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Subject = Ageing;
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Displaying Results 1 - 25 of 566 on page 1 of 23
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?Changes in mitochondrial stability during the progression of the Barrett?s esophagus sequence?.
(2016)
Phelan, James
?Changes in mitochondrial stability during the progression of the Barrett?s esophagus sequence?.
(2016)
Phelan, James
Abstract:
Background: Barrett?s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett?s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis of this disease sequence is poorly understood. Mitochondria are highly susceptible to mutations due to high levels of reactive oxygen species (ROS) coupled with low levels of DNA repair. The timing and levels of mitochondria instability and dysfunction across the Barrett?s disease progression is under studied. Methods: Using an in-vitro model representing the Barrett?s esophagus disease sequence of normal squamous epithelium (HET1A), metaplasia (QH), dysplasia (Go), and esophageal adenocarcinoma (OE33), random mitochondrial mutations, deletions and surrogate markers of mitochondrial function were assessed. In-vivo and ex-vivo tissues were also assessed for instability profiles. Results: Barrett?s metaplastic cells demonstrated increased levels of ROS (p?<?0.005) an...
http://hdl.handle.net/2262/90703
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?Dysregulated bioenergetics: a key regulator of joint inflammation?.
(2016)
Phelan, James
?Dysregulated bioenergetics: a key regulator of joint inflammation?.
(2016)
Phelan, James
Abstract:
Objectives: This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. Methods: Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with hypoxia, dimethyloxalylglycine (DMOG) or metabolic intermediates. Mitochondrial respiration, mitochondrial DNA mutations, cell invasion, cytokines, glucose and lactate were quantified using specific functional assays. RASF metabolism was assessed by the XF24-Flux Analyzer. Mitochondrial structural morphology was assessed by transmission electron microscopy (TEM). In vivo synovial tissue oxygen (tpO2 mmHg) was measured in patients with inflammatory arthritis (n=42) at arthroscopy, and markers of glycolysis/oxidative phosphorylation (glyceraldehyde 3-phosphate dehydrogenase (GAPDH), PKM2, GLUT1, ATP) were quantified by immunohistology. A subgroup of patients underwent contiguous MRI and positron emission tomography (PET)/CT imaging. RASF and human dermal microvascular endot...
http://hdl.handle.net/2262/90704
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?Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity?.
(2016)
Phelan, James
?Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity?.
(2016)
Phelan, James
Abstract:
In Barrett associated tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression. However, the link between energy metabolism and its connection with other central cellular processes within the Barrett microenvironment is unknown. The aim of this study was to examine the relationship between metabolism (ATP5B/GAPDH), hypoxia (HIF1?), inflammation (IL1?/SERPINA3), p53 and obesity status using in-vivo and ex-vivo models of Barrett oesophagus. At the protein level, ATP5B (r?=?0.71, P?<?0.0001) and p53 (r?=?0.455, P?=?0.015) were found to be strongly associated with hypoxia. In addition, levels of ATP5B (r?=?0.53, P?=?0.0031) and GAPDH (r?=??0.39, P?=?0.0357) were positively associated with p53 expression. Moreover, we demonstrate that ATP5B (r?=?0.8, P?<?0.0001) and GAPDH (r?=?0.43, P?=?0.022) were positively associated with IL1? expression. Interestingly, obesity was negatively associated...
http://hdl.handle.net/2262/90711
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?Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival?.
(2016)
Phelan, James
?Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival?.
(2016)
Phelan, James
Abstract:
Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some cases, worsened disease outcome. Here we examine colon cancer patients and show not only that PKC Beta II is a tumour suppressor, but patients with low levels of this isozyme have significantly decreased disease free survival. Specifically, analysis of gene expression levels of all PKC genes in matched normal and cancer tissue samples from colon cancer patients revealed a striking down-regulation of the gene coding PKC Beta in the cancer tissue (n = 21). Tissue microarray analysis revealed a dramatic down-regulation of PKC Beta II protein levels in both the epithelial and stromal diseased tissue (n = 166). Of clinical significance, low levels of the protein in the normal tissue of patients is associated with a low (10%) 10 year survival compared with a much higher (...
