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Displaying Results 201 - 225 of 5958 on page 9 of 239
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A multi-bacteriocin cheese starter system comprising nisin and lacticin 3147 in Lactococcus lactis, in combination with plantaricin from Lactobacillus plantarum
(2017)
Mills, S.; Griffin, Carmel; O'Connor, P. M.; Serrano, L. M.; Meijer, Wilco C.; Hil...
A multi-bacteriocin cheese starter system comprising nisin and lacticin 3147 in Lactococcus lactis, in combination with plantaricin from Lactobacillus plantarum
(2017)
Mills, S.; Griffin, Carmel; O'Connor, P. M.; Serrano, L. M.; Meijer, Wilco C.; Hill, Colin; Ross, R. Paul
Abstract:
Functional starter cultures demonstrating superior technological and food safety properties are advantageous to the food fermentation industry. We evaluated the efficacy of single and double bacteriocin-producing starters of Lactococcus lactis capable of producing the Class I bacteriocins, nisin A and/or lacticin 3147 in terms of starter performance. Single producers were generated by mobilising the conjugative, bacteriophage resistance plasmid pMRC01, encoding lacticin genetic determinants, or the conjugative transposon Tn5276, encoding nisin genetic determinants, to the commercial starter L. lactis CSK2775. The effect of bacteriocin co-production was examined by superimposing pMRC01 into the newly constructed nisin transconjugant. Transconjugants were improved with regard to antimicrobial activity and bacteriophage insensitivity when compared to the recipient strain and the double producer was immune to both bacteriocins. Bacteriocin production in the starter was stable, although ...
http://hdl.handle.net/10468/4092
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A multi-centre phase IIa clinical study of predictive testing for preeclampsia: improved pregnancy outcomes via early detection (IMPROvED)
(2013)
Navaratnam, Kate; Alfirevic, Zarko; Baker, Philip N.; Gluud, Christian; Grüttner, Berth...
A multi-centre phase IIa clinical study of predictive testing for preeclampsia: improved pregnancy outcomes via early detection (IMPROvED)
(2013)
Navaratnam, Kate; Alfirevic, Zarko; Baker, Philip N.; Gluud, Christian; Grüttner, Berthold; Kublickiene, Karolina; Zeeman, Gerda; Kenny, Louise C.
Abstract:
Background: 5% of first time pregnancies are complicated by pre-eclampsia, the leading cause of maternal death in Europe. No clinically useful screening test exists; consequentially clinicians are unable to offer targeted surveillance or preventative strategies. IMPROvED Consortium members have pioneered a personalised medicine approach to identifying blood-borne biomarkers through recent technological advancements, involving mapping of the blood metabolome and proteome. The key objective is to develop a sensitive, specific, high-throughput and economically viable early pregnancy screening test for pre-eclampsia. Methods/Design: We report the design of a multicentre, phase IIa clinical study aiming to recruit 5000 low risk primiparous women to assess and refine innovative prototype tests based on emerging metabolomic and proteomic technologies. Participation involves maternal phlebotomy at 15 and 20 weeks’ gestation, with optional testing and biobanking at 11 and 34 weeks. Blood sam...
http://hdl.handle.net/10468/2259
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A multi-technology approach to identifying the reasons for lateral drift in professional and recreational darts
(2011)
Walsh, Michael; Tyndyk, Magdalena; Barton, John; O'Flynn, Brendan; Ó Mathúna, S. Cian
A multi-technology approach to identifying the reasons for lateral drift in professional and recreational darts
(2011)
Walsh, Michael; Tyndyk, Magdalena; Barton, John; O'Flynn, Brendan; Ó Mathúna, S. Cian
Abstract:
This work performs an extensive charterisation of precision targeted throwing in professional and recreational darts. The goal is to identify the contributing factors for lateral drift or throwing inaccuracy in the horizontal plane. A multitechnology approach is adopted whereby a custom built body area network of wireless inertial measurement devices monitor tilt, force and timing, an optical 3D motion capture system provides a complete kinematic model of the subject, electromyography sensors monitor muscle activation patterns and a force plate and pressure mat capture tactile pressure and force measurements. The study introduces the concept of constant throwing rhythm and highlights how landing errors in the horizontal plane can be attributable to a number of variations in arm force and speed, centre of gravity and the movements of some of the bodies non throw related extremities.
