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A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs. (2013)

Bracken, Adrian

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A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence. (2015)

MC LYSAGHT, AOIFE; BRACKEN, ADRIAN; HEALY, EVAN

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A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings. (2011)

ANNEY, RICHARD; GILL, MICHAEL

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A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2 (2012)

DORMAN, CHARLES

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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. (2007)

Mc Manus, Ross; Feighery, Conleth; Kelleher, Dermot

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A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. (2010)

MOLLOY, ANNE; SCOTT, JOHN

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A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (2011)

HEALY, CLAIRE; TONER, MARY

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A genomewide scan for common alleles affecting risk for autism. (2010)

ANNEY, RICHARD; GALLAGHER, LOUISE; GILL, MICHAEL; BOLSHAKOVA, NADIA; SEGURADO, RICARDO;...

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A global role for Fis in the transcriptional control of metabolic and type III secretion genes of Salmonella enterica serovar Typhimurium (2004)

DORMAN, CHARLES

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A hot spot on interferon ??/?? receptor subunit 1 (IFNAR1) underpins its interaction with interferon-?? and dictates signaling. (2017)

BOURKE, NOLLAIG

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A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts. (2016)

DAVEY, GAVIN

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A longitudinal study of Staphylococcus aureus colonization in pigs in Ireland. (2014)

SHORE, ANNA

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A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila (2010)

RAMASWAMI, MANI

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A NOS1 variant implicated in cognitive performance influences evoked neural responses during a hight density EEG study of early visual perception. (2012)

GILL, MICHAEL; CORVIN, AIDEN; MORRIS, DEREK; DONOHOE, GARY; FAHEY, CIARA

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A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. (2012)

ANNEY, RICHARD; MERIKANGAS, ALISON; MCGRATH, JANE; GALLAGHER, LOUISE

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A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. (2011)

GILL, MICHAEL; GALLAGHER, LOUISE

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A novel multidrug-resistant PVL-negative CC1-MRSA-1 IV clone emerging in Ireland and Germany likely originated in South-Eastern Europe (2019)

Coleman, David; Shore, Anna; Earls, Megan R.; Brennan, Gráinne I.; Simbeck, Alexandra; ...

A novel multidrug-resistant PVL-negative CC1-MRSA-1 IV clone emerging in Ireland and Germany likely originated in South-Eastern Europe (2019)

Coleman, David; Shore, Anna; Earls, Megan R.; Brennan, Gráinne I.; Simbeck, Alexandra; Schneider-Brachert, Wulf; Vremerǎ, Teodora; Dorneanu, Olivia S.; Slickers, Peter; Ehricht, Ralf; Monecke, Stefan; Coleman, David C.

Abstract:

This study investigated the recent emergence of multidrug-resistant Panton-Valentine leukocidin (PVL)-negative CC1-MRSA-IV in Ireland and Germany. Ten CC1-MSSA and 139 CC1-MRSA isolates recovered in Ireland between 2004 and 2017 were investigated. These were compared to 21 German CC1-MRSA, 10 Romanian CC1-MSSA, five Romanian CC1-MRSA and two UAE CC1-MRSA, which were selected from an extensive global database, based on similar DNA microarray profiles to the Irish isolates. All isolates subsequently underwent whole-genome sequencing, core-genome single nucleotide polymorphism (cgSNP) analysis and enhanced SCCmec subtyping. Two PVL-negative clades (A and B1) were identified among four main clades. Clade A included 20 German isolates, 119 Irish isolates, and all Romanian MRSA and MSSA isolates, the latter of which differed from clade A MRSA by 47–130 cgSNPs. Eighty-six Irish clade A isolates formed a tight subclade (A1) exhibiting 0–49 pairwise cgSNPs, 80 of which harboured a 46 kb co...