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Displaying Results 1 - 25 of 19454 on page 1 of 779
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De-institutionalisation of services for children in state care in Ireland A case study of international relevance
(2012)
GILLIGAN, ROBERT
De-institutionalisation of services for children in state care in Ireland A case study of international relevance
(2012)
GILLIGAN, ROBERT
http://hdl.handle.net/2262/73789
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I found that I've been free all along : knowledge, meaning, creativity and holistic science at Schumacher College.
(2015)
WRIDE, MICHAEL
I found that I've been free all along : knowledge, meaning, creativity and holistic science at Schumacher College.
(2015)
WRIDE, MICHAEL
http://hdl.handle.net/2262/73794
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Ireland, India and the British Empire
(2016)
OHLMEYER, JANE
Ireland, India and the British Empire
(2016)
OHLMEYER, JANE
http://hdl.handle.net/2262/75687
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Neither one thing nor the other : The Ulster Protestant community in Cavan, Monaghan and Fermanagh, 1916 - 1923
(2019)
PURCELL, DANIEL THOMAS
Neither one thing nor the other : The Ulster Protestant community in Cavan, Monaghan and Fermanagh, 1916 - 1923
(2019)
PURCELL, DANIEL THOMAS
Abstract:
Histories of Irish partition and discussions of the Irish border portray the six-county settlement as the most natural division of the island. This formulation provides a false impression of a cohesive Ulster Protestant national group with clearly-defined territorial claims. This thesis responds to these problems by examining two peripheral communities for whom the partition of Ireland represented a time of particular crisis. Firstly, it examines Protestants south of the border in Cavan and Monaghan, who exhibited significant demographic differences from their co-religionists in the six counties of Northern Ireland, but who still asserted an Ulster Protestant identity and felt a keen sense of betrayal at the partition settlement. Secondly, it looks at the Protestant community of Fermanagh who, although they were included in the north, were intensely aware of the precarity of their situation, being in the most Catholic county in Northern Ireland. These two communities, bordering on...
http://hdl.handle.net/2262/88805
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Re-Creating Science in Higher Education: Exploring a Creativity Philosophy
(2014)
WRIDE, MICHAEL
Re-Creating Science in Higher Education: Exploring a Creativity Philosophy
(2014)
WRIDE, MICHAEL
http://hdl.handle.net/2262/73793
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Something for the Silly Season : policing and the press in Israel Zangwill s The Big Bow Mystery.
(2015)
CLARKE, CLARE
Something for the Silly Season : policing and the press in Israel Zangwill s The Big Bow Mystery.
(2015)
CLARKE, CLARE
http://hdl.handle.net/2262/74628
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?-adrenoceptor-mediated regulation of matrix metalloproteinase-9 in fibroblasts
(2011)
Rietz, Anne
?-adrenoceptor-mediated regulation of matrix metalloproteinase-9 in fibroblasts
(2011)
Rietz, Anne
Abstract:
THESIS 9260
Adrenoceptor signalling in fibroblasts: Intracellular cAMP levels were measured by a direct cAMP enzyme immunoassay. Isoprenaline (ISO, 1 ?M) increased intracellular cAMP concentration by 1.3 and 4.8 fold, P<0.05, after 10 min in the NIH3T3 fibroblasts and human cardiac ventricular fibroblasts (HCVF) respectively. These effects were abolished by pre-treatment with propranolol (PROP, 10 ?M; P<0.05). Nuclear translocation of phospho-CREB was increased by isoprenaline (0.1 ?M) and phenylephrine (10 ?M) increased in NIH3T3 fibroblasts (P<0.05). Western blot analysis indicated that isoprenaline (1 ?M) and phenylephrine (10 ?M) caused a biphasic increase in p38 MAPK and a sustained increase in ERK1/2 MAPK activation over a 30 min period in NIH3T3 fibroblasts. However, in HCVF cells, isoprenaline (1 ?M) decreased ERKl/2 MAPK phosphorylation by 70% after 30 min, an effect abolished by propranolol (10 ?M; ISO vs. ISO/PROP: 0.30?0.06 vs. 1.05?0.10 AU; P<0.05).