http://hdl.handle.net/10468/499
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A multicentre study of thromboprophylaxis in pregnancy
(2017)
Crowley, Maeve P.; Noone, C.; Higgins, John R.; O'Shea, S.
A multicentre study of thromboprophylaxis in pregnancy
(2017)
Crowley, Maeve P.; Noone, C.; Higgins, John R.; O'Shea, S.
Abstract:
Venous thromboembolism (VTE) is a leading cause of maternal mortality. The risk increases with increasing maternal age, mode of delivery and medical co-morbidities. Thromboprophylaxis with low molecular weight heparin (LMWH) has been shown to be both safe and efficacious. The aim of this study was to prospectively investigate the incidence of maternal risk factors in pregnant women admitted to hospital, to calculate their VTE risk status and to investigate if they were receiving appropriate thromboprophylaxis. All patients admitted to the participating hospitals on the day of investigation were assessed for risk of VTE on the basis of hospital chart review. Five Hundred and forty women were recruited from 16 hospitals. Almost 32% (31.7%) were receiving thromboprophylaxis with LMWH. Just under 80% of patients were on the correct thromboprophylaxis strategy as defined by the RCOG guideline but 49% were under-dosed. The odds of receiving appropriate thromboprophylaxis were significantl...
http://hdl.handle.net/10468/5891
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A nascent peptide signal responsive to endogenous levels of polyamines acts to stimulate regulatory frameshifting on antizyme mRNA.
(2015)
Yordanova, Martina M.; Wu, Cheng; Andreev, Dmitry E.; Sachs, Matthew S.; Atkins, John F.
A nascent peptide signal responsive to endogenous levels of polyamines acts to stimulate regulatory frameshifting on antizyme mRNA.
(2015)
Yordanova, Martina M.; Wu, Cheng; Andreev, Dmitry E.; Sachs, Matthew S.; Atkins, John F.
Abstract:
The protein antizyme is a negative regulator of cellular polyamine concentrations from yeast to mammals. Synthesis of functional antizyme requires programmed +1 ribosomal frameshifting at the 3' end of the first of two partially overlapping ORFs. The frameshift is the sensor and effector in an autoregulatory circuit. Except for Saccharomyces cerevisiae antizyme mRNA, the frameshift site alone only supports low levels of frameshifting. The high levels usually observed depend on the presence of cis-acting stimulatory elements located 5' and 3' of the frameshift site. Antizyme genes from different evolutionary branches have evolved different stimulatory elements. Prior and new multiple alignments of fungal antizyme mRNA sequences from the Agaricomycetes class of Basidiomycota show a distinct pattern of conservation 5' of the frameshift site consistent with a function at the amino acid level. As shown here when tested in Schizosaccharomyces pombe and mammalian HEK293...
http://hdl.handle.net/10468/5717
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A nation preferring visions: moving statues, apparitions and vernacular religion in contemporary Ireland
(2014)
Allen, William
A nation preferring visions: moving statues, apparitions and vernacular religion in contemporary Ireland
(2014)
Allen, William
Abstract:
This thesis examines important issues of Irish vernacular Catholicism, Irish religious and cultural identities, the impacts of modernity plus socio-religious and economic change on traditional religiosity, sacred landscape and topophilia, religious material culture, folk and individual creativity, gender roles and expectations, and devotional subcultures through the vehicle of Marian apparitions and their aftermath in the Republic of Ireland in the late 20th and early 21st centuries. This thesis examines in detail five Irish Marian shrines as case studies; Knock shrine (Co. Mayo), Ballinspittle and Mitchelstown grottoes (Co. Cork), Mount Melleray grotto (Co. Waterford) and the Marian shrines of Inchigeela in West Cork and the attached houses of prayer. Key themes include; vernacular religious theory; the nature of Irish indigenous Catholicism; local, global and transnational trends in contemporary Irish devotional life; areas of individual creativity, fluidity and agency in Marian ...
