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Displaying Results 201 - 225 of 1871 on page 9 of 75

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Antidepressant prescribing in Irish children: secular trends and international comparison in the context of a safety warning. (2015)

O'Sullivan, Katriona; Boland, Fiona; Reulbach, Udo; Motterlini, Nicola; Kelly, Der...

Mark

Antimetastatic activity of a cyclooxygenase-2 inhibitor. (2004)

Roche-Nagle, Graham; Connolly, Elizabeth M; Eng, Molly; Bouchier-Hayes, David J; Harmey...

Mark

Antimicrobial proteins and polypeptides in pulmonary innate defence. (2006)

Rogan, Mark P; Geraghty, Patrick; Greene, Catherine M; O'Neill, Shane J; Taggart, ...

Mark

Antiretroviral treatment in developing countries: the peril of neglecting private providers. (2003)

Brugha, Ruairi

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Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. (2017)

Zuurbier, Linda; Rahman, Arman; Cordes, Martijn; Scheick, Jennifer; Wong, Tse J; Rusten...

Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. (2017)

Zuurbier, Linda; Rahman, Arman; Cordes, Martijn; Scheick, Jennifer; Wong, Tse J; Rustenburg, François; Joseph, Jesu Christopher; Dynoodt, Peter; Casey, Rory; Drillenburg, Paul; Gerhards, Michael; Barat, Ana; Klinger, Rut; Fender, Bozena; O'Connor, Darran P; Betge, Johannes; Ebert, Matthias P; Gaiser, Timo; Prehn, Jochen HM; Griffioen, Arjan W

Abstract:

The original article is available at http://www.oncotarget.com
Bevacizumab (bvz) is currently employed as an anti-angiogenic therapy across several cancer indications. Bvz response heterogeneity has been well documented, with only 10-15% of colorectal cancer (CRC) patients benefitting in general. For other patients, clinical efficacy is limited and side effects are significant. This reinforces the need for a robust predictive biomarker of response. To identify such a biomarker, we performed a DNA microarray-based transcriptional profiling screen with primary endothelial cells (ECs) isolated from normal and tumour colon tissues. Thirteen separate populations of tumour-associated ECs and 10 of normal ECs were isolated using fluorescence-activated cell sorting. We hypothesised that VEGF-induced genes were overexpressed in tumour ECs; these genes could relate to bvz response and serve as potential predictive biomarkers. Transcriptional profiling revealed ...

https://epubs.rcsi.ie/physiolart/120

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Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review. (2009)

Hector, Suzanne; Prehn, Jochen H M

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Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. (2008)

Mendy, Maimuna E; Kaye, Steve; Le Roux, Emilie; Kirk, Gregory D; Jeng-Barry, Adam; McCo...

Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. (2008)

Mendy, Maimuna E; Kaye, Steve; Le Roux, Emilie; Kirk, Gregory D; Jeng-Barry, Adam; McConkey, Samuel; Cotten, Matthew; Kuniholm, Mark H; Leligdowicz, Aleksandra; Hainaut, Pierre; Rowland-Jones, Sarah; Whittle, Hilton

Abstract:

The original article is available at http://jcm.asm.org
Hepatocellular carcinoma (HCC) and cirrhosis are important causes of mortality worldwide. Persistent hepatitis B virus (HBV) infection is a major cause of these diseases. Double mutations in the basal core promoter (BCP) (A1762T and G1764A) and precore (pre-C) (G1896A) regions of the virus are associated with progression to HCC. The current study is aimed at developing a simple method for screening and detecting BCP and pre-C mutations in HBV carriers. We have developed and validated an oligonucleotide ligation assay (OLA) to detect point mutations in the HBV core gene. We have applied OLA methods to samples from HBV-infected carriers recruited from the Gambia Liver Cancer Study (GLCS) comprising asymptomatic HBsAg carriers, patients with cirrhosis, and patients with HCC. We observed an 89.3% and 95.8% concordance between the OLA and DNA sequencing for BCP and pre-C mutations, respectively. OLA d...

https://epubs.rcsi.ie/ihtmart/9

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Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets. (2012)

Pabari, Ritesh M; Ramtoola, Zebunnissa

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Application of real-time PCR to quantify hepatitis B virus DNA in chronic carriers in The Gambia. (2006)

Mendy, Maimuna E; Kaye, Steve; van der Sande, Marianne; Rayco-Solon, Pura; Waight, Paul...

