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Displaying Results 1 - 25 of 230 on page 1 of 10
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‘Melusina after the scream’: Surrealism and the Hybrid Bodies of Leonora Carrington and Remedios Varo
(2019)
Plunkett, Tara
‘Melusina after the scream’: Surrealism and the Hybrid Bodies of Leonora Carrington and Remedios Varo
(2019)
Plunkett, Tara
Abstract:
In his 1944 text, Arcane 17, the Surrealism-founder, André Breton advocated increased political power for women, and yet invoked the hybrid body of the femme-enfant, Melusina as the image through which to articulate his vision. This paper discusses the hybridisation of the female form in Surrealist images and texts by Leonora Carrington and Remedios Varo, to question the role of the female hybrid body within Surrealism. Deliberately transgressive, visceral depictions of beastly hybrids are contrasted with harmonious visions of metamorphosis, to show how the gendering of hybrid bodies as female relates to the artists’ esoteric and exoteric depictions of human subjectivity.
http://hdl.handle.net/10197/10484
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"Pee-in-a-Pot": acceptability and uptake of on-site chlamydia screening in a student population in the Republic of Ireland
(2010)
Vaughan, Deirdre; O'Connell, Emer; Cormican, Martin; Brugha, Ruairi; Faherty, Cole...
"Pee-in-a-Pot": acceptability and uptake of on-site chlamydia screening in a student population in the Republic of Ireland
(2010)
Vaughan, Deirdre; O'Connell, Emer; Cormican, Martin; Brugha, Ruairi; Faherty, Colette; Balfe, Myles; O'Donovan, Diarmuid
Abstract:
<p>The original publication is available from http://www.biomedcentral.com</p>
<p>Background: The aim of the study was to explore the acceptability and uptake of on-campus screening using a youth friendly approach in two Third Level higher education institutions (HEIs). This study is part of wider research exploring the optimal setting for chlamydia screening in Ireland. Methods: Male and female students were given the opportunity to take a free anonymous test for chlamydia during a one week programme of "pee-in-a-pot" days at two HEI campuses in the West of Ireland. The study was set up after extensive consultation with the two HEIs and advertised on the two campuses using a variety of media in the two weeks preceding the screening days. Screening involved the provision and distribution of testing packs at communal areas and in toilet facilities. In Ireland, chlamydia notifications are highest amongst 20-29 year olds and hence the screening criterion...
https://epubs.rcsi.ie/ephmart/9
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A comparison of performances of consultant surgeons, NCHDs and medical students in a modified HPAT examination.
(2010)
Quinn, Alison; Corrigan, Mark A; Broderick, J; McEntee, G; Hill, Arnold DK
A comparison of performances of consultant surgeons, NCHDs and medical students in a modified HPAT examination.
(2010)
Quinn, Alison; Corrigan, Mark A; Broderick, J; McEntee, G; Hill, Arnold DK
Abstract:
<p>The original article is avaliable at <a href="http://www.imj.ie">www.imj.ie</a></p>
<p>Following the implementation of the Fottrell report, entry to medical school in Ireland has undergone significant change. Medical school studentship is now awarded based on a combination of points obtained from the final examination of Irish secondary schools (the leaving certificate) combined with HPAT scores (Health Professions Admissions Test). The HPAT is designed to test a candidate's knowledge in several different fields including problem solving skills, logical and non verbal reasoning. A sample HPAT was administered to a test group composed of consultant surgeons, non consultant hospital doctors, and medical students. Statistical analysis was performed and no significant difference was found between the performances of the groups. This is surprising as it was expected that groups with greater experience at medical problem solving would ha...
https://epubs.rcsi.ie/surgart/18
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A method to assess adherence in inhaler use through analysis of acoustic recordings of inhaler events.
(2014)
D'Arcy, Shona; MacHale, Elaine; Seheult, Jansen; Holmes, Martin S; Hughes, Cian; S...
A method to assess adherence in inhaler use through analysis of acoustic recordings of inhaler events.
