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Subject = Genes & Society;
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Displaying Results 1 - 25 of 348 on page 1 of 14
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A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs.
(2013)
Bracken, Adrian
A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs.
(2013)
Bracken, Adrian
Abstract:
Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et al. (2012a) and Wu et al. (2013) define functionally distinct roles for canonical and noncanonical PRC1 in ESCs.
http://hdl.handle.net/2262/72413
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A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
(2015)
MC LYSAGHT, AOIFE; BRACKEN, ADRIAN; HEALY, EVAN
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
(2015)
MC LYSAGHT, AOIFE; BRACKEN, ADRIAN; HEALY, EVAN
Abstract:
Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such apparent functional redundancy exist in mammals. Here we characterize their divergent roles in both positively and negatively regulating cellular proliferation. We show that while PCL2 and PCL3 are E2F-regulated genes expressed in proliferating cells, PCL1 is a p53 target gene predominantly expressed in quiescent cells. Ectopic expression of any PCL protein recruits PRC2 to repress the INK4A gene; however, only PCL2 and PCL3 confer an INK4A-dependent proliferative advantage. Remarkably, PCL1 has evolved a PRC2- and chromatin-independent function to negatively regulate proliferation. We show that PCL1 binds to and stabilizes p53 to induce cellular quiescence. Moreover, depletion of PCL1 phenocopies the defects in maintaining cellular quiescence associa...
http://hdl.handle.net/2262/76636
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A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings.
(2011)
ANNEY, RICHARD; GILL, MICHAEL
A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings.
(2011)
ANNEY, RICHARD; GILL, MICHAEL
Abstract:
BACKGROUND: Impulsive drive for immediate reward (IDIR) and delay aversion are dissociable elements of the preference for immediate over delayed rewards seen in attention-deficit/hyperactivity disorder (ADHD). We hypothesized that IDIR would be associated with dopamine regulating genes and delay aversion would be associated with serotonin-regulating genes. METHODS: Impulsive drive for immediate reward and delay aversion were measured in 459 male children and adolescents (328 ADHD and 131 unaffected siblings) with a laboratory choice task. The sample was genotyped for the 5HTT (SLC6A4) promoter serotonin-transporter-linked polymorphic region polymorphism and a DAT1 (SLC6A3) 40-base pair variable number tandem repeat located in the 3'-untranslated region of the gene. RESULTS: There was no effect of dopamine transporter (DAT)1 on IDIR. As predicted, serotonin-transporter-linked polymorphic region s-allele carriers were more delay averse. This effect was driven by the s/l genoty...
http://hdl.handle.net/2262/69616
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A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2
(2012)
DORMAN, CHARLES
A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2
(2012)
DORMAN, CHARLES
Abstract:
DNA topology has fundamental control over the ability of transcription factors to access their target DNA sites at gene promoters. However, the influence of DNA topology on protein?DNA and protein?protein interactions is poorly understood. For example, relaxation of DNA supercoiling strongly induces the well-studied pathogenicity gene ssrA (also called spiR) in Salmonella enterica, but neither the mechanism nor the proteins involved are known. We have found that relaxation of DNA supercoiling induces expression of the Salmonella pathogenicity island (SPI)-2 regulator ssrA as well as the SPI-1 regulator hilC through a mechanism that requires the two-component regulator OmpR-EnvZ. Additionally, the ompR promoter is autoregulated in the same fashion. Conversely, the SPI-1 regulator hilD is induced by DNA relaxation but is repressed by OmpR. Relaxation of DNA supercoiling caused an increase in OmpR binding to DNA and a concomitant decrease in binding by the nucleoid-associated protein F...
http://hdl.handle.net/2262/71400
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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
(2007)
Mc Manus, Ross; Feighery, Conleth; Kelleher, Dermot
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
(2007)
Mc Manus, Ross; Feighery, Conleth; Kelleher, Dermot
Abstract:
We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 ? 10?7, empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Association was independently confirmed in two further collections (strongest at rs6822844, 24kB 5' of IL21, meta-analysis P=1.3 ? 10?14, OR 0.63), suggesting genetic variation in this region predisposes to celiac disease.
http://hdl.handle.net/2262/33807
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A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.