http://hdl.handle.net/10468/2105
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A national stakeholder consensus study of challenges and priorities for clinical learning environments in postgraduate medical education
(2017)
Kilty, Caroline; Wiese, Anel; Bergin, Colm; Flood, Patrick; Fu, Na; Horgan, Mary; Higgi...
A national stakeholder consensus study of challenges and priorities for clinical learning environments in postgraduate medical education
(2017)
Kilty, Caroline; Wiese, Anel; Bergin, Colm; Flood, Patrick; Fu, Na; Horgan, Mary; Higgins, Agnes; Maher, Bridget M.; O'Kane, Grainne; Prihodova, Lucia; Slattery, Dubhfeasa; Stoyanov, Slavi; Bennett, Deirdre
Abstract:
Background: High quality clinical learning environments (CLE) are critical to postgraduate medical education (PGME). The understaffed and overcrowded environments in which many residents work present a significant challenge to learning. The purpose of this study was to develop a national expert group consensus amongst stakeholders in PGME to; (i) identify important barriers and facilitators of learning in CLEs and (ii) indicate priority areas for improvement. Our objective was to provide information to focus efforts to provide high quality CLEs. Methods: Group Concept Mapping (GCM) is an integrated mixed methods approach to generating expert group consensus. A multi-disciplinary group of experts were invited to participate in the GCM process via an online platform. Multi-dimensional scaling and hierarchical cluster analysis were used to analyse participant inputs in regard to barriers, facilitators and priorities. Results: Participants identified facilitators and barriers in ten dom...
http://hdl.handle.net/10468/5378
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A neighbour disjoint multipath scheme for fault tolerant wireless sensor networks
(2014)
Sreenan, Cormac J.; Fedor, Szymon; Hossain, A.K.M. Mahtab
A neighbour disjoint multipath scheme for fault tolerant wireless sensor networks
(2014)
Sreenan, Cormac J.; Fedor, Szymon; Hossain, A.K.M. Mahtab
Abstract:
In this paper, we propose a "Neighbour Disjoint Multipath (NDM)" scheme that increases resilience against node or link failures in a wireless sensor network (WSN). Our algorithm chooses the shortest path between a sensor and the sink as the primary path, thus ensuring the algorithm is energy efficient under normal circumstances. In selecting the backup paths, we utilise the disjoint property to ensure that i) when there are k paths between source and sink, no set of k node failures can result in total communication break between them, and ii) by having (k-1) spatially separated backup paths w.r.t. the primary path, the probability of simultaneous failure of the primary and backup paths is reduced in case of localised poor channel quality or node failures. Our algorithm not only ensures the node disjointedness characteristics of the constructed paths, but also tries to minimise the impact of co-located node or link failures where a localised portion of the network may be un...
http://hdl.handle.net/10468/5899
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A neuropsychiatric presentation of seronegative autoimmune encephalitis: a case report
(2015)
Ismail, Muhammad Fahmi; Moloney, Eimer; Costello, Daniel J.; Sweeney, Brian J.; Cassidy...
A neuropsychiatric presentation of seronegative autoimmune encephalitis: a case report
(2015)
Ismail, Muhammad Fahmi; Moloney, Eimer; Costello, Daniel J.; Sweeney, Brian J.; Cassidy, Eugene M.