(2014)
D'Arcy, Shona; MacHale, Elaine; Seheult, Jansen; Holmes, Martin S; Hughes, Cian; Sulaiman, Imran; Hyland, Deirdre; O'Reilly, Conor; Glynn, Senan; Al-Zaabi, Thekra; McCourt, John; Taylor, Terence; Keane, Frank; Killane, Isabelle; Reilly, Richard B; Costello, Richard W
Abstract:
<p>The original article is available at http://journals.plos.org/plosone</p>
<p>RATIONALE: Poor adherence to inhaler use can be due to poor temporal and/or technique adherence. Up until now there has been no way of reliably tracking both these factors in everyday inhaler use.</p> <p>OBJECTIVES: This paper introduces a device developed to create time stamped acoustic recordings of an individual's inhaler use, in which empirical evidence of temporal and technique adherence in inhaler use can be monitored over time. The correlation between clinical outcomes and adherence, as determined by this device, was compared for temporal adherence alone and combined temporal and technique adherence.</p> <p>FINDINGS: The technology was validated by showing that the doses taken matched the number of audio recordings (r2 = 0.94, p20% of their inhaler events. Repeated training reduced this to 7% of participants (p = 0.03). When time of use was consid...
https://epubs.rcsi.ie/medart/75
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A multi-country outbreak of Salmonella Newport gastroenteritis in Europe associated with watermelon from Brazil, confirmed by whole genome sequencing: October 2011 to January 2012.
(2014)
Byrne, Lisa; Fisher, Ian; Peters, Tansy; Mather, Alison; Thomson, Nicholas; Rosner, Bet...
A multi-country outbreak of Salmonella Newport gastroenteritis in Europe associated with watermelon from Brazil, confirmed by whole genome sequencing: October 2011 to January 2012.
(2014)
Byrne, Lisa; Fisher, Ian; Peters, Tansy; Mather, Alison; Thomson, Nicholas; Rosner, Bettina; Bernard, Helen; McKeown, Paul; Cormican, Martin; Cowden, John; Aiyedun, V; Lane, Chris; International Outbreak Control Team
Abstract:
<p>The original article is available at <a href="http://www.eurosurveillance.org">http://www.eurosurveillance.org</a></p>
<p>In November 2011, the presence of Salmonella Newport in a ready-to-eat watermelon slice was confirmed as part of a local food survey in England. In late December 2011, cases of S. Newport were reported in England, Wales, Northern Ireland, Scotland, Ireland and Germany. During the outbreak, 63 confirmed cases of S. Newport were reported across all six countries with isolates indistinguishable by pulsed-field gel electrophoresis from the watermelon isolate.A subset of outbreak isolates were whole-genome sequenced and were identical to, or one single nucleotide polymorphism different from the watermelon isolate.In total, 46 confirmed cases were interviewed of which 27 reported watermelon consumption. Further investigations confirmed the outbreak was linked to the consumption of watermelon imported from Brazil.Although n...
https://epubs.rcsi.ie/ephmart/51
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A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44.
(2014)
Babina, Irina S; McSherry, Elaine A; Donatello, Simona; Hill, Arnold DK; Hopkins, Ann M
A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44.
(2014)
Babina, Irina S; McSherry, Elaine A; Donatello, Simona; Hill, Arnold DK; Hopkins, Ann M
Abstract:
<p>The original article is available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>INTRODUCTION: Most breast cancer-related deaths result from metastasis, a process involving dynamic regulation of tumour cell adhesion and migration. The adhesion protein CD44, a key regulator of cell migration, is enriched in cholesterol-enriched membrane microdomains termed lipid rafts. We recently reported that raft affiliation of CD44 negatively regulates interactions with its migratory binding partner ezrin. Since raft affiliation is regulated by post-translational modifications including palmitoylation, we sought to establish the contribution of CD44 palmitoylation and lipid raft affiliation to cell migration.</p> <p>METHODS: Recovery of CD44 and its binding partners from raft versus non-raft membrane microdomains was profiled in non-migrating and migrating breast cancer cell lines. Site-directed mutagenesis was...
https://epubs.rcsi.ie/surgart/21
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A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.
