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Displaying Results 201 - 225 of 1990 on page 9 of 80
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Anaplastic thyroid cancer Irish epidemiology and novel chemotherapeutic strategies
(2009)
O'Neill, James Paul
Anaplastic thyroid cancer Irish epidemiology and novel chemotherapeutic strategies
(2009)
O'Neill, James Paul
Abstract:
<p>This body of work was conducted over a four year period. Within this timeframe we have conducted a National Epidemiology project, established a National Head and Neck Cancer database and completed Oncology laboratory investigations.</p> <p>Anaplastic thyroid cancer (ATC) is the most aggressive endocrine disease in nature. Within the thyroid gland a heterogeneous group of neoplasms may develop. These can range from well differentiated tumours with an excellent prognosis, to ATC tumours which present with distant dissemination of disease in 20-50% of cases, adjacent tissue invasion in 90% of cases, have a reported tumour volume doubling time of one week, and place the patient at a very real risk of death attributed to upper airway obstruction and suffocation. The mean survival is approximately 3-7 months however the most important prognostic factor appears to be disease burden at the time of diagnosis. The high percentage of dissemination highlights the need for e...
https://epubs.rcsi.ie/mdtheses/4
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Anatomists and geometers : a selection from the published work.
(2009)
Lee, T Clive
Anatomists and geometers : a selection from the published work.
(2009)
Lee, T Clive
Abstract:
<p><strong>A short commentary, not exceeding one thousand words, indicating how each </strong><strong>publication contributes to the total corpus of the candidate’s research</strong></p> <p><strong>BIOENGINEERING</strong></p> <p>The majority of bioengineering papers deal with bone, the detection of microdamage within it, its remodelling and adaptation in health and disease and its behaviour as a material in both theory and practice. The exception (B21) involves mechanical testing of vascular tissue. Paper B1 introduces a new fluorescence-aided technique for quantifying fuchsin-stained microdamage in bone, which was featured on the cover of the <em>Journal o f Anatomy. </em>Paper B4 describes a series of fluorescent agents used, for the first time, to label crack propagation and relate crack growth to changes in the material properties o f bone. Both papers arose from my MD thesis. The fluorescence techniqu...
https://epubs.rcsi.ie/phdtheses/101
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Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF).
(2005)
Byrne, Anne Marie; Bouchier-Hayes, David J; Harmey, Judith H
Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF).
(2005)
Byrne, Anne Marie; Bouchier-Hayes, David J; Harmey, Judith H
Abstract:
<p>The original article is available at <a href="http://www.jcmm.ro">www.jcmm.ro</a></p>
<p>Vascular endothelial growth factor (VEGF) was originally identified as an endothelial cell specific growth factor stimulating angiogenesis and vascular permeability. Some family members, VEGF C and D, are specifically involved in lymphangiogenesis. It now appears that VEGF also has autocrine functions acting as a survival factor for tumour cells protecting them from stresses such as hypoxia, chemotherapy and radiotherapy. The mechanisms of action of VEGF are still being investigated with emerging insights into overlapping pathways and cross-talk between other receptors such as the neuropilins which were not previously associated with angiogenesis. VEGF plays an important role in embryonic development and angiogenesis during wound healing and menstrual cycle in the healthy adult. VEGF is also important in a number of both malignant and non-malignant ...
https://epubs.rcsi.ie/surgart/25
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Angiogenin protects motoneurons against hypoxic injury.
(2009)
Sebastià, Jordi; Kieran, Dairin; Breen, Bridget; King, Matthew A; Netteland, D F; Joyce...
Angiogenin protects motoneurons against hypoxic injury.
(2009)
Sebastià, Jordi; Kieran, Dairin; Breen, Bridget; King, Matthew A; Netteland, D F; Joyce, Doireann; Fitzpatrick, Susan F; Taylor, Cormac T; Prehn, Jochen H.M.
