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Displaying Results 1 - 25 of 1833 on page 1 of 74
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'It's risky to walk in the city with syringes': understanding access to HIV/AIDS services for injecting drug users in the former Soviet Union countries of Ukraine and Kyrgyzstan.
(2011)
Spicer, Neil; Bogdan, Daryna; Brugha, Ruairi; Harmer, Andrew; Murzalieva, Gulgun; Semig...
'It's risky to walk in the city with syringes': understanding access to HIV/AIDS services for injecting drug users in the former Soviet Union countries of Ukraine and Kyrgyzstan.
(2011)
Spicer, Neil; Bogdan, Daryna; Brugha, Ruairi; Harmer, Andrew; Murzalieva, Gulgun; Semigina, Tetiana
Abstract:
<p>The electronic version of this article is the complete one and can also be found online at: <a href="http://www.globalizationandhealth.com/content/7/1/22">http://www.globalizationandhealth.com/content/7/1/22</a></p>
<p>BACKGROUND: Despite massive scale up of funds from global health initiatives including the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund) and other donors, the ambitious target agreed by G8 leaders in 2005 in Gleneagles to achieve universal access to HIV/AIDS treatment by 2010 has not been reached. Significant barriers to access remain in former Soviet Union (FSU) countries, a region now recognised as a priority area by policymakers. There have been few empirical studies of access to HIV/AIDS services in FSU countries, resulting in limited understanding and implementation of accessible HIV/AIDS interventions. This paper explores the multiple access barriers to HIV/AIDS services experienced by a key risk...
https://epubs.rcsi.ie/ephmart/22
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'Reduce Resistance' An Antibiotic stewardship program to change prescribing practices in a Public Dental Service
(2015)
McCafferty, Rosarii
'Reduce Resistance' An Antibiotic stewardship program to change prescribing practices in a Public Dental Service
(2015)
McCafferty, Rosarii
Abstract:
<p>This program implemented an antibiotic stewardship program (ASP) to change prescribing practices in one Public Dental Service with the aim of reducing the number of unnecessary antibiotic prescriptions and ensuring that those antibiotics which are prescribed adhere to best practice guidelines. There is vast scientific evidence that antibiotic resistance is promoted through excessive use of antibiotics and that Dental Surgeons are contributing significantly to this issue due to their inappropriate prescribing practices.</p> <p>The HSE Change Model was used as a framework for the planning and implementation of this multifaceted Antibiotic Stewardship Program (ASP), which involved the implementation of best practice guidelines, clinical audit, an education program, an antibiotic ledger, and individualised clinician feedback. The ASP was designed considering the cultural, contextual and behavioural factors which influence prescribing practices. Staff engagement and ...
https://epubs.rcsi.ie/mscttheses/63
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'Reference rot': A developing problem in Emergency Medicine Australasia.
(2015)
O'Connor, Colm; O'Connor, Alan
'Reference rot': A developing problem in Emergency Medicine Australasia.
(2015)
O'Connor, Colm; O'Connor, Alan
Abstract:
<p>The original article is available at <a href="http://onlinelibrary.wiley.com/doi/10.1111/1742-6723.12459/full" target="_blank">http://onlinelibrary.wiley.com/doi/10.1111/1742-6723.12459/full</a></p>
https://epubs.rcsi.ie/libraryart/8
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'Smart' non-viral delivery systems for targeted delivery of RNAi to the lungs.
(2013)
Ramsey, Joanne M; Hibbitts, Alan; Barlow, James; Sivadas, Neeraj; Cryan, Sally-Ann
'Smart' non-viral delivery systems for targeted delivery of RNAi to the lungs.