(2012)
Reeves, Emer P; Bergin, David A; Fitzgerald, Sean; Hayes, Elaine; Keenan, Joanne; Henry...
A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis.
(2012)
Reeves, Emer P; Bergin, David A; Fitzgerald, Sean; Hayes, Elaine; Keenan, Joanne; Henry, Michael; Meleady, Paula; Vega-Carrascal, Isabel; Murray, Michelle A; Low, Teck Boon; McCarthy, Cormac; O'Brien, Emmet; Clynes, Martin; Gunaratnam, Cedric; McElvaney, Noel G
Abstract:
<p>The original article is available from Elsevier at <a href="http://www.sciencedirect.com/science/article/pii/S156919931100172X" target="_blank" title="http://www.sciencedirect.com/science/article/pii/S156919931100172X">http://www.sciencedirect.com/science</a></p>
<p><strong>BACKGROUND:</strong> The focus of this study was to characterize a novel biomarker for cystic fibrosis (CF) that could reflect exacerbations of the disease and could be useful for therapeutic stratification of patients, or for testing of potential drug treatments. This study focused exclusively on a protein complex containing alpha-1 antitrypsin and CD16b (AAT:CD16b) which is released into the bloodstream from membranes of pro-inflammatory primed neutrophils.</p> <p><strong>METHODS:</strong> Neutrophil membrane expression and extracellular levels of AAT and CD16b were quantified by flow cytometry, Western blot a...
https://epubs.rcsi.ie/medart/49
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A novel statistical method for assessing effective adherence to medication and calculating optimal drug dosages.
(2018)
Greene, Garrett; Costello, Richard W; Cushen, Breda; Sulaiman, Imran; MacHale, Elaine; ...
A novel statistical method for assessing effective adherence to medication and calculating optimal drug dosages.
(2018)
Greene, Garrett; Costello, Richard W; Cushen, Breda; Sulaiman, Imran; MacHale, Elaine; Conroy, Ronan M, Professor; Doyle, Frank
Abstract:
<p>The original article is available at <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195663">https://journals.plos.org</a></p>
<p><strong>OBJECTIVE:</strong> We derive a novel model-based metric for effective adherence to medication, and validate it using data from the INhaler Compliance Assessment device (INCATM). This technique employs dose timing data to estimate the threshold drug concentration needed to maintain optimal health.</p> <p><strong>METHODS:</strong> The parameters of the model are optimised against patient outcome data using maximum likelihood methods. The model is fitted and validated by secondary analysis of two independent datasets from two remote-monitoring studies of adherence, conducted through clinical research centres of 5 Irish hospitals. Training data came from a cohort of asthma patients (~ 47,000 samples from 218 patients). Validation data is fro...
https://epubs.rcsi.ie/medart/106
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A pilot cross-sectional study of patients presenting with cellulitis to emergency departments.
(2014)
Quirke, Michael; Saunders, Jean; O'Sullivan, Ronald; Milenkovski, Hristijan; Wakai...
A pilot cross-sectional study of patients presenting with cellulitis to emergency departments.
(2014)
Quirke, Michael; Saunders, Jean; O'Sullivan, Ronald; Milenkovski, Hristijan; Wakai, Abel
Abstract:
<p>The original article is available at www.imj.ie</p>
<p>To characterise the Emergency Department (ED) prevalence of cellulitis, factors predicting oral antibiotic therapy and the utility of the Clinical Resource Efficiency Support Team (CREST) guideline in predicting patient management in the ED setting, a prospective, cross-sectional study of consecutive adult patients presenting to 3 Irish EDs was performed. The overall prevalence of cellulitis was 12 per 1,000 ED visits. Of 59 patients enrolled, 45.8% were discharged. Predictors of treatment with oral antibiotics were: CREST, Class 1 allocation (odds ratio (OR) 6.81, 95% Cl =1.5-30.1, p=0.012), patient self-referral (OR= 6.2, 95% Cl 1.9- 20.0, p=0.03) and symptom duration longer than 48 hours (OR 1.2, 95% Cl = 1.0-1.5,p=0.049). In conflict with guideline recommendation, 43% of patients in CREST Class 1 received IV therapy. Treatment with oral antibiotics was predicted by CREST Class 1 allocation, self-refe...
https://epubs.rcsi.ie/gpart/100
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A preclinical evaluation of the PI3K alpha/delta dominant inhibitor BAY 80-6946 in HER2-positive breast cancer models with acquired resistance to the HER2-targeted therapies trastuzumab and lapatinib.