Mark

Applying a typology of health worker migration to non-EU migrant doctors in Ireland (2015)

Humphries, Niamh; McAleese, Sara; Tyrrell, Ella; Thomas, Steve; Normand, Charles; Brugh...

Mark

Approaches to Learning in the context of an outcomes-based curriculum (2010)

Joyce, Pauline

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Aromatase inhibitor specific metastasis is driven by the steroid receptor coactivator SRC-1 (2012)

Theissen, Sarah M

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Arrest in hospital: a study of in hospital cardiac arrest outcomes. (2014)

Fennelly, Neil K; McPhillips, Celine; Gilligan, Peadar

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Aspirin "resistance" : an evaluation and explanation (2010)

McCall, Meadhbh

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Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion. (2015)

Cooke, Niamh M; Spillane, Cathy D; Sheils, Orla; O'Leary, John; Kenny, Dermot

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Assessing platelet function using a novel microtitre platelet aggregation assay (2009)

Peace, Aaron

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Assessing potentially inappropriate prescribing (PIP) and predicting patient outcomes in Ontario's older population: a population-based cohort study applying subsets of the STOPP/START and Beers' criteria in large health administrative databases. (2015)

Bjerre, Lise M; Ramsay, Timothy; Cahir, Catriona; Ryan, Cristín; Halil, Roland; Farrell...

Bjerre, Lise M; Ramsay, Timothy; Cahir, Catriona; Ryan, Cristín; Halil, Roland; Farrell, Barbara; Thavorn, Kednapa; Catley, Christina; Hawken, Steven; Gillespie, Ulrika; Manuel, Douglas G

Abstract:

This article is also available at <a href="http://bmjopen.bmj.com/content/5/11/e010146.full.pdf+html">http://bmjopen.bmj.com/content/5/11/e010146.full.pdf+html</a>
INTRODUCTION: Adverse drug events (ADEs) are common in older people and contribute significantly to emergency department (ED) visits, unplanned hospitalisations, healthcare costs, morbidity and mortality. Many ADEs are avoidable if attention is directed towards identifying and preventing inappropriate drug use and undesirable drug combinations. Tools exist to identify potentially inappropriate prescribing (PIP) in clinical settings, but they are underused. Applying PIP assessment tools to population-wide health administrative data could provide an opportunity to assess the impact of PIP on individual patients as well as on the healthcare system. This would open new possibilities for interventions to monitor and optimise medication management on a broader, population-le...

https://epubs.rcsi.ie/spharmart/27

Mark

Assessing the functional performance of post-call hospital doctors using a Nintendo Wii. (2011)

Clancy, K; Brady, P; McHugh, Seamus M; Corrigan, Mark A; Sheikh, Athar S; Lehane, Elain...

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Assessment of a new undergraduate module in musculoskeletal medicine. (2011)

Queally, Joseph M; Cummins, Fionnan; Brennan, Stephen A; Shelly, Martin J; O'Byrne...

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Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach. (2017)

Moran, Bruce; Das, Sudipto; Smeets, Dominiek; Peutman, Gillian; Klinger, Ruth; Fender, ...

Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach. (2017)

Moran, Bruce; Das, Sudipto; Smeets, Dominiek; Peutman, Gillian; Klinger, Ruth; Fender, Bozena; Connor, Kate; Ebert, Matthias; Gaiser, Timo; Prehn, Jochen HM; Bacon, Orna; Kay, Elaine; Hennessy, Bryan; Murphy, Verena; Ylstra, Bauke; Lambrechts, Diether; Byrne, Annette T; Gallagher, William M; O'Connor, Darran P

Abstract:

The original article is available at http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=18296&path[]=58670
DNA methylation is altered in many types of disease, including metastatic colorectal cancer. However, the methylome has not yet been fully described in archival formalin-fixed paraffin embedded (FFPE) samples in the context of matched fresh-frozen (FF) tumor material at base-pair resolution using a targeted approach. Using next-generation sequencing, we investigated three pairs of matched FFPE and FF samples to determine the extent of their similarity. We identified a 'bowing' pattern specific to FFPE samples categorized by a lower CG proportion at the start of sequence reads. We have found no evidence that this affected methylation calling, nor concordance of results. We also found no significant increase in deamination, measured by C>T transitions, previously considered a result of cr...

https://epubs.rcsi.ie/physiolart/119