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Displaying Results 51 - 75 of 150 on page 3 of 6
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European Human Rights Law and Death in Prison: Obligation and Reforms
(2017)
ROGAN, MARY
European Human Rights Law and Death in Prison: Obligation and Reforms
(2017)
ROGAN, MARY
http://hdl.handle.net/2262/81930
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ESSD commentary on oropharyngeal dysphagia management during the COVID-19 pandemic
(2020)
Walshe, Margaret
ESSD commentary on oropharyngeal dysphagia management during the COVID-19 pandemic
(2020)
Walshe, Margaret
Abstract:
Since the World Health Organization declared the COVID-19 pandemic a Global Public Health Emergency, experts in swallowing are seeking guidance on service delivery and clinical procedures. The European Society for Swallowing Disorders provides considerations to support experts in swallowing disorders in clinical practice. During the COVID-19 pandemic, assessment and treatment of patients with oropharyngeal dysphagia should be provided, while at the same time balancing risk of oropharyngeal complications with that of infection of patients and healthcare professionals involved in their management. Elective, non-urgent assessment may be temporarily postponed and patients are triaged to decide whether dysphagia assessment is necessary; instrumental assessment of swallowing is performed only if processing of the instruments can be guaranteed and clinical assessment has not provided enough diagnostic information for treatment prescription. Assessment and management of oropharyngeal dyspha...
http://hdl.handle.net/2262/94163
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EU Equality Law and Precarious Work
(2019)
Bell, Mark
EU Equality Law and Precarious Work
(2019)
Bell, Mark
Abstract:
The late 1990s/early 2000s were a period of dynamism within EU Law that saw the adoption of the Racial Equality and Employment Equality Directives, as well as the enhancement of existing Directives on gender equality. In the same period, EU Labour Law witnessed the emergence of a new body of legislation governing non-standard forms of work, notably the 1997 Part-Time Work Directive and the 1999 Fixed-Term Work Directive. These were later joined, with some delay, by the 2008 Agency Work Directive. From the outset, it was clear that there were connections between these branches of EU Law: notably, there was already considerable case-law tackling the conditions of part-time work via indirect sex discrimination. Yet the two bodies of law were generally treated as conceptually distinct. This paper explores developments since 2000 to consider how EU Equality Directives interact with the legislation on non-standard forms of work. It examines whether the combination of both enhances legal ...
http://hdl.handle.net/2262/90699
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Evaluation of wastewater post-treatment options for reuse purposes in the agricultural sector under rural development conditions
(2016)
PILLA, FRANCESCO
Evaluation of wastewater post-treatment options for reuse purposes in the agricultural sector under rural development conditions
(2016)
PILLA, FRANCESCO
http://hdl.handle.net/2262/75404
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Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.
(2011)
Mc Manus, Ross
Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.
(2011)
Mc Manus, Ross
Abstract:
OBJECTIVE: /st> There is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct underlying aetiological pathways. Recent studies identified single nucleotide polymorphisms (SNPs) in the interleukin 13 (IL-13) gene region as risk factors for PsV. Further investigations in one of these studies found the effect to be primarily restricted to PsA, thus suggesting the discovery of a specific genetic risk factor for PsA. Given this intriguing evidence, association to this gene was investigated in large collections of PsA and PsV patients and healthy controls. METHODS: /st> Two SNPs (rs20541 and rs1800925) mapping to the IL-13 gene were genotyped in 1057 PsA and 778 type I PsV patients using the Sequenom genotyping platform. Genotype frequencies were compared to those of 5575 healthy controls. Additional analyses were performed in phenotypic sub...
