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Subject = Cardiovascular Diseases;
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Displaying Results 1 - 25 of 37 on page 1 of 2
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A Novel in vitro Microfluidic Flow Assay for Quantitative Assessment of Initial Platelet Adhesion on von Willebrand Factor in Arterial Flowing Blood: Assessment of this Platelet Function Assay in Healthy and Cardiovascular Disease States
(2012)
O'Brien, Sinéad
A Novel in vitro Microfluidic Flow Assay for Quantitative Assessment of Initial Platelet Adhesion on von Willebrand Factor in Arterial Flowing Blood: Assessment of this Platelet Function Assay in Healthy and Cardiovascular Disease States
(2012)
O'Brien, Sinéad
Abstract:
<p>Platelet behaviour on immobilized vascular proteins has been explored to great length over the last four decades. While light transmission aggregometry remains the gold standard of platelet function testing, the ability to assess platelet function in more physiological conditions would be preferential.</p> <p>To this end, we have developed a novel shear mediated parallel plate flow chamber with a view to assessing platelet behaviour on reproducible vascular protein surfaces, providing a quantitative assessment of this platelet protein interaction.</p> <p>This thesis will describe in detail the optimization and characterization of immobilized Von Willebrand Factor and collagen protein surfaces to provide reproducible vascular protein surfaces. The development of a custom designed novel software to quantitatively assess this platelet protein interaction, and the subsequent development of a novel hydrodynamically shaped microfluidic flow device to consi...
https://epubs.rcsi.ie/phdtheses/75
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Assessment of a Clinically Relevant Geometric Measure for Identifying Vulnerable Carotid Plaques
(2017)
NOLAN, DAVID; LALLY, CAITRIONA; GHASEMI, MILAD
Assessment of a Clinically Relevant Geometric Measure for Identifying Vulnerable Carotid Plaques
(2017)
NOLAN, DAVID; LALLY, CAITRIONA; GHASEMI, MILAD
http://hdl.handle.net/2262/79985
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Cardiovascular risk factors-using repeated cross-sectional surveys to assess time trends in socioeconomic inequalities in neighbouring countries.
(2017)
Hughes, John; Kabir, Zubair; Kee, Frank; Bennett, Kathleen
Cardiovascular risk factors-using repeated cross-sectional surveys to assess time trends in socioeconomic inequalities in neighbouring countries.
(2017)
Hughes, John; Kabir, Zubair; Kee, Frank; Bennett, Kathleen
Abstract:
<p>The original article is available at <a href="https://bmjopen.bmj.com/content/7/4/e013442.long">bmjopen.bmj.com</a></p>
<p><strong>OBJECTIVES:</strong> This study compares trends in socioeconomic inequalities related to key cardiovascular risk factors in neighbouring countries Northern Ireland (NI) and the Republic of Ireland (RoI).</p> <p><strong>DESIGN:</strong> Repeated cross-sectional studies.</p> <p><strong>SETTING:</strong> Population based.</p> <p><strong>PARTICIPANTS:</strong> 3500-4000 in national surveys in NI and 5000-9000 in RoI, aged 20-69 years.</p> <p><strong>MEASURES:</strong> Educational attainment was used as a socioeconomic indicator by which the magnitude and direction of trends in inequalities for smoking, diabetes, obesity and physical inactivity in NI and RoI were examined between 1997/1998 and 2007/2011. Ge...
https://epubs.rcsi.ie/psycholart/140
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Cognitive impairment and cardiovascular medication use: Results from wave 1 of The Irish Longitudinal Study on Ageing.
(2017)
Rohde, Daniela; Hickey, Anne, Professor; Williams, David; Bennett, Kathleen
Cognitive impairment and cardiovascular medication use: Results from wave 1 of The Irish Longitudinal Study on Ageing.