(2010)
MOLLOY, ANNE; SCOTT, JOHN
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.
(2010)
MOLLOY, ANNE; SCOTT, JOHN
Abstract:
Case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate. SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635?0.778, P = 1.44 ? 10?11; and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292?1.587, P = 5.01 ? 10?12) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance. Stratifying trios into European and Asian ancestry groups revealed differences in statistical significance, although estimated effect sizes remained similar. Replication studies from several populations showed confirming evidence, with families of European ancestry giving stronger evidence for markers in 8q24, whereas Asian families showed stronger evidence for association with MAFB and ABCA4. Expression studies support a role for MAFB in palatal development.
http://hdl.handle.net/2262/75139
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A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
(2011)
HEALY, CLAIRE; TONER, MARY
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
(2011)
HEALY, CLAIRE; TONER, MARY
Abstract:
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p ? 5 ? 10??). Two novel variants were identified, a 4q21 variant (rs1494961, p?=?1?10??) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 varia...
http://hdl.handle.net/2262/57385
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A genomewide scan for common alleles affecting risk for autism.
(2010)
ANNEY, RICHARD; GALLAGHER, LOUISE; GILL, MICHAEL; BOLSHAKOVA, NADIA; SEGURADO, RICARDO;...
A genomewide scan for common alleles affecting risk for autism.
(2010)
ANNEY, RICHARD; GALLAGHER, LOUISE; GILL, MICHAEL; BOLSHAKOVA, NADIA; SEGURADO, RICARDO; HERON, ELIZABETH; MCGRATH, JANE; TANSEY, KATHERINE; BRENNAN, SEAN; MERIKANGAS, ALISON; MERIKANGAS, ALISON KATHLEEN
Abstract:
Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 ? 10?8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 ? 10?8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant asso...
http://hdl.handle.net/2262/52983
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A global role for Fis in the transcriptional control of metabolic and type III secretion genes of Salmonella enterica serovar Typhimurium
(2004)
DORMAN, CHARLES
A global role for Fis in the transcriptional control of metabolic and type III secretion genes of Salmonella enterica serovar Typhimurium
(2004)
DORMAN, CHARLES
http://hdl.handle.net/2262/71362
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A hot spot on interferon ??/?? receptor subunit 1 (IFNAR1) underpins its interaction with interferon-?? and dictates signaling.
(2017)
BOURKE, NOLLAIG
A hot spot on interferon ??/?? receptor subunit 1 (IFNAR1) underpins its interaction with interferon-?? and dictates signaling.
(2017)
BOURKE, NOLLAIG
http://hdl.handle.net/2262/81962
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A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts.
(2016)
DAVEY, GAVIN
A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts.
(2016)
DAVEY, GAVIN
http://hdl.handle.net/2262/76782
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A longitudinal study of Staphylococcus aureus colonization in pigs in Ireland.
(2014)
SHORE, ANNA
A longitudinal study of Staphylococcus aureus colonization in pigs in Ireland.
(2014)
SHORE, ANNA
Abstract:
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) in livestock has refocused attention on S. aureus colonization and transmission in pigs. This study investigated the effect of the S. aureus colonization status of a sow on the colonization status of her piglets, and whether pigs carry the same strain of S. aureus throughout production. Nasal swabs were collected from the piglets of six healthy sows two days after birth and two days before and two days after they were moved into each production stage. The average prevalence of S. aureus colonization varied between 26% and 73%. The odds of being S. aureus positive were almost 12 times higher for piglets born to nasal-positive sows than for those born to nasal-negative sows, and three times higher again for piglets born to sows that were both nasal- and vaginal-positive. Isolates recovered from piglets immediately after birth were indistinguishable from those of the dam as determined by phenotypic and molecular typing...