http://hdl.handle.net/2262/54843
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Field Trial Testing of an Electricity-Producing Portable Biomass Cooking Stove in Rural Malawi
(2014)
ROBINSON, ANTHONY; O'SHAUGHNESSY, SEAMUS
Field Trial Testing of an Electricity-Producing Portable Biomass Cooking Stove in Rural Malawi
(2014)
ROBINSON, ANTHONY; O'SHAUGHNESSY, SEAMUS
Abstract:
A novel off - grid electricity - producing device has been designed for integration with biomass - fuelled improved cooking stoves commonly in use in the developing world. The device operates on the thermoelectric principle whereby small amounts of electricity can be produced in response to a temperature difference across a thermoelectric generator, or TEG. The energy produced by the integrated g enerator can be used for direct charging or stored in a rechargeable lithium - iron - phosphate (LiFePo 4 ) battery. The generator is equipped with a standard USB output which allows the user to charge a variety of 5 Volt appliances. Five technology demonstrator electricity generating stoves have been integrated with locally produced clay cooking stoves in the Balaka district of Malawi, Africa. This study details the results from an 80 - day field trial of the devices. The data reveals that the stoves are in use fo r a greater time than was anticipat...
http://hdl.handle.net/2262/74590
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First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru
(2014)
WINDLE, HENRY
First detected Helicobacter pylori infection in infancy modifies the association between diarrheal disease and childhood growth in Peru
(2014)
WINDLE, HENRY
Abstract:
BACKGROUND: In endemic settings, Helicobacter pylori infection can occur shortly after birth and may be associated with a reduction in childhood growth. MATERIALS AND METHODS: This study investigated what factors promote earlier age of first H. pylori infection and evaluated the role of H. pylori infection in infancy (6-11 months) versus early childhood (12-23 months) on height. We included 183 children near birth from a peri-urban shanty town outside of Lima, Peru. Field-workers collected data on socioeconomic status (SES), daily diarrheal and breast-feeding history, antibiotic use, anthropometrics, and H. pylori status via carbon 13-labeled urea breath test up to 24 months after birth. We used a proportional hazards model to assess risk factors for earlier age at first detected infection and linear mixed-effects models to evaluate the association of first detected H. pylori infection during infancy on attained height. RESULTS: One hundred and forty (77%) were infected before 12...
http://hdl.handle.net/2262/76564
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Folate and vitamin B12 in idiopathic male infertility.
(2011)
MOLLOY, ANNE
Folate and vitamin B12 in idiopathic male infertility.
(2011)
MOLLOY, ANNE
Abstract:
Although methylenetetrahydrofolate reductase, a folate enzyme gene, has been associated with idiopathic male infertility, few studies have examined other folate-related metabolites and genes. We investigated whether idiopathic male infertility is associated with variants in folate, vitamin B(12) (B12) and total homocysteine (tHcy)-related genes and measured these metabolites in blood. We conducted a case-control study that included 153 men with idiopathic infertility and 184 fertile male controls recruited at the Fertility Center and Antenatal Care Center, University Hospital, Malm? and Lund, Sweden. Serum folate, red cell folate (RCF), serum B12, plasma tHcy and semen quality were measured. Subjects were genotyped for 20 common variants in 12 genes related to folate/B12/homocysteine metabolism. Metabolite concentrations and genotype distributions were compared between cases and controls using linear and logistic regression with adjustment for covariates. The phosphatidylethanolamin...
http://hdl.handle.net/2262/75133
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Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.
(2008)
MOLLOY, ANNE; SCOTT, JOHN; ORR, DAVID
Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.
(2008)
MOLLOY, ANNE; SCOTT, JOHN; ORR, DAVID
Abstract:
BACKGROUND Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folate-related genes associated with clefts have, however, often been inconclusive. This study examined four SNPs related to folate metabolism (MTHFR 677 C?T, MTHFR 1298 A?C, MTHFD1 1958 G?A, and TC II 776 C?G) in a large Irish population to clarify their relationship with clefts. METHODS Cases and their parents were recruited from major surgical centers performing cleft repairs in Ireland and a support organization. Data on risk factors, medical history, and DNA were collected. Controls were pregnant women from the greater Dublin area (n = 1,599). RESULTS CLP cases numbered 536 and CPO cases 426 after exclusions. CPO mothers were significantly more likely than controls to be MTHFR 677 TT, OR 1.50 (95% CI: 1.05?2.16; p = .03). Log-linear analysis showed a borderline association (p = .07). Isolated C...
