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Displaying Results 1 - 25 of 805 on page 1 of 33
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‘….All the most approved modern arrangements': Building for mental health care at Monaghan, 1886-1950s
(2015)
NicGhabhann, Niamh
‘….All the most approved modern arrangements': Building for mental health care at Monaghan, 1886-1950s
(2015)
NicGhabhann, Niamh
Abstract:
n/a
This essay considers the building of St. Davnet's Hospital in Monaghan town, which was opened in 1869 as the Cavan and Monaghan District Lunatic Asylum. Based on extensive primary research from the records on site, this essay explores the history of this building within the context of institutional architecture in Ireland, across the British Empire, and the fate of the asylums within the Irish Free State.
http://hdl.handle.net/10344/4431
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‘Around the edges’: Using behaviour change techniques to characterise a multilevel implementation strategy for a fall prevention programme
(2018)
McHugh, Sheena M.; Sinnott, C.; Racine, Emmy; Timmons, Suzanne; Byrne, M.; Kearney, Pat...
‘Around the edges’: Using behaviour change techniques to characterise a multilevel implementation strategy for a fall prevention programme
(2018)
McHugh, Sheena M.; Sinnott, C.; Racine, Emmy; Timmons, Suzanne; Byrne, M.; Kearney, Patricia M.
Abstract:
Background: Implementation strategies are needed to ensure that evidence-based healthcare interventions are adopted successfully. However, strategies are generally poorly described and those used in everyday practice are seldom reported formally or fully understood. Characterising the active ingredients of existing strategies is necessary to test and refine implementation. We examined whether an implementation strategy, delivered across multiple settings targeting different stakeholders to support a fall prevention programme, could be characterised using the Behaviour Change Technique (BCT) Taxonomy. Methods: Data sources included project plans, promotional material, interviews with a purposive sample of stakeholders involved in the strategy’s design and delivery and observations of staff training and information meetings. Data were analysed using TIDieR to describe the strategy and determine the levels at which it operated (organisational, professional, patient). The BCT Taxonomy i...
http://hdl.handle.net/10468/9207
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‘I hated being ghosted’ – The relevance of social participation for living well with post-stroke aphasia: Qualitative interviews with working aged adults
(2021)
Manning, Molly; MacFarlane, Anne E.; Hickey, Anne; Galvin, Rose; Franklin, Sue
‘I hated being ghosted’ – The relevance of social participation for living well with post-stroke aphasia: Qualitative interviews with working aged adults
(2021)
Manning, Molly; MacFarlane, Anne E.; Hickey, Anne; Galvin, Rose; Franklin, Sue
Abstract:
Background In the context of increasing incidence of stroke in working aged adults, there is a specific need to explore the views of working aged adults with post-stroke aphasia, whose communication difficulties may result in restricted social participation, loss of employment and changed relationship and parenting roles. This study aimed to explore the perspectives of working aged adults with post-stroke aphasia in relation to social participation and living well with aphasia (LWA). Design and participants We conducted qualitative interviews with 14 people with post-stroke aphasia (PWA). Data were analysed following principles of reflexive, thematic analysis. Patient or Public Contribution: A Public and Patient Involvement aphasia advisory group inputted into the study design and interpretation of data. Results Social participation spanned 5 themes: Relationships and roles; Social support; Peer network, Aphasia awareness; and Employment and training. Meaningful, interesting soci...
http://hdl.handle.net/10344/10463
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‘If relevant, yes; if not, no’: general practitioner (GP) users and GP perceptions about asking ethnicity questions in Irish general practice: A qualitative analysis using normalization process theory
(2021)
Roura, Maria; LeMaster, Joseph W.; Hannigan, Ailish; Papyan, Anna; McCarthy, Sharon; Nu...
‘If relevant, yes; if not, no’: general practitioner (GP) users and GP perceptions about asking ethnicity questions in Irish general practice: A qualitative analysis using normalization process theory
(2021)
Roura, Maria; LeMaster, Joseph W.; Hannigan, Ailish; Papyan, Anna; McCarthy, Sharon; Nurse, Diane; Villarroe, Nazmy; MacFarlane, Anne E.