http://hdl.handle.net/2262/75580
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A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila
(2010)
RAMASWAMI, MANI
A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila
(2010)
RAMASWAMI, MANI
Abstract:
Techniques to induce activity-dependent neuronal plasticity in vivo allow the underlying signaling pathways to be studied in their biological context. Here, we demonstrate activity-induced plasticity at neuromuscular synapses of Drosophila double mutant for comatose (an NSF mutant) and Kum (a SERCA mutant), and present an analysis of the underlying signaling pathways. comt; Kum (CK) double mutants exhibit increased locomotor activity under normal culture conditions, concomitant with a larger neuromuscular junction synapse and stably elevated evoked transmitter release. The observed enhancements of synaptic size and transmitter release in CK mutants are completely abrogated by: a) reduced activity of motor neurons; b) attenuation of the Ras/ERK signaling cascade; or c) inhibition of the transcription factors Fos and CREB. all of which restrict synaptic properties to near wild type levels. Together, these results document neural activity-dependent plasticity of motor synapses in CK an...
http://hdl.handle.net/2262/38787
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A NOS1 variant implicated in cognitive performance influences evoked neural responses during a hight density EEG study of early visual perception.
(2012)
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; DONOHOE, GARY; FAHEY, CIARA
A NOS1 variant implicated in cognitive performance influences evoked neural responses during a hight density EEG study of early visual perception.
(2012)
GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; DONOHOE, GARY; FAHEY, CIARA
Abstract:
Background: The nitric oxide synthasase?1 gene (NOS1) has been implicated in mental disorders including schizophrenia and variation in cognition. The NOS1 variant rs6490121 identified in a genome wide association study of schizophrenia has recently been associated with variation in general intelligence and working memory in both patients and healthy participants. Whether this variant is also associated with variation in early sensory processing remains unclear. Methods: We investigated differences in the P1 visual evoked potential in a high density EEG study of 54 healthy participants. Given both NOS1's association with cognition and recent evidence that cognitive performance and P1 response are correlated, we investigated whether NOS1's effect on P1 response was independent of its effects on cognition using CANTAB's spatial working memory (SWM) task. Results: We found that carriers of the previously identified risk ?G? allele showed significantly lower P1 responses t...
http://hdl.handle.net/2262/89878
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A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
(2012)
ANNEY, RICHARD; MERIKANGAS, ALISON; MCGRATH, JANE; GALLAGHER, LOUISE
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
(2012)
ANNEY, RICHARD; MERIKANGAS, ALISON; MCGRATH, JANE; GALLAGHER, LOUISE
Abstract:
Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetics, overall, the high heritability of ASD (~90%) remains poorly explained by common genetic risk variants. However, recent studies suggest that rare genomic variation, in particular copy number variation, may account for a significant proportion of the genetic basis of ASD. We present a large scale analysis to identify candidate genes which may contain low-frequency recessive variation contributing to ASD while taking into account the potential contribution of population differences to the genetic heterogeneity of ASD. Our strategy, homozygous haplotype (HH) mapping, aims to detect homozygous segments of identical haplotype structure that are shared at a higher frequenc...
http://hdl.handle.net/2262/72308
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A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
(2011)
GILL, MICHAEL; GALLAGHER, LOUISE
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
(2011)
GILL, MICHAEL; GALLAGHER, LOUISE
http://hdl.handle.net/2262/75289
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A novel multidrug-resistant PVL-negative CC1-MRSA-1 IV clone emerging in Ireland and Germany likely originated in South-Eastern Europe
(2019)
Coleman, David; Shore, Anna; Earls, Megan R.; Brennan, Gr?inne I.; Simbeck, Alexandra; ...
A novel multidrug-resistant PVL-negative CC1-MRSA-1 IV clone emerging in Ireland and Germany likely originated in South-Eastern Europe
(2019)
Coleman, David; Shore, Anna; Earls, Megan R.; Brennan, Gr?inne I.; Simbeck, Alexandra; Schneider-Brachert, Wulf; Vremer?, Teodora; Dorneanu, Olivia S.; Slickers, Peter; Ehricht, Ralf; Monecke, Stefan; Coleman, David C.