http://hdl.handle.net/2262/75143
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Food Security and WTO Domestic Support Disciplines post-Bali
(2014)
MATTHEWS, ALAN
Food Security and WTO Domestic Support Disciplines post-Bali
(2014)
MATTHEWS, ALAN
http://hdl.handle.net/2262/70575
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Food security, developing countries and multilateral trade rules
(2015)
MATTHEWS, ALAN
Food security, developing countries and multilateral trade rules
(2015)
MATTHEWS, ALAN
http://hdl.handle.net/2262/75630
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Gaming for Peace Interviews
(2019)
Holohan, Anne
Gaming for Peace Interviews
(2019)
Holohan, Anne
http://hdl.handle.net/2262/92898
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Gender equality policy and gender mainstreaming in Irish Aid: From diffusion to dilution to disappearance
(2019)
Reilly, Niamh
Gender equality policy and gender mainstreaming in Irish Aid: From diffusion to dilution to disappearance
(2019)
Reilly, Niamh
Abstract:
This article offers a critical analysis of Irish Aid s treatment of gender equality and gender mainstreaming. Informed by key concepts in policy process and feminist scholarship, it examines the evidence of Irish Aid s progress in this area. The author finds that gender equality has low salience in Irish Aid and a record of weak implementation. It is argued that while the adoption of a Gender Equality Policy in Irish Aid reflects global policy diffusion, Ireland s rhetorical endorsement of gender equality in international affairs stems chiefly from an instrumental interest in the reputational gains it can offer and represents a form of soft coercion rather than a principled interest in achieving gender equality. The weakness of state feminism in Ireland and the weak links between officials and women s movement actors are also factors. Further, while the disadvantage of low salience can be offset by the presence of effective policy entrepreneurs using discretionary power to augme...
http://hdl.handle.net/10379/15621
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Glass Ceilings and Iron Bars: Women, Gender, and Poverty in the Post-2015 Development Agenda
(2015)
MURPHY, SUSAN
Glass Ceilings and Iron Bars: Women, Gender, and Poverty in the Post-2015 Development Agenda
(2015)
MURPHY, SUSAN
http://hdl.handle.net/2262/79591
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Heart of Darkness Redux
(2002)
Travis, Charles
Heart of Darkness Redux
(2002)
Travis, Charles
http://hdl.handle.net/2262/91487
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Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development.
(2004)
O'FARRELLY, CLIONA; DOHERTY, DEREK
Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development.
(2004)
O'FARRELLY, CLIONA; DOHERTY, DEREK
Abstract:
Interleukin 15 (IL-15) is critical for the development of human and murine natural killer (NK) cells and hepatic-derived NK T cells (NKT) in mice, and for the homeostatic maintenance of NK/NKT and CD8(+) memory T cells. The lymphocyte repertoire of an adult human liver includes significant populations of NK and NKT-like cells, which may arise locally from hepatic haematopoietic stem cells (HSCs). We investigated hepatic IL-15 levels and the expression of IL-2/IL-15-receptor beta-chain (IL-2/IL-15Rbeta; CD122) on mature hepatic lymphocytes and HSCs. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect secreted/intracellular IL-15 transcripts. IL-15 protein was localized using immunohistochemistry; levels were measured by enzyme-linked immunosorbent assay IL-2/IL-15Rbeta expression by flow-cytometry. Normal hepatic IL-15 protein was detected at 0.43 ng/100 mg total protein (n = 11, range 0.10 ng-0.9 ng). There was a significant increase in HCV-infected tissue (1...
