein may be extended such that they function on sports content of a similar nature such as American Football, Australian Rules, Rugby Union etc.
http://doras.dcu.ie/244/
Marked
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A companding approach for nonuniform quantization of digital holograms of three-dimensional objects
(2006)
Shortt, Alison; Naughton, Thomas J.; Javidi, Bahram
A companding approach for nonuniform quantization of digital holograms of three-dimensional objects
(2006)
Shortt, Alison; Naughton, Thomas J.; Javidi, Bahram
Abstract:
We apply two novel nonuniform quantization techniques to digital holograms of three-dimensional real-world objects. Our companding approach, combines the efficiency of uniform quantization with the improved performance of nonuniform quantization. We show that the performance of companding techniques can be comparable with k-means clustering and a competitive neural network, while only requiring a single-pass processing step. The quantized holographic pixels are coded using lossless techniques for the calculation of compression ratio.
http://eprints.maynoothuniversity.ie/8628/
Marked
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A comparative study of the structural, mechanical and tribological characteristics of TiSiC-Cr coatings prepared in CH4 and C2H2 reactive atmosphere by cathodic vacuum arc
(2017)
Braic, Mariana; Vladescu, Alina; Balaceanu, Mihai; Luculescu, Catalin; Padmanabhan, Sib...
A comparative study of the structural, mechanical and tribological characteristics of TiSiC-Cr coatings prepared in CH4 and C2H2 reactive atmosphere by cathodic vacuum arc
(2017)
Braic, Mariana; Vladescu, Alina; Balaceanu, Mihai; Luculescu, Catalin; Padmanabhan, Sibu C.; Constantin, Lidia; Morris, Michael A.; Braic, Viorel; Grigorescu, Cristiana E. A.; Ionescu, Paul; Dracea, Maria Diana; Logofatu, Constantin
Abstract:
TiSiC-Cr coatings, with Cr and Si as additional elements, were deposited on Si, C 45 and 316 L steel substrates via cathodic arc evaporation. Two series of coatings with thicknesses in the range of 3.6–3.9 μm were produced, using either CH4 or C2H2 as carbon containing gas. For each series, different coatings were prepared by varying the carbon rich gas flow rate between 90 and 130 sccm, while maintaining constant cathode currents (110 and 100 A at TiSi and Cr cathodes, respectively), substrate bias (–200 V) and substrate temperature (∼320 °C). The coatings were analyzed for their mechanical characteristics (hardness, adhesion) and tribological performance (friction, wear), along with their elemental and phase composition, chemical bonds, crystalline structure and cross-sectional morphology. The coatings were found to be formed with nano-scale composite structures consisting of carbide crystallites (grain size of 3.1–8.2 nm) and amorphous hydrogenated carbon. The experimental result...
http://hdl.handle.net/10468/3460
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A comparison framework and review of service brokerage solutions for cloud architectures
(2013)
Fowley, Frank; Pahl, Claus; Zhang, Li
A comparison framework and review of service brokerage solutions for cloud architectures
(2013)
Fowley, Frank; Pahl, Claus; Zhang, Li
Abstract:
Cloud service brokerage has been identified as a key concern for future cloud technology development and research. We compare service brokerage solutions. A range of specific concerns like architecture, programming and quality will be looked at. We apply a 2-pronged classification and comparison framework.We will identify challenges and wider research objectives based on an identification of cloud broker architecture concerns and technical requirements for service brokerage solutions. We will discuss complex cloud architecture concerns such as commoditisation and federation of integrated, vertical cloud stacks.
http://doras.dcu.ie/19640/
Marked
Mark
A Comparison of Ensemble and Case-Base Maintenance Techniques for Handling Concept Drift in Spam Filtering
(2005)
Delany, Sarah Jane; Cunningham, Padraig; Tsymbal, Alexey
A Comparison of Ensemble and Case-Base Maintenance Techniques for Handling Concept Drift in Spam Filtering
(2005)
Delany, Sarah Jane; Cunningham, Padraig; Tsymbal, Alexey
Abstract:
TCD-CS-2005-19
The problem of concept drift has recently received considerable attention in machine learning research. One important practical problem where concept drift needs to be addressed is spam filtering. The literature on concept drift shows that among the most promising approaches are ensembles and a variety of techniques for ensemble construction has been proposed. In this paper we consider an alternative lazy learning approach to concept drift whereby a single case-based classifier for spam filtering keeps itself up-to-date through a case-base maintenance protocol. We present an evaluation that shows that the case-base maintenance approach is more effective than a variety of ensemble techniques. The evaluation is complicated by the overriding importance of False Positives (FPs) in spam filtering. The ensemble approaches can have very good performance on FPs because it is possible to bias an ensemble more strongly away from FPs than it is to bias the single classifer. ...
http://hdl.handle.net/2262/13439
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A comparison of score, rank and probability-based fusion methods for video shot retrieval
(2005)
McDonald, Kieran; Smeaton, Alan F.