Abstract:
<p>This article is available at http://www.nature.com/cdd/journal/v16/n9/abs/cdd200952a.html</p>
<p>Cells can adapt to hypoxia through the activation of hypoxia-inducible factor-1 (HIF-1), which in turn regulates the expression of hypoxia-responsive genes. Defects in hypoxic signaling have been suggested to underlie the degeneration of motoneurons in amyotrophic lateral sclerosis (ALS). We have recently identified mutations in the hypoxia-responsive gene, angiogenin (ANG), in ALS patients, and have shown that ANG is constitutively expressed in motoneurons. Here, we show that HIF-1alpha is sufficient and required to activate ANG in cultured motoneurons exposed to hypoxia, although ANG expression does not change in a transgenic ALS mouse model or in sporadic ALS patients. Administration of recombinant ANG or expression of wild-type ANG protected motoneurons against hypoxic injury, whereas gene silencing of ang1 significantly increased hypoxia-induced cell death. ...
https://epubs.rcsi.ie/physiolart/6
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Anhedonia predicts adverse cardiac events in people with acute coronary syndromes
(2010)
Doyle, Frank
Anhedonia predicts adverse cardiac events in people with acute coronary syndromes
(2010)
Doyle, Frank
Abstract:
<p>This commentary is also available at, <a href="http://ebmh.bmj.com">http://ebmh.bmj.com</a></p>
https://epubs.rcsi.ie/psycholart/33
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Antenatal maternal education for improving postnatal perineal healing for women who have birthed in a hospital setting.
(2017)
O'Kelly, Sonia M; Moore, Zena EH
Antenatal maternal education for improving postnatal perineal healing for women who have birthed in a hospital setting.
(2017)
O'Kelly, Sonia M; Moore, Zena EH
Abstract:
<p>This review is published as a Cochrane Review in the <em>Cochrane Database of Systematic Reviews</em> 2016, Issue 3. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the <em>Cochrane Database of Systematic Reviews</em> should be consulted for the most recent version of the Review. O’Kelly SM, Moore ZEH. Antenatal maternal education for improving postnatal perineal healing for women who have birthed in a hospital setting. Cochrane Database of Systematic Reviews 2017, Issue 12. Art. No.: CD012258. DOI: 10.1002/14651858.CD012258.pub2</p>
<p>BACKGROUND: The female perineum becomes suffused and stretched during pregnancy, and further strain during vaginal childbirth contributes to approximately 85% of women experiencing some degree of trauma to the perineal region. Multiple factors play a role in the type and severity of trauma experienced, including parity, delivery method, and...
https://epubs.rcsi.ie/snursmidart/6
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Anti tumour necrosis factor - alpha : does it rescue bone loss in inflammatory bowel disease patients?
(2011)
Veerappan, Sundaram G
Anti tumour necrosis factor - alpha : does it rescue bone loss in inflammatory bowel disease patients?
(2011)
Veerappan, Sundaram G
Abstract:
<p>I. I inflammatory Bowe1 Disease</p> <p>I. I. I General Overview</p> <p>Inflammatory bowel disease (IBD) is a group of disorders of the gastrointestinal tract characterized by intestinal inflammation and a chronic relapsing course. IBD has traditionally been categorized as either ulcerative colitis (UC) or Crohn's disease (CD) on the basis of clinical, radiological, endoscopic and histological criteria [I], (Figure 1.1 and Figure 1.2). About 10 % of colitis cases show overlapping features of the two major forms and are designated intermediate colitis [I]. Both UC and CD are commonly characterized by a series of clinical exacerbations and remissions requiring long term use of medications, and frequently necessitating surgical interventions.</p> <p><strong>Figure 1.1: </strong>Endoscopic appearance of Ulcerative colitis [2] - <em>marked by diffuse,</em></p> <p><em>superficial inflammation of the...
https://epubs.rcsi.ie/mdtheses/40
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Anti-angiogenic efficacy of Bevacizumab alone and in combination with a dual PI3K/mTOR inhibitor in an orthotopic model of malignant glioma: A multimodal neuro-imaging approach
(2017)
O'Halloran, Philip J
Anti-angiogenic efficacy of Bevacizumab alone and in combination with a dual PI3K/mTOR inhibitor in an orthotopic model of malignant glioma: A multimodal neuro-imaging approach
(2017)
O'Halloran, Philip J
Abstract:
<p>The treatment of glioblastoma represents one of the main oncological challenges of the 21st century. Despite intensive therapeutic efforts, the median survival remains 15-18 months.</p> <p>Initially, we conducted a single center retrospective study, at the National Neurosurgical Center in Beaumont Hospital, examining the use of bevacizumab in an homogenous Irish glioblastoma population. We demonstrated the importance of tumour location, MGMT (O6-methylguanine- methyl-transferase gene) methylation, IDH (Isocitrate Dehydrogenase) and extent of resection (EOR) as prognostic factors in the setting of recurrent glioblastoma. Our findings also supported the hypothesis that bevacizumab should not be withheld in elderly patients of good performance status. However, no phase III trials have demonstrated an overall survival benefit primary or recurrent glioblastoma setting, treated with bevacizumab. Current evidence suggests that glioblastoma cells are able to circumvent ...
https://epubs.rcsi.ie/phdtheses/199
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Anti-apoptotic BCL-2 family proteins in acute neural injury.