(2015)
Elster, Naomi; Cremona, Mattia; Morgan, Carys; Toomey, Sinead; Carr, Aoife; O'Grad...
A preclinical evaluation of the PI3K alpha/delta dominant inhibitor BAY 80-6946 in HER2-positive breast cancer models with acquired resistance to the HER2-targeted therapies trastuzumab and lapatinib.
(2015)
Elster, Naomi; Cremona, Mattia; Morgan, Carys; Toomey, Sinead; Carr, Aoife; O'Grady, A; Hennessy, Bryan T; Eustace, Alex J
Abstract:
<p><em>The final publication is available at Springer via <a href="http://dx.doi.org/%5binsert">http://dx.doi.org/10.1007/s10549-014-3239-5</a></em></p>
<p>The PI3K pathway is a key mechanism of trastuzumab resistance, but early attempts to indirectly target this pathway with mTOR inhibitors have had limited success. We present the results of a preclinical study of the selective alpha/delta isoform dominant PI3K inhibitor BAY 80-6946 tested alone and in combination with HER2-targeted therapies in HER2-positive cell lines, including models with acquired resistance to trastuzumab and/or lapatinib. A panel of HER2-positive breast cancer cells were profiled for their mutational status using Sequenom MassARRAY, PTEN status by Western blot, and anti-proliferative response to BAY 80-6946 alone and in combination with the HER2-targeted therapies trastuzumab, lapatinib and afatinib. Reverse phase protein array was used to determine the ...
https://epubs.rcsi.ie/molmedart/28
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A profile of elderly fallers referred for physiotherapy in the emergency department of a Dublin teaching hospital.
(2013)
Crehan, Fiona; O'Shea, D; Ryan, John M; Horgan, Frances
A profile of elderly fallers referred for physiotherapy in the emergency department of a Dublin teaching hospital.
(2013)
Crehan, Fiona; O'Shea, D; Ryan, John M; Horgan, Frances
Abstract:
<p>The original article is available at <a href="http://www.imj.ie">www.imj.ie</a></p>
<p>Ireland has an ageing population and the elderly are over-represented in Emergency Departments (ED)--a quarter of these presentations resulting from falls. A prospective study design was employed using a convenience sample to profile elderly fallers referred for physiotherapy in ED. Forty-subjects were assessed over 14 weeks. Mean age was 84.88 years (s.d. 7.3) and 31 (77.5%) were female. All demonstrated slow walking speed and 26 (65%) demonstrated poor grip strength. A quarter of subjects reported fear of falling and 30 (75%) were classified as frail. Elderly fallers in ED are a frail group of socially vulnerable patients who demonstrate a risk of further falls. Osteoporosis had been diagnosed in 9 (22.5%) subjects--a low prevalence compared with international research, but 25 (62.5%) subjects had never had a DEXA scan. The prevalence of frailty in ...
https://epubs.rcsi.ie/sphysioart/15
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Aldosterone-mediated apical targeting of ENaC subunits is blunted in rats with streptozotocin-induced diabetes mellitus.
(2008)
O'Neill, Heidi; Lebeck, Janne; Collins, Patrick B; Kwon, Tae-Hwan; Frøkiaer, Jørge...
Aldosterone-mediated apical targeting of ENaC subunits is blunted in rats with streptozotocin-induced diabetes mellitus.