http://hdl.handle.net/2262/90707
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'Níl aon tinteán mar do thinteán féin' / 'There's no place like home' A mixed methods exploratory study of ageing in place
(2014)
McGrath, Margaret
'Níl aon tinteán mar do thinteán féin' / 'There's no place like home' A mixed methods exploratory study of ageing in place
(2014)
McGrath, Margaret
Abstract:
Background Ageing in place refers to the practice of older adults continuing to live in their own homes. Existing research has highlighted both the importance and complexity of ageing in place for older people, however limited attention has been paid to the associated processes. This study explored these processes among a sample of older people living in Ireland. Methodology This study used a two-phase mixed methods exploratory design. In phase one a cross sectional survey design was used to explore older adults' (N=159) beliefs regarding control over their home environment. Sequential multiple regression analysis was used to identify how housing related control beliefs could be predicted by selected demographic, housing and health related characteristics. Phase two of the research used a case study design. Nine cases were purposively selected from participants who were involved in phase one of the study. Data in the form of in-depth interviews, diary entries and photo elicita...
http://hdl.handle.net/10379/4518
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'Positive ageing - starts now!' The national positive ageing strategy
(2013)
Department of Health (DoH)
'Positive ageing - starts now!' The national positive ageing strategy
(2013)
Department of Health (DoH)
http://hdl.handle.net/10147/301527
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"Eating is My Worst Nightmare": The Epidemiological Investigation of Oral Stage Dysphagia in Adult Patients with Temporomandibular Disorders
(2017)
Gilheaney, Orla; Stassen, Leo; Walshe, Margaret
"Eating is My Worst Nightmare": The Epidemiological Investigation of Oral Stage Dysphagia in Adult Patients with Temporomandibular Disorders
(2017)
Gilheaney, Orla; Stassen, Leo; Walshe, Margaret
http://hdl.handle.net/2262/92724
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"It's really very disturbing ot me": The Social Reality and Real-Life Challenges of Living with Oro-Pharyngeal Dysphagia
(2015)
Scully, Hannah; Walsh, Irene
"It's really very disturbing ot me": The Social Reality and Real-Life Challenges of Living with Oro-Pharyngeal Dysphagia
(2015)
Scully, Hannah; Walsh, Irene
Abstract:
This piece of research sought to explore the psychosocial experiences of oro-pharyngeal dysphagia, through means of analysing online first person, personal accounts, in an effort to improve general understanding of the disorder and enhance clinical practice. By exploring first person accounts of living with oro-pharyngeal dysphagia, one can gain insight into individuals? perspectives and attitudes regarding their difficulties, helping to identify the real-life challenges for this clinical population. A qualitative, inductive approach to research was carried out using an interpretative phenomenological approach (IPA) to analyse the data. This approach is concerned with the examination of how individuals make sense of major life experiences, and is concerned with an individual?s personal perception of a particular event and/or series of events (Smith & Osborn, 2007). For the purpose of this study, eight first person, oral and written accounts documenting adults? experience of l...
http://hdl.handle.net/2262/89894
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α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
(2015)
LYNCH, MARINA; LYNCH, MARINA ANNETTA
α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
(2015)
LYNCH, MARINA; LYNCH, MARINA ANNETTA
Abstract:
The immunoregulatory function of single-Ig-interleukin-1 related receptor (SIGIRR) is derived from its ability to constrain the inflammatory consequences of interleukin (IL)-1R and toll-like receptor (TLR)4 activation. This role extends to the brain, where SIGIRR deficiency increases the synaptic and cognitive dysfunction associated with IL-1R- and TLR4-mediated signalling. The current study set out to investigate the interaction between SIGIRR and TLR2 in brain tissue and the data demonstrate that the response to the TLR2 agonist, Pam3CysSK4 (Pam3Cys4), is enhanced in glial cells from SIGIRR-/- animals. Consistent with the view that ?-amyloid peptide (A?) signals through activation of TLR2, the data also show that A?-induced changes are exaggerated in glia from SIGIRR-/- animals. We report that microglia, rather than astrocytes, are the primary glial cell expressing both TLR2 and SIGIRR. While A? increased TLR2 expression, it decreased SIGIRR expression in microglia. This was mimic...