Abstract:
Context The use of ethnic identifiers in health systems is recommended in several European countries as a means to identify and address heath inequities. There are barriers to implementation that have not been researched. Objective This study examines whether and how ethnicity data can be collected in Irish general practices in a meaningful and acceptable way. Methods Qualitative case study data generation was informed by Normalization Process Theory (NPT) constructs about ‘sense’ making and ‘engagement’. It consisted of individual interviews and focus group discussions based on visual participatory techniques. There were 70 informants, including 62 general practitioner (GP) users of diverse ethnic backgrounds recruited through community organisations and eight GPs identified through an inter-agency steering group. Data were analysed according to principles of thematic analysis using NPT.
http://hdl.handle.net/10344/10091
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‘Participation is integral’: understanding the levers and barriers to the implementation of community participation in primary healthcare: a qualitative study using normalisation process theory
(2019)
McEvoy, Rachel; Tierney, Edel; MacFarlane, Anne E.
‘Participation is integral’: understanding the levers and barriers to the implementation of community participation in primary healthcare: a qualitative study using normalisation process theory
(2019)
McEvoy, Rachel; Tierney, Edel; MacFarlane, Anne E.
Abstract:
Background: Many international health policies recognise the World Health Organization’s (2008) vision that communities should be involved in shaping primary healthcare services. However, researchers continue to debate definitions, models, and operational challenges to community participation. Furthermore, there has been no use of implementation theory to study how community participation is introduced and embedded in primary healthcare in order to generate insights and transferrable lessons for making this so. Using Normalisation Process Theory (NPT) as a conceptual framework, this qualitative study was designed to explore the levers and barriers to the implementation of community participation in primary healthcare as a routine way of working. Methods: We conducted two qualitative studies based on a national Initiative designed to support community participation in primary care in Ireland. We had a combined multi-stakeholder purposeful sample (n = 72), utilising documentary eviden...
http://hdl.handle.net/10344/8005
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"Nobody really gets it”: A qualitative exploration of youth mental health in deprived urban areas
(2014)
Schaffalitzky, Elizabeth; Leahy, Dorothy; Armstrong, Claire; Gavin, Blanaid; Latham, Li...
"Nobody really gets it”: A qualitative exploration of youth mental health in deprived urban areas
(2014)
Schaffalitzky, Elizabeth; Leahy, Dorothy; Armstrong, Claire; Gavin, Blanaid; Latham, Linda; McNicholas, Fiona; O'Connor, Ray; O'Toole, Thomas P.; Smyth, Bobby P.; Cullen, Walter
Abstract:
Aim: To explore and describe the experience of mental health and addiction for young people living in urban deprived areas in Ireland. Method: Semi-structured qualitative interviews were conducted with 20 young adults attending health and social care agencies in two deprived urban areas, and analysed using thematic analysis. Results: Five main themes were identified: experiencing symptoms, symptom progression, delay accessing help, loss of control/crisis point, and consequences of mental health and substance use issues. As young people delayed help, symptoms disrupted normal life progression and they found themselves unable to engage in every-day activities. Living in deprivation made it harder to avoid developing problems: many had added stressors, less familial support and early exposure to violence, addiction and bereavement. Conclusion: Young people in urban deprived areas are vulnerable to mental health and addiction issues. Early identification is necessary to halt this progre...
http://hdl.handle.net/10344/4533
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2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC)
(1997)
O'NEILL, LUKE ANTHONY JOHN
2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC)
(1997)
O'NEILL, LUKE ANTHONY JOHN
Abstract:
The metal chelator and anti-oxidant pyrollidine dithiocarbamate (PDTC) has been used extensively in studies implicating reactive oxygen intermediates in the activation of nuclear factor kappa B (NF kappa B). In agreement with other studies, we have shown that PDTC inhibits NF kappa B activation in response to the pro-inflammatory cytokines interleukin 1 (IL1) and tumour necrosis factor (TNF). However, we have found that the inhibition was reversed by treatment of inhibited nuclear extracts with the reducing agent 2-mercaptoethanol. This was observed in extracts prepared from IL1-treated EL4.NOB-1 thymoma cells and TNF-treated Jurkat E6.1 lymphoma cells. These results suggested that the inhibition was caused by oxidation of NF kappa B on a sensitive thiol, possibly on the p50 subunit (which was detected in NF kappa B complexes in both cell types), and not by inhibition of the activation pathway. The possibility that PDTC was acting as a pro-oxidant was therefore investigated. PDTC ca...