http://hdl.handle.net/2262/75163
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How do community health committees build capacity for maternal and child health?: A realist evaluation protocol
(2016)
GILMORE, BRYNNE
How do community health committees build capacity for maternal and child health?: A realist evaluation protocol
(2016)
GILMORE, BRYNNE
http://hdl.handle.net/2262/82437
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Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals
(2005)
Mc Manus, Ross; Kelleher, Dermot; Windle, Henry
Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals
(2005)
Mc Manus, Ross; Kelleher, Dermot; Windle, Henry
Abstract:
BACKGROUND: In this study, we identify the nature of the immunological response of human peripheral blood mononuclear cells (PBMC) and lamina propria gastric lymphocytes (LPL) to two Helicobacter pylori antigens, the neutrophil activating protein (NapA) and alkyl hydroperoxide reductase (AphC). These antigens were identified and selected for study based on the observation that serological recognition of these proteins was associated with H pylori negative status in humans. AIMS: The aim was to study the serological, proliferative, and cytokine responses of PBMC and LPL, obtained from H pylori infected and uninfected individuals, to these antigens. METHODS: Patient serum, PBMC, and LPL were used to determine antibody isotype, and proliferative and cytokine responses to recombinant forms of NapA and AphC using western blotting and ELISA. RESULTS: Western blotting revealed antibody reactivity to recombinant NapA and AphC among the H pylori negative population studied. Both the prolifer...
http://hdl.handle.net/2262/33845
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Identification of a new antinociceptive alkaloid isopropyl N-methylanthranilate from the essential oil of Choisya ternata Kunth
(2011)
WALDREN, STEPHEN; DE SOUSA MENEZES, FABIO; PARNELL, JOHN
Identification of a new antinociceptive alkaloid isopropyl N-methylanthranilate from the essential oil of Choisya ternata Kunth
(2011)
WALDREN, STEPHEN; DE SOUSA MENEZES, FABIO; PARNELL, JOHN
Abstract:
Ethnopharmacological relevance: Mexican people employed infusion of leaves of Choisya ternata Kunth for their antispasmodic and ?simulative properties? Aim of the study: In the present study the detailed GC and GC-MS analyses of the essential oil of Choisya ternata Kunth (Rutaceae) were performed. The presence of a minor constituent isopropyl N-methylanthranilate (1) was revealed among other identified volatiles. A synthesis of 1 was undertaken in order to corroborate this find and obtain gram quantities that would allow the testing of its biological activity (peripheral and central antinociceptive activity) Material and methods: The oils were investigated by GC and GC-MS. Synthesized compounds were spectrally characterized (UV-Vis, IR, 1D and 2D NMR, MS). The obtained synthetic samples of compounds were assayed for peripheral and central antinociceptive activity in two models (effects on acetic acid induced writhing in mice and the hot plate test for nociception). Results: Detailed...
http://hdl.handle.net/2262/55877
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IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer.
(2013)
DOHERTY, DEREK; BAIRD, ANNE-MARIE; GRAY, STEVEN; O'BYRNE, KEN
IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer.
(2013)
DOHERTY, DEREK; BAIRD, ANNE-MARIE; GRAY, STEVEN; O'BYRNE, KEN
Abstract:
The Interleukin-23 (IL-23)/IL-23R signaling axis is an important inflammatory pathway, involved in the stimulation and regulation of the T helper (Th) 17 lymphocytes, resulting in the production of IL-17. Aside from auto-immunity, this cytokine has also been linked to carcinogenesis and polymorphisms in the IL-23R gene are associated with an increased risk for the development of a number of different cancers. Activation of the IL-23 pathway results in the up-regulation of STAT3 and it is thought that the pathological consequences associated with this are in part due to the production of IL-17. We have previously identified IL-23A as pro-proliferative and epigenetically regulated in non-small cell lung cancer (NSCLC). The current study aims to evaluate IL-23R in greater detail in NSCLC. We demonstrate that IL-23R is expressed and epigenetically regulated in NSCLC through histone post-translation modifications and CpG island methylation. In addition, Gemcitabine treatment, a chemother...
http://hdl.handle.net/2262/71223
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Impact and mortality of COVID-19 on people living with dementia: cross-country report
(2020)
Cahill, Suzanne
Impact and mortality of COVID-19 on people living with dementia: cross-country report
(2020)
Cahill, Suzanne
Abstract:
We have collected data on impact and mortality of COVID-19 in people living with dementia in 9 countries: The United Kingdom (UK), Spain, Ireland, Italy, Australia, the United States (US), India, Kenya and Brazil. The share of people whose deaths were linked to COVID-19 in care homes who had dementia ranges from 29% to 75% across those countries. Within countries, people with dementia account for 25% of all COVID-19 related deaths in England and Wales, 31% in Scotland and 19% in Italy. We did not find nation-level data for the rest of the countries. The high rates of deaths in people living with dementia seem to be linked to death rates in care homes, where many residents have dementia. Direct comparison between countries is not possible due to differences in systems of information: the types of data collected and ways in which they are reported, metrics used and varying definitions of COVID-19 cases and care home facilities. The different approaches to collecting and reporting data...