Abstract:
Autoimmune encephalitis with negative paraneoplastic, infectious and serology markers poses a considerable diagnostic and therapeutic challenge. We described a case with neuropsychiatric presentation of seronegative autoimmune encephalitis. Paraneoplastic, infectious and metabolic etiologies were excluded. The patient responded to immunotherapy and achieved full remission.
http://hdl.handle.net/10468/5177
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A new cavity ring-down instrument for airborne monitoring of N2O5, NO3, NO2 and O3 in the upper troposphere lower stratosphere
(2016)
Goulette, Marc; Brown, Steven; Dinesan, Hemanth; Dubé, W. P.; Hübler, Gerhard; Orphal, ...
A new cavity ring-down instrument for airborne monitoring of N2O5, NO3, NO2 and O3 in the upper troposphere lower stratosphere
(2016)
Goulette, Marc; Brown, Steven; Dinesan, Hemanth; Dubé, W. P.; Hübler, Gerhard; Orphal, Johannes; Ruth, Albert A.; Zahn, Andreas
Abstract:
A new airborne instrument based on pulsed cavity ring-down spectroscopy for simultaneous detection of N2O5, NO3, NO2 and O3 in the upper troposphere lower stratosphere is being developed for global atmospheric monitoring. OCIS codes: 010.0010, 120.0120, 140.0140, 280.0280, 300.0300, 300.6260, 300.6360.
http://hdl.handle.net/10468/3481
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A new latching control technology for improving wave energy conversion
(2014)
Sheng, Wanan; Alcorn, Raymond; Lewis, Anthony
A new latching control technology for improving wave energy conversion
(2014)
Sheng, Wanan; Alcorn, Raymond; Lewis, Anthony
Abstract:
Extracting wave energy from seas has been proven to be very difficult although various technologies have been developed since 1970s. Among the proposed technologies, only few of them have been actually progressed to the advanced stages such as sea trials or pre-commercial sea trial and engineering. One critical question may be how we can design an efficient wave energy converter or how the efficiency of a wave energy converter can be improved using optimal and control technologies, because higher energy conversion efficiency for a wave energy converter is always pursued and it mainly decides the cost of the wave energy production. In this first part of the investigation, some conventional optimal and control technologies for improving wave energy conversion are examined in a form of more physical meanings, rather than the purely complex mathematical expressions, in which it is hoped to clarify some confusions in the development and the terminologies of the technologies and to help t...
http://hdl.handle.net/10468/2681
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A new method for estimating frequency-dependent core shifts in active galactic nucleus jets
(2011)
Kudryavtseva, N. A.; Gabuzda, Denise; Aller, M. F.; Aller, H. D.
A new method for estimating frequency-dependent core shifts in active galactic nucleus jets
(2011)
Kudryavtseva, N. A.; Gabuzda, Denise; Aller, M. F.; Aller, H. D.
Abstract:
We discuss the opacity in the core regions of active galactic nuclei observed with Very Long Baseline Interferometry (VLBI), and describe a new method for deriving the frequency-dependent shifts of the VLBI core from the frequency-dependent time lags of flares observed with single-dish observations. Application of the method to the core shifts of the quasar 3C 345 shows a very good agreement between the core shifts directly measured from VLBI observations and derived from flares in the total flux density using the proposed method. The frequency-dependent time lags of flares can be used to derive physical parameters of the jets, such as distance from the VLBI core to the base of the jet and the magnetic fields in the core region. Our estimates for 3C 345 indicate core magnetic fields similar or equal to 0.1 G and magnetic field at 1 pc similar or equal to 0.4 G.