http://hdl.handle.net/2262/33734
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A cohort study to investigate sex‑specific differences in ANCA‑associated glomerulonephritis outcomes
(2021)
Scott, Jennifer; Canepa, Carolina; Buettner, Antonia; Ryan, Louise; Moloney, Bróna; Cor...
A cohort study to investigate sex‑specific differences in ANCA‑associated glomerulonephritis outcomes
(2021)
Scott, Jennifer; Canepa, Carolina; Buettner, Antonia; Ryan, Louise; Moloney, Bróna; Cormican, Sarah; Walsh, Cathal Dominic; White, Arthur; Salama, Alan D.; Little, Mark A.
Abstract:
Data surrounding sex-specific differences in ANCA-associated vasculitis glomerulonephritis (ANCA-GN) outcomes is sparse. We hypothesised that the previously observed increased risk of end-stage kidney disease (ESKD) in males is driven by sex-specific variation in immunosuppression dosing. Patients were recruited to the Irish Rare Kidney Disease Registry or followed by the Royal Free Hospital vasculitis team (2012–2020). Inclusion criteria: prior diagnosis of ANCA-GN (biopsy proven pauci-immune glomerulonephritis) and positive serology for anti-MPO or -PR3 antibodies. Renal and patient survival, stratified by sex and Berden histological class, was analysed. The cumulative- and starting dose/kilogram of induction agents and prednisolone, respectively, was compared between sexes. 332 patients were included. Median follow-up was time 40.2 months (IQR 17.3–69.2). 73 (22%) reached ESKD and 47 (14.2%) died. Overall 1- and 5-year renal survival was 82.2% and 76.7% in males and 87....
http://hdl.handle.net/10344/10293
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A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma
(2001)
KELLEHER, DERMOT P; MCMANUS, ROSS
A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma
(2001)
KELLEHER, DERMOT P; MCMANUS, ROSS
Abstract:
peer-reviewed
The incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares some p53-like activity, but in addition, may also play a role in gastrointestinal epithelial inflammatory responses. A non-coding p73 polymorphism (denoted AT or GC) may be functionally significant. We investigated whether this polymorphism might play a role in the aetiopathogenesis of oesophageal cancer. This was a case?control, retrospective study. 84 cases of oesophageal cancer (25 squamous and 59 adenocarcinoma) and 152 normal population controls were genotyped for this polymorphism. Informative cases were examined for p73 LOH within the tumour. AT/AT homozygotes were significantly less prevalent in the oesophageal cancer population (1/84 = 1.2%) compared to controls (15/152 = 9.9%) (P < 0.02), corresponding to an odds ratio of 0.11 (95% ...
http://hdl.handle.net/2262/33836
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A comparative evaluation of surrogate measures of adiposity as indictors of cardiometabolic disease
(2016)
Millar, Sean R.
A comparative evaluation of surrogate measures of adiposity as indictors of cardiometabolic disease
(2016)
Millar, Sean R.