Abstract:
This study investigated the recent emergence of multidrug-resistant Panton-Valentine leukocidin (PVL)-negative CC1-MRSA-IV in Ireland and Germany. Ten CC1-MSSA and 139 CC1-MRSA isolates recovered in Ireland between 2004 and 2017 were investigated. These were compared to 21 German CC1-MRSA, 10 Romanian CC1-MSSA, five Romanian CC1-MRSA and two UAE CC1-MRSA, which were selected from an extensive global database, based on similar DNA microarray profiles to the Irish isolates. All isolates subsequently underwent whole-genome sequencing, core-genome single nucleotide polymorphism (cgSNP) analysis and enhanced SCCmec subtyping. Two PVL-negative clades (A and B1) were identified among four main clades. Clade A included 20 German isolates, 119 Irish isolates, and all Romanian MRSA and MSSA isolates, the latter of which differed from clade A MRSA by 47?130 cgSNPs. Eighty-six Irish clade A isolates formed a tight subclade (A1) exhibiting 0?49 pairwise cgSNPs, 80 of which harboured a 46?kb co...
http://hdl.handle.net/2262/90730
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A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up
(2003)
Kelleher, Dermot; Keeling, Paul; Mc Manus, Ross; Ryan, Barbara
A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up
(2003)
Kelleher, Dermot; Keeling, Paul; Mc Manus, Ross; Ryan, Barbara
Abstract:
BACKGROUND AND AIMS: Mutant tumour derived DNA has been detected in the sera of colorectal cancer patients. We investigated if mutant serum KRAS2 was detectable preoperatively in a large group of patients with colorectal neoplasia. A prospective study of 94 patients who underwent putative curative resection for colorectal carcinoma (CRC) was performed to ascertain if serum mutant KRAS2 could be used postoperatively as a disease marker. METHODS: Preoperative sera from 78 patients were analysed (group A). Sera from 94 patients were obtained three monthly for up to three years during the postoperative period (group B). Codon 12 and 13 KRAS2 mutations were analysed in matched tumour and serum samples. RESULTS: In the preoperative group (group A), KRAS2 mutation was found in 41/78 (53%) tumours and in 32/78 (41%) preoperative sera. Of 41 tumour KRAS2 mutation positive cases, 31/41 (76%) had an identical serum mutation detectable. In group B, the postoperative follow up group, 60/94 cases...
http://hdl.handle.net/2262/33840
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A Ser29Leu SUBSTITUTION IN THE CYTOSINE DEAMINASE Fca1p IS RESPONSIBLE FOR CLADE-SPECIFIC 5-FLUCYTOSINE RESISTANCE IN Candida dubliniensis
(2009)
SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY; MCMANUS, BRENDA ANN
A Ser29Leu SUBSTITUTION IN THE CYTOSINE DEAMINASE Fca1p IS RESPONSIBLE FOR CLADE-SPECIFIC 5-FLUCYTOSINE RESISTANCE IN Candida dubliniensis
(2009)
SULLIVAN, DEREK; COLEMAN, DAVID; MORAN, GARY; MCMANUS, BRENDA ANN
Abstract:
The population structure of the opportunistic yeast pathogen Candida dubliniensis is composed of three main multilocus sequence typing clades (clades C1 to C3), and clade C3 predominantly consists of isolates from the Middle East that exhibit high-level resistance (MIC(50) > or = 128 microg/ml) to the fungicidal agent flucytosine (5FC). The close relative of C. dubliniensis, C. albicans, also exhibits clade-specific resistance to 5FC, and resistance is most commonly mediated by an Arg101Cys substitution in the FUR1 gene encoding uracil phosphoribosyltransferase. Broth microdilution assays with fluorouracil (5FU), the toxic deaminated form of 5FC, showed that both 5FC-resistant and 5FC-susceptible C. dubliniensis isolates exhibited similar 5FU MICs, suggesting that the C. dubliniensis cytosine deaminase (Fca1p) encoded by C. dubliniensis FCA1 (CdFCA1) may play a role in mediating C. dubliniensis clade-specific 5FC resistance. Amino acid sequence analysis of the CdFCA1 open reading...
http://hdl.handle.net/2262/40202
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A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display.