A comparison of score, rank and probability-based fusion methods for video shot retrieval
(2005)
McDonald, Kieran; Smeaton, Alan F.
Abstract:
It is now accepted that the most effective video shot retrieval is based on indexing and retrieving clips using multiple, parallel modalities such as text-matching, image-matching and feature matching and then combining or fusing these parallel retrieval streams in some way. In this paper we investigate a range of fusion methods for combining based on multiple visual features (colour, edge and texture), for combining based on multiple visual examples in the query and for combining multiple modalities (text and visual). Using three TRECVid collections and the TRECVid search task, we specifically compare fusion methods based on normalised score and rank that use either the average, weighted average or maximum of retrieval results from a discrete Jelinek-Mercer smoothed language model. We also compare these results with a simple probability-based combination of the language model results that assumes all features and visual examples are fully independent.
http://doras.dcu.ie/269/
Marked
Mark
A computational model of counterfactual thinking: The temporal order effect
(2001)
BYRNE, RUTH MARY JOSEPHINE
A computational model of counterfactual thinking: The temporal order effect
(2001)
BYRNE, RUTH MARY JOSEPHINE
Abstract:
People generate counterfactual alternatives to realitywhen they think about how things might have happeneddifferently, 'if only?'. There are considerableregularities in the sorts of past events that peoplementally undo, for example, they tend to mentally undothe most recent event in an independent sequence.Consider a game in which two contestants will win#1000 if they both pick cards from the same color suite.The first player picks black and the second red and theylose. Most people spontaneously undo the outcome bythinking, if only the second player had picked black. Wedescribe a computational model that simulates our theoryof the mental representations and cognitive processesunderlying this temporal order effect. The computermodel is corroborated by tests of the novel predictions ofour theory: it should be possible to reverse the temporalorder effect by manipulating the way in which thewinning conditions are described.
http://hdl.handle.net/2262/39493
Marked
Mark
A computer vision based approach for reducing false alarms caused by spiders and cobwebs in surveillance camera networks
(2014)
Hebbalaguppe, Ramya
A computer vision based approach for reducing false alarms caused by spiders and cobwebs in surveillance camera networks
(2014)
Hebbalaguppe, Ramya
http://doras.dcu.ie/19748/
Marked
Mark
A Delay-aware Packet Prioritisation Mechanism for Voice over IP in Wireless Mesh Networks
(2016)
Olariu, Cristian; Fitzpatrick, John; Ghamri-Doudane, Yacine; Murphy, Liam, B.E.
A Delay-aware Packet Prioritisation Mechanism for Voice over IP in Wireless Mesh Networks
(2016)
Olariu, Cristian; Fitzpatrick, John; Ghamri-Doudane, Yacine; Murphy, Liam, B.E.
Abstract:
This work proposes a novel Delay-aware Packet Prioritisation Mechanism (DPPM) to uniformly distribute the Quality of Service (QoS) level across all Voice Over IP (VoIP) calls in a Wireless Mesh Network (WMN). The method prioritises VoIP packets based on the amount of queueing delay that has been accumulated across multiple hops within the WMN. The accumulated queueing delay is piggybacked over every VoIP packet and is used at the enqueueing phase to place more delayed packets towards the head of the queue. This assures higher priority for more delayed VoIP packets over less delayed VoIP packets. The influence of the queueing delay on voice call quality is further reduced by utilising the proposed DPPM in conjunction with WiFi frame aggregation. This conjunction increases the network's VoIP call capacity, and this is validated through NS-3 simulations.
http://hdl.handle.net/10197/7656
Marked
Mark
A demonstration of wireless sensing for long-term monitoring of water quality
(2009)
Regan, Fiona; Lawlor, Antoin; O'Flynn, Brendan; Torres-Sanchez, Javier; Martínez-C...