Abstract:
This thesis contributes to the current evidence base regarding methods to detect patients with type 2 diabetes, and those at increased obesity-related cardiometabolic risk. In particular, it aimed to determine how useful surrogate measures of adiposity might be to identify high-risk patients within a clinical setting. Using a cross-sectional sample of 2,047 middle-aged men and women, the main objectives were: (1) to examine the rationale for adiposity assessment within clinical practice, and whether methods used for disease classification and anthropometric measurement procedure are important for diagnosing cardiometabolic risk and type 2 diabetes; (2) to compare adiposity variable relationships with a range of cardiometabolic disease features, biomarkers of chronic low-grade inflammation and type 2 diabetes; (3) to explore whether central adiposity indices provide additional information regarding disease and risk status, compared to general adiposity characterised by body mass inde...
http://hdl.handle.net/10468/5417
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A comparison, for older people with diabetes, of health and health care utilisation in two different health systems on the island of Ireland
(2020)
Pierse, Tom; Barry, Luke; Glynn, Liam G.; Murphy, Andrew W.; Cruise, Sharon; O'Nei...
A comparison, for older people with diabetes, of health and health care utilisation in two different health systems on the island of Ireland
(2020)
Pierse, Tom; Barry, Luke; Glynn, Liam G.; Murphy, Andrew W.; Cruise, Sharon; O'Neill, Ciaran
Abstract:
Background: There are social and economic differences between Northern Ireland (NI) and the Republic of Ireland (ROI). There are also differences in the health care systems in the two jurisdictions. The aims of this study are to compare health (prevalence of diabetes and related complications) and health care utilisation (general practitioner, outpatient or accident and emergency utilisation) among older people with diabetes in the NI and ROI. Methods: Large scale comparable surveys of people over 50years of age in Northern Ireland (NICOLA, wave 1) and the Republic of Ireland (TILDA, wave 1) are used to compare people with diabetes (type I and type II) in the two jurisdictions. The combined data set comprises 1536 people with diabetes. A coarsened exact matching approach is used to compare health care utilisation among people with diabetes in NI and ROI with equivalent demographic, lifestyle and illness characteristics (age, gender, education, smoking status and self-relat...
http://hdl.handle.net/10344/9290
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A cost-analysis of complex workplace nutrition education and environmental dietary modification interventions
(2017)
Fitzgerald, Sarah; Kirby, Ann; Murphy, Aileen; Geaney, Fiona; Perry, Ivan J.
A cost-analysis of complex workplace nutrition education and environmental dietary modification interventions
(2017)
Fitzgerald, Sarah; Kirby, Ann; Murphy, Aileen; Geaney, Fiona; Perry, Ivan J.
Abstract:
Background: The workplace has been identified as a priority setting to positively influence individuals’ dietary behaviours. However, a dearth of evidence exists regarding the costs of implementing and delivering workplace dietary interventions. This study aimed to conduct a cost-analysis of workplace nutrition education and environmental dietary modification interventions from an employer’s perspective. Methods: Cost data were obtained from a workplace dietary intervention trial, the Food Choice at Work Study. Micro-costing methods estimated costs associated with implementing and delivering the interventions for 1 year in four multinational manufacturing workplaces in Cork, Ireland. The workplaces were allocated to one of the following groups: control, nutrition education alone, environmental dietary modification alone and nutrition education and environmental dietary modification combined. A total of 850 employees were recruited across the four workplaces. For comparison purposes,...
http://hdl.handle.net/10468/3474
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A different perspective on consumer engagement: exploring the experience of using health apps to support healthier food purchasing
(2019)
Flaherty, Sarah Jane; McCarthy, Mary; Collins, Alan M.; McAuliffe, Fionnuala M.
A different perspective on consumer engagement: exploring the experience of using health apps to support healthier food purchasing
(2019)
Flaherty, Sarah Jane; McCarthy, Mary; Collins, Alan M.; McAuliffe, Fionnuala M.
Abstract:
Healthy food purchasing behaviour may be facilitated through the use of health apps if used for the necessary time period. However, little is known on the factors that influence the user experience and facilitate or impede their continued use. The purpose of the present research is to explore the lived experience of using a health app to support healthier food purchasing behaviour. Findings identify the presence of behaviour change motivation and anticipated effort levels as drivers of app engagement. It appeared that behavioural, cognitive and emotional dimensions of engagement may influence one another, driven by contextual influences, to simultaneously contribute to the intrinsic experience of engagement. The research makes practical and theoretical contributions to the consumer engagement literature and highlights the need to focus on understanding and capturing the specific engagement context to better understand engagement.
http://hdl.handle.net/10468/11433
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A guidance framework to aid in the selection of nursing and midwifery care process metrics and indicators
(2019)
Murphy, Fiona A.; Doody, Owen; Lyons, Rosemary; Brenner, Maria; O'Connor, Laserina...