(2013)
Ramsey, Joanne M; Hibbitts, Alan; Barlow, James; Sivadas, Neeraj; Cryan, Sally-Ann
Abstract:
<p>This article is also available at <a href="http://www.future-science.com/doi/abs/10.4155/tde.12.133?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed">http://www.future-science.com/doi/abs/10.4155/tde.12.133?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed</a></p>
<p>The emergence of RNAi offers a potentially exciting new therapeutic paradigm for respiratory diseases. However, effective delivery remains a key requirement for their translation into the clinic and has been a major factor in the limited clinical success seen to date. Inhalation offers tissue-specific targeting of the RNAi to treat respiratory diseases and a diminished risk of off-target effects. In order to deliver RNAi directly to the respiratory tract via inhalation, 'smart' non-viral carriers are required to protect the RNAi during delivery/aerosolization and enhance cell-specific uptake to target ce...
https://epubs.rcsi.ie/spharmart/13
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'Suing the Pope' and Scandalising the People: Irish Attitudes to Sexual Abuse by Clergy Pre- and Post-Screening of a Critical Documentary
(2009)
Breen, Michael J; McGee, Hannah; O'Boyle, Ciaran; Goode, Helen; Devereux, Eoin
'Suing the Pope' and Scandalising the People: Irish Attitudes to Sexual Abuse by Clergy Pre- and Post-Screening of a Critical Documentary
(2009)
Breen, Michael J; McGee, Hannah; O'Boyle, Ciaran; Goode, Helen; Devereux, Eoin
Abstract:
This article is from Irish Communications Review and is available at http://www.icr.dit.ie
The Sexual abuse of children became a significant public issue in Ireland in the 1990s, with frequent media reports about the issue. In the main these focused on the issue of abuse of children by members of the clergy and religious orders. Headline cases included the abuse perpetrated by Fr Brendan Smyth, a priest of a religious order who was convicted of multiple counts of sexual abuse of children and subsequently died in prison, and Fr Seán Fortune, a diocesan priest, who committed suicide before his court trial for abuse. While child sexual abuse by clergy was widely exposed in the early 1990s, a subsequent additional scandal was the failure of the institutional Catholic Church to respond adequately to earlier complaints of abuse, and, in particular, to respond adequately to those who experienced abuse. As part of its response to the problem, the Irish Catholic bishops commissioned an ...
https://epubs.rcsi.ie/psycholart/22
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‘Emigration is a matter of self-preservation. The working conditions . . . are killing us slowly’: qualitative insights into health professional emigration from Ireland
(2015)
Humphries, Niamh; McAleese, Sara; Matthews, Anne; Brugha, Ruairi
‘Emigration is a matter of self-preservation. The working conditions . . . are killing us slowly’: qualitative insights into health professional emigration from Ireland
(2015)
Humphries, Niamh; McAleese, Sara; Matthews, Anne; Brugha, Ruairi
Abstract:
<p>The original article is also available at <a href="http://www.human-resources-health.com/content/13/1/35/abstract" target="_blank">http://www.human-resources-health.com/content/13/1/35/abstract</a></p>
<p><strong>Background</strong> Achieving a sustainable health workforce involves training and retaining sufficient staff to deliver health services. The Irish health workforce is characterised by a high level of emigration of Irish-trained staff and a heavy reliance on internationally trained staff. This paper presents qualitative findings from a mixed - method study of doctors, nurses and midwives who have recently emigrated from Ireland.</p> <p><strong> Methods</strong> Using Facebook, this study elicited 556 (388 completed) responses to an exploratory mixed-method online survey in July 2014. Respondents provided rich responses to two free-text questions, one on health worker return (N = 343...
http://dx.doi.org/10.1186/s12960-015-0022-6
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‘Potentially inappropriate or specifically appropriate?’ Qualitative evaluation of general practitioners views on prescribing, polypharmacy and potentially inappropriate prescribing in older people.
(2016)
Clyne, Barbara; Cooper, Janine A; Hughes, Carmel M; Fahey, Tom; Smith, Susan M; OPTI-SC...
‘Potentially inappropriate or specifically appropriate?’ Qualitative evaluation of general practitioners views on prescribing, polypharmacy and potentially inappropriate prescribing in older people.
