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A novelmc1rallele for black coat colour reveals the polynesian ancestry and hybridization patterns of hawaiian feral pigs (2018)

Linderholm, Anna; Spencer, Daisy; Battista, Vincent; Frantz, Laurent; Barnett, Ross; Fl...

A novelmc1rallele for black coat colour reveals the polynesian ancestry and hybridization patterns of hawaiian feral pigs (2018)

Linderholm, Anna; Spencer, Daisy; Battista, Vincent; Frantz, Laurent; Barnett, Ross; Fleischer, Robert C.; James, Helen F.; Duffy, Dave; Sparks, Jed P.; Clements, David R.; Andersson, Leif; Dobney, Keith; Leonard, Jennifer A.; Larson, Greger

Abstract:

Pigs (Sus scrofa) have played an important cultural role in Hawaii since Polynesians first introduced them in approximately AD 1200. Additional varieties of pigs were introduced following Captain Cook's arrival in Hawaii in 1778 and it has been suggested that the current pig population may descend primarily, or even exclusively, from European pigs. Although populations of feral pigs today are an important source of recreational hunting on all of the major islands, they also negatively impact native plants and animals. As a result, understanding the origins of these feral pig populations has significant ramifications for discussions concerning conservation management, identity and cultural continuity on the islands. Here, we analysed a neutral mitochondrial marker and a functional nuclear coat colour marker in 57 feral Hawaiian pigs. Through the identification of a new mutation in the MC1R gene that results in black coloration, we demonstrate that Hawaiian feral pigs are mostly ...

http://hdl.handle.net/10379/12460

Mark

A qualitative study of the development of health literacy capacities of participants attending a community-based cardiovascular health programme (2018)

McKenna, Verna; Sixsmith, Jane; Barry, Margaret

Mark

An evolution of learner grammar: Insights from the English Grammar Profile (2016)

O'Keeffe, Anne; Mark, Geraldine

Mark

Common polygenic variation in coeliac disease and confirmation of znf335 and nifa as disease susceptibility loci (2018)

Coleman, Ciara; Quinn, Emma M; Ryan, Anthony W; Conroy, Judith; Trimble, Valerie; Mahmu...

Common polygenic variation in coeliac disease and confirmation of znf335 and nifa as disease susceptibility loci (2018)

Coleman, Ciara; Quinn, Emma M; Ryan, Anthony W; Conroy, Judith; Trimble, Valerie; Mahmud, Nasir; Kennedy, Nicholas; Corvin, Aiden P; Morris, Derek W.; Donohoe, Gary; O'Morain, Colm; MacMathuna, Padraic; Byrnes, Valerie; Kiat, Clifford; Trynka, Gosia; Wijmenga, Cisca; Kelleher, Dermot; Ennis, Sean; Anney, Richard JL; McManus, Ross

Abstract:

Coeliac disease (CD) is a chronic immune-mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Specific HLA-DQA1 and HLA-DQB1 alleles are established coeliac susceptibility genes and are required for the presentation of gliadin to the immune system resulting in damage to the intestinal mucosa. In the largest association analysis of CD to date, 39 non-HLA risk loci were identified, 13 of which were new, in a sample of 12 014 individuals with CD and 12 228 controls using the Immunochip genotyping platform. Including the HLA, this brings the total number of known CD loci to 40. We have replicated this study in an independent Irish CD case-control population of 425 CD and 453 controls using the Immunochip platform. Using a binomial sign test, we show that the direction of the effects of previously described risk alleles were highly correlated with those reported in the Irish population, (P= 2.2 x 10(-16)). Usin...

http://hdl.handle.net/10379/10836