http://hdl.handle.net/10468/4963
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A new world a new American foreign policy: the Carter administration, Nicaragua, and the legacy of the Vietnam War, 1977-1981
(2012)
McLaughlin, Ivan Eugene
A new world a new American foreign policy: the Carter administration, Nicaragua, and the legacy of the Vietnam War, 1977-1981
(2012)
McLaughlin, Ivan Eugene
Abstract:
The impact of the Vietnam War conditioned the Carter administration’s response to the Nicaraguan revolution in ways that reduced US engagement with both sides of the conflict. It made the countries of Latin America counter the US approach and find their own solution to the crisis, and allowed Cuba to play a greater role in guiding the overthrow of Nicaraguan dictator Anastasio Somoza Debayle. This thesis re-evaluates Carter’s policy through the legacy of the Vietnam War, because US executive anxieties about military intervention, Congress’s increasing influence, and US public concerns about the nation’s global responsibilities, shaped the Carter approach to Nicaragua. Following a background chapter, the Carter administration’s policy towards Nicaragua is evaluated, before and after the fall of Somoza in July 1979. The extent of the Vietnam influence on US-Nicaraguan relations is developed by researching government documents on the formation of US policy, including material from t...
http://hdl.handle.net/10468/712
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A next application prediction service using the BaranC framework
(2016)
Hashemi, Mohammad; Herbert, John
A next application prediction service using the BaranC framework
(2016)
Hashemi, Mohammad; Herbert, John
Abstract:
Predicting user behaviour enables user assistant services provide personalized services to the users. This requires a comprehensive user model that can be created by monitoring user interactions and activities. BaranC is a framework that performs user interface (UI) monitoring (and collects all associated context data), builds a user model, and supports services that make use of the user model. A prediction service, Next-App, is built to demonstrate the use of the framework and to evaluate the usefulness of such a prediction service. Next-App analyses a user's data, learns patterns, makes a model for a user, and finally predicts, based on the user model and current context, what application(s) the user is likely to want to use. The prediction is pro-active and dynamic, reflecting the current context, and is also dynamic in that it responds to changes in the user model, as might occur over time as a user's habits change. Initial evaluation of Next-App indicates a high-level...
http://hdl.handle.net/10468/3286
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A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa
(2013)
Reen, F. Jerry; Haynes, Jill M.; Mooij, Marlies J.; O'Gara, Fergal
A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa
(2013)
Reen, F. Jerry; Haynes, Jill M.; Mooij, Marlies J.; O'Gara, Fergal
Abstract:
LysR-type transcriptional regulators (LTTRs) are emerging as key circuit components in regulating microbial stress responses and are implicated in modulating oxidative stress in the human opportunistic pathogen Pseudomonas aeruginosa. The oxidative stress response encapsulates several strategies to overcome the deleterious effects of reactive oxygen species. However, many of the regulatory components and associated molecular mechanisms underpinning this key adaptive response remain to be characterised. Comparative analysis of publically available transcriptomic datasets led to the identification of a novel LTTR, PA2206, whose expression was altered in response to a range of host signals in addition to oxidative stress. PA2206 was found to be required for tolerance to H2O2 in vitro and lethality in vivo in the Zebrafish embryo model of infection. Transcriptomic analysis in the presence of H2O2 showed that PA2206 altered the expression of 58 genes, including a large repertoire of oxid...
http://hdl.handle.net/10468/2395
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A nonlinear analysis of spatial compliant parallel modules: Multi-beam modules
(2011)
Hao, Guangbo; Kong, Xianwen; Reuban, Robert L.
A nonlinear analysis of spatial compliant parallel modules: Multi-beam modules
(2011)
Hao, Guangbo; Kong, Xianwen; Reuban, Robert L.
Abstract:
This paper presents normalized, nonlinear and analytical models of spatial compliant parallel modules: multi-beam modules with a large range of motion. The models address the nonlinearity of load-equilibrium equations, applied in the deformed configuration, under small deflection hypothesis. First, spatial nonlinear load-displacement equations of the tip of a beam, conditions of geometry compatibility and load-equilibrium conditions for a spatial three-beam module are derived. The nonlinear and analytical load-displacement equations for the three-beam module are then solved using three methods: approximate analytical method, improved analytical method and numerical method. The nonlinear-analytical solutions, linear solutions and large-deflection FEA solutions are further analyzed and compared. FEA verifies that the accuracy of the proposed nonlinear-analytical model is acceptable. Moreover, a class of multi-beam modules with four or more beams is proposed, and their general nonlinea...
http://hdl.handle.net/10468/717
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A nonlinear model of newborn EEG with nonstationary inputs
(2010)
Stevenson, Nathan J.; Mesbah, Mostefa; Boylan, Geraldine B.; Colditz, Paul B.; Boashash...
