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Limited By:	Subject = Johne’s disease;

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Association of genetic polymorphisms related to Johne’s disease with estimated breeding values of Holstein sires for milk ELISA test scores (2020)

Mallikarjunappa, Sanjay; Schenkel, Flavio S; Brito, Luiz F; Bissonnette, Nathalie; Migl...

Association of genetic polymorphisms related to Johne’s disease with estimated breeding values of Holstein sires for milk ELISA test scores (2020)

Mallikarjunappa, Sanjay; Schenkel, Flavio S; Brito, Luiz F; Bissonnette, Nathalie; Miglior, Filippo; Chesnais, Jacques; Lohuis, Michael; Meade, Kieran G; Karrow, Niel A

Abstract:

Background Johne’s disease (JD) is a chronic intestinal inflammatory disease caused by Mycobacterium avium subsp. paratuberculosis (MAP) infection in ruminants. Since there are currently no effective vaccine or treatment options available to control JD, genetic selection may be an alternative strategy to enhance JD resistance. Numerous Single Nucleotide Polymorphisms (SNPs) have been reported to be associated with MAP infection status based on published genome-wide association and candidate gene studies. The main objective of this study was to validate these SNPs that were previously identified to be associated with JD by testing their effect on Holstein bulls’ estimated breeding values (EBVs) for milk ELISA test scores, an indirect indicator of MAP infection status in cattle. Results Three SNPs, rs41810662, rs41617133 and rs110225854, located on Bos taurus autosomes (BTA) 16, 23 and 26, respectively, were confirmed as significantly associated with Holstein bulls’ EBVs for milk EL...

http://hdl.handle.net/11019/2168

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Associations between paratuberculosis ELISA results and test-day records of cows enrolled in the Irish Johne's Disease Control Program (2018)

Botaro, Bruno G.; Ruelle, Elodie; More, Simon John; Strain, Sam; Graham, David A.; O�...

Associations between paratuberculosis ELISA results and test-day records of cows enrolled in the Irish Johne's Disease Control Program (2018)

Botaro, Bruno G.; Ruelle, Elodie; More, Simon John; Strain, Sam; Graham, David A.; O'Flaherty, Joe; Shalloo, Laurence

Abstract:

The effect of the Mycobacterium avium ssp. paratuberculosis (MAP) ELISA status on test-day milk performance of cows from Irish herds enrolled in the pilot national voluntary Johne's disease control program during 2013 to 2015 was estimated. A data set comprising 92,854 cows and 592,623 complete test-day records distributed across 1,700 herds was used in this study. The resulting ELISA outcome (negative, inconclusive, and positive) of each cow within each year of the program was used to allocate the cow into different scenarios representing the MAP status. At MAPscenario1, all cows testing ELISA nonnegative (i.e., inconclusive and positive) were assigned a MAP-positive status; at MAPscenario2 only cows testing ELISA-positive were assigned a MAP-positive status; at MAPscenario3 only cows testing ELISA nonnegative (inconclusive or positive) and gathered exclusively from herds where at least 2 further ELISA nonnegative (inconclusive or positive) cows were found were assigned a MAP-...

http://hdl.handle.net/10197/9474

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Characterization of the bovine salivary gland transcriptome associated with Mycobacterium avium subsp. paratuberculosis experimental challenge (2020)

Mallikarjunappa, Sanjay; Adnane, Mounir; Cormican, Paul; Karrow, Niel A.; Meade, Kieran G

Characterization of the bovine salivary gland transcriptome associated with Mycobacterium avium subsp. paratuberculosis experimental challenge (2020)

Mallikarjunappa, Sanjay; Adnane, Mounir; Cormican, Paul; Karrow, Niel A.; Meade, Kieran G

Abstract:

Background Mycobacterium avium subsp. paratuberculosis (MAP), the etiologic agent of Johne’s disease is spread between cattle via the fecal-oral route, yet the functional changes in the salivary gland associated with infection remain uncharacterized. In this study, we hypothesized that experimental challenge with MAP would induce stable changes in gene expression patterns in the salivary gland that may shed light on the mucosal immune response as well as the regional variation in immune capacity of this extensive gland. Holstein-Friesian cattle were euthanized 33 months’ post oral challenge with MAP strain CIT003 and both the parotid and mandibular salivary glands were collected from healthy control (n = 5) and MAP exposed cattle (n = 5) for histopathological and transcriptomic analysis. Results A total of 205, 21, 61, and 135 genes were significantly differentially expressed between control and MAP exposed cattle in dorsal mandibular (M1), ventral mandibular (M2), dorsal parotid (...

http://hdl.handle.net/11019/2085

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Characterization of the bovine salivary gland transcriptome associated with Mycobacterium avium subsp. paratuberculosis experimental challenge (2020)

Mallikarjunappa, Sanjay; Adnane, Mounir; Cormican, Paul; Karrow, Niel A; Meade, Kieran G

Characterization of the bovine salivary gland transcriptome associated with Mycobacterium avium subsp. paratuberculosis experimental challenge (2020)

Mallikarjunappa, Sanjay; Adnane, Mounir; Cormican, Paul; Karrow, Niel A; Meade, Kieran G

Abstract:

http://hdl.handle.net/11019/2234

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Epidemiology and economic impact of Johne's disease in Irish dairy herds (2015)

Mee, John F; Richardson, Esther K. B.