(2014)
Anilkumar, Ujval; Prehn, Jochen HM
Anti-apoptotic BCL-2 family proteins in acute neural injury.
(2014)
Anilkumar, Ujval; Prehn, Jochen HM
Abstract:
<p>This article is also available at <a href="http://journal.frontiersin.org/article/10.3389/fncel.2014.00281/abstract">http://journal.frontiersin.org/article/10.3389/fncel.2014.00281/abstract</a></p>
<p>Cells under stress activate cell survival and cell death signaling pathways. Cell death signaling frequently converges on mitochondria, a process that is controlled by the activities of pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) proteins. In this review, we summarize current knowledge on the control of neuronal survival, development and injury by anti-apoptotic BCL-2 family proteins. We discuss overlapping and differential effects of the individual family members BCL-2, BCL-extra long (BCL-XL), myeloid cell leukemia 1 (MCL-1), and BCL2-like 2 (BCL-W) in the control of survival during development and pathophysiological processes such as trophic factor withdrawal, ischemic injury, excitotoxicity, oxidative stress and energy stress. ...
https://epubs.rcsi.ie/physiolart/60
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Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells.
(2017)
Tivnan, Amanda; Heilinger, Tatjana; Ramsey, Joanne M; O'Connor, Gemma; Pokorny, Je...
Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells.
(2017)
Tivnan, Amanda; Heilinger, Tatjana; Ramsey, Joanne M; O'Connor, Gemma; Pokorny, Jenny L; Sarkaria, Jann N; Stringer, Brett W; Day, Bryan W; Boyd, Andrew W; Kim, Ella L; Lode, Holger N; Cryan, Sally-Ann; Prehn, Jochen H.M.
Abstract:
<p>The original paper is available at http://www.oncotarget.com/</p>
<p>Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies. We tested the hypothesis that targeted aromatase inhibition in an aggressive brain cancer called glioblastoma (GBM) may represent a new treatment strategy. In this study, aromatase inhibition was achieved using third generation inhibitor, Letrozole, encapsulated within the core of biodegradable poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs). PLGA-NPs were conjugated to human/mouse chimeric anti-GD2 antibody ch14.18/CHO, enabling specific targeting of GD2-positive GBM cells. Treatment of primary and recurrent patient-derived GBM cells with free-Letrozole (0.1 μM) led to significant decrease in cell proliferation and migration; in addition to reduced spheroid formation. Anti-GD2-ch14.18/CHO-NPs displayed specific targeting of GBM...
https://epubs.rcsi.ie/physiolart/134
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Anti-oxidant mediated normalisation of raised intracellular cytokines in patients with reproductive failure.
(2018)
Marron, Kevin; Kennedy, John F; Harrity, Conor
Anti-oxidant mediated normalisation of raised intracellular cytokines in patients with reproductive failure.
(2018)
Marron, Kevin; Kennedy, John F; Harrity, Conor
Abstract:
<p>The original article is available at<a href="https://www.biomedcentral.com/"> www.biomedcentral.com</a></p>
<p><strong>Background:</strong> Raised intracellular cytokine ratios (CKR) are proposed as a significant risk factor for adverse reproductive outcome. An elevated cytokine ratio, such as between TNFa and/or IFNg to IL-10 is associated with recurrent miscarriage (RM). The use of pharmacological immunomodulators such as TNFα inhibitors in these patients is controversial and not generally recommended due to a lack of conclusive data supporting their use. We evaluated whether the use of anti-oxidants/dietary supplements as an alternative could positively influence CKR's in ART patients.</p> <p><strong>Methods:</strong> A prospective non-placebo control trial of antioxidant treatment for abnormal peripheral inflammatory cytokine ratios was performed. CKRs were assessed using flow cytometry in st...
https://epubs.rcsi.ie/obsgynart/36
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Antibiotics and antiseptics for pressure ulcers.