http://hdl.handle.net/2262/79331
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?-Defensins: Farming the microbiome for homeostasis and health
(2019)
O'Farrelly, Cliona; Meade, Kieran
?-Defensins: Farming the microbiome for homeostasis and health
(2019)
O'Farrelly, Cliona; Meade, Kieran
Abstract:
Diverse commensal populations are now regarded as key to physiological homeostasis and protection against disease. Although bacteria are the most abundant component of microbiomes, and the most intensively studied, the microbiome also consists of viral, fungal, archael, and protozoan communities, about which comparatively little is known. Host-defense peptides (HDPs), originally described as antimicrobial, now have renewed significance as curators of the pervasive microbial loads required to maintain homeostasis and manage microbiome diversity. Harnessing HDP biology to transition away from non-selective, antibiotic-mediated treatments for clearance of microbes is a new paradigm, particularly in veterinary medicine. One family of evolutionarily conserved HDPs, ?-defensins which are produced in diverse combinations by epithelial and immune cell populations, are multifunctional cationic peptides which manage the cross-talk between host and microbes and maintain a healthy yet dynamic e...
http://hdl.handle.net/2262/89582
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?-Lactalbumin-oleic acid complex : structure function dynamics
(2015)
Xie, Yongjing
?-Lactalbumin-oleic acid complex : structure function dynamics
(2015)
Xie, Yongjing
Abstract:
THESIS 10852
Human alpha-lactalbumin made lethal to tumor cells (HAMLET) and its analogues are partially unfolded protein-oleic acid complexes that exhibit selective tumoricidal activity normally absent in the native protein itself, in order to understand the nature of the interaction between a-lactalbumin and oleic acid moieties, charge-specific chemical modifications of lysine residues involving citraconylation, acetylation and guanidination were employed and the biophysical and biological properties of the wild type and chemically modified bovine a-lactalbumin-oleic acid complexes were characterized.
http://hdl.handle.net/2262/80548
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?? T cells and NK cells ? Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity.
(2015)
MILLS, KINGSTON
?? T cells and NK cells ? Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity.
(2015)
MILLS, KINGSTON
Abstract:
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease that affects the central nervous system (CNS) resulting in progressive cognitive decline and physical disability. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS that has been used to understand the cellular and molecular mechanisms underlying CNS inflammation and autoimmunity. Since the discovery of IL-17-sereting CD4+ T cells (Th17 cells) over 10 years ago, these cells have been the main focus of attention as mediators of pathology in MS and EAE (1, 2). However, in recent years evidence has emerged that lymphocytes with innate-like properties are potent producers of IL-17 and related pro-inflammatory cytokines (3?6). ?? T cells, NKT, and innate lymphoid cells have been shown to be major sources of IL-17 in host control of a variety of bacterial, viral, and fungal infections. However, dysregulation of these innate-like lymphocytes can also result in severe pathology in EAE and other mo...
http://hdl.handle.net/2262/77420
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??????????????????: ????????????????
(2014)
Hadley, James; Akashi, Motoko
??????????????????: ????????????????
(2014)
Hadley, James; Akashi, Motoko
Abstract:
The domestication-foreignization paradigm of translator visibility originally formulated by Lawrence Venuti has come to dominate much translation research. However, much of the discussion relating to the use of this paradigm has historically centred on the subjective nature of the terminology, or even the ideological specificities of the American context in which Venuti produced the paradigm. This article aims to demonstrate that a more fundamental issue with using the visibility paradigm is a tendency to focus on textual analysis at the expense of broader social and contextual details. Using textual analysis to explore the translation work of Haruki Murakami, arguably one of the most visible contemporary translators, the article demonstrates the often contradictory results that can arise from extrapolating translator visibility in this way. It advocates further analysis of celebrity translators? work for the production of a more sophisticated paradigm of translator visibility, app...
http://hdl.handle.net/2262/91312
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?????14?
