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Displaying Results 1 - 25 of 296 on page 1 of 12
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1/f noise in MgO double-barrier magnetic tunnel junctions
(2011)
COEY, JOHN MICHAEL DAVID; FENG, JIA-FENG; DIAO, ZHU
1/f noise in MgO double-barrier magnetic tunnel junctions
(2011)
COEY, JOHN MICHAEL DAVID; FENG, JIA-FENG; DIAO, ZHU
Abstract:
Low frequency noise has been investigated in MgO double-barrier magnetic tunnel junctions (DMTJs) with tunneling magnetoresistance (TMR) ratios up to 250% at room temperature. The noise shows a 1/f frequency spectrum and the minimum of the noise magnitude parameter is 1.2 x 10(-10) mu m(2) in the parallel state for DMTJs annealed at 375 degrees C. The bias dependence of noise and TMR suggests that DMTJs with MgO barriers can be useful for magnetic field sensor applications.
http://hdl.handle.net/2262/54964
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Eliciting audio evoked potentials using continuous stimuli
(2007)
LALOR, EDMUND; REILLY, RICHARD
Eliciting audio evoked potentials using continuous stimuli
(2007)
LALOR, EDMUND; REILLY, RICHARD
Abstract:
peer-reviewed
Noise input signals are commonly used in both linear and non-linear system identification of physiological systems. This method can be applied to electrophysiological analysis of the human auditory system by controlling the modulation of the amplitude of a sound stimulus using a pre- computed noise signal. In this study we describe how one can obtain an estimate of the linear response of the auditory system using noise signals and we compare it to a standard auditory evoked potential (AEP). Two different noise modulated sounds are tested, broadband noise (BBN) and a 2kHz tone. Results show that the BBN is better at eliciting notable responses. Results also show that although the SNR of the proposed response to the modulated BBN is generally lower than the standard AEP the two responses do correlate well suggesting that the spread spectrum stimulus is a valid method for elicitation of an AEP.
http://hdl.handle.net/2262/17641
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3-Urea-1,8-naphthalimides are good chemosensors: a highly selective dual colorimetric and fluorescent ICT based anion sensor for fluoride
(2011)
GUNNLAUGSSON, THORFINNUR; DUKE, REBECCA MONICA
3-Urea-1,8-naphthalimides are good chemosensors: a highly selective dual colorimetric and fluorescent ICT based anion sensor for fluoride
(2011)
GUNNLAUGSSON, THORFINNUR; DUKE, REBECCA MONICA
Abstract:
he 1,8-naphthalimide sensor 1 was developed as a colorimetric and fluorescent sensor for anions. Being the first example of such anion sensors, where the 3-position of the naphthalimide ring is used to incorporate the anion recognition moiety, in this case a trifluromethyl derived aryl urea moiety, the sensors gave rise to significant changes in both the absorption and the emission spectra, which were both red shifted upon interacting with anions. The changes were most pronounced for fluoride, and to a lesser extent for acetate and hydrogen phosphate, in DMSO, making 1 a highly selective sensor for F¯.
http://hdl.handle.net/2262/51421
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3D visualisation of confocal flourescence microscopy data
(2004)
O'SULLIVAN, CAROL ANN
3D visualisation of confocal flourescence microscopy data
(2004)
O'SULLIVAN, CAROL ANN
Abstract:
peer-reviewed
Confocal microscopes are able to non-invasively capture sub-micron details of fluorescent-labelled specimens at multiple depths, but there is a lack of applications capable of displaying this collected information in a meaningful and useful manner. We present a hardware-accelerated volume visualisation application developed for displaying and exploring confocal fluorescence microscopy data. Programmable graphics hardware is employed to improve visual quality and aid in highlighting significant properties of the volume, and an adapted marching cubes algorithm implemented to generate polygonal isosurfaces.
http://hdl.handle.net/2262/18380
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Using Pseudo Feedback to Improve Cross-Lingual Ontology Mapping
(2011)
O'SULLIVAN, DECLAN; BRENNAN, ROB; FU, BO
Using Pseudo Feedback to Improve Cross-Lingual Ontology Mapping
(2011)
O'SULLIVAN, DECLAN; BRENNAN, ROB; FU, BO
Abstract:
Translation techniques are often employed by cross-lingual ontology mapping (CLOM) approaches to turn a cross-lingual mapping problem into a monolingual mapping problem which can then be solved by state of the art monolingual ontology matching tools. However in the process of doing so, noisy translations can compromise the quality of the matches generated by the subsequent monolingual matching techniques. In this paper, a novel approach to improve the quality of cross-lingual ontology mapping is presented and evaluated. The proposed approach adopts the pseudo feedback technique that is similar to the well understood relevance feedback mechanism used in the field of information retrieval. It is shown through the evaluation that pseudo feedback can improve the matching quality in a CLOM scenario.