(2016)
Clyne, Barbara; Cooper, Janine A; Hughes, Carmel M; Fahey, Tom; Smith, Susan M; OPTI-SCRIPT Study Team
Abstract:
<p>The original article is available at www.biomedcentral.com</p>
<p><strong>Background:</strong> Potentially inappropriate prescribing (PIP) is common in older people in primary care, as evidenced by a significant body of quantitative research. However, relatively few qualitative studies have investigated the phenomenon of PIP and its underlying processes from the perspective of general practitioners (GPs). The aim of this paper is to explore qualitatively, GP perspectives regarding prescribing and PIP in older primary care patients.</p> <p><strong>Method:</strong> Semi-structured qualitative interviews were conducted with GPs participating in a randomised controlled trial (RCT) of an intervention to decrease PIP in older patients (≥70 years) in Ireland. Interviews were conducted with GP participants (both intervention and control) from the OPTI-SCRIPT cluster RCT as part of the trial process evaluation between January and J...
https://epubs.rcsi.ie/gpart/97
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‘You do not cross them’: Hierarchy and emotion in doctors' narratives of power relations in specialist training
(2017)
Crowe, Sophie; Clarke, Nicholas; Brugha, Ruairi F
‘You do not cross them’: Hierarchy and emotion in doctors' narratives of power relations in specialist training
(2017)
Crowe, Sophie; Clarke, Nicholas; Brugha, Ruairi F
Abstract:
<p>This article is also available at <a href="https://www.journals.elsevier.com/social-science-and-medicine/open-access-articles">https://www.journals.elsevier.com/social-science-and-medicine/open-access-articles</a></p>
<p>Studies of medical education often focus on experiences and socialisation processes among undergraduate students, with fewer examining emotionality among postgraduate trainees. This article explores the relationship between power and emotion, questioning how affective relations between senior and junior doctors are patterned on the hierarchical structure of medicine. The study employs qualitative methods of in-depth, face-to-face and telephone interviews with fifty doctors at initial and advanced stages of specialist postgraduate training in teaching hospitals across Ireland, conducted between May and July, 2015. The study found that respect for hierarchy, anger and fear, intimidation, and disillusion were key themes in...
https://epubs.rcsi.ie/ephmart/72
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"An unspoken world of unspoken things": a study identifying and exploring core beliefs underlying self-stigma among people living with HIV and AIDS in Ireland.
(2015)
France, Nadine Ferris; Mcdonald, Steve H; Conroy, Ronán R; Byrne, Elaine; Mallouris, Ch...
"An unspoken world of unspoken things": a study identifying and exploring core beliefs underlying self-stigma among people living with HIV and AIDS in Ireland.
(2015)
France, Nadine Ferris; Mcdonald, Steve H; Conroy, Ronán R; Byrne, Elaine; Mallouris, Chris; Hodgson, Ian; Larkan, Fiona N
Abstract:
<p>The original article is available at <a href="http://www.smw.ch/content/smw-2015-14113/">http://www.smw.ch/content/smw-2015-14113/</a></p>
<p>PRINCIPLES: Human immunodeficiency virus (HIV) related self-stigma--negative self-judgements resulting in shame, worthlessness and self-blame - negatively influences access to care and treatment, and overall quality of life for people living with HIV (PLHIV). Despite evidence that high levels of self-stigma exist among PLHIV, and is experienced to a far greater extent than stigma received from the broader community, there is a paucity of research aimed at understanding causes and functions of self-stigma, and an absence of interventions to mitigate its harmful effects. Understanding the core beliefs underlying self-stigma is therefore essential.</p> <p>METHODS: This pilot study used a qualitative approach to analyse interviews and written statements to uncover core beliefs underlying s...
https://epubs.rcsi.ie/ephmart/58
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"I found myself staying" - A case study of the job embeddedness and retention of qualified health workers in rural and remote areas of Uganda
(2015)
Maniple, Everd B
"I found myself staying" - A case study of the job embeddedness and retention of qualified health workers in rural and remote areas of Uganda
(2015)
Maniple, Everd B
Abstract:
<p>Global health worker maldistribution affects poor countries and rural areas most adversely, despite their high disease burden. Health workers reject rural areas due to isolation, and lack of facilities. Recommended extrinsic interventions to address rural-urban imbalance are costly and not sustainable in most developing countries. However, some health workers serve in rural areas without such interventions, suggesting existence of strong intrinsic motives for rural practice choice and retention, knowledge of which could be used to select retainable staff. This PhD research, a mixed-methods case study of 50 purposively-selected doctors and nurses retained in 12 Ugandan rural government and private general hospitals for three or more years, sought to find the reasons some qualified health workers get retained in rural areas, and the role of job embeddedness, a construct which predicts employee turnover, in their retention.</p> <p>Rural practice choices were made f...