(2017)
Rohde, Daniela; Hickey, Anne, Professor; Williams, David; Bennett, Kathleen
Abstract:
<p><strong><em>This is the peer reviewed version of the following article: Rohde D, Hickey A, Williams D, Bennett K. Cognitive impairment and cardiovascular medication use: Results from wave 1 of The Irish Longitudinal Study on Ageing. Cardiovascular Therapeutics. 2017;35(6):, which has been published in final form at <a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/1755-5922.12300">https://onlinelibrary.wiley.com/doi/epdf/10.1111/1755-5922.12300</a> . This article may be used for non-commercial purposes in accordance with <a href="http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms">Wiley Terms and Conditions for Self-Archiving</a>.</em></strong></p>
<p><strong>AIM:</strong> To explore the association between cardiovascular medication use and cognitive impairment in adults aged 50 years and over.</p> <p><strong>METHOD:</strong> This cross...
https://epubs.rcsi.ie/psycholart/125
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Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort
(2019)
Rohde, Daniela; Gaynor, Eva; Large, Margaret; Mellon, Lisa; Bennett, Kathleen; Williams...
Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort
(2019)
Rohde, Daniela; Gaynor, Eva; Large, Margaret; Mellon, Lisa; Bennett, Kathleen; Williams, David; Brewer, Linda; Hall, Patricia; Callaly, Elizabeth; Dolan, Eamon; Hickey, Anne
Abstract:
<p>The original article is available at <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223997">journals.plos.org</a></p>
<p><strong>Background</strong></p> <p>Control of vascular risk factors is essential for secondary stroke prevention. However, adherence to secondary prevention medications is often suboptimal, and may be affected by cognitive impairment. Few studies to date have examined associations between cognitive impairment and medication adherence post-stroke, and none have considered whether adherence to secondary prevention medications might affect subsequent cognitive function. The aim of this study was to explore prospective associations between cognitive impairment and medication non-adherence post-stroke.</p> <p><strong>Methods</strong></p> <p>A five-year follow-up of 108 stroke survivors from the Action on Secondary Prevention Interventi...
https://epubs.rcsi.ie/psycholart/144
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Cognitive Impairment, Vulnerability, and Mortality Post Ischemic Stroke: A Five-Year Follow-Up of the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) Cohort
(2018)
Gaynor, Eva; Rohde, Daniela; Large, Margaret; Mellon, Lisa; Hall, Patricia; Brewer, Lin...
Cognitive Impairment, Vulnerability, and Mortality Post Ischemic Stroke: A Five-Year Follow-Up of the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) Cohort
(2018)
Gaynor, Eva; Rohde, Daniela; Large, Margaret; Mellon, Lisa; Hall, Patricia; Brewer, Linda; Conway, Orla; Hickey, Anne; Bennett, Kathleen; Dolan, Eamon; Callaly, Elizabeth; Williams, David
Abstract:
<p>The original article is available at <a>www.sciencedirect.com</a></p>
<h4 id="x-x-x-x-x-x-x-x-absSec_1">Background</h4> <p id="x-x-x-x-x-x-x-x-sp0010">The aim of this study was to examine predictors of mortality in patients 5 years after ischemic stroke, focusing on cognitive impairment, vulnerability, and vascular risk factors assessed at 6 months post stroke.</p> <h4 id="x-x-x-x-x-x-x-x-absSec_2">Materials and Methods</h4> <p id="x-x-x-x-x-x-x-x-sp0015">Patients from the Action on Secondary Prevention Interventions and Rehabilitation in Stroke (ASPIRE-S) cohort were followed up 5 years post ischemic stroke. Vascular risk factors, cognitive impairment, and vulnerability were assessed at 6 months post stroke. Cognitive impairment was assessed using a cutoff score lower than 26 on the Montreal Cognitive Assessment (MoCA). Vulnerability was defined as a score of 3 or higher...