(2016)
Norman, Gill; Dumville, Jo C; Moore, Zena EH; Tanner, Judith; Christie, Janice; Goto, S...
Antibiotics and antiseptics for pressure ulcers.
(2016)
Norman, Gill; Dumville, Jo C; Moore, Zena EH; Tanner, Judith; Christie, Janice; Goto, Saori
Abstract:
<p>This review is published as a Cochrane Review in the <em>Cochrane Database of Systematic Reviews</em> 2016, Issue 3. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the <em>Cochrane Database of Systematic Reviews</em> should be consulted for the most recent version of the Review.</p> <p>Norman G, Dumville JC, Moore ZE, Tanner J, Christie J, Goto S. Antibiotics and antiseptics for pressure ulcers. 2016, Issue 4. Art. No.: CD011586. DOI: 10.1002/14651858.CD011586.pub2.</p>
<p>BACKGROUND: Pressure ulcers, also known as bedsores, decubitus ulcers and pressure injuries, are localised areas of injury to the skin or the underlying tissue, or both. A range of treatments with antimicrobial properties, including impregnated dressings, are widely used in the treatment of pressure ulcers. A clear and current overview is required to facilitate decision making regarding use ...
https://epubs.rcsi.ie/snursmidart/4
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Antibiotics for acute bronchitis.
(2014)
Smith, Susan M; Fahey, Tom; Smucny, John; Becker, Lorne A
Antibiotics for acute bronchitis.
(2014)
Smith, Susan M; Fahey, Tom; Smucny, John; Becker, Lorne A
Abstract:
<p>This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2014, Issue 3. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.</p> <p>The review is also available at <a href="http://dx.doi.org/10.1002/14651858.CD000245.pub3" target="_blank">http://dx.doi.org/10.1002/14651858.CD000245.pub3</a></p>
<p>BACKGROUND: The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care.</p> <p>OBJECTIVES: To assess the effects of antibiotics in improving outcomes and assess adverse effects of antibiotic therapy for patients with a clinical diagnosis of acute bronchitis.</p> <p>SEARCH METHODS: We searched CENTRAL 2013, Issue 12, ...
https://epubs.rcsi.ie/gpart/55
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Antidepressant prescribing in Irish children: secular trends and international comparison in the context of a safety warning.
(2015)
O'Sullivan, Katriona; Boland, Fiona; Reulbach, Udo; Motterlini, Nicola; Kelly, Der...
Antidepressant prescribing in Irish children: secular trends and international comparison in the context of a safety warning.
(2015)
O'Sullivan, Katriona; Boland, Fiona; Reulbach, Udo; Motterlini, Nicola; Kelly, Dervla; Bennett, Kathleen; Fahey, Tom
Abstract:
<p>The original article is available at www.biomedcentral.com</p>
<p>BACKGROUND: In 2003, the Irish Medicines Board (IMB) warned against the treatment of childhood depression with selective serotonin reuptake inhibitors (SSRIs) due to increased risk of suicide. This study examined the effect of this warning on the prevalence of anti-depressants in Irish children and compared age and gender trends and international comparisons of prescription rates.</p> <p>METHODS: A retrospective cohort study of the Irish Health Service Executive (HSE) pharmacy claims database for the General Medical Services (GMS) scheme for dispensed medication. Data were obtained for 2002-2011 for those aged ≤15 years. Prevalence of anti-depressants per 1000 eligible population, along with 95 % confidence intervals, were calculated. A negative binomial regression analysis was used to investigate trends and compare rates across years, sex and age groups (0-4, 5-11, 12-15 years). I...
https://epubs.rcsi.ie/gpart/87
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Antimetastatic activity of a cyclooxygenase-2 inhibitor.
(2004)
Roche-Nagle, Graham; Connolly, Elizabeth M; Eng, Molly; Bouchier-Hayes, David J; Harmey...
Antimetastatic activity of a cyclooxygenase-2 inhibitor.