(2018)
Holm, Poul
?????14?
(2018)
Holm, Poul
http://hdl.handle.net/2262/90171
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?A Rare Case of Adult Scalp Pyoderma gangrenosum with cranial osteolysis?
(2018)
Aljohmani, Lylas
?A Rare Case of Adult Scalp Pyoderma gangrenosum with cranial osteolysis?
(2018)
Aljohmani, Lylas
http://hdl.handle.net/2262/82508
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An investigation of natural and anthropogenic factors influencing species richness and distribution in woodland & hedgerow habitats of north county Dublin
(2011)
McCourt, Shawn C.
An investigation of natural and anthropogenic factors influencing species richness and distribution in woodland & hedgerow habitats of north county Dublin
(2011)
McCourt, Shawn C.
Abstract:
THESIS 9558
In Ireland, hedgerows are estimated to cover an area roughly 2-3 times that of deciduous woodland on an island-wide basis (Webb 1985); however, to date, the processes involved in the formation of hedgerow plant communities remains poorly understood. It is generally assumed that hedgerows are linear strips of woodland and they have been advocated as potential surrogate habitat for forest species in other fragmented agricultural landscapes, especially in North America (Corbitt et al. 1999) and elsewhere in western and central Europe (Baudry et al. 2000, Wehling & Diekmann 2009).
http://hdl.handle.net/2262/79232
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?An Incalculable Amount of Misery?: The Smallpox Epidemic of 1871-3 and the South Dublin Union
(2018)
Zimmerman, Shelby Beth
?An Incalculable Amount of Misery?: The Smallpox Epidemic of 1871-3 and the South Dublin Union
(2018)
Zimmerman, Shelby Beth
Abstract:
From 1871-3, Ireland experienced one of the deadliest smallpox outbreaks in the nineteenth century with at least 3,248 fatalities during the peak, yet was overshadowed by the Famine, fever, and cholera in the historiography. This dissertation seeks to determine how the South Dublin Union responded to the threat of smallpox and the influence of the medical community in preventing and managing the disease. It looks at Dublin during the epidemic and the public health factors that made people susceptible to infection and how the Poor Law Commission and the Corporation of Dublin remedied the crisis. This research also looks at the contemporary understanding of smallpox and contagion and its impact on public health, disease prevention, and ward design. When disaster struck in 1871, the Irish Poor Law of 1838 and Medical Charities Act of 1851 became a mirage. These institutions were ill equipped to handle an epidemic of this scale and the arrival of smallpox exposed the flaws in the system...
http://hdl.handle.net/2262/93688
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?Apotropaic? Tactics in the Matthean Temptation
(2014)
Michael Morris, Michael
?Apotropaic? Tactics in the Matthean Temptation
(2014)
Michael Morris, Michael
Abstract:
Among the Dead Sea Scrolls are a number of texts that provide insight into demonological beliefs and practices in Second Temple Judaism. Some passages are concerned principally with providing safety from demonic influence. This anti-demonic orientation is expressed in two fundamental ways: the first is exorcistic and intends to relieve a person of current demonic affliction; the second is apotropaic and seeks protection from future demonic harm. Assessments of exorcistic and apotropaic works have benefited scholars of both early Jewish and early Christian literature. However, the majority of discussions which intersect Qumran studies with demonological traditions in the Synoptic Gospels have typically focused on exorcism. Still, the growing interest in preventative, apotropaic prayer and the illumination of this tradition by the Qumran material is resulting in recent endeavours to broaden the conversation about anti-demonic elements in the gospels. Building on the latest contributio...
http://hdl.handle.net/2262/73637
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?Changes in mitochondrial stability during the progression of the Barrett?s esophagus sequence?.
(2016)
Phelan, James
?Changes in mitochondrial stability during the progression of the Barrett?s esophagus sequence?.