https://epubs.rcsi.ie/psycholart/123
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Computer aided diagnosis of early vascular disease from ultrasound images
(2016)
Kavanagh, Liam N
Computer aided diagnosis of early vascular disease from ultrasound images
(2016)
Kavanagh, Liam N
Abstract:
<p>This thesis consists of 2 separate ultrasound (US) based studies, performed with the common aim of improving the diagnosis of early vascular disease from US images.</p> <p><strong>Study 1 </strong></p> <p><strong>Introduction: </strong>Flow mediated dilatation (FMD) is an endothelium-dependent process reflecting the dilatation of a conduit artery when it is exposed to increased blood flow and therefore increased shear stress. FMD requires a healthy endothelium and is depressed in those with cardiovascular risk factors. Current 2D US assessment is limited as a research tool only secondary to variable reproducibility, technical difficulties and difficulties determining true diameter measurement. To our knowledge this is the first study comparing 2D and 3D US assessment of FMD.</p> <p><strong>Methods:</strong> This was a cross sectional reproducibility study with 27 male patients. 2D and 3D FMD were perfor...
https://epubs.rcsi.ie/mdtheses/75
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Cross-sectional analysis of the prevalence and predictors of statin utilisation in Ireland with a focus on primary prevention of cardiovascular disease.
(2018)
Byrne, Paula; Cullinan, John; Murphy, Catríona; Smith, Susan M
Cross-sectional analysis of the prevalence and predictors of statin utilisation in Ireland with a focus on primary prevention of cardiovascular disease.
(2018)
Byrne, Paula; Cullinan, John; Murphy, Catríona; Smith, Susan M
Abstract:
<p>The original article is available at <a href="https://bmjopen.bmj.com/content/8/2/e018524.long">bmjopen.bmj.com </a></p>
<p><strong>OBJECTIVE:</strong> To describe the prevalence of statin utilisation by people aged over 50 years in Ireland and the factors associated with the likelihood of using a statin, focusing particularly on those using statins for primary prevention of cardiovascular disease (CVD).</p> <p><strong>METHODS:</strong> This is a cross-sectional analysis of cardiovascular risk and sociodemographic factors associated with statin utilisation from wave 1 of The Irish Longitudinal Study on Ageing. A hierarchy of indications for statin utilisation, consisting of eight mutually exclusive levels of CVD-related diagnoses, was created. Participants were assigned one level of indication. The prevalence of statin utilisation was calculated. The likelihood that an individual was using a statin wa...
https://epubs.rcsi.ie/gpart/139
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Dairy fats and cardiovascular disease: do we really need to be concerned?
(2018)
Lordan, Ronan; Tsoupras, Alexandros; Mitra, Bhaskar; Zabetakis, Ioannis
Dairy fats and cardiovascular disease: do we really need to be concerned?
(2018)
Lordan, Ronan; Tsoupras, Alexandros; Mitra, Bhaskar; Zabetakis, Ioannis
Abstract:
Cardiovascular diseases (CVD) remain a major cause of death and morbidity globally and diet plays a crucial role in the disease prevention and pathology. The negative perception of dairy fats stems from the effort to reduce dietary saturated fatty acid (SFA) intake due to their association with increased cholesterol levels upon consumption and the increased risk of CVD development. Institutions that set dietary guidelines have approached dairy products with negative bias and used poor scientific data in the past. As a result, the consumption of dairy products was considered detrimental to our cardiovascular health. In western societies, dietary trends indicate that generally there is a reduction of full-fat dairy product consumption and increased low-fat dairy consumption. However, recent research and meta-analyses have demonstrated the benefits of full-fat dairy consumption, based on higher bioavailability of high-value nutrients and anti-inflammatory properties. In this review, th...
http://hdl.handle.net/10344/6860
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Discovery of small molecule FcγRIIa Antagonists
(2015)
Thai Trung King, Michael
Discovery of small molecule FcγRIIa Antagonists
(2015)
Thai Trung King, Michael
Abstract:
<p>Antibodies are Y-shaped proteins that are secreted by B-cells that makes up part of the defence mechanism in the adaptive immune system. Upon infection via invading bacteria and viruses, specific antibodies are produced to target the pathogens. An antibody pathogen complex is formed and this complex interacts with its antibody receptor to be phagocytised or opsonized and is then removed from the body. IgG is one of five classes of antibodies and is the most abundant antibody found in circulation that represents over 75% of serum antibodies in the body. The IgG antibody complex can interact with cells expressing its antibody receptor inducing activation, amplification and release of pro-inflammatory cytokines that is detrimental to the body when unintended. IgG has nine receptors of which the low affinity activating receptor FcγRIIa is implicated in many autoimmune and infectious diseases. Previously within our group, based on molecular modelling of the IgG-FcγRIIa interacti...
https://epubs.rcsi.ie/phdtheses/184
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Does cognitive impairment impact adherence? A systematic review and meta-analysis of the association between cognitive impairment and medication non-adherence in stroke.