http://hdl.handle.net/2262/73330
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Designing a Proactive, Person-Centred, Digital Integrated Care System
(2017)
Hannigan, Caoimhe; Murphy, Emma; Dinsmore, John
Designing a Proactive, Person-Centred, Digital Integrated Care System
(2017)
Hannigan, Caoimhe; Murphy, Emma; Dinsmore, John
http://hdl.handle.net/2262/82016
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2012 - That was the year that was
(2013)
O'NEILL, DESMOND
2012 - That was the year that was
(2013)
O'NEILL, DESMOND
Abstract:
Geriatric medicine has an encyclopaedic sweep, reflecting the complexity of both the ageing process and of our patient group. Keeping up with, and making sense of, the relevant scientific literature is challenging, especially as ageing has increased in prominence as a focus of research across many branches of the sciences and the humanities. This review of research published in 2012 in generalist, geriatric medicine and gerontology journals has been compiled with a view to extracting those aspects of research into ageing which could be considered relevant not only to the practice of geriatric medicine, but also to our understanding of the ageing process and the relationship of geriatric medicine to other medical specialties and public health. The research discussed includes new insights into global ageing and the compression of morbidity; nosological, clinical and therapeutic aspects of dementia; an innovative study on the microbiome and ageing; epidemiological perspectives into mul...
http://hdl.handle.net/2262/73038
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The specification of new technology to support assisted living (AL) from a biopsychosocial and stakeholder relationship perspective
(2016)
CAHILL, JOAN
The specification of new technology to support assisted living (AL) from a biopsychosocial and stakeholder relationship perspective
(2016)
CAHILL, JOAN
http://hdl.handle.net/2262/78765
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24-hour ambulatory electrocardiographic monitoring is unhelpful in the investigation of older persons with recurrent falls
(2005)
Kenny, Rose
24-hour ambulatory electrocardiographic monitoring is unhelpful in the investigation of older persons with recurrent falls
(2005)
Kenny, Rose
Abstract:
doi: https://doi.org/10.1093/ageing/afi108
Background: although frequently used in the assessment of patients with falls, it is unclear whether 24-hour ambulatory electrocardiography contributes to their assessment in older persons. Objective: to identify electrocardiographic abnormalities in patients with recurrent falls and case controls, and determine whether 24-hour ambulatory electrocardiography identifies causal arrhythmias for falls. Design: prospective case?control study. Methods: 24-hour ambulatory electrocardiography recordings were compared for the type and prevalence of arrhythmias andsymptom correlation in consecutive older subjects with recurrent falls attending the accident and emergency department and in case controls (no previous falls or syncope). ECG abnormalities were categorised as major (ventricular arrhythmia, pauses, <30 b.p.m.,Mobitz II, complete heart block) and minor (multiple ectopics, paroxysmal atrial a...
http://hdl.handle.net/2262/89277
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The impact of carer 'shared (disease management) responsibility' on 'shared decision making' for older persons managing multimorbidity
(2017)
DINSMORE, JOHN; MURPHY, EMMA; HANNIGAN, CAOIMHE
The impact of carer 'shared (disease management) responsibility' on 'shared decision making' for older persons managing multimorbidity
(2017)
DINSMORE, JOHN; MURPHY, EMMA; HANNIGAN, CAOIMHE
Abstract:
Introduction: For older persons with multimorbidity (PwMs), self-management is a complex process that involves integration of knowledge and tasks for multiple, and often interacting, chronic diseases (1). Shared decision making (SDM) refers to clinicians working together with patients and/or their caregivers to decide which care plan best fits individual patients and their lives, when there is more than one reasonable option (2). The current study aimed to understand the role of caregiver support related to SDM for older PwMs (aged over 65). The data presented were collected as part of an extensive requirements gathering exercise to inform the design of ProACT, a digital health ecosystem that aims to support self-management and improve integration of care for older PwMs. Methods: Semi-structured qualitative interviews and focus groups were conducted with 38 older PwMs,17 informal carers and 22 formal care workers across the Irish and Belgian health systems. Interviews and focus grou...
http://hdl.handle.net/2262/81986
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Key Note: Designing a Behavioural Change Intervention for Multimorbidity Self-Management
(2018)
Dinsmore, John
Key Note: Designing a Behavioural Change Intervention for Multimorbidity Self-Management
(2018)
Dinsmore, John
http://hdl.handle.net/2262/89775
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5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice
(2018)
KELLY, VINCENT; Saitoh, Shinichi; Okano, Satoshi; Nohara, Hidekazu; Nakano, Hiroshi; Sh...