(2004)
Roche-Nagle, Graham; Connolly, Elizabeth M; Eng, Molly; Bouchier-Hayes, David J; Harmey, Judith H
Abstract:
<p>The original article is available at <a href="http://www.nature.com">www.nature.com</a></p>
<p>Cyclooxygenase-2 (COX-2) expression is increased in breast cancer and surgery has been shown to increase the growth of metastatic tumours. We investigated the effect of selective COX-2 inhibition on the growth of metastases in either an experimental metastasis model or following excision of a murine primary breast tumour. 50,000 4T1 mammary carcinoma cells were injected into the mammary fat pad of female BALB/c mice. When the mean TD reached 8+/-0.4 mm, tumours were excised and the mice were randomised into two groups (n=12 per group) to receive daily intraperitoneal injections of the selective COX-2 inhibitor, SC-236 or drug vehicle for 14 days. Alternatively, experimental metastases were established by tail-vein injection of 50,000 4T1 cells. Mice received either the selective COX-2 inhibitor, SC-236 or drug vehicle for 14 days (n=12 per gro...
https://epubs.rcsi.ie/surgart/27
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Antimicrobial proteins and polypeptides in pulmonary innate defence.
(2006)
Rogan, Mark P; Geraghty, Patrick; Greene, Catherine M; O'Neill, Shane J; Taggart, ...
Antimicrobial proteins and polypeptides in pulmonary innate defence.
(2006)
Rogan, Mark P; Geraghty, Patrick; Greene, Catherine M; O'Neill, Shane J; Taggart, Clifford C; McElvaney, Noel G
Abstract:
<p>This is published in Respiratory Research 2006, 7:29 doi:10.1186/1465-9921-7-29. This article is available from http://respiratory-research.com/content/7/1/29. PMID 16503962</p>
<p>Inspired air contains a myriad of potential pathogens, pollutants and inflammatory stimuli. In the normal lung, these pathogens are rarely problematic. This is because the epithelial lining fluid in the lung is rich in many innate immunity proteins and peptides that provide a powerful anti-microbial screen. These defensive proteins have anti-bacterial, anti- viral and in some cases, even anti-fungal properties. Their antimicrobial effects are as diverse as inhibition of biofilm formation and prevention of viral replication. The innate immunity proteins and peptides also play key immunomodulatory roles. They are involved in many key processes such as opsonisation facilitating phagocytosis of bacteria and viruses by macrophages and monocytes. They act as important mediators in infla...
https://epubs.rcsi.ie/medart/2
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Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer.
(2017)
Zuurbier, Linda; Rahman, Arman; Cordes, Martijn; Scheick, Jennifer; Wong, Tse J; Rusten...
Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer.
(2017)
Zuurbier, Linda; Rahman, Arman; Cordes, Martijn; Scheick, Jennifer; Wong, Tse J; Rustenburg, François; Joseph, Jesu Christopher; Dynoodt, Peter; Casey, Rory; Drillenburg, Paul; Gerhards, Michael; Barat, Ana; Klinger, Rut; Fender, Bozena; O'Connor, Darran P; Betge, Johannes; Ebert, Matthias P; Gaiser, Timo; Prehn, Jochen HM; Griffioen, Arjan W
Abstract:
<p>The original article is available at http://www.oncotarget.com</p>
<p>Bevacizumab (bvz) is currently employed as an anti-angiogenic therapy across several cancer indications. Bvz response heterogeneity has been well documented, with only 10-15% of colorectal cancer (CRC) patients benefitting in general. For other patients, clinical efficacy is limited and side effects are significant. This reinforces the need for a robust predictive biomarker of response. To identify such a biomarker, we performed a DNA microarray-based transcriptional profiling screen with primary endothelial cells (ECs) isolated from normal and tumour colon tissues. Thirteen separate populations of tumour-associated ECs and 10 of normal ECs were isolated using fluorescence-activated cell sorting. We hypothesised that VEGF-induced genes were overexpressed in tumour ECs; these genes could relate to bvz response and serve as potential predictive biomarkers. Transcriptional profiling revealed ...
https://epubs.rcsi.ie/physiolart/120
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Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review.
(2009)
Hector, Suzanne; Prehn, Jochen H M
Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review.
(2009)
Hector, Suzanne; Prehn, Jochen H M
Abstract:
<p>This article is availabe at http://www.sciencedirect.com/science</p>
<p>Colorectal cancer is a leading cause of cancer related mortality in the Western world. In recent years, combination 5-fluorouracil based adjuvant chemotherapy as first line treatment of this disease has led to improved disease free and overall survival. However drug resistance, both innate and acquired, remains an obstacle in the effective treatment of this disease. Apoptotic pathways are frequently altered in both tumor progression and drug resistance; therefore proteins associated with this pathway may have potential as prognostic biomarkers for this disease. Identification of clinical biomarkers that are able to identify patients who are more likely to respond to specific chemotherapy will lead to more personalized, effective, and less toxic therapy. This review focuses on the current status of apoptosis related proteins as biomarkers for colorectal cancer and discusses the possible a...
https://epubs.rcsi.ie/physiolart/3
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Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus.