https://epubs.rcsi.ie/phdtheses/181
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"I won't be staying here for long": a qualitative study on the retention of migrant nurses in Ireland.
(2009)
Humphries, Niamh; Brugha, Ruairi; McGee, Hannah
"I won't be staying here for long": a qualitative study on the retention of migrant nurses in Ireland.
(2009)
Humphries, Niamh; Brugha, Ruairi; McGee, Hannah
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This is an open access article under the terms of the Creative Commons Attribution License.The full article can be found at http://www.human-resources-health.com/content/7/1/68.
ABSTRACT: BACKGROUND: Although international nurse recruitment campaigns have succeeded in attracting large numbers of migrant nurses to countries such as Ireland, where domestic supply has not kept pace with demand, the long-term success of such initiatives from a workforce planning perspective will depend on the extent to which these nurses can be retained in destination countries. METHODS: This paper draws on qualitative, in-depth interviews undertaken with 21 migrant nurses in Ireland, focusing specifically on their future migration intentions. RESULTS: Our findings indicate that more than half of the respondents are considering migration onwards, for the most part because the destination country has failed to provide them with sufficient stability, particularly in terms of citizenship and family reu...
https://epubs.rcsi.ie/ephmart/3
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"Pee-in-a-Pot": acceptability and uptake of on-site chlamydia screening in a student population in the Republic of Ireland
(2010)
Vaughan, Deirdre; O'Connell, Emer; Cormican, Martin; Brugha, Ruairi; Faherty, Cole...
"Pee-in-a-Pot": acceptability and uptake of on-site chlamydia screening in a student population in the Republic of Ireland
(2010)
Vaughan, Deirdre; O'Connell, Emer; Cormican, Martin; Brugha, Ruairi; Faherty, Colette; Balfe, Myles; O'Donovan, Diarmuid
Abstract:
<p>The original publication is available from http://www.biomedcentral.com</p>
<p>Background: The aim of the study was to explore the acceptability and uptake of on-campus screening using a youth friendly approach in two Third Level higher education institutions (HEIs). This study is part of wider research exploring the optimal setting for chlamydia screening in Ireland. Methods: Male and female students were given the opportunity to take a free anonymous test for chlamydia during a one week programme of "pee-in-a-pot" days at two HEI campuses in the West of Ireland. The study was set up after extensive consultation with the two HEIs and advertised on the two campuses using a variety of media in the two weeks preceding the screening days. Screening involved the provision and distribution of testing packs at communal areas and in toilet facilities. In Ireland, chlamydia notifications are highest amongst 20-29 year olds and hence the screening criterion...
https://epubs.rcsi.ie/ephmart/9
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"Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice.
(2015)
Coughlan, Karen S; Mitchem, Mollie R; Hogg, Marion C; Prehn, Jochen HM
"Preconditioning" with latrepirdine, an adenosine 5'-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1(G93A) mice.
(2015)
Coughlan, Karen S; Mitchem, Mollie R; Hogg, Marion C; Prehn, Jochen HM
Abstract:
<p>This article is also available at <a href="http://www.neurobiologyofaging.org/article/S0197-4580(14)00628-9/abstract">http://www.neurobiologyofaging.org/article/S0197-4580(14)00628-9/abstract</a></p>
<p>Adenosine 5'-monophosphate-activated protein kinase (AMPK) is a master regulator of energy balance. As energy imbalance is documented as a key pathologic feature of amyotrophic lateral sclerosis (ALS), we investigated AMPK as a pharmacologic target in SOD1(G93A) mice. We noted a strong activation of AMPK in lumbar spinal cords of SOD1(G93A) mice. Pharmacologic activation of AMPK has shown protective effects in neuronal "preconditioning" models. We tested the hypothesis that "preconditioning" with a small molecule activator of AMPK, latrepirdine, exerts beneficial effects on disease progression. SOD1(G93A) mice (n = 24 animals per group; sex and litter matched) were treated with latrepirdine (1 μg/kg, intraperiton...