(2017)
Rohde, Daniela; Merriman, Niamh A; Doyle, Frank; Bennett, Kathleen; Williams, David; Hi...
Does cognitive impairment impact adherence? A systematic review and meta-analysis of the association between cognitive impairment and medication non-adherence in stroke.
(2017)
Rohde, Daniela; Merriman, Niamh A; Doyle, Frank; Bennett, Kathleen; Williams, David; Hickey, Anne
Abstract:
<p>The original article is available at http://journals.plos.org</p>
<p><strong>BACKGROUND</strong>: While medication adherence is essential for the secondary prevention of stroke, it is often sub-optimal, and can be compromised by cognitive impairment. This study aimed to systematically review and meta-analyse the association between cognitive impairment and medication non-adherence in stroke.</p> <p><strong>METHODS</strong>: A systematic literature search of longitudinal and cross-sectional studies of adults with any stroke type, which reported on the association between any measure of non-adherence and cognitive impairment, was carried out according to PRISMA guidelines. Odds ratios and 95% confidence intervals were the primary measure of effect. Risk of bias was assessed using the Cochrane Bias Methods Group's Tool to Assess Risk of Bias in Cohort Studies, with evidence quality assessed according to the GRADE approac...
https://epubs.rcsi.ie/psycholart/117
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Electronic health physical activity behavior change intervention to self-manage cardiovascular disease: qualitative exploration of patient and health professional requirements
(2018)
Walsh, Deirdre M.J.; Moran, Kieran A.; Cornelissen, Veronique A.; Buys, Roselien; Corne...
Electronic health physical activity behavior change intervention to self-manage cardiovascular disease: qualitative exploration of patient and health professional requirements
(2018)
Walsh, Deirdre M.J.; Moran, Kieran A.; Cornelissen, Veronique A.; Buys, Roselien; Cornelis, Nils; Woods, Catherine B.
Abstract:
Background: Cardiovascular diseases are a leading cause of premature death worldwide. International guidelines recommend routine delivery of all phases of cardiac rehabilitation. Uptake of traditional cardiac rehabilitation remains suboptimal, as attendance at formal hospital-based cardiac rehabilitation programs is low, with community-based cardiac rehabilitation rates and individual long-term exercise maintenance even lower. Home-based cardiac rehabilitation programs have been shown to be equally effective in clinical and health-related quality of life outcomes and yet are not readily available. Objective: Given the potential that home-based cardiac rehabilitation programs have, it is important to explore how to appropriately design any such intervention in conjunction with key stakeholders. The aim of this study was to engage with individuals with cardiovascular disease and other professionals within the health ecosystem to (1) understand the personal, social, and physical factor...
http://hdl.handle.net/10344/6842
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Exploring the cardiovascular disease continuum: blood pressure and target organ damage
(2016)
O'Flynn, Anne Marie
Exploring the cardiovascular disease continuum: blood pressure and target organ damage
(2016)
O'Flynn, Anne Marie
Abstract:
Introduction The objectives of this thesis are to: (1) examine how ambulatory blood pressure monitoring (ABPM) refines office blood pressure (BP) measurement; (2) determine if absolute ambulatory BP or dipping status is better associated with target organ damage (TOD); (3) explore the association of isolated nocturnal hypertension (INH) with TOD; and (4) investigate the association of night-time BP with ultrasound markers of cardiovascular damage. Methods Data from the Mitchelstown Cohort Study was analysed to deliver objectives 1 and 2. Objective 3 was addressed by a systematic review and analysis of data from the Mitchelstown Study. A sample of participants from the Mitchelstown Study underwent an echocardiogram for speckle tracking analysis and carotid ultrasound to achieve objective 4. Results ABPM reclassifies hypertension status in approximately a quarter of individuals, with white coat and masked hypertension prevalence rates of 11% and 13% respectively. Night-time systolic B...