(2008)
O'Neill, Heidi; Lebeck, Janne; Collins, Patrick B; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Nielsen, Søren
Abstract:
Published by Oxford University Press http://ndt.oxfordjournals.org/cgi/reprint/23/5/1546
BACKGROUND: Diabetes mellitus (DM) is associated with a significant polyuria and natriuesis as well as increased plasma aldosterone and anti-diuretic hormone arginine vasopressin (AVP). This study aimed to determine whether diabetic kidneys compensate for the urinary sodium and water losses by increasing apical targeting of epithelial sodium channel (ENaC) subunits and aquaporin-2 (AQP2) in the collecting duct, in addition to the previously observed changes in ENaC subunit protein expression in different kidney zones. METHODS: Female rats were investigated 2 weeks after induction of DM by streptozotocin administration. Kidneys were examined by immunohistochemisty and semiquantitative immunoblotting. RESULTS: We demonstrated that the protein expression of renal AQP2, Ser-256 phosphorylated AQP2, AQP3, beta- and gamma-ENaC (but not alpha-ENaC) increased consistently with an increased AVP respo...
https://epubs.rcsi.ie/mctart/15
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An audit on virological efficacy of anti-retroviral therapy in a specialist infectious disease clinic.
(2009)
Reyad, A; Waldron, Carmel; Canning, R; O'Shea, Daire; Coakley, P; McConkey, Samuel
An audit on virological efficacy of anti-retroviral therapy in a specialist infectious disease clinic.
(2009)
Reyad, A; Waldron, Carmel; Canning, R; O'Shea, Daire; Coakley, P; McConkey, Samuel
Abstract:
<p>The original article is available at www.imj.ie</p>
<p>We have assessed the efficacy of anti retroviral therapy (ART) using undetectable viral load (VL) (/ml) as a marker of virological success, in patients who have Human Immunodeficiency Virus (HIV) attending the Department of Infectious Disease. A cross-sectional review of patients' case notes was used to obtain their demographics and treatment details. 79% (253) of the hospital case notes of clinic population was available for analysis, which represents 90% of those receiving ART in the clinic. 166/253 of the cohort were receiving treatment at the time of this study and 95% (157/166) of these were on treatment for greater than 6 months. The total virological success rate is 93%, which is comparable to other centres and are as good as those from published clinical trials. 56% of those on therapy who have virological failure were Intravenous Drug Users (IVDUs). Case by case investigation for those with...
https://epubs.rcsi.ie/ihtmart/5
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An evaluation of an online peer support forum for university students with depressive symptoms
(2013)
Horgan, Aine M.; McCarthy, Geraldine; Sweeney, John F.
An evaluation of an online peer support forum for university students with depressive symptoms
(2013)
Horgan, Aine M.; McCarthy, Geraldine; Sweeney, John F.
Abstract:
Background: Depression is the most common mental health problem among young people, particularly university students, with prevalence rates as high as 48% reported. This population however, is reluctant to seek professional help. Online interventions may be particularly appealing to students, with evidence suggesting that they use the Internet for mental health support. While there are many mental health resources on the Internet few focus specifically on the needs of young people and few have been evaluated. This research aimed to develop and pilot test an online peer support intervention for students experiencing depressive symptoms. Methods: A depression support Web site (www.losetheblues.ie) was designed specifically for 18-24. year old students. The study used a mixed method, involving quantitative descriptive, pre- and post-test and qualitative descriptive designs. Data were collected using the Centre for Epidemiological Studies Depression Scale (CES-D), a background questionn...
http://hdl.handle.net/10468/3010
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Anaesthesia for caesarean section in a patient with Sturge-Weber syndrome following acute neurological deterioration.
(2011)
Tadrous, R; Ni Mhuirchteagh, R; McCaul, C
Anaesthesia for caesarean section in a patient with Sturge-Weber syndrome following acute neurological deterioration.