https://epubs.rcsi.ie/physiolart/61
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"The problem is ours, it is not CRAIDS' ". Evaluating sustainability of Community Based Organisations for HIV/AIDS in a rural district in Zambia.
(2012)
Walsh, Aisling; Mulambia, Chishimba; Brugha, Ruairi; Hanefeld, Johanna
"The problem is ours, it is not CRAIDS' ". Evaluating sustainability of Community Based Organisations for HIV/AIDS in a rural district in Zambia.
(2012)
Walsh, Aisling; Mulambia, Chishimba; Brugha, Ruairi; Hanefeld, Johanna
Abstract:
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>ABSTRACT: BACKGROUND: While sustainability of health programmes has been the subject of empirical studies, there is little evidence specifically on the sustainability of Community Based Organisations (CBOs) for HIV/AIDS. Debates around optimal approaches in community health have centred on utilitarian versus empowerment approaches. This paper, using the World Bank Multi-Country AIDS Program (MAP) in Zambia as a case study, seeks to evaluate whether or not this global programme contributed to the sustainability of CBOs working in the area of HIV/AIDS in Zambia. Lessons for optimising sustainability of CBOs in lower income countries are drawn. METHODS: In-depth interviews with representatives of all CBOs that received CRAIDS funding (n = 18) and district stakeholders (n= 10) in Mumbwa rural district in Zambia, in 2010; and national ...
https://epubs.rcsi.ie/ephmart/37
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"The way the country has been carved up by researchers": ethics and power in north-south public health research.
(2016)
Walsh, Aisling M; Brugha, Ruairi F; Byrne, Elaine
"The way the country has been carved up by researchers": ethics and power in north-south public health research.
(2016)
Walsh, Aisling M; Brugha, Ruairi F; Byrne, Elaine
Abstract:
<p>The original article is available at www.biomedcentral.com</p>
<p>BACKGROUND: Despite the recognition of power as being central to health research collaborations between high income countries and low and middle income countries, there has been insufficient detailed analysis of power within these partnerships. The politics of research in the global south is often considered outside of the remit of research ethics. This article reports on an analysis of power in north-south public health research, using Zambia as a case study.</p> <p>METHODS: Primary data were collected in 2011/2012, through 53 in-depth interviews with: Zambian researchers (n = 20), Zambian national stakeholders (n = 8) and northern researchers who had been involved in public health research collaborations involving Zambia and the global north (n = 25). Thematic analysis, utilising a situated ethics perspective, was undertaken using Nvivo 10.</p> <p>RESULTS: Most interv...
https://epubs.rcsi.ie/ephmart/68
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"TORNADO" - Theranostic One-Step RNA Detector; microfluidic disc for the direct detection of microRNA-134 in plasma and cerebrospinal fluid.
(2017)
McArdle, Hazel; Jimenez-Mateos, Eva M; Raoof, Rana; Carthy, Eadaoin; Boyle, David; ElNa...
"TORNADO" - Theranostic One-Step RNA Detector; microfluidic disc for the direct detection of microRNA-134 in plasma and cerebrospinal fluid.