http://hdl.handle.net/10468/3244
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Identification and characterization of novel a11bB3-integrin binding proteins in human platelets
(2012)
Alhashmi, Rand
Identification and characterization of novel a11bB3-integrin binding proteins in human platelets
(2012)
Alhashmi, Rand
Abstract:
<p>The pathological role of platelets in cardiovascular disease is well established. The major platelet cell adhesion molecule, am,(33 has been a target for research into anti-thrombotic agents. It is a cell-surface cell adhesion molecule belonging to the integrin family and it plays a critical role in platelet function. It is present on the plasma membrane of circulating platelets in an inactive or quiescent state. Following vascular injury or thrombotic triggers, it ‘activates’ by undergoing a profound change of conformation. However, little is known about the molecular mechanisms underlying this activation. Previous work has identified a regulatory sequence (KVGFFKR) within the cytoplasmic tail that controls integrin activation (Stephens et al., 1998). Subsequently a number of novel platelet cytoplasmic proteins were discovered that interact with this regulatory region. They include CIB1 (Naik et al., 1997), AUP-1 (Kato et al., 2002), PP1 (Vijayan et al., 2004), PP2A (Gushi...
https://epubs.rcsi.ie/mscrestheses/15
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Improving risk factor management for patients with poorly controlled type 2 diabetes: a systematic review of healthcare interventions in primary care and community settings.
(2017)
Murphy, Mark E; Byrne, Molly; Galvin, Rose; Boland, Fiona; Fahey, Tom; Smith, Susan M
Improving risk factor management for patients with poorly controlled type 2 diabetes: a systematic review of healthcare interventions in primary care and community settings.
(2017)
Murphy, Mark E; Byrne, Molly; Galvin, Rose; Boland, Fiona; Fahey, Tom; Smith, Susan M
Abstract:
<p>The original article is available at <a href="https://bmjopen.bmj.com/content/7/8/e015135.long">bmjopen.bmj.com</a></p>
<p><strong>OBJECTIVES:</strong> Poorly controlled type 2 diabetes mellitus (T2DM) is a major international health problem. Our aim was to assess the effectiveness of healthcare interventions, specifically targeting patients with poorly controlled T2DM, which seek to improve glycaemic control and cardiovascular risk in primary care settings.</p> <p><strong>DESIGN:</strong> Systematic review.</p> <p><strong>SETTING:</strong> Primary care and community settings.</p> <p><strong>INCLUDED STUDIES:</strong> Randomised controlled trials (RCTs) targeting patients with poor glycaemic control were identified from Pubmed, Embase, Web of Science, Cochrane Library and SCOPUS. Poor glycaemic control was defined as HbA1c over 59 mmol/mol (7.5%).</p&...
https://epubs.rcsi.ie/gpart/142
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Individual Platelet Adhesion (iPA): A novel assay of platelet function
(2014)
Lopez Alonso, Ana
Individual Platelet Adhesion (iPA): A novel assay of platelet function
(2014)
Lopez Alonso, Ana
Abstract:
<p>Cardiovascular disease is the leading cause of mortality in the developed countries and platelet related thrombosis the main complication in this condition. Anti-platelet agents are commonly used in the prevention of acute cardiovascular events. According to the American Heart Association and the American College of Cardiology (Circulation 2012), a class IIb recommendation is given for the use of platelet function test. This approach has been implemented in several clinical trials in order to improve outcomes in cardiovascular patients [1]. There are a number of platelet function tests available for clinical use but there is a lack of correlation between the different tests and none of them are routinely used to assess anti-platelet therapy effect. We report a rapid and accurate methodology to quantify platelet-protein interactions termed <em>iPA</em>. This novel technique contains a micro-array of 6-μm fibrinogen dots which can capture platelets from whole bloo...