A demonstration of wireless sensing for long-term monitoring of water quality
(2009)
Regan, Fiona; Lawlor, Antoin; O'Flynn, Brendan; Torres-Sanchez, Javier; Martínez-Català, Rafael V.; Ó Mathúna, S. Cian; Wallace, John
Abstract:
At a time when technological advances are providing new sensor capabilities, novel network capabilities, long-range communications technologies and data interpreting and delivery formats via the World Wide Web, we never before had such opportunities to sense and analyse the environment around us. However, the challenges exist. While measurement and detection of environmental pollutants can be successful under laboratory-controlled conditions, continuous in-situ monitoring remains one of the most challenging aspects of environmental sensing. This paper describes the development and test of a multi-sensor heterogeneous real-time water monitoring system. A multi-sensor system was deployed in the River Lee, County Cork, Ireland to monitor water quality parameters such as pH, temperature, conductivity, turbidity and dissolved oxygen. The R. Lee comprises of a tidal water system that provides an interesting test site to monitor. The multi-sensor system set-up is described and results o...
http://hdl.handle.net/10468/180
Marked
Mark
A disciplined innovation approach to health technology solutions
(2017)
Carroll, Noel; Richardson, Ita
A disciplined innovation approach to health technology solutions
(2017)
Carroll, Noel; Richardson, Ita
Abstract:
Despite the potential of innovation-driven healthcare technology services to increase the quality, accessibility and quality of care, the realization and success of such promise has yet to be achieved. This prompted us to explore the barriers towards success for healthcare software companies and examine what frameworks are employed across industry to support their growth in the digital healthcare market. As part of a three-phase study, this article reports on the first phase -to synthesize the literature on the readiness factors for healthcare technology companies. The findings of this research will guide our second phase of this research in surveying industry healthcare software companies. In so doing, we can establish readiness factors for healthcare software companies with a view to offering a more structured and disciplined approach to healthcare innovation.
ACCEPTED
peer-reviewed
http://hdl.handle.net/10344/6384
Marked
Mark
A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors
(2011)
WINDLE, HENRY; GILMER, JOHN FRANCIS; KELLEHER, DERMOT P; KEOGH, BRIAN; REILLY, MARY
A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors
(2011)
WINDLE, HENRY; GILMER, JOHN FRANCIS; KELLEHER, DERMOT P; KEOGH, BRIAN; REILLY, MARY
Abstract:
The design, synthesis and delivery potential of a new type of benzenesulfonamide cyclo-oxygenase-2 (COX-2) inhibitor prodrug is investigated using celecoxib. The approach involves a double prodrug that is activated first by azoreductases and then by cyclization triggering drug release. We studied the intramolecular aminolysis of the acylsulfonamide. The cyclization was surprisingly rapid at physiological pH and very fast at pH 5. The prodrug is activated specifically under conditions found in the colon but highly stable in the presence of human and rodent intestinal extracts. Finally, the prototype with celecoxib was transported much more slowly in the Caco-2 transepithelial model than the parent. The design therefore shows significant promise for the site specific delivery of benzenesulfonamide COX-2 inhibitors to the colon.
http://hdl.handle.net/2262/60695
Marked
Mark
A framework for generating operational characteristic curves for semiconductor manufacturing systems using flexible and reusable discrete event simulations
(2012)
Byrne, Néill M.
A framework for generating operational characteristic curves for semiconductor manufacturing systems using flexible and reusable discrete event simulations
(2012)
Byrne, Néill M.
Abstract:
This thesis proposes a framework for generating operating curves for semiconductor manufacturing facilities using a modular flexible discrete event simulation (DES) model embedded in an application that automates the design of experiments for the simulations. Typically, operating curves are generated using analytical queueing models that are difficult to implement and hence, can only be used for benchmarking purposes. Alternatively, DES models are more capable of capturing the complexities of a semiconductor manufacturing facility such as re-entrancy, rework and non-identical toolsets. However, traditional craft-based simulations require much time and resources. The proposed methodology aims to reduce this time by automatically calculating the parameters for experimentation and generating the simulation model. It proposes a novel method to more appropriately allocate simulation effort by selecting design points more relevant to the operating curve. The methodology was initially...
http://doras.dcu.ie/16922/
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