http://hdl.handle.net/2262/58997
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A comparison of strain and fluid shear stress in stimulating bone cell responses - a computational and experimental study
(2005)
PRENDERGAST, PATRICK JOHN
A comparison of strain and fluid shear stress in stimulating bone cell responses - a computational and experimental study
(2005)
PRENDERGAST, PATRICK JOHN
Abstract:
Bone undergoes continuous remodeling in response to mechanical loading. However, the underlying mechanisms by which bone cells respond to their changing mechanical environment, that is, strain in the load-bearing matrix or fluid flow through the canalicular network, are not well understood. It has been established in vitro that bone cells respond differently to substrate strain and fluid shear stress treatments. Uncovering the mechanical basis of these differences represents a significant challenge to our understanding of cellular mechanotransduction and bone remodeling. To investigate this problem, we developed a biomechanical model of an adherent cell, to test the hypothesis that bone cells respond differently to 0.6 Pa fluid shear stress and 1,000 mu(epsilon) substrate strain stimulation because of qualitative and quantitative differences in the cellular deformation caused. Fluid shear stress loading conditions resulted in maximum displacements at the apical surface of the cell a...
http://hdl.handle.net/2262/39597
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A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.
(2007)
FARRELL, ERIC RAYMOND; PRENDERGAST, PATRICK JOHN; CAMPBELL, VERONICA ANN; BYRNE, ELAINE
A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.
(2007)
FARRELL, ERIC RAYMOND; PRENDERGAST, PATRICK JOHN; CAMPBELL, VERONICA ANN; BYRNE, ELAINE
Abstract:
Adult mesenchymal stem cells (MSCs) have the capability to differentiate along several lineages including those of bone, cartilage, tendon and muscle, thus offering huge potential for the field of tissue engineering. The purpose of this study was to characterise the differentiation capacity of rat MSCs cultured on standard plastic coverslips in 2 dimensions and on a novel collagen glycosaminoglycan scaffold in the presence of a standard combination of osteoinductive factors. Cells were cultured for 3, 7, 14 and 21 days and several markers of osteogenesis were analysed. While the initial response of the cells in 3-D seemed to be faster than cells cultured in 2-D, as evidenced by collagen type I expression, later markers showed that osteogenic differentiation of MSCs took longer in the 3-D environment of the collagen GAG scaffold compared to standard 2-D culture conditions. Furthermore, it was shown that complete scaffold mineralisation could be evoked within a 6 week timeframe. This ...
http://hdl.handle.net/2262/39604
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A context information service using ontology-based queries
(2004)
CONLAN, OWEN; LEWIS, DAVID; O'SULLIVAN, DECLAN; POWER, RUAIDHRI SEAN; WADE, VINCEN...
A context information service using ontology-based queries
(2004)
CONLAN, OWEN; LEWIS, DAVID; O'SULLIVAN, DECLAN; POWER, RUAIDHRI SEAN; WADE, VINCENT PATRICK
Abstract:
peer-reviewed
Ubiquitous computing environments have the potential to provide rich sources of information about a user and their surroundings. However, the nature of context information means that it must be gathered in an ad-hoc and distributed manner with many devices and sensors storing potentially relevant data. In an ad-hoc ubiquitous computing environment, retrieval of context information cannot rely on a fixed meta-data schema. This works shows how an ontology driven context service architecture may perform distributed open schema queries over heterogeneous context sources in a potentially decentralised manner.
http://hdl.handle.net/2262/22604
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A demonstration of wireless sensing for long-term monitoring of water quality
(2009)
Regan, Fiona; Lawlor, Antoin; O'Flynn, Brendan; Torres, J; Martínez-Català, Rafael...
