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A chromatin-independent role of polycomb-like 1 to stabilize p53 and promote cellular quiescence (2018)

Brien, Gerard L.; Healy, Evan; Jerman, Emilia; Conway, Eric; Fadda, Elisa; O'Donov...

A chromatin-independent role of polycomb-like 1 to stabilize p53 and promote cellular quiescence (2018)

Brien, Gerard L.; Healy, Evan; Jerman, Emilia; Conway, Eric; Fadda, Elisa; O'Donovan, Darragh; Krivtsov, Andrei V.; Rice, Alan M.; Kearney, Conor J.; Flaus, Andrew; McDade, Simon S.; Martin, Seamus J.; McLysaght, Aoife; O'Connell, David J.; Armstrong, Scott A.; Bracken, Adrian P.

Abstract:

Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such apparent functional redundancy exist in mammals. Here we characterize their divergent roles in both positively and negatively regulating cellular proliferation. We show that while PCL2 and PCL3 are E2F-regulated genes expressed in proliferating cells, PCL1 is a p53 target gene predominantly expressed in quiescent cells. Ectopic expression of any PCL protein recruits PRC2 to repress the INK4A gene; however, only PCL2 and PCL3 confer an INK4A-dependent proliferative advantage. Remarkably, PCL1 has evolved a PRC2- and chromatin-independent function to negatively regulate proliferation. We show that PCL1 binds to and stabilizes p53 to induce cellular quiescence. Moreover, depletion of PCL1 phenocopies the defects in maintaining cellular quiescence associa...

Full-text link

http://hdl.handle.net/10379/10538

NUI Galway

Journal article

unknown

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A F-bridged Mn(II) molecular square (2013)

Meally, Sean T.; McArdle, Patrick; Ryder, Alan G.; Jones, Leigh F.

NUI Galway

Journal article

peer-reviewed

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Alternating bimetallic Na/Mn covalent and ionic chains (2013)

Berg, Nelly; Jones, Leigh F.

NUI Galway

Journal article

peer-reviewed

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Cationic and PEGylated amphiphilic cyclodextrins: co-formulation opportunities for neuronal siRNA delivery (2013)

O'Mahony, Aoife M.; Ogier, Julien R.; Darcy, Raphael; Cryan, John F.; O'Drisc...

University College Cork

Journal article

peer-reviewed

Science Foundation Ireland

Irish Research Council for Science Engineering and Technology

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Cocrystals of fenamic acids with nicotinamide (2011)

Fábián, László; Hamill, Noel; Eccles, Kevin S.; Moynihan, Humphrey A.; Maguire, Anita R...

University College Cork

Journal article

peer-reviewed

Science Foundation Ireland

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Comprehensive definition of oxidation state (iupac recommendations 2016) (2018)

Karen, Pavel; McArdle, Patrick; Takats, Josef

NUI Galway

Journal article

unknown

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Computational homology of &lt;mml:math altimg=&quot;si1.gif&quot; display=&quot;inline&quot; overflow=&quot;scroll&quot; xmlns:xocs=&quot;http://www.elsevier.com/xml/xocs/dtd&quot; xmlns:xs=&quot;http://www.w3.org/2001/xmlschema&quot; xmlns:xsi=&quot;http://www.w3.org/2001/xmlschema-instance&quot; xmlns=&quot;http://www.elsevier.com/xml/ja/dtd&quot; xmlns:ja=&quot;http://www.elsevier.com/xml/ja/dtd&quot; xmlns:mml=&quot;http://www.w3.org/1998/math/mathml&quot; xmlns:tb=&quot;http://www.elsevier.com/xml/common/table/dtd&quot; xmlns:sb=&quot;http://www.elsevier.com/xml/common/struct-bib/dtd&quot; xmlns:ce=&quot;http://www.elsevier.com/xml/common/dtd&quot; xmlns:xlink=&quot;http://www.w3.org/1999/xlink&quot; xmlns:cals=&quot;http://www.elsevier.com/xml/common/cals/dtd&quot;&gt;&lt;mml:mi&gt;n&lt;/mml:mi&gt;&lt;/mml:math&gt;-types (2018)

Ellis, Graham; Luyen, Le Van

NUI Galway

Journal article

unknown

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Decoherence-assisted energy transfer and quantum criticalities (2012)

Giorgi, Gian Luca; Busch, Thomas

University College Cork

Journal article

peer-reviewed

Science Foundation Ireland

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Dna repair: the importance of phosphorylating histone h2ax (2018)

Lowndes, Noel F.; Toh, Geraldine W.-L.