A guidance framework to aid in the selection of nursing and midwifery care process metrics and indicators
(2019)
Murphy, Fiona A.; Doody, Owen; Lyons, Rosemary; Brenner, Maria; O'Connor, Laserina; Hunter, Andrew; Devane, Declan; Sezgin, Duygu
Abstract:
Aim: To describe the development of a guidance framework to assist nurses and midwives in selecting nursing and midwifery care process metrics and indicators for use in practice. Background: Process metrics are measures of care provision activities by nurses and midwives. Methods: Phase 1 was a rapid review assessment of the literature conducted to identify an initial framework. Six electronic databases were searched with Google Scholar and reference tracking performed. Phase 2 was expert review of the developing framework by nursing and midwifery experts in practice, academia and an international expert in quality care metrics. Results: The literature assessment yielded 28 papers with 59 metric attributes identified. From this, a six‐domain framework was developed. Following expert review, the framework was reduced to four domains: “Process Focused,” “Important,” “Operational” and “Feasible.” Conclusions: This is the first framework specifically to guide nurses and midwives in sele...
http://hdl.handle.net/10344/7797
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A life course examination of the physical environmental determinants of physical activity behaviour: A "Determinants of Diet and Physical Activity" (DEDIPAC) umbrella systematic literature review
(2017)
Carlin, Angela; Perchoux, Camille; Puggina, Anna; Aleksovska, Katina; Buck, Christoph; ...
A life course examination of the physical environmental determinants of physical activity behaviour: A "Determinants of Diet and Physical Activity" (DEDIPAC) umbrella systematic literature review
(2017)
Carlin, Angela; Perchoux, Camille; Puggina, Anna; Aleksovska, Katina; Buck, Christoph; Burns, Con; Cardon, Greet; Chantal, Simon; Ciarapica, Donatella; Condello, Giancarlo; Coppinger, Tara; Cortis, Cristina; D'Haese, Sara; De Craemer, Marieke; Di Blasio, Andrea; Hansen, Sylvia; Iacoviello, Licia; Issartel, Johann; Izzicupo, Pascal; Jaeschke, Lina
Abstract:
Background Participation in regular physical activity is associated with a multitude of health benefits across the life course. However, many people fail to meet PA recommendations. Despite a plethora of studies, the evidence regarding the environmental (physical) determinants of physical activity remains inconclusive. Objective To identify the physical environmental determinants that influence PA across the life course. Methods An online systematic literature search was conducted using MEDLINE, ISI Web of Science, Scopus and SPORTDiscus. The search was limited to studies published in English (January 2004 to April 2016). Only systematic literature reviews (SLRs) and meta-analyses (MAs) of observational studies, that investigated the association between physical determinants and physical activity outcomes, were eligible for inclusion. The extracted data were assessed on the importance of determinants, strength of evidence and methodological quality. Results The literature search ide...
http://hdl.handle.net/10344/6227
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A method to investigate radial glia cell behavior using two-photon time-lapse microscopy in an ex vivo model of spinal cord development
(2014)
Pakan, Janelle M. P.; McDermott, Kieran W.
A method to investigate radial glia cell behavior using two-photon time-lapse microscopy in an ex vivo model of spinal cord development
(2014)
Pakan, Janelle M. P.; McDermott, Kieran W.