(2014)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display.
(2014)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
http://hdl.handle.net/2262/69293
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A taxonomic revision of the genus Eragrostis (Poaceae) in Thailand
(2013)
HODKINSON, TREVOR
A taxonomic revision of the genus Eragrostis (Poaceae) in Thailand
(2013)
HODKINSON, TREVOR
Abstract:
A taxonomic account of Eragrostis in Thailand is provided, in which 23 species are recognized. An artificial key to species and species descriptions is provided along with distributional and ecological data for all taxa. The taxonomic status of several Thai Eragrostis taxa is updated. Four species: E. alopecuroides, E. malayana, E. spartinoides, and E. zeylanica are reduced to synonymies of E. ciliata, E. montana, E. brownii, and E. brownii, respectively, and three species, E. ciliaris, E. cylindrica, and E. tef, are reported to occur in Thailand for the first time.
http://hdl.handle.net/2262/72725
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Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
(2011)
Porter, Richard
Absence of mitochondrial uncoupling protein 3: Effect on thymus and spleen in the fed and fasted mice
(2011)
Porter, Richard
Abstract:
Mitochondrial uncoupling protein 3 (UCP3) is consituitively expressed in mitochondria from thymus and spleen of mice, and confocal microscopy has been used to visualize UCP3 in situ in mouse thymocytes. UCP3 is present decrease by a half in thymus and a fifth in spleen after three weeks, probably reflecting the suckling to weaning transition. UCP3 protein levels increase ~3-fold in thymus on starvation, but expression levels in spleen were unaffected by starvation. Lack of UCP3 had little effect on thymus mass or thymocyte number . However, lack of UCP3 affected spleen mass and splenocyte number (in the fasted state) and results in reduced CD4+ single positive cell numbers and reduced double negative cells in the thymus, but as a 2-fold increase in the proportion of CD4 + , CD8 + and DP cells in spleen. Starvation attenuates these proportionate differences in the spleen. A lack of UCP3 had no apparent effect on basal oxygen consumption of thymocytes or splenocytes or on ox...
http://hdl.handle.net/2262/59261
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Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.
(2010)
QUINN, EMMA; KENNY, ELAINE; CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK
Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.
(2010)
QUINN, EMMA; KENNY, ELAINE; CORVIN, AIDEN; GILL, MICHAEL; MORRIS, DEREK
Abstract:
Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases, such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. Under these circumstances, we expect that CNV events in cases should impact brain-function genes more frequently than those events in controls. Previous publications have applied ``pathway?? analyses to genes within neuropsychiatric case CNVs to show enrichment for brainfunctions. While such analyses have been suggestive, they often have not rigorously compared the rates of CNVs impacting genes with brain function in cases to controls, and therefore do not address important confounders such as the large size of brain genes and overall differences in rates and sizes of CNVs. To demonstrate the potential impact of confounders, we genotyped rare CNV events in 2,415 unaffected controls with Affymetrix 6.0; we then applied standard pathway analyses using four sets of brain-functio...
http://hdl.handle.net/2262/57167
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ADHD-Derived Coding Variation in the Dopamine Transporter Disrupts Microdomain Targeting and Trafficking Regulation.
(2012)
GILL, MICHAEL
ADHD-Derived Coding Variation in the Dopamine Transporter Disrupts Microdomain Targeting and Trafficking Regulation.
(2012)
GILL, MICHAEL
http://hdl.handle.net/2262/75294
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Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
(2014)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
(2014)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
Abstract:
Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. Structural and functional analysis has identified four distinct classes of surface proteins, of which microbial surface component recognizing adhesive matrix molecules (MSCRAMMs) are the largest class. These surface proteins have numerous functions, including adhesion to and invasion of host cells and tissues, evasion of immune responses and biofilm formation. Thus, cell wall-anchored proteins are essential virulence factors for the survival of S. aureus in the commensal state and during invasive infections, and targeting them with vaccines could combat S. aureus infections.
http://hdl.handle.net/2262/93120
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