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Displaying Results 1 - 25 of 58 on page 1 of 3

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2-D difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of ten specific proteins (2007)

Dowling, Paul; O'Driscoll, Lorraine; Meleady, Paula; Henry, Michael; Roy, Shunil; ...

Mark

A germline mutation in the brca13’utr predicts stage iv breast cancer (2018)

Dorairaj, Jemima J; Salzman, David W; Wall, Deirdre; Rounds, Tiffany; Preskill, Carina;...

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A systematic review of the psychobiological burden of informal caregiving for patients with dementia: focus on cognitive and biological markers of chronic stress (2016)

Allen, Andrew P.; Curran, Eileen A.; Duggan, Áine; Cryan, John F.; Ní Chorcoráin, Aoife...

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An analysis of the phosphoproteome of immune cell lines exposed to the immunomodulatory mycotoxin deoxynivalenol (2011)

Nogueira da Costa, Andre; Kenn, Jeffrey N.; Wild, Christopher P.; Findlay, John B. C.

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Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis (2008)

Dowling, Paul; Wormald, Robert; Meleady, Paula; Henry, Michael; Curran, Aongus; Clynes,...

Mark

Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. (2017)

Zuurbier, Linda; Rahman, Arman; Cordes, Martijn; Scheick, Jennifer; Wong, Tse J; Rusten...

Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer. (2017)

Zuurbier, Linda; Rahman, Arman; Cordes, Martijn; Scheick, Jennifer; Wong, Tse J; Rustenburg, François; Joseph, Jesu C; Dynoodt, Peter; Casey, Rory; Drillenburg, Paul; Gerhards, Michael; Barat, Ana; Klinger, Rut; Fender, Bozena; O'Connor, Darran P; Betge, Johannes; Ebert, Matthias P; Gaiser, Timo; Prehn, Jochen HM; Griffioen, Arjan W

Abstract:

<p>The original article is available at http://www.oncotarget.com</p>
<p>Bevacizumab (bvz) is currently employed as an anti-angiogenic therapy across several cancer indications. Bvz response heterogeneity has been well documented, with only 10-15% of colorectal cancer (CRC) patients benefitting in general. For other patients, clinical efficacy is limited and side effects are significant. This reinforces the need for a robust predictive biomarker of response. To identify such a biomarker, we performed a DNA microarray-based transcriptional profiling screen with primary endothelial cells (ECs) isolated from normal and tumour colon tissues. Thirteen separate populations of tumour-associated ECs and 10 of normal ECs were isolated using fluorescence-activated cell sorting. We hypothesised that VEGF-induced genes were overexpressed in tumour ECs; these genes could relate to bvz response and serve as potential predictive biomarkers. Transcriptional profiling revealed ...

https://epubs.rcsi.ie/physiolart/120

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Application of statistical process control to qualitative molecular diagnostic assays. (2014)

O'BRIEN, CATHAL; FINN, STEPHEN

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Assessing the immune phenotype of cardiac syndrome x: a prospective study of biomarkers (2016)

Dollard, James

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Blood-brain barrier response in the context of sports-related TBI (2020)

O'KEEFFE, EOIN

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Changes in urinary metabolomic profile during relapsing renal vasculitis (2016)

LITTLE, MARK; O'BRIEN, EOIN; MOK, KENNETH

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Characterization of post-traumatic immunosuppression and its partial reversal by autologous salvaged blood transfusion (2015)

Islam, Nahidul

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Circulating nucleosomes and nucleosome modifications as biomarkers in cancer (2018)

McAnena, Peter; Brown, James; Kerin, Michael

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Co-acting gene networks predict trail responsiveness of tumour cells with high accuracy (2018)

O’Reilly, Paul; Ortutay, Csaba; Gernon, Grainne; O’Connell, Enda; Seoighe, Cathal; Boyc...

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Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles. (2019)

O'Driscoll, Lorraine

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Differential expression of the inflammation marker IL12p40 in the at-risk mental state for psychosis: a predictor of transition to psychotic disorder? (2016)

Föcking, Melanie M; Dicker, Patrick; Lopez, Lorna M; Cannon, Mary; Schäfer, Miriam R; M...

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Electrochemiluminescent array to detect oxidative damage in ds-dna using [os(bpy)2(phen-benz-cooh)]2+/nafion/graphene films (2018)

Bist, Itti; Song, Boya; Mosa, Islam M.; Keyes, Tia E.; Martin, Aaron; Forster, Robert J...

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Evaluation of neuroimaging biomarkers in amyotrophic lateral sclerosis (2017)

SCHUSTER, CHRISTINA

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Exosome-encapsulated microRNAs as circulating biomarkers for breast cancer (2017)

Joyce, Doireann

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Exosome-encapsulated micrornas as circulating biomarkers for breast cancer (2018)

Joyce, Doireann P.; Kerin, Michael J.; Dwyer, Róisín M.

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Functions and therapeutic roles of exosomes in cancer. (2014)

O'BYRNE, KEN

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High-sensitivity cardiac troponin concentration and risk of first-ever cardiovascular outcomes in 154,052 participants (2017)

Willeit, Peter; Welsh, Paul; Evans, Jonathan D. W.; Tschiderer, Lena; Boachie, Charles;...

High-sensitivity cardiac troponin concentration and risk of first-ever cardiovascular outcomes in 154,052 participants (2017)

Willeit, Peter; Welsh, Paul; Evans, Jonathan D. W.; Tschiderer, Lena; Boachie, Charles; Jukema, J. Wouter; Ford, Ian; Trompet, Stella; Stott, David J.; Kearney, Patricia M.; Mooijaart, Simon P.; Kiechl, Stefan; Di Angelantonio, Emanuele; Sattar, Naveed

Abstract:

BACKGROUND High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-cTnT) in individuals with no clinically manifest myocardial injury. OBJECTIVES The goal of this study was to assess associations of cardiac troponin concentration with cardiovascular disease (CVD) outcomes in primary prevention studies. METHODS A search was conducted of PubMed, Web of Science, and EMBASE for prospective studies published up to September 2016, reporting on associations of cardiac troponin concentration with first-ever CVD outcomes (i.e., coronary heart disease [CHD], stroke, or the combination of both). Study-specific estimates, adjusted for conventional risk factors, were extracted by 2 independent reviewers, supplemented with de novo data from PROSPER (Pravastatin in Elderly Individuals at Risk of Vascular Disease Study), then pooled by using random effects meta-analysis. RESULTS A total of 28 relevant studies were identified involving 154,052 participants. Cardiac troponin was d...

http://hdl.handle.net/10468/4799