http://hdl.handle.net/2262/94263
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Impact of a new electronic handover system in surgery
(2011)
Ryan, Siobhan; Conlon, Kevin; Tierney, Sean; Ridgway, Paul; O'Riordan, James
Impact of a new electronic handover system in surgery
(2011)
Ryan, Siobhan; Conlon, Kevin; Tierney, Sean; Ridgway, Paul; O'Riordan, James
Abstract:
Changing patterns of workflow in the hospital setting have highlighted the need for improvements in effective and safe handover of patient details. Financial constraints mean that hospitals are under increasing pressure to maximise efficiency and reduce length of stay of patients in hospitals and to reduce overtime bills for junior doctors. The European Working Time Directive (EWTD) for junior doctors also requires hospitals to comply with the 48 hour working week. This means the introduction of a shift-based work practice for junior doctors and subsequently an increased number of handovers between surgical on-call teams.
http://hdl.handle.net/2262/53329
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Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters.
(2013)
MOLLOY, ANNE
Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of Folic Acid Supplementation in the Second and Third Trimesters.
(2013)
MOLLOY, ANNE
Abstract:
BACKGROUND: Supplementation with folic acid (FA) is recommended worldwide before and during early pregnancy because of its proven effect in preventing neural tube defects, but the role of FA after the 12th gestational week (GW) is much less clear. OBJECTIVE: We investigated maternal folate and homocysteine responses and related effects in the newborn that resulted from continued FA supplementation after the first trimester of pregnancy. DESIGN: Pregnant women, aged 18-35 y, who were attending an antenatal clinic in Northern Ireland with singleton uncomplicated pregnancies and reported taking FA supplements in the first trimester, were randomly assigned at the start of trimester 2 to receive 400 ?g FA/d or a placebo capsule. RESULTS: A total of 119 women (60 women in the placebo group; 59 women in the treatment group) completed the trial. From GWs 14-36, mean (?SD) serum folate decreased (from 45.7 ? 21.3 to 19.5 ? 16.5 nmol/L; P < 0.001) in unsupplemented women, whereas plasm...
http://hdl.handle.net/2262/75124
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Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate.
(2014)
MOLLOY, ANNE
Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate.
(2014)
MOLLOY, ANNE
Abstract:
Malaria remains the leading cause of mortality and morbidity in children under the age of 5 years and pregnant women. To counterbalance the malaria burden in pregnancy, an intermittent preventive treatment strategy has been developed. This is based on the use of the antifolatesulfadoxine/pyrimethamine, taken at specified intervals duringpregnancy,andreportsshowthatthisapproachreducesthemalariaburdeninpregnancy.Pregnancyisalso associated with the risk of neural tube defects (NTDs), especially in women with low folate status, and folic acid supplementation is recommended in pregnancy to lower the risk of NTDs. Thus, in malaria-endemic areas, preg- nant women have to take both antifolate medication to prevent malaria and folic acid to lower the risk of NTDs. However,theconcomitantuseoffolateandantifolateisassociatedwithadecreaseinantifolateefficacy,exposing pregnant women to malaria. Thus, there is genuine concern that this strategy may not be appropriate. We have reviewedworkcarriedou...
http://hdl.handle.net/2262/75123
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Improving the performance of community health workers in humanitarian emergencies: a realist evaluation protocol for the PIECES programme
(2016)
GILMORE, BRYNNE
Improving the performance of community health workers in humanitarian emergencies: a realist evaluation protocol for the PIECES programme
(2016)
GILMORE, BRYNNE
http://hdl.handle.net/2262/82436
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