Abstract:
The mammalian central nervous system (CNS) develops from multipotent progenitor cells, which proliferate and differentiate into the various cell types of the brain and spinal cord. Despite the wealth of knowledge from progenitor cell culture studies, there is a significant lack of understanding regarding dynamic progenitor cell behavior over the course of development. This is in part due to shortcomings in the techniques available to study these processes in living tissues as they are occurring. In order to investigate cell behavior under physiologically relevant conditions we established an ex vivo model of the developing rat spinal cord. This method allows us to directly observe specific populations of cells ex vivo in real time and over extended developmental periods as they undergo proliferation, migration, and differentiation in the CNS. Previous investigations of progenitor cell behavior have been limited in either spatial or temporal resolution (or both) due to the necessity ...
http://hdl.handle.net/10344/5183
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A modelling approach to investigate the impact of consumption of three different beef compositions on human dietary fat intakes
(2019)
Lenighan, Yvonne M.; Nugent, Anne P.; Moloney, Aidan P.; Monahan, Frank J.; Walton, Jan...
A modelling approach to investigate the impact of consumption of three different beef compositions on human dietary fat intakes
(2019)
Lenighan, Yvonne M.; Nugent, Anne P.; Moloney, Aidan P.; Monahan, Frank J.; Walton, Janette; Flynn, Albert; Roche, Helen M.; McNulty, Breige A.
Abstract:
Objective: To apply a dietary modelling approach to investigate the impact of substituting beef intakes with three types of alternative fatty acid (FA) composition of beef on population dietary fat intakes. Design: Cross-sectional, national food consumption survey – the National Adult Nutrition Survey (NANS). The fat content of the beef-containing food codes (n 52) and recipes (n 99) were updated with FA composition data from beef from animals receiving one of three ruminant dietary interventions: grass-fed (GRASS), grass finished on grass silage and concentrates (GSC) or concentrate-fed (CONC). Mean daily fat intakes, adherence to dietary guidelines and the impact of altering beef FA composition on dietary fat sources were characterised. Setting: Ireland. Participants: Beef consumers (n 1044) aged 18–90 years. Results: Grass-based feeding practices improved dietary intakes of a number of individual FA, wherein myristic acid (C14 : 0) and palmitic acid (C16 : 0) were decreased, with...
http://hdl.handle.net/10468/11881
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A murine model in which protection correlates with pertussis vaccine efficacy in children demonstrates complementary roles for humoral and cell mediated immunity in protection against Bordetella pertussis
(1998)
MILLS, KINGSTON
A murine model in which protection correlates with pertussis vaccine efficacy in children demonstrates complementary roles for humoral and cell mediated immunity in protection against Bordetella pertussis
(1998)
MILLS, KINGSTON
Abstract:
peer-reviewed
The results of phase 3 efficacy trials have shown that acellular and whole-cell pertussis vaccines can confer protection against whooping cough. However, despite the advances in vaccine development, clinical trials have not provided significant new information on the mechanism of protective immunity against Bordetella pertussis. Classical approaches based on measurement of antibody responses to individual antigens failed to define an immunological correlate of protection. A reliable animal model, predictive of acellular and whole-cell pertussis vaccine potency in children, would facilitate an elucidation of the mechanism of immune protection against B. pertussis and would assist in the regulatory control and future development of pertussis vaccines. In this study, we have shown that the rate of B. pertussis clearance following respiratory challenge of immunized mice correlated with vaccine efficacy in children. Using this model together with mice with targeted disr...
http://hdl.handle.net/2262/33375
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A nation of couch potatoes? Physical activity, sedentary behaviour and health in Ireland
(2015)
Donnelly, Alan Edward; MacDonncha, Ciaran; Dowd, Kieran P.; Ling, Fiona
A nation of couch potatoes? Physical activity, sedentary behaviour and health in Ireland
(2015)
Donnelly, Alan Edward; MacDonncha, Ciaran; Dowd, Kieran P.; Ling, Fiona
Abstract:
Effective national level health guidelines and policy must be based on accurate information about how physical activity and sedentary behaviour contribute to health. Research undertaken at the University of Limerick has utilised technology to accurately quantify levels of physical activity and sedentary behaviours, and has related these measures to both health indices and behavioural determinants. Publications based on these findings have been widely reported in the national media and referenced at government level. Members of UL’s Centre of Physical Activity and Health Research have contributed to the National Guidelines on Physical Activity for Ireland, Ireland’s National Physical Activity Plan and Ireland’s 2014 Report Card on Physical Activity in Children and Youth. The centre is currently taking a leading role in the Determinants of Diet and Physical Activity Choice (DEDIPAC) Knowledge Hub (www.dedipac.eu).
http://hdl.handle.net/10344/9413
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A national stakeholder consensus study of challenges and priorities for clinical learning environments in postgraduate medical education
(2017)
Kilty, Caroline; Wiese, Anel; Bergin, Colm; Flood, Patrick; Fu, Na; Horgan, Mary; Higgi...