https://epubs.rcsi.ie/phdtheses/121
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Novel markers of plaque rupture in patients with chest pain
(2017)
Bajrangee, Amrit
Novel markers of plaque rupture in patients with chest pain
(2017)
Bajrangee, Amrit
Abstract:
<p>Chest pain presentations to the accident and emergency department account for approximately 20% of admissions. Determining those patients at high risk of plaque rupture the squeal of which is ischemia and myocardial necrosis continues to be clinically challenging. Current clinical pathways identify those who have undergone plaque rupture utilizing cardiac troponins and electrocardiogram changes but this confirms plaque rupture after myocardial injury.</p> <p>We previously identified a number of proteins in an Apolipoprotien B mouse model that were present at significantly higher or lower levels in the serum prior to plaque rupture and thus were predictive of a higher risk of plaque rupture in mice. None of these proteins had been identified in plaque rupture previously.</p> <p>My MD thesis evaluated the clinical utility of these markers in an unselected cohort of 203 patients presenting with chest pain to either the accident and emergency department ...
https://epubs.rcsi.ie/mdtheses/85
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Optimising implementation of European guidelines on cardiovascular disease prevention in clinical practice: what is needed?
(2020)
Mc Kee, Gabrielle; Graham, Ian
Optimising implementation of European guidelines on cardiovascular disease prevention in clinical practice: what is needed?
(2020)
Mc Kee, Gabrielle; Graham, Ian
Abstract:
Cardiovascular disease is a model example of a preventable condition for which practice guidelines are particularly important. In 2016, the joint task force created by the European Society of Cardiology (ESC) together with 10 other societies released the new version of the European guidelines on cardiovascular disease prevention. To facilitate the implementation of the ESC guidelines, a dedicated prevention implementation committee has been established within the European Association of Preventive Cardiology. The paper will first explore potential barriers to the guidelines? implementation. It then develops a discussion that seeks to inform the future development of the committee?s work, including a new definition of the guidelines? stakeholders (health policy-makers, healthcare professionals and health educators, patient organisations, entrepreneurs and the general public), future activities within four specific areas: strengthening awareness of the guidelines among stakeholders; s...
http://hdl.handle.net/2262/94651
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Participants’ experiences of a sexual counseling intervention during cardiac rehabilitation: A nested qualitative study within the CHARMS pilot randomized controlled trial
(2019)
D’Eath, Maureen; Byrne, Molly; Murphy, Patrick; Jaarsma, Tiny; McSharry, Jenny; Casey, ...
Participants’ experiences of a sexual counseling intervention during cardiac rehabilitation: A nested qualitative study within the CHARMS pilot randomized controlled trial
(2019)
D’Eath, Maureen; Byrne, Molly; Murphy, Patrick; Jaarsma, Tiny; McSharry, Jenny; Casey, Dympna; Murphy, Andrew W.; Doherty, Sally; Noone, Chris
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BACKGROUND: International guidelines recommend sexual assessment and counseling be offered to all patients with cardiovascular disease during cardiac rehabilitation. However, sexual problems are infrequently addressed. The Cardiac Health and Relationship Management and Sexuality (CHARMS) intervention is a complex, multilevel intervention designed to increase the provision of sexual counseling in cardiac rehabilitation. It was piloted in 2 cardiac rehabilitation centers to assess the acceptability and feasibility of the intervention and to inform and refine a definitive cluster randomized controlled trial protocol. OBJECTIVES: The aim of this study was to explore the experiences, perceptions, and opinions of patients, partners, and cardiac rehabilitation staff who participated in the CHARMS staff-led patient education class. METHODS: A qualitative, descriptive study using semistructured interviews to collect the data. Cardiac rehabilitation staff (n = 8) were interviewed when the i...
http://hdl.handle.net/10379/15187
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PATHway I: Design and rationale for the investigation of the feasibility, clinical effectiveness and cost-effectiveness of a technology enabled cardiac rehabilitation platform.
(2017)
Claes, Jomme; Buys, Roselien; Woods, Catherine B.; Briggs, Andrew; Geue, Claudia; Aitke...
PATHway I: Design and rationale for the investigation of the feasibility, clinical effectiveness and cost-effectiveness of a technology enabled cardiac rehabilitation platform.