NUI Galway

Journal article

unknown

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Early Medieval Dwellings and Settlements in Ireland, AD 400-1100: Vol. 1 Text. (2019)

O'Sullivan, Aidan; McCormick, Finbar; Harney, Lorcan; et al.

University College Dublin

Other

unknown

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Early-stage development of novel cyclodextrin-sirna nanocomplexes allows for successful postnebulization transfection of bronchial epithelial cells (2018)

Hibbitts, A.; O'Mahony, A.M.; Forde, E.; Nolan, L.; Ogier, J.; Desgranges, S.; Dar...

NUI Galway

Journal article

unknown

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Enhanced electrochemiluminescence and charge transport through films of metallopolymer-gold nanoparticle composites (2010)

Devadoss, A.; Spehar-Déleze, A.M.; Tanner, David A.; Bertoncello, P.; Marthi, R.; Keyes...

University of Limerick

Journal article

peer-reviewed

Science Foundation Ireland

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Ferromagnetic exchange in a twisted, oxime-bridged [mniii2] dimer (2018)

Houton, Edel; Taylor, Stephanie M.; Beedle, Christopher C.; Cano, Joan; Piligkos, Sterg...

NUI Galway

Journal article

unknown

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First principles static and dynamic calculations for the transition metal hydride series MH4L3 (M = Fe, Ru and Os; L = NH3, PH3 and PF3) (2015)

Sieffert, Nicolas; Kendrick, Thomas; Tiana, Davide; Morrison, Carole A.

University College Cork

Journal article

peer-reviewed

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Homo- and heterometallic planes, chains and cubanes (2018)

Meally, Seán T.; Taylor, Stephanie M.; Brechin, Euan K.; Piligkos, Stergios; Jones, Lei...

NUI Galway

Journal article

unknown

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Investigating the solid state hosting abilities of homo- and hetero-valent [Co-7] metallocalix[6]arenes (2013)

Meally, Sean T.; McDonald, Cecelia; Kealy, Patrick; Jones, Leigh F.

NUI Galway

Journal article

peer-reviewed

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Investigation of additive effects in enantioselective copper-catalysed C-H insertion and aromatic addition reactions of α-diazocarbonyl compounds (2012)

Slattery, Catherine N.; Clarke, Leslie-Ann; O'Neill, Shane T.; Ring, Aoife; Ford, ...

University College Cork

Journal article

peer-reviewed

Irish Research Council for Science Engineering and Technology

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Magnetism in metal–organic capsules (2018)

Atwood, Jerry L.; Brechin, Euan K.; Dalgarno, Scott J.; Inglis, Ross; Jones, Leigh F.; ...

NUI Galway

Journal article

unknown

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Molecular pac-man and tacos: layered cu(ii) cages from ligands with high binding site concentrations (2018)

McDonald, Cecelia; Williams, David W.; Comar, Priyanka; Coles, Simon J.; Keene, Tony D....

NUI Galway

Journal article

unknown

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Morse theory from an algebraic viewpoint (2018)

Sköldberg, Emil

NUI Galway

Journal article

unknown

Mark

Pathways of superoxide (o2–) decay in the eastern tropical north atlantic (2018)

Wuttig, Kathrin; Heller, Maija I.; Croot, Peter L.

NUI Galway

Journal article

unknown

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Physical and functional modularity of the protein network in yeast (2018)

Wilhelm, Thomas; Nasheuer, Heinz-Peter; Huang, Sui

NUI Galway

Journal article

unknown

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Planar [Ni-7] discs as double-bowl, pseudo metallacalix[6]arene host cavities (2013)

Meally, Sean T.; Dunne, Peter W.; McArdle, Patrick; Jones, Leigh F.

NUI Galway

Journal article

peer-reviewed

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Progressive decoration of pentanuclear cu(ii) 12-metallacrown-4 nodes towards targeted 1- and 2d extended networks (2018)

McDonald, Cecelia; Whyte, Teresa; Taylor, Stephanie M.; Sanz, Sergio; Brechin, Euan K.;...

NUI Galway

Journal article

unknown

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Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome (2018)

Nedjai, Belinda; Hitman, Graham A.; Quillinan, Niamh; Coughlan, Robert J.; Church, Leig...

NUI Galway

Journal article

unknown

Displaying Results 1 - 25 of 30 on page 1 of 2

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