A demonstration of wireless sensing for long-term monitoring of water quality
(2009)
Regan, Fiona; Lawlor, Antoin; O'Flynn, Brendan; Torres, J; Martínez-Català, Rafael V.; Ó Mathúna, S. Cian; Wallace, John
Abstract:
Science Foundation Ireland (CSET - Centre for Science, Engineering and Technology 07/CE/I1147); Environmental Protection Agency (NDP); Marine Institute (NDP)
At a time when technological advances are providing new sensor capabilities, novel network capabilities, long-range communications technologies and data interpreting and delivery formats via the World Wide Web, we never before had such opportunities to sense and analyse the environment around us. However, the challenges exist. While measurement and detection of environmental pollutants can be successful under laboratory-controlled conditions, continuous in-situ monitoring remains one of the most challenging aspects of environmental sensing. This paper describes the development and test of a multi-sensor heterogeneous real-time water monitoring system. A multi-sensor system was deployed in the River Lee, County Cork, Ireland to monitor water quality parameters such as pH, temperature, conductivity, turbidity and dissolved ...
http://hdl.handle.net/10468/180
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A facile spin-cast route for cation exchange of multilayer perpendicularly-aligned nanorod assemblies
(2011)
Kelly, Dervla; Singh, Ajay; Barrett, Christopher A.; O'Sullivan, Catriona; Coughla...
A facile spin-cast route for cation exchange of multilayer perpendicularly-aligned nanorod assemblies
(2011)
Kelly, Dervla; Singh, Ajay; Barrett, Christopher A.; O'Sullivan, Catriona; Coughlan, Claudia; Laffir, Fathima R.; O'Dwyer, Colm; Ryan, Kevin M.
Abstract:
A facile spin cast route was developed to convert perpendicularly aligned nanorod assemblies of cadmium chalcogenides into their silver and copper analogues. The assemblies are rapidly cation exchanged without affecting either the individual rod dimensions or collective superlattice order extending over several multilayers.
http://hdl.handle.net/10197/3416
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A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways
(2000)
O'NEILL, LUKE ANTHONY JOHN
A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways
(2000)
O'NEILL, LUKE ANTHONY JOHN
Abstract:
peer-reviewed
Physicochemical properties are potentially useful in predicting functional differences between aligned protein subfamilies. We present a method that considers physicochemical properties from ancestral sequences predicted to have given rise to the subfamilies of interest by gene duplication. Comparison between two map kinases subfamilies, p38 and ERK, revealed a region that had an excess of change in properties after gene duplication followed by conservation within the two subfamilies. This region corresponded to that experimentally defined as important for substrate and pathway specificity. The derived scores for the region of interest were found to differ significantly in their distribution compared to the rest of the protein when the Kolmogorov-Smirnov test was applied (p = 0.005). Thus, the incorporation of ancestral physicochemical properties is useful in predicting functional differences between protein subfamilies. In addition, the method was applied to the M...
http://hdl.handle.net/2262/33702
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A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
(2008)
MCELLIGOTT, ANTHONY
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
(2008)
MCELLIGOTT, ANTHONY
Abstract:
peer-reviewed
The ordered, directional migration of T-lymphocytes is a key process during immune surveillance, immune response, and development. A novel series of pyrrolo-1,5-benzoxazepines have been shown to potently induce apoptosis in variety of human chemotherapy resistant cancer cell lines, indicating their potential in the treatment of both solid tumors and tumors derived from the hemopoietic system. Pyrrolobenzoxazepine 4-acetoxy-5-(1-naphtyl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]-oxazepine (PBOX-15) has been shown to depolymerize tubulin in vitro and in the MCF7 breast cancer cell line. We hypothesized that this may suggest a role for this compound in modulating integrin-induced T-cell migration, which is largely dependent on the microtubule dynamics. Experiments were performed using human T lymphoma cell line Hut78 and peripheral blood T-lymphocytes isolated from healthy donors. We observed that human T-lymphocytes exposed to PBOX-15 have severely impaired ability to polariz...
http://hdl.handle.net/2262/34446
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A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow.
(2010)
O'BRIEN, FERGAL
A prediction of cell differentiation and proliferation within a collagen-glycosaminoglycan scaffold subjected to mechanical strain and perfusive fluid flow.