5-aminolevulinic acid (ALA) deficiency causes impaired glucose tolerance and insulin resistance coincident with an attenuation of mitochondrial function in aged mice
(2018)
KELLY, VINCENT; Saitoh, Shinichi; Okano, Satoshi; Nohara, Hidekazu; Nakano, Hiroshi; Shirasawa, Nobuyuki; Naito, Akira; Yamamoto, Masayuki; Kelly, Vincent P.; Takahashi, Kiwamu; Tanaka, Tohru; Nakajima, Motowo; Nakajima, Osamu
Abstract:
In vertebrates, the initial step in heme biosynthesis is the production of 5-aminolevulinic acid (ALA) by ALA synthase (ALAS). ALA formation is believed to be the rate-limiting step for cellular heme production. Recently, several cohort studies have demonstrated the potential of ALA as a treatment for individuals with prediabetes and type-2 diabetes mellitus. These studies imply that a mechanism exists by which ALA or heme can control glucose metabolism. The ALAS1 gene encodes a ubiquitously expressed isozyme. Mice heterozygous null for ALAS1 (A1+/-s) experience impaired glucose tolerance (IGT) and insulin resistance (IR) beyond 20-weeks of age (aged A1+/-s). IGT and IR were remedied in aged A1+/-s by the oral administration of ALA for 1 week. However, the positive effect of ALA proved to be reversible and was lost upon termination of ALA administration. In the skeletal muscle of aged A1+/-s an attenuation of mitochondrial function is observed, coinciding with IGT and IR. Oral admin...
http://hdl.handle.net/2262/91383
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Patterns of multimorbidity in an ageing population of people with an intellectual disability: Results from the intellectual disability supplement to the Irish longitudinal study on ageing (IDS-TILDA)
(2013)
MCCARRON, MARY; MCCALLION, PHILIP; MCGLINCHEY, EIMEAR
Patterns of multimorbidity in an ageing population of people with an intellectual disability: Results from the intellectual disability supplement to the Irish longitudinal study on ageing (IDS-TILDA)
(2013)
MCCARRON, MARY; MCCALLION, PHILIP; MCGLINCHEY, EIMEAR
Abstract:
Multimorbidity (2 or more chronic conditions) is being widely studied in older populations and this study explores both the relevance of emerging conceptualizations and the extent to which multimorbidity is a feature of aging in persons with an intellectual disability. METHODS: Data was generated from wave one of the intellectual disability supplement to the Irish longitudinal study on aging (IDS-TILDA) which included 753 persons with an ID aged 40 years and over. Information on the presence of 12 chronic conditions was collected using a standardized protocol administered in face to face interviews with persons with ID and/or their caregivers. Prevalence of multimorbidity was established and patterns were examined using logistic regression models. The patterns of multimorbidity for people with ID that emerged were then compared with those reported for other older adults. RESULTS: Multimorbidity was established for 71% of the IDS-TILDA sample with women at highest risk and rates of...
http://hdl.handle.net/2262/71471
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The Relationships Between Executive Function, Cognitive Processing Speed And Two Models of Frailty Are Mediated By Sustained Attention In The Older Adult Population.
(2013)
O'HALLORAN, AISLING
The Relationships Between Executive Function, Cognitive Processing Speed And Two Models of Frailty Are Mediated By Sustained Attention In The Older Adult Population.
(2013)
O'HALLORAN, AISLING
http://hdl.handle.net/2262/71308
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A commentary on King, M. The challenge of research into religion and spirituality. Journal for the Study of Spirituality 4, no. 2 (2014): 106-120
(2016)
TIMMINS, FIONA
A commentary on King, M. The challenge of research into religion and spirituality. Journal for the Study of Spirituality 4, no. 2 (2014): 106-120
(2016)
TIMMINS, FIONA
http://hdl.handle.net/2262/78930
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A common awareness and knowledge platform for studying and enabling independent living – CAPSIL
(2010)
Bennis, Caoimhe; McGrath, Denise; Caulfield, Brian; Knapp, Ben; Coghlan, Niall
A common awareness and knowledge platform for studying and enabling independent living – CAPSIL
(2010)
Bennis, Caoimhe; McGrath, Denise; Caulfield, Brian; Knapp, Ben; Coghlan, Niall
Abstract:
Presented at the AGEmap 2010 Workshop on Roadmaps towards a strategic research agenda for ICT in active ageing at the 4th International conference on Pervasive Computing for Healthcare 2010 Conference (AGEMAP Workshop), Munich, Germany, March 22-25, 2010
The population of the world is growing older, and the balance of old to young is shifting so that by 2050 over 30% of the population is expected to be over 60 years old, with particularly high ratios of old to young in the EU, USA and Japan. CAPSIL is an FP7 Coordinating Support Action that incorporates a strategic international coalition of University and Industrial partners that already have extensive teams developing hardware/software/knowledge solutions to independent living based on user requirements. CAPSIL has two fundamental goals: 1. To carry out an analysis of the state of the art with regards to technology, healthcare and public policy in the EU, US and Japan for enabling independent living for older adults. Based o...
http://hdl.handle.net/10197/2290
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A Comparison of Beers and STOPP Criteria in Assessing Potentially Inappropriate Medications in Nursing Home Residents Attending the Emergency Department.