Epidemiology and economic impact of Johne's disease in Irish dairy herds (2015)

Mee, John F; Richardson, Esther K. B.

Abstract:

End of project report
This project addressed two aspects of an emerging infectious disease of Irish cattle; the epidemiology and the economic impacts of Johne’s disease (paratuberculosis). Though this disease has been present in Irish cattle herds for decades, only since the introduction of the Single European Market in 1992 has it become more widespread. In addition to this change in the epidemiology of the disease in Irish cattle, there is increasing evidence that the causative organism, Mycobacterium avium subsp. paratuberculosis (MAP) may be implicated in a human illness, Crohn’s disease, though proof of a zoonotic link is currently disputed (Tremblay, 2004). Against this background a collaborative research project was set up by Teagasc and funded by Irish dairy farmers.

http://hdl.handle.net/11019/826

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Evaluation of testing strategies to identify infected animals at a single round of testing within dairy herds known to be infected with Mycobacterium avium subspecies paratuberculosis (2016)

More, Simon John; Cameron, A. R.; Strain, Sam; et al.

Evaluation of testing strategies to identify infected animals at a single round of testing within dairy herds known to be infected with Mycobacterium avium subspecies paratuberculosis (2016)

More, Simon John; Cameron, A. R.; Strain, Sam; et al.

Abstract:

As part of a broader control strategy within herds known to be infected with Mycobacterium avium ssp. paratuberculosis (MAP), individual animal testing is generally conducted to identify infected animals for action, usually culling. Opportunities are now available to quantitatively compare different testing strategies (combinations of tests) in known infected herds. This study evaluates the effectiveness, cost, and cost-effectiveness of different testing strategies to identify infected animals at a single round of testing within dairy herds known to be MAP infected. A model was developed, taking account of both within-herd infection dynamics and test performance, to simulate the use of different tests at a single round of testing in a known infected herd. Model inputs included the number of animals at different stages of infection, the sensitivity and specificity of each test, and the costs of testing and culling. Testing strategies included either milk or serum ELISA alone or with ...

http://hdl.handle.net/10197/7787

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Is TB testing associated with increased blood interferon-gamma levels? (2017)

Kennedy, Aideen E.; O'Mahony, Jim; Byrne, Noel; MacSharry, John; Sayers, Riona G.

Is TB testing associated with increased blood interferon-gamma levels? (2017)

Kennedy, Aideen E.; O'Mahony, Jim; Byrne, Noel; MacSharry, John; Sayers, Riona G.

Abstract:

The Republic of Ireland reports a relatively low prevalence of Johne’s disease (JD) compared to international counterparts. Postulated reasons for this include a lower average herd size and a grass-based production system. Ireland also engages in high levels of bovine tuberculosis (bTB) testing. As interferon-gamma (IFN-γ) is believed to play a key role in protecting against JD, it is our hypothesis that administration of purified protein derivative (PPD), as part of the bTB test, is associated with a systemic increase in IFN-γ production, which may potentially limit clinical progression of the disease. We studied 265 cows (202 Friesian and 63 “Non-Friesian,” e.g., JerseyX, Norwegian Red) to assess IFN-γ levels and Mycobacterium avium subspecies paratuberculosis (MAP) antibody response before and after the bTB test. As part of the compulsory annual bTB test, avian and bovine PPD were administered at two separate cervical sites. To assess IFN-γ production, blood samples were taken be...

http://hdl.handle.net/10468/5153

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The effect of paratuberculosis on milk yield—A systematic review and meta-analysis (2020)

McAloon, Conor G.; Whyte, Paul; More, Simon J.; Green, Martin J.; O’Grady, Luke; Garcia...

The effect of paratuberculosis on milk yield—A systematic review and meta-analysis (2020)

McAloon, Conor G.; Whyte, Paul; More, Simon J.; Green, Martin J.; O’Grady, Luke; Garcia, AnaBelen; Doherty, Michael L.

Abstract:

Bovine paratuberculosis is a disease characterized by chronic granulomatous enteritis causing protein-losing enteropathy. Adverse effects on animal productivity are key drivers in the attempt to control paratuberculosis at the farm level. Economic models require an accurate estimation of the production effects associated with paratuberculosis. The aim of this study was to conduct a systematic review and meta-analysis to investigate the effect of paratuberculosis on milk production. A total of 20 effect estimates from 15 studies were included in the final meta-analysis. Substantial between-study heterogeneity was observed. Subgroup analysis by case definition and study design was carried out to investigate heterogeneity. The majority of between-study variation was attributed to studies that defined cases on serology. Calculation of a pooled effect estimate was only appropriate for studies that defined cases by organism detection. A reduction in milk yield, corrected for lactation num...

http://hdl.handle.net/11019/2095