A nonlinear model of newborn EEG with nonstationary inputs
(2010)
Stevenson, Nathan J.; Mesbah, Mostefa; Boylan, Geraldine B.; Colditz, Paul B.; Boashash, Boualem
Abstract:
Newborn EEG is a complex multiple channel signal that displays nonstationary and nonlinear characteristics. Recent studies have focussed on characterizing the manifestation of seizure on the EEG for the purpose of automated seizure detection. This paper describes a novel model of newborn EEG that can be used to improve seizure detection algorithms. The new model is based on a nonlinear dynamic system; the Duffing oscillator. The Duffing oscillator is driven by a nonstationary impulse train to simulate newborn EEG seizure and white Gaussian noise to simulate newborn EEG background. The use of a nonlinear dynamic system reduces the number of parameters required in the model and produces more realistic, life-like EEG compared with existing models. This model was shown to account for 54% of the linear variation in the time domain, for seizure, and 85% of the linear variation in the frequency domain, for background. This constitutes an improvement in combined performance of 6%, with a re...
http://hdl.handle.net/10468/629
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A nonparametric feature for neonatal EEG seizure detection based on a representation of pseudo-periodicity
(2012)
Stevenson, Nathan J.; O'Toole, John M.; Rankine, Luke J.; Boylan, Geraldine B.; Bo...
A nonparametric feature for neonatal EEG seizure detection based on a representation of pseudo-periodicity
(2012)
Stevenson, Nathan J.; O'Toole, John M.; Rankine, Luke J.; Boylan, Geraldine B.; Boashash, Boualem
Abstract:
Automated methods of neonatal EEG seizure detection attempt to highlight the evolving, stereotypical, pseudo-periodic, nature of EEG seizure while rejecting the nonstationary, modulated, coloured stochastic background in the presence of various EEG artefacts. An important aspect of neonatal seizure detection is, therefore, the accurate representation and detection of pseudo-periodicity in the neonatal EEG. This paper describes a method of detecting pseudo-periodic components associated with neonatal EEG seizure based on a novel signal representation; the nonstationary frequency marginal (NFM). The NFM can be considered as an alternative time-frequency distribution (TFD) frequency marginal. This method integrates the TFD along data-dependent, time-frequency paths that are automatically extracted from the TFD using an edge linking procedure and has the advantage of reducing the dimension of a TFD. The reduction in dimension simplifies the process of estimating a decision statistic des...
http://hdl.handle.net/10468/836
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A normalization-based approach to the mobility analysis of spatial compliant multi-beam modules
(2013)
Hao, Guangbo; Kong, Xianwen
A normalization-based approach to the mobility analysis of spatial compliant multi-beam modules
(2013)
Hao, Guangbo; Kong, Xianwen
Abstract:
This paper presents a normalization-based approach to the mobility analysis of spatial compliant multi-beam modules to address the dimensional-inhomogeneity issue of motion/load. Firstly, two spatial non-tilted and tilted multi-beam modules, composed of uniform beams with symmetrical cross sections and same length, are proposed. Using a normalization technique, the compliance matrices of these spatial multi-beam modules are derived, from which the DOF (degrees-of-freedom) of the compliant modules can be obtained by direct observation and/or screw representation. The results are compared with those obtained without normalization. It is shown that the DOF of these compliant modules can be identified more easily using the proposed approach than the approach without normalization. Then, two spatial double non-tilted and tilted three-beam modules are proposed and analyzed for potential applications such as acting as building blocks of new compliant manipulators. The normalization-based a...
http://hdl.handle.net/10468/719
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A novel and miniaturized 433/868MHz multi-band wireless sensor platform for body sensor network applications
(2012)
Buckley, John; O'Flynn, Brendan; Loizou, Loizos; Haigh, Peter; Boyle, David; Angov...