(2010)
O'BRIEN, FERGAL
Abstract:
Mesenchymal stem cell (MSC) differentiation can be influenced by biophysical stimuli imparted by the host scaffold. Yet, causal relationships linking scaffold strain magnitudes and inlet fluid velocities to specific cell responses are thus far underdeveloped. This investigation attempted to simulate cell responses in a collagen-glycosaminoglycan (CG) scaffold within a bioreactor. CG scaffold deformation was simulated using mu-computed tomography (CT) and an in-house finite element solver (FEEBE/linear). Similarly, the internal fluid velocities were simulated using the afore-mentioned mu CT dataset with a computational fluid dynamics solver (ANSYS/CFX). From the ensuing cell-level mechanics, albeit octahedral shear strain or fluid velocity, the proliferation and differentiation of the representative cells were predicted from deterministic functions. Cell proliferation patterns concurred with previous experiments. MSC differentiation was dependent on the level of CG scaffold strain an...
http://hdl.handle.net/2262/40225
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A spectrum of colors: investigating the temporal frequency characteristics of the human visual system using a system identification approach
(2006)
LALOR, EDMUND; REILLY, RICHARD
A spectrum of colors: investigating the temporal frequency characteristics of the human visual system using a system identification approach
(2006)
LALOR, EDMUND; REILLY, RICHARD
Abstract:
peer-reviewed
Noise input signals are commonly used in both linear and nonlinear system identification of physiological systems. This method can be applied to electrophysiological analysis of the human visual system by controlling the modulation of the contrast of a checkerboard stimulus using a pre-computed noise waveform. In this study we describe how one can obtain an estimate of the linear impulse response of the visual system using noise waveforms. Furthermore, we examine the impulse responses obtained using noise signals with different frequency characteristics, in an attempt to investigate the temporal frequency characteristics of the human visual system. We show that noise signals with frequency content greater than 15 Hz are more effective at evoking these responses than those with little or no power at high frequencies.
http://hdl.handle.net/2262/19639
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A stated preference analysis of real-time public transit stop information
(2009)
CAULFIELD, BRIAN; O'MAHONY, MARGARET MARY
A stated preference analysis of real-time public transit stop information
(2009)
CAULFIELD, BRIAN; O'MAHONY, MARGARET MARY
Abstract:
This paper presents the results of a study conducted to examine the benefits derived from real-time public transit stop information. This research examines the preferences between several options of receiving real-time public transit stop information. The literature states that one of the main reasons individuals access real-time information is to remove the uncertainty when using public transit. This relationship was examined to ascertain if the provision of real-time public transit information can remove the uncertainty and frustration associated with using public transit. A nested logit model structure was applied in this study to examine the benefits derived from accessing real-time public transit information. These models are estimated on segments of the dataset to ascertain how the mode of transport used by the respondents impacts the benefits derived from using real-time public transit information. The results of this study demonstrate that passengers derive the greatest bene...
http://hdl.handle.net/2262/39191
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A zero-mode quantization of the Skyrmion
(2006)
HOUGHTON, CONOR JAMES
A zero-mode quantization of the Skyrmion
(2006)
HOUGHTON, CONOR JAMES
Abstract:
peer-reviewed
In the semi-classical approach to the Skyrme model, nuclei are approximated by quantum mechanical states on a finite-dimensional space of field configurations; in zero-mode quantization this space is generated by rotations and isorotations. Here, simulated annealing is used to find the axially symmetric Skyrme configuration which extremizes the zero-mode quantized energy for the nucleon.
http://hdl.handle.net/2262/22159
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Absolute photoionization cross-section measurements of the Kr I isoelectronic sequence
(2007)
Kilbane, Deirdre; Folkmann, F.; Bizau, J.-M.; Banahan, Caroline; Scully, S.; Kjeldsen, ...
Absolute photoionization cross-section measurements of the Kr I isoelectronic sequence
(2007)
Kilbane, Deirdre; Folkmann, F.; Bizau, J.-M.; Banahan, Caroline; Scully, S.; Kjeldsen, H.; van Kampen, Paul; Mansfield, M.; Costello, John T.; West, J.
Abstract:
Photoionization spectra have been recorded in the 4s, 4p, and 3d resonance regions for the Kr I isoelectronic sequence using both the dual laser produced plasma (DLP) technique (at DCU) to produce photoabsorption spectra, and the merged ion beam and synchrotron radiation technique (at ASTRID) to measure absolute photoionization cross sections. Profile parameters are compared for the 4s-np resonances of Rb+ and Sr2+. Many 4p→ns, md transitions are identified with the aid of Hartree-Fock calculations, and consistent quantum defects are observed for the various ns and md Rydberg series. Absolute single and double photoionization cross sections recorded in the 3d region for Rb+ and Sr2+ ions show preferential decay via double photoionization. This is only the second report to our knowledge where both the DLP technique and the merged-beam technique have been used simultaneously to record photoionization spectra, and the advantages of both techniques (i.e., better resolution in the case o...