(2017)
McArdle, Hazel; Jimenez-Mateos, Eva M; Raoof, Rana; Carthy, Eadaoin; Boyle, David; ElNaggar, Hany; Delanty, Norman; Hamer, Hajo; Dogan, Muejgdan; Huchtemann, Tessa; Kӧrtvelyessy, Peter; Rosenow, Felix; Forster, Robert J; Henshall, David C; Spain, Elaine
Abstract:
<p>The original article is available at www.nature.com</p>
<p>Diagnosis of seizure disorders such as epilepsy currently relies on clinical examination and electroencephalogram recordings and is associated with substantial mis-diagnosis. The miRNA, miR-134 (MIR134 in humans), has been found to be elevated in brain tissue after experimental status epilepticus and in human epilepsy cells and their detection in biofluids may serve as unique biomarkers. miRNAs from unprocessed human plasma and human cerebrospinal fluid samples were used in a novel electrochemical detection based on electrocatalytic platinum nanoparticles inside a centrifugal microfluidic device where the sandwich assay is formed using an event triggered release system, suitable for the rapid point-of-care detection of low abundance biomarkers of disease. The device has the advantage of controlling the rotation speed of the centrifugal device to pump nanoliter volumes of fluid at a set time and manip...
https://epubs.rcsi.ie/physiolart/128
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“I am kind of in stalemate”. The experiences of non-EU migrant doctors in Ireland
(2014)
Humphries, Niamh; Bidwell, Posy; Tyrrell, Ella; Brugha, Ruairi; Thomas, Steve; Normand,...
“I am kind of in stalemate”. The experiences of non-EU migrant doctors in Ireland
(2014)
Humphries, Niamh; Bidwell, Posy; Tyrrell, Ella; Brugha, Ruairi; Thomas, Steve; Normand, Charles
Abstract:
<p>The original article is available in the document at <a href="http://www.euro.who.int/__data/assets/pdf_file/0006/248343/Health-Professional-Mobility-in-a-Changing-Europe.pdf?ua=1" target="_blank">http://www.euro.who.int/__data/assets/pdf_file/0006/248343/Health-Professional-Mobility-in-a-Changing-Europe.pdf?ua=1</a></p>
<p><strong>Introduction (extract):</strong></p> <p>Although historically a source country for health workers, Ireland began actively recruiting health workers internationally in the early 2000s and is becoming the OECD country with the second highest dependency on foreign-trained doctors (OECD, 2010) and the highest dependency on foreign-trained nurses (OECD, 2010). Between 2000 and 2009, 40% of all newly registered nurses in Ireland were from outside the EU (Humphries, Brugha & McGee, 2009). The number of foreign-trained doctors registered on the Irish Medical Register<sup>1&...
https://epubs.rcsi.ie/ephmart/54
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“O brave new world” CRISPR Mediated Gene Editing in Somatic and Germ Line Contexts for Therapeutics and Enhancement of the Human Species – an Ethical and Legal Discussion.
(2016)
Farrell, Cathal B
“O brave new world” CRISPR Mediated Gene Editing in Somatic and Germ Line Contexts for Therapeutics and Enhancement of the Human Species – an Ethical and Legal Discussion.
(2016)
Farrell, Cathal B
Abstract:
<p>Gene editing has been a topic of controversy since the late 1970’s, however as of 2015 the topic of gene editing and its potential applications has shot to the forefront of biomedical, ethical and legal debate. CRISPR is a new molecular technology, which is essentially a molecular scissors capable of cutting a single gene, or multiple genes out of the genome of any species. Scientists have further manipulated CRISPR so that after it has excised a gene, or genes, it can then insert a gene of choice, into the excised area. The ramifications of CRISPR mediated gene editing technology are huge in the cellular therapeutics arena (somatic), and in the preventative medicine landscape (germ line). CRISPR mediated gene editing requires us to reflect on how as a society we view genetically driven diseases, and disabilities. Furthermore, there are calls from scientists for clarification on the legal and regulatory landscape of gene editing, in all its platforms, within their jurisdict...
https://epubs.rcsi.ie/mscttheses/113
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2009 A/H1N1 influenza vaccination in pregnancy: uptake and pregnancy outcomes - a historical cohort study.