(2011)
Tadrous, R; Ni Mhuirchteagh, R; McCaul, C
Abstract:
Abstract Sturge-Weber syndrome consists of facial capillary malformation (port-wine stain) and abnormal blood vessels in the brain or eye. Seizures, developmental delay and intracranial and airway angiomata are principal concerns. We report a 28-year-old primiparous woman at 41 weeks of gestation with Sturge-Weber syndrome who developed unilateral weakness, aphasia, blurred vision and confusion. Preeclampsia was excluded. Neuroimaging showed left sided cerebral oedema and a right parieto-occipital lesion, most likely an angioma. Caesarean section was planned to avoid the risk of angioma rupture during labour. General anesthesia was avoided due to the haemodynamic response to laryngoscopy and reports of seizure-related mortality. Despite the possibility of raised intracranial pressure and precipitation of cerebral herniation, a lumbar epidural block was administered but failed. A subarachnoid block was successfully performed and a healthy infant delivered. The choice of anaesthesia w...
http://hdl.handle.net/10147/208152
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Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury.
(2014)
Pfeiffer, Shona; Anilkumar, Ujval; Chen, Gang; Ramírez-Peinado, S; Galindo-Moreno, J; M...
Analysis of BH3-only proteins upregulated in response to oxygen/glucose deprivation in cortical neurons identifies Bmf but not Noxa as potential mediator of neuronal injury.
(2014)
Pfeiffer, Shona; Anilkumar, Ujval; Chen, Gang; Ramírez-Peinado, S; Galindo-Moreno, J; Muñoz-Pinedo, C; Prehn, Jochen HM
Abstract:
<p>This article is also available at <a href="http://www.nature.com/cddis/journal/v5/n10/full/cddis2014426a.html">http://www.nature.com/cddis/journal/v5/n10/full/cddis2014426a.html</a></p>
<p>Stress signaling in response to oxygen/glucose deprivation (OGD) and ischemic injury activates a group of pro-apoptotic genes, the Bcl-2 homology domain 3 (BH3)-only proteins, which are capable of activating the mitochondrial apoptosis pathway. Targeted studies previously identified the BH3-only proteins Puma, Bim and Bid to have a role in ischemic/hypoxic neuronal injury. We here investigated the transcriptional activation of pro-apoptotic BH3-only proteins after OGD-induced injury in murine neocortical neurons. We observed a potent and early upregulation of noxa at mRNA and protein level, and a significant increase in Bmf protein levels during OGD in neocortical neurons and in the ipsilateral cortex of mice subjected to transient middle cerebral art...
https://epubs.rcsi.ie/physiolart/59
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Analysis of care of HIV positive patients: hospital and general practice components.
(1995)
Bradley, Fiona; Bury, Gerard; O'Kelly, Fergus; Shannon, William; Hickey, Anne; Mul...
Analysis of care of HIV positive patients: hospital and general practice components.
(1995)
Bradley, Fiona; Bury, Gerard; O'Kelly, Fergus; Shannon, William; Hickey, Anne; Mulcahy, Fiona
Abstract:
<p>The original article is available at www.imj.ie</p>
<p>Fifty-seven HIV positive adults (mostly injecting drug users) attending two inner city Dublin general practices were followed for one year to identify the general practice and hospital components of their care. Many patients had advanced disease; during the year 10/57 (17.5%) died. The group made a median of seven visits to general practice (range 0-35) and two visits to hospital HIV clinics (range 0-21). A quarter of the group (14/57) was seen only in general practice and did not attend hospital; only two patients did not attend either the HIV Clinic or the GP during the year. Hospital admission was needed for 15/57 (26.3%) patients on a total of 31 occasions with an average length of stay of 10 days per admission; 80% of these admissions were generated by 10 patients with AIDS. The indication for almost all admissions was serious physical illness or diagnostic or therapeutic procedure. Patients with sy...
https://epubs.rcsi.ie/psycholart/135
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Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer.
(2012)
McCawley, Niamh; Conlon, Susan; Hector, Suzanne; Cummins, Robert J; Dicker, Patrick; Jo...
Analyzing proteasomal subunit expression reveals Rpt4 as a prognostic marker in stage II colorectal cancer.
