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Displaying Results 201 - 225 of 1990 on page 9 of 80

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Anaplastic thyroid cancer Irish epidemiology and novel chemotherapeutic strategies (2009)

O'Neill, James Paul

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Anatomists and geometers : a selection from the published work. (2009)

Lee, T Clive

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Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). (2005)

Byrne, Anne Marie; Bouchier-Hayes, David J; Harmey, Judith H

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Angiogenin protects motoneurons against hypoxic injury. (2009)

Sebastià, Jordi; Kieran, Dairin; Breen, Bridget; King, Matthew A; Netteland, D F; Joyce...

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Anhedonia predicts adverse cardiac events in people with acute coronary syndromes (2010)

Doyle, Frank

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Antenatal maternal education for improving postnatal perineal healing for women who have birthed in a hospital setting. (2017)

O'Kelly, Sonia M; Moore, Zena EH

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Anti tumour necrosis factor - alpha : does it rescue bone loss in inflammatory bowel disease patients? (2011)

Veerappan, Sundaram G

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Anti-angiogenic efficacy of Bevacizumab alone and in combination with a dual PI3K/mTOR inhibitor in an orthotopic model of malignant glioma: A multimodal neuro-imaging approach (2017)

O'Halloran, Philip J

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Anti-apoptotic BCL-2 family proteins in acute neural injury. (2014)

Anilkumar, Ujval; Prehn, Jochen HM

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Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells. (2017)

Tivnan, Amanda; Heilinger, Tatjana; Ramsey, Joanne M; O'Connor, Gemma; Pokorny, Je...

Tivnan, Amanda; Heilinger, Tatjana; Ramsey, Joanne M; O'Connor, Gemma; Pokorny, Jenny L; Sarkaria, Jann N; Stringer, Brett W; Day, Bryan W; Boyd, Andrew W; Kim, Ella L; Lode, Holger N; Cryan, Sally-Ann; Prehn, Jochen H.M.

Abstract:

The original paper is available at http://www.oncotarget.com/
Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies. We tested the hypothesis that targeted aromatase inhibition in an aggressive brain cancer called glioblastoma (GBM) may represent a new treatment strategy. In this study, aromatase inhibition was achieved using third generation inhibitor, Letrozole, encapsulated within the core of biodegradable poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs). PLGA-NPs were conjugated to human/mouse chimeric anti-GD2 antibody ch14.18/CHO, enabling specific targeting of GD2-positive GBM cells. Treatment of primary and recurrent patient-derived GBM cells with free-Letrozole (0.1 μM) led to significant decrease in cell proliferation and migration; in addition to reduced spheroid formation. Anti-GD2-ch14.18/CHO-NPs displayed specific targeting of GBM...

https://epubs.rcsi.ie/physiolart/134

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Anti-oxidant mediated normalisation of raised intracellular cytokines in patients with reproductive failure. (2018)

Marron, Kevin; Kennedy, John F; Harrity, Conor

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Antibiotics and antiseptics for pressure ulcers. (2016)

Norman, Gill; Dumville, Jo C; Moore, Zena EH; Tanner, Judith; Christie, Janice; Goto, S...

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Antibiotics for acute bronchitis. (2014)

Smith, Susan M; Fahey, Tom; Smucny, John; Becker, Lorne A

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Antidepressant prescribing in Irish children: secular trends and international comparison in the context of a safety warning. (2015)

O'Sullivan, Katriona; Boland, Fiona; Reulbach, Udo; Motterlini, Nicola; Kelly, Der...

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Antimetastatic activity of a cyclooxygenase-2 inhibitor. (2004)

Roche-Nagle, Graham; Connolly, Elizabeth M; Eng, Molly; Bouchier-Hayes, David J; Harmey...

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Antimicrobial proteins and polypeptides in pulmonary innate defence. (2006)

Rogan, Mark P; Geraghty, Patrick; Greene, Catherine M; O'Neill, Shane J; Taggart, ...

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Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. (2017)

Zuurbier, Linda; Rahman, Arman; Cordes, Martijn; Scheick, Jennifer; Wong, Tse J; Rusten...

Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. (2017)

Zuurbier, Linda; Rahman, Arman; Cordes, Martijn; Scheick, Jennifer; Wong, Tse J; Rustenburg, François; Joseph, Jesu Christopher; Dynoodt, Peter; Casey, Rory; Drillenburg, Paul; Gerhards, Michael; Barat, Ana; Klinger, Rut; Fender, Bozena; O'Connor, Darran P; Betge, Johannes; Ebert, Matthias P; Gaiser, Timo; Prehn, Jochen HM; Griffioen, Arjan W

Abstract:

The original article is available at http://www.oncotarget.com
Bevacizumab (bvz) is currently employed as an anti-angiogenic therapy across several cancer indications. Bvz response heterogeneity has been well documented, with only 10-15% of colorectal cancer (CRC) patients benefitting in general. For other patients, clinical efficacy is limited and side effects are significant. This reinforces the need for a robust predictive biomarker of response. To identify such a biomarker, we performed a DNA microarray-based transcriptional profiling screen with primary endothelial cells (ECs) isolated from normal and tumour colon tissues. Thirteen separate populations of tumour-associated ECs and 10 of normal ECs were isolated using fluorescence-activated cell sorting. We hypothesised that VEGF-induced genes were overexpressed in tumour ECs; these genes could relate to bvz response and serve as potential predictive biomarkers. Transcriptional profiling revealed ...

https://epubs.rcsi.ie/physiolart/120

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Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review. (2009)

Hector, Suzanne; Prehn, Jochen H M

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Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. (2008)

Mendy, Maimuna E; Kaye, Steve; Le Roux, Emilie; Kirk, Gregory D; Jeng-Barry, Adam; McCo...

Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. (2008)

Mendy, Maimuna E; Kaye, Steve; Le Roux, Emilie; Kirk, Gregory D; Jeng-Barry, Adam; McConkey, Samuel; Cotten, Matthew; Kuniholm, Mark H; Leligdowicz, Aleksandra; Hainaut, Pierre; Rowland-Jones, Sarah; Whittle, Hilton

Abstract:

The original article is available at http://jcm.asm.org
Hepatocellular carcinoma (HCC) and cirrhosis are important causes of mortality worldwide. Persistent hepatitis B virus (HBV) infection is a major cause of these diseases. Double mutations in the basal core promoter (BCP) (A1762T and G1764A) and precore (pre-C) (G1896A) regions of the virus are associated with progression to HCC. The current study is aimed at developing a simple method for screening and detecting BCP and pre-C mutations in HBV carriers. We have developed and validated an oligonucleotide ligation assay (OLA) to detect point mutations in the HBV core gene. We have applied OLA methods to samples from HBV-infected carriers recruited from the Gambia Liver Cancer Study (GLCS) comprising asymptomatic HBsAg carriers, patients with cirrhosis, and patients with HCC. We observed an 89.3% and 95.8% concordance between the OLA and DNA sequencing for BCP and pre-C mutations, respectively. OLA d...

https://epubs.rcsi.ie/ihtmart/9