(2014)
Cleary, Brian J; Rice, Úna; Eogan, Maeve; Metwally, Nehad; McAuliffe, Fionnuala
2009 A/H1N1 influenza vaccination in pregnancy: uptake and pregnancy outcomes - a historical cohort study.
(2014)
Cleary, Brian J; Rice, Úna; Eogan, Maeve; Metwally, Nehad; McAuliffe, Fionnuala
Abstract:
<p>NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Obstetrics and Gynecology and Reproductive Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cleary BJ, Rice Ú, Eogan M, Metwally N, McAuliffe F. 2009 A/H1N1 influenza vaccination in pregnancy: uptake and pregnancy outcomes - a historical cohort study. European Journal of Obstetrics and Gynecology and Reproductive Biology. 2014;178:163-8. doi: 10.1016/j.ejogrb.2014.04.015.</p>
<p>OBJECTIVES: To describe the uptake of 2009 A/H1N1 influenza vaccination among pregnant women and determine if vaccination was associated with adverse pregnancy outcomes.</p> <p>STUDY DESIGN: A h...
https://epubs.rcsi.ie/spharmart/12
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3 hours of perfusion culture prior to 28 days of static culture, enhances osteogenesis by human cells in a collagen GAG scaffold.
(2011)
Keogh, Michael B; Partap, Sonia; Daly, Jacqueline; O'Brien, Fergal J
3 hours of perfusion culture prior to 28 days of static culture, enhances osteogenesis by human cells in a collagen GAG scaffold.
(2011)
Keogh, Michael B; Partap, Sonia; Daly, Jacqueline; O'Brien, Fergal J
Abstract:
<p>The definitive version is available at www3.interscience.wiley.com</p>
<p>In tissue engineering bioreactors can be used to aid in the in vitro development of new tissue by providing biochemical and physical regulatory signals to cells and encouraging them to undergo differentiation and/or to produce extracellular matrix prior to in vivo implantation. This study examined the effect of short term flow perfusion bioreactor culture, prior to long term static culture, on human osteoblast cell distribution and osteogenesis within a collagen glycosaminoglycan (CG) scaffold for bone tissue engineering. Human Foetal Osteoblasts (hFOB 1.19) were seeded onto CG scaffolds and pre-cultured for 6 days. Constructs were then placed into the bioreactor and exposed to 3×1hr bouts of steady flow (1ml/min) separated by 7hrs of no flow over a 24hr period. The constructs were then cultured under static osteogenic conditions for up to 28 days. Results show that the bioreactor and ...
https://epubs.rcsi.ie/anatart/43
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3.0 Tesla MRI analysis of the Intra-Uterine Growth Restricted Infant Brain - Comparison of Infants with Normal and Abnormal Antenatal Doppler's.
(2017)
Boyle, Michael A
3.0 Tesla MRI analysis of the Intra-Uterine Growth Restricted Infant Brain - Comparison of Infants with Normal and Abnormal Antenatal Doppler's.
(2017)
Boyle, Michael A
Abstract:
<p>Intra-uterine growth restriction (IUGR) is defined as a failure of a fetus to achieve its expected weight for a given gestational age. These infants have increased mortality and morbidity rates compared to appropriately grown infants. Deficits in cognition, language and social functions may occur. StOOPs (Short-term Outcome Of PORTO study) is a national study incorporating brain imaging to investigate differences in brain development and organisation between two groups of IUGR infants; those with normal and abnormal antenatal Doppler measurements. Antenatal Doppler examination of blood flow in the umbilical artery is used to monitor pregnancies affected with IUGR.</p> <p>Singleton infants without aneuploidy or congenital anomaly and with an estimated fetal weight < 10th centile were enrolled nationally. Prospective data of delivery and infant characteristics was collected. Non-sedated 3 Tesla MRI of brain was acquired at term corrected gestation. 34 IUGR infa...
https://epubs.rcsi.ie/phdtheses/192
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A 10-year (2000-2010) systematic review of interventions to improve quality of care in hospitals.
(2012)
Conry, Mary C; Humphries, Niamh; Morgan, Karen; McGowan, Yvonne; Montgomery, Anthony; V...
A 10-year (2000-2010) systematic review of interventions to improve quality of care in hospitals.