(2016)
Phelan, James
Abstract:
Background: Barrett?s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett?s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis of this disease sequence is poorly understood. Mitochondria are highly susceptible to mutations due to high levels of reactive oxygen species (ROS) coupled with low levels of DNA repair. The timing and levels of mitochondria instability and dysfunction across the Barrett?s disease progression is under studied. Methods: Using an in-vitro model representing the Barrett?s esophagus disease sequence of normal squamous epithelium (HET1A), metaplasia (QH), dysplasia (Go), and esophageal adenocarcinoma (OE33), random mitochondrial mutations, deletions and surrogate markers of mitochondrial function were assessed. In-vivo and ex-vivo tissues were also assessed for instability profiles. Results: Barrett?s metaplastic cells demonstrated increased levels of ROS (p?<?0.005) an...
http://hdl.handle.net/2262/90703
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?Collaborative production? and the Irish boom: work organisation, partnership and direct involvement in Irish workplaces
(2000)
Roche, William K.; Geary, John F.
?Collaborative production? and the Irish boom: work organisation, partnership and direct involvement in Irish workplaces
(2000)
Roche, William K.; Geary, John F.
Abstract:
A significant strand of recent social-scientific writing on Ireland has assigned great importance to various forms of ?collaborative production?: new forms of work organisation, partnership and direct employee involvement ? even suggesting that their growing diffusion might have played a major role in Ireland?s exceptional economic performance during the 1990s. This paper draws on the University College Dublin national workplace survey of employee relations to present an assessment of the degree to which new modes of collaborative production have gained ground in Ireland during the 1990s. While collaborative production is undoubtedly significant in many Irish workplaces, ?exclusionary? forms of decision-making are shown to dominate the postures of establishments towards the handling of change. Arguments pointing to the ?transformation?, actual or imminent, of work practices and employment relations in Ireland are rejected. Change in Ireland is shown to have much in common with devel...
http://hdl.handle.net/2262/62651
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?critures africaines de l'exil parisien
(2001)
N? Loingsigh, Aed?n
?critures africaines de l'exil parisien
(2001)
N? Loingsigh, Aed?n
Abstract:
THESIS 6298
This thesis is an analysis of the representation of Parisian exile in seven African novels in French. The novels are studied in chronological order, thus illustrating the social and psychological evolution of the theme of exile in African literature in French from the colonial era to the contemporary post-colonial context. The introduction to the thesis illustrates how the colonial history of French-speaking Africa requires a reappraisal of the ?universal? meaning of exile. This, in turn, leads to an analysis of critical approaches to the theme of exile in the colonial and post-colonial contexts. In the first two chapters, which study two novels written during the colonial era, the structures of colonial society are shown to be the African writer?s first experience of exile. Rather than representing an escape from cultural and historical isolation, the journey to Paris is ultimately seen to be a return to this initial exile. In the French capital, racial and sexual i...
http://hdl.handle.net/2262/85490
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?Drawing Illusions? ? a case study in the incorrectness of diagrammatic reasoning
(1999)
Lemon, Oliver
?Drawing Illusions? ? a case study in the incorrectness of diagrammatic reasoning
(1999)
Lemon, Oliver
Abstract:
TCD-CS-1999-17
In ?Something to Reckon With? [6], a system for diagramming syllogistic inferences using straight line segments is presented (see also Englebretsen [5]). In the light of recent research on the representational power of diagrammatic representation systems (Lemon and Pratt [12, 13]) we point out some problems with the proposal, and indeed, with any proposal for representing logically possible situations diagrammatically. We shall first outline the proposed linear diagrammatic system of Englebretsen [5], and then show by means of counterexamples that it is inadequate as a representation scheme for general logical inferences (the task for which the system is intended). We also show that modifications to the system fail to remedy the problems. The considerations we present are not limited to the particular proposals of Englebretsen [5, 6]; we thus draw a more general moral about the use of spatial relations in representation systems.
http://hdl.handle.net/2262/13012
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?Dysregulated bioenergetics: a key regulator of joint inflammation?.
(2016)
Phelan, James
?Dysregulated bioenergetics: a key regulator of joint inflammation?.