(2012)
McCawley, Niamh; Conlon, Susan; Hector, Suzanne; Cummins, Robert J; Dicker, Patrick; Johnston, Patrick G; Kay, Elaine W; McNamara, Deborah A; Prehn, Jochen HM; Concannon, Caoimhín G
Abstract:
<p>This article is also available at <a href="http://onlinelibrary.wiley.com/doi/10.1002/ijc.26468/abstract">http://onlinelibrary.wiley.com/doi/10.1002/ijc.26468/abstract</a></p>
<p>Colorectal cancer is a leading cause of cancer-related deaths worldwide. Early diagnosis and treatment of colorectal cancer is the key to improving survival rates and as such a need exists to identify patients who may benefit from adjuvant chemotherapy. The dysregulation of the ubiquitin-proteasome system (UPS) has been implicated in oncogenesis and cancer cell survival, and proteasome inhibitors are in clinical use for a number of malignancies including multiple myeloma. In our study, we examined the protein expression of several key components of the UPS in colorectal cancer using immunohistochemistry to determine expression levels of ubiquitinylated proteins and the proteasomal subunits, 20S core and Rpt4 in a cohort of 228 patients with colon cancer. Multiv...
https://epubs.rcsi.ie/physiolart/62
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Anatomical characterisation of the cricothyroid membrane in females of childbearing age using computed tomography.
(2014)
Long, N; Ng, S; Donnelly, G; Owens, M; McNicholas, M; McCarthy, K; McCaul, C
Anatomical characterisation of the cricothyroid membrane in females of childbearing age using computed tomography.
(2014)
Long, N; Ng, S; Donnelly, G; Owens, M; McNicholas, M; McCarthy, K; McCaul, C
Abstract:
In the event of failure to secure the airway by conventional means, it may be necessary to perform invasive airway access via the cricothyroid membrane. No studies have addressed anatomy of this structure in the obstetric population. We aimed to review the anatomical variation of this structure in a population of childbearing age.
http://hdl.handle.net/10147/326273
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Antenatal Education: What do women want?: a descriptive study.
(2012)
Antenatal Education: What do women want?: a descriptive study.
(2012)
http://hdl.handle.net/10147/209791
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Antenatal maternal education for improving postnatal perineal healing for women who have birthed in a hospital setting.
(2017)
O'Kelly, Sonia M; Moore, Zena EH
Antenatal maternal education for improving postnatal perineal healing for women who have birthed in a hospital setting.
(2017)
O'Kelly, Sonia M; Moore, Zena EH
Abstract:
<p>This review is published as a Cochrane Review in the <em>Cochrane Database of Systematic Reviews</em> 2016, Issue 3. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the <em>Cochrane Database of Systematic Reviews</em> should be consulted for the most recent version of the Review. O’Kelly SM, Moore ZEH. Antenatal maternal education for improving postnatal perineal healing for women who have birthed in a hospital setting. Cochrane Database of Systematic Reviews 2017, Issue 12. Art. No.: CD012258. DOI: 10.1002/14651858.CD012258.pub2</p>
<p>BACKGROUND: The female perineum becomes suffused and stretched during pregnancy, and further strain during vaginal childbirth contributes to approximately 85% of women experiencing some degree of trauma to the perineal region. Multiple factors play a role in the type and severity of trauma experienced, including parity, delivery method, and...
https://epubs.rcsi.ie/snursmidart/6
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Antimetastatic activity of a cyclooxygenase-2 inhibitor.
(2004)
Roche-Nagle, Graham; Connolly, Elizabeth M; Eng, Molly; Bouchier-Hayes, David J; Harmey...
Antimetastatic activity of a cyclooxygenase-2 inhibitor.
(2004)
Roche-Nagle, Graham; Connolly, Elizabeth M; Eng, Molly; Bouchier-Hayes, David J; Harmey, Judith H
Abstract:
<p>The original article is available at <a href="http://www.nature.com">www.nature.com</a></p>
<p>Cyclooxygenase-2 (COX-2) expression is increased in breast cancer and surgery has been shown to increase the growth of metastatic tumours. We investigated the effect of selective COX-2 inhibition on the growth of metastases in either an experimental metastasis model or following excision of a murine primary breast tumour. 50,000 4T1 mammary carcinoma cells were injected into the mammary fat pad of female BALB/c mice. When the mean TD reached 8+/-0.4 mm, tumours were excised and the mice were randomised into two groups (n=12 per group) to receive daily intraperitoneal injections of the selective COX-2 inhibitor, SC-236 or drug vehicle for 14 days. Alternatively, experimental metastases were established by tail-vein injection of 50,000 4T1 cells. Mice received either the selective COX-2 inhibitor, SC-236 or drug vehicle for 14 days (n=12 per gro...
https://epubs.rcsi.ie/surgart/27
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Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.
