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Subject = GSTO1-1 glutathione;
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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
(2019)
Mills, Kingston; Corr, Sinead
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation
(2019)
Mills, Kingston; Corr, Sinead
Abstract:
NLRP3 inflammasome activation contributes to chronic inflammationassociated with autoinflammatorydisease, yet understanding of NLRP3inflammasome regulation is incomplete.Hughes et al. show that thedeglutathionylating enzyme GSTO1-1promotes NLRP3 inflammasomeactivation through deglutathionylation ofNEK7. Furthermore, the GSTO1-1inhibitor C1-27 reduces NLRP3inflammasome activationin vitroandin vivo.
http://hdl.handle.net/2262/90894
Displaying Results 1 - 1 of 1 on page 1 of 1
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