(2016)
Phelan, James
Abstract:
Objectives: This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. Methods: Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with hypoxia, dimethyloxalylglycine (DMOG) or metabolic intermediates. Mitochondrial respiration, mitochondrial DNA mutations, cell invasion, cytokines, glucose and lactate were quantified using specific functional assays. RASF metabolism was assessed by the XF24-Flux Analyzer. Mitochondrial structural morphology was assessed by transmission electron microscopy (TEM). In vivo synovial tissue oxygen (tpO2 mmHg) was measured in patients with inflammatory arthritis (n=42) at arthroscopy, and markers of glycolysis/oxidative phosphorylation (glyceraldehyde 3-phosphate dehydrogenase (GAPDH), PKM2, GLUT1, ATP) were quantified by immunohistology. A subgroup of patients underwent contiguous MRI and positron emission tomography (PET)/CT imaging. RASF and human dermal microvascular endot...
http://hdl.handle.net/2262/90704
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'Constructions of 'Europe', identity and citizenship in post-primary social studies curricula in the Republic of Ireland'
(2012)
Faas, Daniel
'Constructions of 'Europe', identity and citizenship in post-primary social studies curricula in the Republic of Ireland'
(2012)
Faas, Daniel
http://hdl.handle.net/2262/75815
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?Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity?.
(2016)
Phelan, James
?Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity?.
(2016)
Phelan, James
Abstract:
In Barrett associated tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression. However, the link between energy metabolism and its connection with other central cellular processes within the Barrett microenvironment is unknown. The aim of this study was to examine the relationship between metabolism (ATP5B/GAPDH), hypoxia (HIF1?), inflammation (IL1?/SERPINA3), p53 and obesity status using in-vivo and ex-vivo models of Barrett oesophagus. At the protein level, ATP5B (r?=?0.71, P?<?0.0001) and p53 (r?=?0.455, P?=?0.015) were found to be strongly associated with hypoxia. In addition, levels of ATP5B (r?=?0.53, P?=?0.0031) and GAPDH (r?=??0.39, P?=?0.0357) were positively associated with p53 expression. Moreover, we demonstrate that ATP5B (r?=?0.8, P?<?0.0001) and GAPDH (r?=?0.43, P?=?0.022) were positively associated with IL1? expression. Interestingly, obesity was negatively associated...
http://hdl.handle.net/2262/90711
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?Insufficient for the support of a family?: wages on the public works during the Great Irish Famine
(2004)
McGregor, Pat
?Insufficient for the support of a family?: wages on the public works during the Great Irish Famine
(2004)
McGregor, Pat
Abstract:
This paper presents a model of the money wage paid on the public works during the Irish Famine. The administrators are assumed to minimise a cost function that includes the divergence from the target as well as the increase compared to the wage that current information is available on. Estimation reveals a lag of four weeks existed between price changes occurring and adjustment to the money wages. Most seriously, the administrators systematically failed to take full account of the extent of price changes.
http://hdl.handle.net/2262/60517
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How to Foster PPI With Those Excluded From Public Involvement Itself?
(2018)
Dinsmore, John
How to Foster PPI With Those Excluded From Public Involvement Itself?
(2018)
Dinsmore, John
Abstract:
Background While there is encouragement of public involvement in the development of health interventions and healthcare issues, PPI seeks to go a step further with this involvement ?with recognition of the need to engage citizens not only in providing feedback on health-care delivery or interventions, but in processes whereby decisions are made...? (Baxter, Clowes, Muir et al., 2016). But what happens to those citizens who find themselves socially excluded from their healthcare needs? One such group is our homeless population. This presentation, drawing upon previous research on health seeking behaviours of homeless individuals (N? Cheallaigh, Cullivan, Sears, et al., 2017), will challenge PPI to go further in how it seeks to understand involvement. We argue that a way of achieving this is through applying experience- centred design (ECD), which gives ?...people the chance to have a richer life, to include people who otherwise feel excluded, and to ensure that everybody has a chance...
http://hdl.handle.net/2262/85308
Displaying Results 1 - 25 of 19454 on page 1 of 779
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