(2017)
Claes, Jomme; Buys, Roselien; Woods, Catherine B.; Briggs, Andrew; Geue, Claudia; Aitken, Moira; Moyna, Niall M.; Moran, Kieran A.; McCaffery, Noel; Chouvarda, Ioanna; Walsh, Deirdre M.J.; Budts, Werner; Filos, Dimitris; Triantafyllidis, Andreas; Maglaveras, Nicos; Cornelissen, Veronique A.
Abstract:
Introduction Exercise-based cardiac rehabilitation (CR) independently alters the clinical course of cardiovascular diseases resulting in a significant reduction in all-cause and cardiac mortality. However, only 15%–30% of all eligible patients participate in a phase 2 ambulatory programme. The uptake rate of community-based programmes following phase 2 CR and adherence to long-term exercise is extremely poor. Newer care models, involving telerehabilitation programmes that are delivered remotely, show considerable promise for increasing adherence. In this view, the PATHway (Physical Activity Towards Health) platform was developed and now needs to be evaluated in terms of its feasibility and clinical efficacy. Methods and analysis In a multicentre randomised controlled pilot trial, 120 participants (m/f, age 40– 80 years) completing a phase 2 ambulatory CR programme will be randomised on a 1:1 basis to PATHway or usual care. PATHway involves a comprehensive, internetenabled, sensor-ba...
http://hdl.handle.net/10344/5884
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Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians.
(2005)
Dolan, Ciara; Shields, Denis C; Stanton, Alice; O'Brien, Eoin; Lambert, Deborah M;...
Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians.
(2005)
Dolan, Ciara; Shields, Denis C; Stanton, Alice; O'Brien, Eoin; Lambert, Deborah M; O'Brien, John K; Treacy, Eileen P
Abstract:
<p>The original article is available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND: The recessive disorder trimethylaminuria is caused by defects in the FMO3 gene, and may be associated with hypertension. We investigated whether common polymorphisms of the FMO3 gene confer an increased risk for elevated blood pressure and/or essential hypertension.</p> <p>METHODS: FMO3 genotypes (E158K, V257M, E308G) were determined in 387 healthy subjects with ambulatory systolic and diastolic blood pressure measurements, and in a cardiovascular disease population of 1649 individuals, 691(41.9%) of whom had a history of hypertension requiring drug treatment. Haplotypes were determined and their distribution noted.</p> <p>RESULTS: There was no statistically significant association found between any of the 4 common haplotypes and daytime systolic blood pressure in the healthy population (p = 0....
https://epubs.rcsi.ie/mctart/65
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Predicted 10-year risk of cardiovascular mortality in the 40 to 69 year old general population without cardiovascular diseases in Germany
(2018)
Diederichs, Claudia; Neuhauser, Hannelore; Rücker, Viktoria; Busch, Markus A.; Keil, Ul...
Predicted 10-year risk of cardiovascular mortality in the 40 to 69 year old general population without cardiovascular diseases in Germany
(2018)
Diederichs, Claudia; Neuhauser, Hannelore; Rücker, Viktoria; Busch, Markus A.; Keil, Ulrich; Fitzgerald, Anthony P.; Heuschmann, Peter U.
Abstract:
Aims To estimate the 10-year risk of fatal cardiovascular disease (CVD) in the 40 to 69 year old general population in Germany stratified by sex and to analyze differences between socio-economic status (SES), region and community size in individuals without CVD. The analysis is based on the newly recalibrated SCORE Deutschland risk charts and considered other comorbidities for the classification of the high CVD risk group according to the guidelines of the European Society of Cardiology. Methods and results In 3,498 participants (40–69 years) from the German Health Examination Survey for Adults 2008–2011 (DEGS1) without a history of CVD (myocardial infarction, coronary heart disease, heart failure, stroke) we estimated the proportion with a low (SCORE <1%), moderate (SCORE 1-<5%) and high 10-year CVD mortality risk (SCORE ≥5% or diabetes, renal insufficiency, SBP/DPB ≥180/110 mmHg or cholesterol >8 mmol/l). The prevalence of low, moderate and high risk was 42.8%, 38.5% and ...
http://hdl.handle.net/10468/5488
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Preeclampsia and cardiovascular disease in a large UK pregnancy cohort of linked electronic health records: a CALIBER study
(2019)
Leon, Lydia J.; McCarthy, Fergus P.; Direk, Kenan; Gonzalez-Izquierdo, Arturo; Prieto-M...