A national stakeholder consensus study of challenges and priorities for clinical learning environments in postgraduate medical education
(2017)
Kilty, Caroline; Wiese, Anel; Bergin, Colm; Flood, Patrick; Fu, Na; Horgan, Mary; Higgins, Agnes; Maher, Bridget M.; O'Kane, Grainne; Prihodova, Lucia; Slattery, Dubhfeasa; Stoyanov, Slavi; Bennett, Deirdre
Abstract:
Background: High quality clinical learning environments (CLE) are critical to postgraduate medical education (PGME). The understaffed and overcrowded environments in which many residents work present a significant challenge to learning. The purpose of this study was to develop a national expert group consensus amongst stakeholders in PGME to; (i) identify important barriers and facilitators of learning in CLEs and (ii) indicate priority areas for improvement. Our objective was to provide information to focus efforts to provide high quality CLEs. Methods: Group Concept Mapping (GCM) is an integrated mixed methods approach to generating expert group consensus. A multi-disciplinary group of experts were invited to participate in the GCM process via an online platform. Multi-dimensional scaling and hierarchical cluster analysis were used to analyse participant inputs in regard to barriers, facilitators and priorities. Results: Participants identified facilitators and barriers in ten dom...
http://hdl.handle.net/10468/5378
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A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
(2008)
MCELLIGOTT, ANTHONY
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
(2008)
MCELLIGOTT, ANTHONY
Abstract:
peer-reviewed
The ordered, directional migration of T-lymphocytes is a key process during immune surveillance, immune response, and development. A novel series of pyrrolo-1,5-benzoxazepines have been shown to potently induce apoptosis in variety of human chemotherapy resistant cancer cell lines, indicating their potential in the treatment of both solid tumors and tumors derived from the hemopoietic system. Pyrrolobenzoxazepine 4-acetoxy-5-(1-naphtyl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]-oxazepine (PBOX-15) has been shown to depolymerize tubulin in vitro and in the MCF7 breast cancer cell line. We hypothesized that this may suggest a role for this compound in modulating integrin-induced T-cell migration, which is largely dependent on the microtubule dynamics. Experiments were performed using human T lymphoma cell line Hut78 and peripheral blood T-lymphocytes isolated from healthy donors. We observed that human T-lymphocytes exposed to PBOX-15 have severely impaired ability to polariz...
http://hdl.handle.net/2262/34446
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A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa
(2013)
Reen, F. Jerry; Haynes, Jill M.; Mooij, Marlies J.; O'Gara, Fergal
A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa
(2013)
Reen, F. Jerry; Haynes, Jill M.; Mooij, Marlies J.; O'Gara, Fergal
Abstract:
LysR-type transcriptional regulators (LTTRs) are emerging as key circuit components in regulating microbial stress responses and are implicated in modulating oxidative stress in the human opportunistic pathogen Pseudomonas aeruginosa. The oxidative stress response encapsulates several strategies to overcome the deleterious effects of reactive oxygen species. However, many of the regulatory components and associated molecular mechanisms underpinning this key adaptive response remain to be characterised. Comparative analysis of publically available transcriptomic datasets led to the identification of a novel LTTR, PA2206, whose expression was altered in response to a range of host signals in addition to oxidative stress. PA2206 was found to be required for tolerance to H2O2 in vitro and lethality in vivo in the Zebrafish embryo model of infection. Transcriptomic analysis in the presence of H2O2 showed that PA2206 altered the expression of 58 genes, including a large repertoire of oxid...
http://hdl.handle.net/10468/2395
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A novel erythromycin resistance plasmid from Bacillus sp strain HS24, isolated from the marine sponge Haliclona simulans
(2014)
Barbosa, Teresa M.; Phelan, Robert W.; Leong, Dara; Morrissey, John P.; Adams, Claire; ...