A novel and miniaturized 433/868MHz multi-band wireless sensor platform for body sensor network applications
(2012)
Buckley, John; O'Flynn, Brendan; Loizou, Loizos; Haigh, Peter; Boyle, David; Angove, Philip; Barton, John; Ó Mathúna, S. Cian; Popovici, Emanuel M.; O'Connell, Seán
Abstract:
Body Sensor Network (BSN) technology is seeing a rapid emergence in application areas such as health, fitness and sports monitoring. Current BSN wireless sensors typically operate on a single frequency band (e.g. utilizing the IEEE 802.15.4 standard that operates at 2.45GHz) employing a single radio transceiver for wireless communications. This allows a simple wireless architecture to be realized with low cost and power consumption. However, network congestion/failure can create potential issues in terms of reliability of data transfer, quality-of-service (QOS) and data throughput for the sensor. These issues can be especially critical in healthcare monitoring applications where data availability and integrity is crucial. The addition of more than one radio has the potential to address some of the above issues. For example, multi-radio implementations can allow access to more than one network, providing increased coverage and data processing as well as improved interoperability betw...
http://hdl.handle.net/10468/955
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A novel approach to challenging consensus in evaluations: The Agitation Workshop
(2013)
McAvoy, John; Nagle, Tadhg; Sammon, David
A novel approach to challenging consensus in evaluations: The Agitation Workshop
(2013)
McAvoy, John; Nagle, Tadhg; Sammon, David
Abstract:
As researchers evaluate organisations, projects, and teams, there is a desire for a consensus from those within the organisations who are participating in the research. A common consensual perspective from a team appears to reflect an optimal state where those being evaluated have a common understanding of the current state of events within the context of their environment. The question arises, though, whether an evaluation finding consensus reflects the reality: there are a variety of reasons why a common understanding may be false consensus. Hidden behind this false consensus may be a variety of unaddressed issues which are actually the core of the problem. This paper proposes an evaluation method incorporating the principles of sensemaking and devil’s advocate, where a consensus of perspectives is challenged before they are considered valid. This is achieved in a workshop where participants reflect on their own perception of reality and represent this reality in a matrix of influ...
http://hdl.handle.net/10468/5119
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A novel CE microchip with micro pillars column & double-L injection design for Capacitance Coupled Contactless Conductivity detection technology
(2016)
Wang, Yineng; Messina, Walter; Cao, Xi; Hogan, Anna; van Zalen, Ed; Moore, Eric J.
A novel CE microchip with micro pillars column & double-L injection design for Capacitance Coupled Contactless Conductivity detection technology
(2016)
Wang, Yineng; Messina, Walter; Cao, Xi; Hogan, Anna; van Zalen, Ed; Moore, Eric J.
Abstract:
This novel capillary electrophoresis microchip, or also known as μTAS (micro total analysis system) was designed to separate complex aqueous based compounds, similar to commercial CE & microchip (capillary electrophoresis) systems, but more compact. This system can be potentially used for mobile/portable chemical analysis equipment. Un-doped silicon wafer & ultra-thin borofloat glass (Pyrex) wafers have been used to fabricate the device. Double-L injection feature, micro pillars column, bypass separation channel & hybrid- referenced C4D electrodes were designed to achieve a high SNR (signal to noise ratio), easy- separation, for a durable and reusable μTAS for CE use.
http://hdl.handle.net/10468/3317
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A novel cold active esterase from a deep sea sponge Stelletta normani metagenomic library
(2017)
Borchert, Erik; Selvin, Joseph; Kiran, Seghal G.; Jackson, Stephen A.; O'Gara, Fer...