http://doras.dcu.ie/15653/
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Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus
(2003)
KELLY, AINE; LYNCH, MARINA ANNETTA; MILLS, KINGSTON
Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus
(2003)
KELLY, AINE; LYNCH, MARINA ANNETTA; MILLS, KINGSTON
Abstract:
peer-reviewed
Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, has been shown to induce profound changes both peripherally and centrally. It has recently been reported that intraperitoneal injection of LPS inhibited long term potentiation (LTP) in perforant path-granule cell synapses and that this effect was coupled with an increase in the concentration of the proinflammatory cytokine, interleukin-1β (IL-1β). The LPS-induced effects were abrogated by inhibition of caspase-1, suggesting that IL-1β may mediate the effects of LPS. Here we report that the inhibition of LTP induced by LPS and IL-1β was coupled with stimulation of the stress-activated protein kinase p38 in hippocampus and entorhinal cortex and that this effect was abrogated by the p38 inhibitor SB203580, while the effect of LPS was markedly attenuated in C57BL/6 IL-1RI-/- mice. The data also indicate that activation of the transcription factor, nuclear factor κB (NFκB), may play a role...
http://hdl.handle.net/2262/33331
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Adaptive medial-axis approximation for sphere-tree construction
(2004)
BRADSHAW, GARETH; O'SULLIVAN, CAROL ANN
Adaptive medial-axis approximation for sphere-tree construction
(2004)
BRADSHAW, GARETH; O'SULLIVAN, CAROL ANN
Abstract:
peer-reviewed
Hierarchical object representations play an important role in performing efficient collision handling. Many different geometric primitives have been used to construct these representations, which allow areas of interaction to be localized quickly. For time-critical algorithms, there are distinct advantages to using hierarchies of spheres, known as sphere-trees, for object representation. This paper presents a novel algorithm for the construction of sphere-trees. The algorithm presented approximates objects, both convex and non-convex, with a higher degree of fit than existing algorithms. In the lower levels of the representations, there is almost an order of magnitude decrease in the number of spheres required to represent the objects to a given accuracy.
http://hdl.handle.net/2262/18759
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Alignment instability caused by anchoring of the in-plane directors to the rubbing direction in the V-shaped switching
(2000)
FUKUDA, ATSUO; VIJ, JAGDISH KUMAR; PANARIN, YURI PETROVICH
Alignment instability caused by anchoring of the in-plane directors to the rubbing direction in the V-shaped switching
(2000)
FUKUDA, ATSUO; VIJ, JAGDISH KUMAR; PANARIN, YURI PETROVICH
Abstract:
In order to investigate the molecular alignment in the smectic liquid crystals showing the V-shaped switching behavior, two types of the liquid crystal cells, a sandwiched cell and an open cell, were prepared. Homogeneous alignment with the smectic layer normal formed at y12³ with respect to the rubbing direction r is obtained in the Sm-A phase in both cells. However, in the open cell, the director n is rotated towards r when the Sm-A sample is cooled into the tilted Sm-X* phase. In addition, its maximum rotation angle is y12³. In this con®guration, the molecules lie along r. Meanwhile, the sandwiched cell with the one-side rubbing treatment exhibits the averaged optical axis almost parallel to the layer normal in the Sm-X* phase. In this paper, a simple small-twisted state in the thin sandwiched cell is suggested to account for the experimental results.
http://hdl.handle.net/2262/40545
Marked
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Alternating and direct current characterization and photoinduced absorption studies of modified conjugated polymer thin films
(2004)
BLAU, WERNER; COLEMAN, JONATHAN NESBIT; DRURY, ANNA
Alternating and direct current characterization and photoinduced absorption studies of modified conjugated polymer thin films
(2004)
BLAU, WERNER; COLEMAN, JONATHAN NESBIT; DRURY, ANNA
Abstract:
Control of interchain separation enables the optical properties of polymer thin films to be altered. We present a thin film preparation technique that increases the free volume fraction in spin coated polymer thin films resulting in reduced interchain interaction. The polaron yield, measured using photoinduced absorption, was significantly reduced as a direct result of the increased interchain separation, leading to a higher value for the measured photoluminescence efficiency. Impedance spectroscopy showed an increase in permittivity, probably due to greater polarizability. Increases approaching one order of magnitude were observed for direct current hole conductivity and mobility values. Space charge limited conduction analysis suggests a narrowing of the highest occupied molecular orbital band tail on treatment resulting in reduced trapping. Single layer light emitting devices prepared using this technique were found to be significantly brighter and to have longer operating lifeti...