(2008)
Mendy, Maimuna E; Kaye, Steve; Le Roux, Emilie; Kirk, Gregory D; Jeng-Barry, Adam; McCo...
Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus.
(2008)
Mendy, Maimuna E; Kaye, Steve; Le Roux, Emilie; Kirk, Gregory D; Jeng-Barry, Adam; McConkey, Samuel; Cotten, Matthew; Kuniholm, Mark H; Leligdowicz, Aleksandra; Hainaut, Pierre; Rowland-Jones, Sarah; Whittle, Hilton
Abstract:
<p>The original article is available at http://jcm.asm.org</p>
<p>Hepatocellular carcinoma (HCC) and cirrhosis are important causes of mortality worldwide. Persistent hepatitis B virus (HBV) infection is a major cause of these diseases. Double mutations in the basal core promoter (BCP) (A1762T and G1764A) and precore (pre-C) (G1896A) regions of the virus are associated with progression to HCC. The current study is aimed at developing a simple method for screening and detecting BCP and pre-C mutations in HBV carriers. We have developed and validated an oligonucleotide ligation assay (OLA) to detect point mutations in the HBV core gene. We have applied OLA methods to samples from HBV-infected carriers recruited from the Gambia Liver Cancer Study (GLCS) comprising asymptomatic HBsAg carriers, patients with cirrhosis, and patients with HCC. We observed an 89.3% and 95.8% concordance between the OLA and DNA sequencing for BCP and pre-C mutations, respectively. OLA d...
https://epubs.rcsi.ie/ihtmart/9
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Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets.
(2012)
Pabari, Ritesh M; Ramtoola, Zebunnissa
Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets.
(2012)
Pabari, Ritesh M; Ramtoola, Zebunnissa
Abstract:
<p>The original article is also available at <a href="http://www.sciencedirect.com/science/article/pii/S0378517312002438" target="_blank">http://www.sciencedirect.com/science/article/pii/S0378517312002438</a></p>
<p>A two factor, three level (3(2)) face centred, central composite design (CCD) was applied to investigate the main and interaction effects of tablet diameter and compression force (CF) on hardness, disintegration time (DT) and porosity of mannitol based orodispersible tablets (ODTs). Tablet diameters of 10, 13 and 15 mm, and CF of 10, 15 and 20 kN were studied. Results of multiple linear regression analysis show that both the tablet diameter and CF influence tablet characteristics. A negative value of regression coefficient for tablet diameter showed an inverse relationship with hardness and DT. A positive value of regression coefficient for CF indicated an increase in hardness and DT with increasing CF as a result of ...
https://epubs.rcsi.ie/spharmart/7
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Application of real-time PCR to quantify hepatitis B virus DNA in chronic carriers in The Gambia.
(2006)
Mendy, Maimuna E; Kaye, Steve; van der Sande, Marianne; Rayco-Solon, Pura; Waight, Paul...
Application of real-time PCR to quantify hepatitis B virus DNA in chronic carriers in The Gambia.
(2006)
Mendy, Maimuna E; Kaye, Steve; van der Sande, Marianne; Rayco-Solon, Pura; Waight, Pauline A; Shipton, Deborah; Awi, Dorka; Snell, Paul; Whittle, Hilton; McConkey, Samuel J
Abstract:
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND/AIM: The study aimed at developing a real-time quantitative PCR assay to monitor HBV serum virus load of chronic carriers enrolled in therapeutic trials.</p> <p>METHOD: Quantitative real-time PCR assay was carried out using SYBR-Green signal detection and primers specific to the S gene. Thermal cycling was performed in an ABi 5700 sequence detection system. The assay was calibrated against an international HBV DNA standard and inter- and intra-assay reproducibility determined. Levels of viral load were monitored for 1-year in lamivudine treated carriers. Correlation between HBV DNA levels and HBeAg sero-status was determined in untreated carriers.</p> <p>RESULTS: The qPCR assay showed good intra- and inter-assay reproducibility over a wide dynamic range (1.5 x 103 to 1.5 x 108 copies/mL) and corr...
https://epubs.rcsi.ie/ihtmart/2
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Applying a typology of health worker migration to non-EU migrant doctors in Ireland
(2015)
Humphries, Niamh; McAleese, Sara; Tyrrell, Ella; Thomas, Steve; Normand, Charles; Brugh...
