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2-(3-Chlorophenyl)-1-ferrocenylmethyl-1H-1,3-benzimidazole: an electroactive agent for anion sensor and malarial parasite studies (2001)

Gallagher, John F.; Hanlon, Keith; Howarth, Joshua; Thomas, Jean-Luc

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A methylcellulose and collagen based temperature responsive hydrogel promotes encapsulated stem cell viability and proliferation in vitro (2018)

Payne, Christina; Dolan, Eimear B.; O’Sullivan, Janice; Cryan, Sally-Ann; Kelly, Helena M.

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A narrative exploration into the experiences of mothers living with HIV in Ireland. (2014)

Proudfoot, Denise

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A remote access CT colonography training system (2007)

Luauté, Vincent

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A study of symptom profile and clinical subtypes of delirium (2012)

Meagher, David

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Acoustic radiation force impulse imaging for aneurysms (2009)

Tierney, Áine P.; Dumont, Douglas; Callanan, Anthony; McGloughlin, Timothy M.

Irish Research Council for Science Engineering and Technology

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Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase i dose-escalation trial (2018)

Pers, Yves-Marie; Rackwitz, Lars; Ferreira, Rosanna; Pullig, Oliver; Delfour, Christoph...

Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase i dose-escalation trial (2018)

Pers, Yves-Marie; Rackwitz, Lars; Ferreira, Rosanna; Pullig, Oliver; Delfour, Christophe; Barry, Frank; Sensebe, Luc; Casteilla, Louis; Fleury, Sandrine; Bourin, Philippe; Noël, Danièle; Canovas, François; Cyteval, Catherine; Lisignoli, Gina; Schrauth, Joachim; Haddad, Daniel; Domergue, Sophie; Noeth, Ulrich; Jorgensen, Christian; ,

Abstract:

Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study aimed at evaluating the safety of a dose-escalation protocol of intra-articular injected adipose-derived stromal cells (ASCs) in patients with knee OA, as well as clinical efficacy as secondary endpoint. A bicentric, uncontrolled, open phase I clinical trial was conducted in France and Germany with regulatory agency approval for ASC expansion procedure in both countries. From April 2012 to December 2013, 18 consecutive patients with symptomatic and severe knee OA were treated with a single intra-articular injection of autologous ASCs. The study design consisted of three consecutive cohorts (six patients each) with dose escalation: low dose (2 x 10(6) cells), medium dose (10 x 10(6)), and high dose (50 x 10(6)). The primary outcome parameter was safety evaluated by...

http://hdl.handle.net/10379/13455

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Adolescents' embodied experiences of living with chronic kidney disease (2020)

O Neill, Colleen

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An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica. (2020)

Smith, David; Cwiklinski, Krystyna; Jewhurst, Heather; Tikhonova, Irina G.; Dalton, Joh...

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Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer - synthesis, physicochemical characterisation and in vitro evaluation (2016)

Fitzgerald, Kathleen A.; Rahme, Kamil; Guo, Jianfeng; Holmes, Justin D.; O'Driscol...

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Ap1s3 mutations cause skin autoinflammation by disrupting keratinocyte autophagy and up-regulating il-36 production (2018)

Mahil, Satveer K.; Twelves, Sophie; Farkas, Katalin; Setta-Kaffetzi, Niovi; Burden, A. ...

Ap1s3 mutations cause skin autoinflammation by disrupting keratinocyte autophagy and up-regulating il-36 production (2018)

Mahil, Satveer K.; Twelves, Sophie; Farkas, Katalin; Setta-Kaffetzi, Niovi; Burden, A. David; Gach, Joanna E.; Irvine, Alan D.; Képíró, László; Mockenhaupt, Maja; Oon, Hazel H.; Pinner, Jason; Ranki, Annamari; Seyger, Marieke M.B.; Soler-Palacin, Pere; Storan, Eoin R.; Tan, Eugene S.; Valeyrie-Allanore, Laurence; Young, Helen S.; Trembath, Richard C.; Choon, Siew-Eng

Abstract:

Prominent skin involvement is a defining characteristic of autoinflammatory disorders caused by abnormal IL-1 signaling. However, the pathways and cell types that drive cutaneous autoinflammatory features remain poorly understood. We sought to address this issue by investigating the pathogenesis of pustular psoriasis, a model of autoinflammatory disorders with predominant cutaneous manifestations. We specifically characterized the impact of mutations affecting AP1S3, a disease gene previously identified by our group and validated here in a newly ascertained patient resource. We first showed that AP1S3 expression is distinctively elevated in keratinocytes. Because AP1S3 encodes a protein implicated in autophagosome formation, we next investigated the effects of gene silencing on this pathway. We found that AP1S3 knockout disrupts keratinocyte autophagy, causing abnormal accumulation of p62, an adaptor protein mediating NF-kappa B activation. We showed that as a consequence, AP1S3-def...

http://hdl.handle.net/10379/12592

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Applications of fluorescent biosensors for non-invasive glucose monitoring (2016)

Bruen, Danielle; Delaney, Colm; Florea, Larisa; Diamond, Dermot

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Automated on-disc total RNA extraction from whole blood towards point-of-care for early-stage diagnostics (2013)

Dimov, Nikolay; Gaughran, Jennifer; Clancy, Eoin; Barry, Thomas; Smith, J. Terry; Ducré...

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Book review: South Africa pushed to the limit by Hein Marais (2011)

Sheehan, Helena

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Boronic acid derivatives for sugar sensing (2015)

Bruen, Danielle; Florea, Larisa; Diamond, Dermot

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Brain injury in the international multicenter randomized SafeBoosC phase II feasibility trial: cranial ultrasound and magnetic resonance imaging assessments (2016)

Plomgaard, Anne M.; Hagmann, Cornelia; Alderliesten, Thomas; Austin, Topun; van Bel, Fr...

Brain injury in the international multicenter randomized SafeBoosC phase II feasibility trial: cranial ultrasound and magnetic resonance imaging assessments (2016)

Plomgaard, Anne M.; Hagmann, Cornelia; Alderliesten, Thomas; Austin, Topun; van Bel, Frank; Claris, Olivier; Dempsey, Eugene M.; Franz, Axel; Fumagalli, Monica; Gluud, Christian; Greisen, Gorm; Hyttel-Sorensen, Simon; Lemmers, Petra; Pellicer, Adelina; Pichler, Gerhard; Benders, Manon

Abstract:

BACKGROUND: Abnormal cerebral perfusion during the first days of life in preterm infants is associated with higher grades of intraventricular hemorrhages and lower developmental score. In SafeBoosC II, we obtained a significant reduction of cerebral hypoxia by monitoring cerebral oxygenation in combination with a treatment guideline. Here, we describe (i) difference in brain injury between groups, (ii) feasibility of serial cranial ultrasound (cUS) and magnetic resonance imaging (MRI), (iii) local and central cUS assessment. METHODS: Hundred and sixty-six extremely preterm infants were included. cUS was scheduled for day 1, 4, 7, 14, and 35 and at term-equivalent age (TEA). cUS was assessed locally (unblinded) and centrally (blinded). MRI at TEA was assessed centrally (blinded). Brain injury classification: no, mild/moderate, or severe. RESULTS: Severe brain injury did not differ significantly between groups: cUS (experimental 10/80, control 18/77, P = 0.32) and MRI (5/46 vs. 3/38, ...

http://hdl.handle.net/10468/4599