(2015)
Cooke, Niamh M; Spillane, Cathy D; Sheils, Orla; O'Leary, John; Kenny, Dermot
Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.
(2015)
Cooke, Niamh M; Spillane, Cathy D; Sheils, Orla; O'Leary, John; Kenny, Dermot
Abstract:
<p>The original article is available at www.biomedcentral.com</p>
<p>BACKGROUND: Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian cancers have different metastatic phenotypes. To investigate if platelet-cancer cell interactions play a role, we characterized the response of ovarian cancer cell lines to platelets both functionally and at a molecular level.</p> <p>METHODS: Cell lines 59 M and SK-OV-3 were used as in vitro model systems of metastatic ovarian cancer. Platelet cloaking of each cell line was quantified by flow cytometry. Matrigel invasion chamber assays were used to assess the invasive capacity of the cell lines. The induction of an EMT was assessed by morphology analysis and by gene expression analysis of a panel of 11 EMT markers using TaqMan RT-PCR.</p> <p>RESULTS: ...
https://epubs.rcsi.ie/mctart/76
Marked
Mark
Assessing the functional performance of post-call hospital doctors using a Nintendo Wii.
(2011)
Clancy, K; Brady, P; McHugh, Seamus M; Corrigan, Mark A; Sheikh, Athar S; Lehane, Elain...
Assessing the functional performance of post-call hospital doctors using a Nintendo Wii.
(2011)
Clancy, K; Brady, P; McHugh, Seamus M; Corrigan, Mark A; Sheikh, Athar S; Lehane, Elaine; Hill, Arnold DK
Abstract:
<p>The original article is available at <a href="http://www.imj.ie">www.imj.ie</a></p>
<p>Sleep deprivation is an established part of the working life for Non-Consultant Hospital Doctors (NCHDs) in Ireland. Concern exists about the effect of extended NCHD work hours. We utilised a Nintendo Wii to evaluate motor function of NCHDs both prior to their on-call shift and the day afterwards. Data was exported to SPSS ver. 15 for statistical analysis with p < 0.05 considered significant. A total of 72 NCHDs were invited to participate in this study. There was a 62.5% (45) rate of follow-up. Overall 27 (60%) NCHDs were on medical call, with 18 (40%) on surgical call. There was no statistically significant difference between NCHDs pre-and post-call motor assessment scores. The majority of study participants (75.5%, n = 34) had four or more hours sleep. On-call duty allows for a greater than anticipated amount of sleep per on-call shift and there...
https://epubs.rcsi.ie/surgart/16
Marked
Mark
Bare Below the Elbows: A comparative study of a tertiary and district general hospital.
(2013)
Collins, Anne M; Connaughton, James; Hill, Arnold DK; Ridgway, Paul F
Bare Below the Elbows: A comparative study of a tertiary and district general hospital.
(2013)
Collins, Anne M; Connaughton, James; Hill, Arnold DK; Ridgway, Paul F
Abstract:
<p>The original article is available at www.imj.ie</p>
<p>A 'Bare Below the Elbows' (BBTE) dress code policy has been introduced by the majority of NHS trusts in the UK. The aim of this Irish study was to evaluate the impact of an educational intervention on perception of medical attire. The study was carried out in two centres: a tertiary referral centre (Beaumont Hospital) and a district hospital (MRH, Portlaoise). Two questionnaires, incorporating photographic evaluation of appropriate attire for consultants and junior doctors, were completed pre and post BBTE education. One hundred and five patients participated. Analysis pre BBTE education indicated patients considered formal attire and white coats most appropriate for consultants and junior doctors respectively. Post-intervention analysis revealed a significant reduction in the popularity of both (p</p>
https://epubs.rcsi.ie/surgart/37
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