Preeclampsia and cardiovascular disease in a large UK pregnancy cohort of linked electronic health records: a CALIBER study
(2019)
Leon, Lydia J.; McCarthy, Fergus P.; Direk, Kenan; Gonzalez-Izquierdo, Arturo; Prieto-Merino, David; Casas, Juan P.; Chappell, Lucy
Abstract:
Background: The associations between pregnancy hypertensive disorders and common cardiovascular disorders have not been investigated at scale in a contemporaneous population. We aimed to investigate the association between preeclampsia, hypertensive disorders of pregnancy, and subsequent diagnosis of 12 different cardiovascular disorders. Methods: We used linked electronic health records from 1997 to 2016 to recreate a UK population-based cohort of 1.3 million women, mean age at delivery 28 years, with nearly 1.9 million completed pregnancies. We used multivariable Cox models to determine the associations between hypertensive disorders of pregnancy, and preeclampsia alone (term and preterm), with 12 cardiovascular disorders in addition to chronic hypertension. We estimated the cumulative incidence of a composite end point of any cardiovascular disorder according to preeclampsia exposure. Results: During the 20-year study period, 18 624 incident cardiovascular disorders were observed...
http://hdl.handle.net/10468/8793
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Quality of Life and Functional Capacity following Peripheral Arterial Disease Exercise Programme
(2010)
Guidon, Marie; McGee, Hannah; Kelly, Cathal
Quality of Life and Functional Capacity following Peripheral Arterial Disease Exercise Programme
(2010)
Guidon, Marie; McGee, Hannah; Kelly, Cathal
Abstract:
<p>Peripheral arterial disease (PAD) is a manifestation of generalised atherosclerotic disease in which the arterial lumen becomes progressively narrowed by atherosclerotic plaques. This results in reduced blood flow to the tissues causing pain on exercise, relieved by rest (Intermittent Claudication [IC]). As PAD is a chronic, progressive disease with a significant cardiovascular and cerebrovascular risk burden it has a considerable impact on functional capacity and quality of life (QOL). Current evidence suggests that 27 million people in Europe and North America have PAD1. The main aim of treatment is maintenance or improvement in quality of life by eliminating ischaemic symptoms and preventing progression to vascular occlusion. The use of patient-based measures of treatment effect including functional capacity and disease-specific quality of life questionnaires has been recommended.</p>
https://epubs.rcsi.ie/sphysioproc/2
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Recruitment to Exercise Programmes: Challenges in the Peripheral Arterial Disease Population
(2008)
Guidon, Marie; Chavira, Melissa; McGee, Hannah; Sheahan, Ricky; Kelly, Cathal
Recruitment to Exercise Programmes: Challenges in the Peripheral Arterial Disease Population
(2008)
Guidon, Marie; Chavira, Melissa; McGee, Hannah; Sheahan, Ricky; Kelly, Cathal
Abstract:
<p>Current evidence suggests that 27 million people in Europe and North America have peripheral arterial disease (PAD). Although only 3% of patients with intermittent claudication (IC) require amputation, a significant number will require hospital admission and other surgical intervention for IC and associated cardiac and cerebrovascular complications. An important aim of exercise therapy in the peripheral arterial disease population is to decrease cardiovascular risk factors and consequent morbidity and mortality. Several studies have demonstrated that exercise programmes result in significant improvements in walking distances but the long-term benefits are unknown. A randomised controlled trial is currently being conducted in Beaumont Hospital to determine the effects of a supervised exercise programme on quality of life, risk factor modification and morbidity and mortality in patients with PAD.</p>
https://epubs.rcsi.ie/sphysioproc/1
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