(2012)
Conry, Mary C; Humphries, Niamh; Morgan, Karen; McGowan, Yvonne; Montgomery, Anthony; Vedhara, Kavita; Panagopoulou, Efharis; McGee, Hannah
Abstract:
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>ABSTRACT: BACKGROUND: Against a backdrop of rising healthcare costs, variability in care provision and an increased emphasis on patient satisfaction, the need for effective interventions to improve quality of care has come to the fore. This is the first ten year (2000--2010) systematic review of interventions which sought to improve quality of care in a hospital setting. This review moves beyond a broad assessment of outcome significance levels and makes recommendations for future effective and accessible interventions. METHODS: Two researchers independently screened a total of 13,195 English language articles from the databases PsychInfo, Medline, PubMed, EmBase and CinNahl. There were 120 potentially relevant full text articles examined and 20 of those articles met the inclusion criteria. RESULTS: Included studies were heterogen...
https://epubs.rcsi.ie/psycholart/47
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A 6-gene signature identifies four molecular subgroups of neuroblastoma.
(2011)
Abel, Frida; Dalevi, Daniel; Nethander, Maria; Jörnsten, Rebecka; De Preter, Katleen; V...
A 6-gene signature identifies four molecular subgroups of neuroblastoma.
(2011)
Abel, Frida; Dalevi, Daniel; Nethander, Maria; Jörnsten, Rebecka; De Preter, Katleen; Vermeulen, Joëlle; Stallings, Raymond L; Kogner, Per; Maris, John; Nilsson, Staffan
Abstract:
<p>This article is also available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND: There are currently three postulated genomic subtypes of the childhood tumour neuroblastoma (NB); Type 1, Type 2A, and Type 2B. The most aggressive forms of NB are characterized by amplification of the oncogene MYCN (MNA) and low expression of the favourable marker NTRK1. Recently, mutations or high expression of the familial predisposition gene Anaplastic Lymphoma Kinase (ALK) was associated to unfavourable biology of sporadic NB. Also, various other genes have been linked to NB pathogenesis.</p> <p>RESULTS: The present study explores subgroup discrimination by gene expression profiling using three published microarray studies on NB (47 samples). Four distinct clusters were identified by Principal Components Analysis (PCA) in two separate data sets, which could be verified by an unsupervised hierarchical clu...
https://epubs.rcsi.ie/cangenart/4
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A biomimetic multi-layered collagen-based scaffold for osteochondral repair.
(2014)
Levingstone, Tanya J; Matsiko, Amos; Dickson, Glenn R; O'Brien, Fergal J; Gleeson,...
A biomimetic multi-layered collagen-based scaffold for osteochondral repair.
(2014)
Levingstone, Tanya J; Matsiko, Amos; Dickson, Glenn R; O'Brien, Fergal J; Gleeson, John P
Abstract:
<p>This is the author’s version of a work that was accepted for publication in Acta Biomaterialia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Acta Biomaterialia, 2014;10(5):1996-2004. DOI 10.1016/j.actbio.2014.01.00</p> <p>This article is available at <a href="http://www.journals.elsevier.com/acta-biomaterialia/">http://www.journals.elsevier.com/acta-biomaterialia/</a></p>
<p>Cartilage and osteochondral defects pose a significant challenge in orthopedics. Tissue engineering has shown promise as a potential method for the treatment of such defects; however, a long-lasting repair strategy has yet to be realized. This study focuses on the development of a lay...
https://epubs.rcsi.ie/anatart/63
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A Case of Autoimmune Pancreatitis Presenting as a Deterioration in Glycaemic Control in a Patient with Pre-Existing Type 2 Diabetes.
(2017)
Forde, Hannah; Slattery, D; Swan, N; Smith, D
A Case of Autoimmune Pancreatitis Presenting as a Deterioration in Glycaemic Control in a Patient with Pre-Existing Type 2 Diabetes.
(2017)
Forde, Hannah; Slattery, D; Swan, N; Smith, D
Abstract:
<p>The original article is available at www.imj.ie</p>
<p>We report a case of Type 1 autoimmune pancreatitis presenting as a rare cause of worsening hyperglycaemia in a patient with Type 2 diabetes and discuss the difficulties in differentiating this disease from pancreatic cancer.</p>
https://epubs.rcsi.ie/medart/79
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