A novel cold active esterase from a deep sea sponge Stelletta normani metagenomic library
(2017)
Borchert, Erik; Selvin, Joseph; Kiran, Seghal G.; Jackson, Stephen A.; O'Gara, Fergal; Dobson, Alan D. W.
Abstract:
Esterases catalyze the hydrolysis of ester bonds in fatty acid esters with short-chain acyl groups. Due to the widespread applications of lipolytic enzymes in various industrial applications, there continues to be an interest in novel esterases with unique properties. Marine ecosystems have long been acknowledged as a significant reservoir of microbial biodiversity and in particular of bacterial enzymes with desirable characteristics for industrial use, such as for example cold adaptation and activity in the alkaline pH range. We employed a functional metagenomic approach to exploit the enzymatic potential of one particular marine ecosystem, namely the microbiome of the deep sea sponge Stelletta normani. Screening of a metagenomics library from this sponge resulted in the identification of a number of lipolytic active clones. One of these encoded a highly, cold-active esterase 7N9, and the recombinant esterase was subsequently heterologously expressed in Escherichia coli. The estera...
http://hdl.handle.net/10468/4898
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A novel erythromycin resistance plasmid from Bacillus sp strain HS24, isolated from the marine sponge Haliclona simulans
(2014)
Barbosa, Teresa M.; Phelan, Robert W.; Leong, Dara; Morrissey, John P.; Adams, Claire; ...
A novel erythromycin resistance plasmid from Bacillus sp strain HS24, isolated from the marine sponge Haliclona simulans
(2014)
Barbosa, Teresa M.; Phelan, Robert W.; Leong, Dara; Morrissey, John P.; Adams, Claire; Dobson, Alan D. W.; O'Gara, Fergal
Abstract:
A better understanding of the origin and natural reservoirs of resistance determinants is fundamental to efficiently tackle antibiotic resistance. This paper reports the identification of a novel 5.8 kb erythromycin resistance plasmid, from Bacillus sp. HS24 isolated from the marine sponge Haliclona simulans. pBHS24B has a mosaic structure and carries the erythromycin resistance gene erm(T). This is the first report of an erythromycin resistance plasmid from a sponge associated bacteria and of the Erm(T) determinant in the genus Bacillus.
http://hdl.handle.net/10468/2318
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A novel method of microsatellite genotyping-by-sequencing using individual combinatorial barcoding
(2016)
Vartia, Salla; Villanueva-Cañas, José L.; Finarelli, John; Farrell, Edward D.; Collins,...
A novel method of microsatellite genotyping-by-sequencing using individual combinatorial barcoding
(2016)
Vartia, Salla; Villanueva-Cañas, José L.; Finarelli, John; Farrell, Edward D.; Collins, Patrick C.; Hughes, Graham M.; Carlsson, Jeanette E. L.; Gauthier, David T.; McGinnity, Philip; Cross, Thomas F.; FitzGerald, Richard D.; Mirimin, Luca; Crispie, Fiona; Cotter, Paul D.; Carlsson, Jens
Abstract:
This study examines the potential of next-generation sequencing based 'genotyping-by-sequencing' (GBS) of microsatellite loci for rapid and cost-effective genotyping in large-scale population genetic studies. The recovery of individual genotypes from large sequence pools was achieved by PCR-incorporated combinatorial barcoding using universal primers. Three experimental conditions were employed to explore the possibility of using this approach with existing and novel multiplex marker panels and weighted amplicon mixture. The GBS approach was validated against microsatellite data generated by capillary electrophoresis. GBS allows access to the underlying nucleotide sequences that can reveal homoplasy, even in large datasets and facilitates cross laboratory transfer. GBS of microsatellites, using individual combinatorial barcoding, is potentially faster and cheaper than current microsatellite approaches and offers better and more data.
http://hdl.handle.net/10468/5701
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