A novel erythromycin resistance plasmid from Bacillus sp strain HS24, isolated from the marine sponge Haliclona simulans
(2014)
Barbosa, Teresa M.; Phelan, Robert W.; Leong, Dara; Morrissey, John P.; Adams, Claire; Dobson, Alan D. W.; O'Gara, Fergal
Abstract:
A better understanding of the origin and natural reservoirs of resistance determinants is fundamental to efficiently tackle antibiotic resistance. This paper reports the identification of a novel 5.8 kb erythromycin resistance plasmid, from Bacillus sp. HS24 isolated from the marine sponge Haliclona simulans. pBHS24B has a mosaic structure and carries the erythromycin resistance gene erm(T). This is the first report of an erythromycin resistance plasmid from a sponge associated bacteria and of the Erm(T) determinant in the genus Bacillus.
http://hdl.handle.net/10468/2318
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A phenomenological exploration of change towards healthier food purchasing behaviour in women from a lower socioeconomic background using a health app
(2019)
Flaherty, Sarah Jane; McCarthy, Mary; Collins, Alan M.; McCafferty, Claire; McAuliffe, ...
A phenomenological exploration of change towards healthier food purchasing behaviour in women from a lower socioeconomic background using a health app
(2019)
Flaherty, Sarah Jane; McCarthy, Mary; Collins, Alan M.; McCafferty, Claire; McAuliffe, Fionnuala M.
Abstract:
Food purchasing is dominated by routines and habits that may hamper the use of reflective decision-making and impede change. Disrupting existing behavioural patterns may address this challenge. Individuals from a lower socioeconomic background are more likely to report unhealthier purchasing and targeted initiatives are required. Health apps offer a potential approach although little evidence is available for this specific context. This research examines the individual's experience of changing food purchasing behaviour using an app focusing on women from a lower socioeconomic background. Multiple methods across different time-points explored the individual's experience over an 8–11 week period. An accompanied shop, incorporating think-aloud and researcher observations, was undertaken at baseline, followed by an in-depth interview and questionnaire. A reflective account of the individual's experience was recorded at four weeks and grocery receipts were shared for the d...
http://hdl.handle.net/10468/11432
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A pilot study of performance among hospitalised elderly patients on a novel test of visuospatial cognition: the letter and shape drawing (LSD) test.
(2016)
White, D.; Williams, O.A.; Leonard, Maeve; Exton, Chris; Adamis, Dimitrios; Hannigan, A...
A pilot study of performance among hospitalised elderly patients on a novel test of visuospatial cognition: the letter and shape drawing (LSD) test.
(2016)
White, D.; Williams, O.A.; Leonard, Maeve; Exton, Chris; Adamis, Dimitrios; Hannigan, Ailish; Cullen, Walter; Dunne, Colum P.; Meagher, David
Abstract:
Objectives. Conventional bedside tests of visuospatial function such as the clock drawing (CDT) and intersecting pentagons tests (IPT) are subject to considerable inconsistency in their delivery and interpretation. We compared performance on a novel test – the letter and shape drawing (LSD) test –with these conventional tests in hospitalised elderly patients. Methods. The LSD, IPT, CDT and the Montreal Cognitive Assessment (MoCA) were performed in 40 acute elderly medical inpatients at University Hospital Limerick The correlation between these tests was examined as well as the accuracy of the visuospatial tests to identify significant cognitive impairment on the MoCA. Results. The patients (mean age 81.0±7.71; 21 female) had a median MoCA score of 15.5 (range = 1–29). There was a strong, positive correlation between the LSD and both the CDT (r = 0.56) and IPT (r = 0.71). The correlation between the LSD and MoCA (r = 0.91) was greater than for the CDT and IPT (both 0.67). The LSD cor...
http://hdl.handle.net/10344/7724
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