(2014)
O'NEILL, DESMOND; KENNELLY, SEAN; COUGHLAN, TARA; ROMERO-ORTUNO, ROMAN
A Comparison of Beers and STOPP Criteria in Assessing Potentially Inappropriate Medications in Nursing Home Residents Attending the Emergency Department.
(2014)
O'NEILL, DESMOND; KENNELLY, SEAN; COUGHLAN, TARA; ROMERO-ORTUNO, ROMAN
http://hdl.handle.net/2262/75571
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A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).
(2010)
LAWLOR, BRIAN; KENNY, ROSE; ROMERO ORTUNO, ROMAN; WALSH, CATHAL
A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).
(2010)
LAWLOR, BRIAN; KENNY, ROSE; ROMERO ORTUNO, ROMAN; WALSH, CATHAL
Abstract:
Background: A frailty paradigm would be useful in primary care to identify older people at risk, but appropriate metrics at that level are lacking. We created and validated a simple instrument for frailty screening in Europeans aged [greater than or equal to]50. Our study is based on the first wave of the Survey of Health, Ageing and Retirement in Europe (SHARE, http://www.share-project.org), a large population-based survey conducted in 2004-2005 in twelve European countries. Methods: Subjects: SHARE Wave 1 respondents (17,304 females and 13,811 males). Measures: five SHARE variables approximating Fried's frailty definition. Analyses (for each gender): 1) estimation of a discreet factor (DFactor) model based on the frailty variables using LatentGOLD(R). A single DFactor with three ordered levels or latent classes (i.e. non-frail, pre-frail and frail) was modelled; 2) the latent classes were characterised against a biopsychosocial range of Wave 1 variables; 3) the prospective m...
http://hdl.handle.net/2262/41047
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A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts.
(2016)
DAVEY, GAVIN
A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts.
(2016)
DAVEY, GAVIN
http://hdl.handle.net/2262/76782
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A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
(2011)
LYNCH, MARINA ANNETTA; COWLEY, THELMA
A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
(2011)
LYNCH, MARINA ANNETTA; COWLEY, THELMA
Abstract:
Neuroglial activation is a typical hallmark of ageing within the hippocampus, and correlates with age-related cognitive deficits. We have used quantitative immunohistochemistry and morphometric analyses to investigate whether systemic treatment with the Neural Cell Adhesion Molecule (NCAM)-derived peptide FG Loop (FGL) specifically alters neuroglial activation and population densities within the aged rat hippocampus (22 months of age). A series of 50 ?m paraformaldehyde/acrolein-fixed sections taken throughout the dorsal hippocampus (5 animals per group) were immunostained to detect astrocytes (GFAP and S100?) and microglial cells (CD11b/OX42 and MHCII/OX6), and analyzed using computerised image analysis and optical segmentation (Image-Pro Plus, Media Cybernetics). FGL treatment reduced the density of CD11b + and MHCII + microglia in aged animals, concomitant with a reduction in immunoreactivity for these phenotypic markers. FGL treatment also markedly reduced GFAP immunoreactivity ...
http://hdl.handle.net/2262/60697
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A pharmacological perspective of Chloroquine in SARS-CoV-2 infection
(2020)
Romero-Ortuno, Roman
A pharmacological perspective of Chloroquine in SARS-CoV-2 infection
(2020)
Romero-Ortuno, Roman
Abstract:
The pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is having serious consequences on health and the economy worldwide. All evidence-based treatment strategies need to be considered to combat this new virus. Drugs need to be considered on scientific grounds of efficacy, safety and cost. Chloroquine (CQ) and hydroxychloroquine (HCQ) are old drugs used in the treatment of malaria; in addition, their antiviral properties have been previously studied, including in coronaviruses, where evidence of efficacy has been found. The safety of CQ and HCQ has been studied for over 50 years. In the current race against time triggered by the SARS-CoV-2 pandemic, the search for new antivirals is very important. However, consideration should be given to old drugs with known anti-coronavirus activity, such as CQ and HCQ; these could be integrated into current treatment strategies while novel treatm...
http://hdl.handle.net/2262/92892
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