Applying a typology of health worker migration to non-EU migrant doctors in Ireland
(2015)
Humphries, Niamh; McAleese, Sara; Tyrrell, Ella; Thomas, Steve; Normand, Charles; Brugha, Ruairi
Abstract:
<p>The original article is available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>Abstract Background: Research on health worker migration in the Irish context has categorized migrant health workers by country or region of training (for example, non-EU nurses or doctors) or recruitment mechanism (for example, actively recruited nurses). This paper applies a new typology of health worker migrants – livelihood, career-oriented, backpacker, commuter, undocumented and returner migrants (European Observatory on Health Systems and Policies and WHO, vol. 2:129-152, 2014) – to the experiences of non-EU migrant doctors in Ireland and tests its utility for understanding health worker migration internationally. Methods: The paper draws on quantitative survey (N = 366) and qualitative interview (N = 37) data collected from non-EU migrant doctors in Ireland between 2011 and 2013. Results: Categorizing non-EU migrant doctor...
https://epubs.rcsi.ie/ephmart/53
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Approaches to Learning in the context of an outcomes-based curriculum
(2010)
Joyce, Pauline
Approaches to Learning in the context of an outcomes-based curriculum
(2010)
Joyce, Pauline
Abstract:
<p>Poster presented at the RCSI Medical Education Research Group (MERG); 2010 February 24.</p>
<p>How does an outcomes-based curriculum influence approaches to learning in an interprofessional postgraduate programme for healthcare professionals?</p>
https://epubs.rcsi.ie/ilhmproc/4
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Aromatase inhibitor specific metastasis is driven by the steroid receptor coactivator SRC-1
(2012)
Theissen, Sarah M
Aromatase inhibitor specific metastasis is driven by the steroid receptor coactivator SRC-1
(2012)
Theissen, Sarah M
Abstract:
<p><strong>Introduction</strong></p> <p>Breast cancer is the second most common cancer in women worldwide. Approximately 80% of breast cancer patients are postmenopausal women and about two thirds of those are diagnosed with hormone receptor positive breast cancer. Therefore, endocrine therapy to block ER activity and signaling is the most successful and most commonly used therapy. Aromatase Inhibitors (Als) are currently one of the most promising treatments for estrogen-receptor positive breast cancer in postmenopausal women. Even though many women initially respond to the treatment, approximately 40% will acquire resistance and relapse within 5 year. The mechanisms involved in the development of resistance to Als however are poorly understood as long-term follow up is only now becoming available.</p> <p>It is though that the development of resistance and resulting tumour recurrence is due, at least in part, to cellular plasticity leading t...
https://epubs.rcsi.ie/phdtheses/59
Marked
Mark
Arrest in hospital: a study of in hospital cardiac arrest outcomes.
(2014)
Fennelly, Neil K; McPhillips, Celine; Gilligan, Peadar
Arrest in hospital: a study of in hospital cardiac arrest outcomes.
(2014)
Fennelly, Neil K; McPhillips, Celine; Gilligan, Peadar
Abstract:
<p>The original article is available at www.imj.ie</p>
<p>The effect of advances in cardiac arrest management over the last five decades on in-hospital cardiac arrest survival rates is not clear. Data on 212 arrests between January 2010 and May 2013 were retrospectively analyzed by means of an audit form based upon the Utstein template for in-hospital cardiac arrest, with a view to identifying significant associations between arrest characteristics and return of spontaneous circulation or survival to discharge. Significant associations were identified between return of spontaneous circulation and location (ward, 36 patients (38%) vs. ICU, 33 Patients (56%); P = 0.032), whether an arrest was witnessed or not (82 patients (52%) vs. 9 patients (30%); P = 0.029), whether the initial rhythm was shockable or non-shockable (28 patients (85%) vs. 38 patients (31%); P < 0.001), whether the first dose of adrenaline was administered within 2 minutes of arrest onset or ...
https://epubs.rcsi.ie/emermedart/1
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