http://hdl.handle.net/2262/28386
Marked
Mark
Alternating and direct current characterization and photoinduced absorption studies of modified conjugated polymer thin films
(2004)
COLEMAN, JONATHAN NESBIT; BLAU, WERNER; DRURY, ANNA
Alternating and direct current characterization and photoinduced absorption studies of modified conjugated polymer thin films
(2004)
COLEMAN, JONATHAN NESBIT; BLAU, WERNER; DRURY, ANNA
Abstract:
Control of interchain separation enables the optical properties of polymer thin films to be altered. We present a thin film preparation technique that increases the free volume fraction in spin coated polymer thin films resulting in reduced interchain interaction. The polaron yield, measured using photoinduced absorption, was significantly reduced as a direct result of the increased interchain separation, leading to a higher value for the measured photoluminescence efficiency. Impedance spectroscopy showed an increase in permittivity, probably due to greater polarizability. Increases approaching one order of magnitude were observed for direct current hole conductivity and mobility values. Space charge limited conduction analysis suggests a narrowing of the highest occupied molecular orbital band tail on treatment resulting in reduced trapping. Single layer light emitting devices prepared using this technique were found to be significantly brighter and to have longer operating lifetimes
http://hdl.handle.net/2262/40264
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Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
(2008)
KLYUBIN, IGOR; ANWYL, ROGER
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization.
(2008)
KLYUBIN, IGOR; ANWYL, ROGER
Abstract:
The current development of immunotherapy for Alzheimer's disease is based on the assumption that human-derived amyloid beta protein (Abeta) can be targeted in a similar manner to animal cell-derived or synthetic Abeta. Because the structure of Abeta depends on its source and the presence of cofactors, it is of great interest to determine whether human-derived oligomeric Abeta species impair brain function and, if so, whether or not their disruptive effects can be prevented using antibodies. We report that untreated ex vivo human CSF that contains Abeta dimers rapidly inhibits hippocampal long-term potentiation in vivo and that acute systemic infusion of an anti-Abeta monoclonal antibody can prevent this disruption of synaptic plasticity. Abeta monomer isolated from human CSF did not affect long-term potentiation. These results strongly support a strategy of passive immunization against soluble Abeta oligomers in early Alzheimer's disease.
http://hdl.handle.net/2262/40188
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An active approach to guaranteed arrival times based on traffic shaping.
(2010)
CAHILL, VINNY; BOUROCHE, MELANIE
An active approach to guaranteed arrival times based on traffic shaping.
(2010)
CAHILL, VINNY; BOUROCHE, MELANIE
Abstract:
To address the goal of providing drivers on highways with guaranteed arrival times, we propose a traffic management system that combines virtual slots with semiautonomous driving to shape traffic and prevent congestion. Two algorithms that address aligning vehicles into slots and efficient merging from three to two lanes are proposed. Furthermore, an implementation and evaluation of these algorithms using the VISSIM traffic simulator is presented. Our initial results indicate that a slot-based system has the potential to be used to guarantee arrival times and provide a significant overall increase in efficiency when compared against a human driving model.
http://hdl.handle.net/2262/56456
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An Approach to Aggregating Ensembles of Lazy Learners that Supports Explanation
(2002)
Zenobi, Gabriele; Cunningham, Pádraig
An Approach to Aggregating Ensembles of Lazy Learners that Supports Explanation
(2002)
Zenobi, Gabriele; Cunningham, Pádraig
Abstract:
TCD-CS-2002-20
Ensemble research has shown that the aggregated output of an ensemble of predictors can be more accurate than a single predictor. This is true also for lazy learning systems like Case-Based Reasoning (CBR) and k-Nearest- Neighbour. Aggregation is normally achieved by voting in classification tasks and by averaging in regression tasks. For CBR, this increased accuracy comes at the cost of interpretability however. If we consider the use of retrieved cases for explanation to be one of the advantages of CBR then this is lost in an ensemble. This is because a large number of cases will have been retrieved by the ensemble members. In this paper we present a new technique for aggregation that obtains excellent results and identifies a small number of cases for use in explanation. This new approach might be viewed as a transformation process whereby cases are transformed from their feature based representation to a representation based on the predictions of ensemble memb...
http://hdl.handle.net/2262/13160
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