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Subject = Ligands;
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Displaying Results 1 - 25 of 38 on page 1 of 2
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Alternating bimetallic Na/Mn covalent and ionic chains
(2013)
Berg, Nelly; Jones, Leigh F.
Alternating bimetallic Na/Mn covalent and ionic chains
(2013)
Berg, Nelly; Jones, Leigh F.
Abstract:
Journal article (post-print)
The first coordination polymers constructed using the 2,2'-biphenol ligand are described along with their ionic supramolecular counterparts.
IRCSET
http://hdl.handle.net/10379/3868
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Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF).
(2005)
Byrne, Anne Marie; Bouchier-Hayes, David J; Harmey, Judith H
Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF).
(2005)
Byrne, Anne Marie; Bouchier-Hayes, David J; Harmey, Judith H
Abstract:
<p>The original article is available at <a href="http://www.jcmm.ro">www.jcmm.ro</a></p>
<p>Vascular endothelial growth factor (VEGF) was originally identified as an endothelial cell specific growth factor stimulating angiogenesis and vascular permeability. Some family members, VEGF C and D, are specifically involved in lymphangiogenesis. It now appears that VEGF also has autocrine functions acting as a survival factor for tumour cells protecting them from stresses such as hypoxia, chemotherapy and radiotherapy. The mechanisms of action of VEGF are still being investigated with emerging insights into overlapping pathways and cross-talk between other receptors such as the neuropilins which were not previously associated with angiogenesis. VEGF plays an important role in embryonic development and angiogenesis during wound healing and menstrual cycle in the healthy adult. VEGF is also important in a number of both malignant and non-malignant ...
https://epubs.rcsi.ie/surgart/25
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Assessment of charged AuNPs: from synthesis to innate immune recognition
(2018)
Rahme, Kamil; Minassian, G.; Sarkis, M.; Nakhl, M.; El Hage, Roland; Souaid, E.; Holmes...
Assessment of charged AuNPs: from synthesis to innate immune recognition
(2018)
Rahme, Kamil; Minassian, G.; Sarkis, M.; Nakhl, M.; El Hage, Roland; Souaid, E.; Holmes, Justin D.; Ghanem, E.
Abstract:
Gold nanoparticle (AuNP) physicochemical characteristics, mainly size and charge, modulate their biodistribution, cytotoxicity, and immunorecognition as reported from in vitro and in vivo studies. While data from in vitro studies could be biased by several factors including activation of cells upon isolation and lack of sera proteins in the microenvironment of primary generated cell lines, in vivo studies are costly and time-consuming and require ethics consideration. In this study, we developed a simple and novel in vivo-like method to test for NP immunorecognition from freshly withdrawn human blood samples. AuNPs with a size range of 30 ± 5 nm coated with cationic poly(L-lysine) (PLL) dendrigraft and slightly negative poly(vinyl alcohol) (PVA) were synthesized in water. PLL-capped AuNPs were further coated with poly(ethylene glycol) (PEG) to obtain nearly neutrally charged PEG-AuNPs. Physicochemical properties were determined using zeta potential measurements, UV-Vis spectroscopy,...
http://hdl.handle.net/10468/6716
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Au(III) and Pt(II) Complexes of a Novel and Versatile 1,4-Disubstituted 1,2,3-Triazole-Based Ligand Possessing Diverse Secondary and Tertiary Coordinating Groups.
(2018)
Kitteringham, Eolann; Zhou, Zehao; Twamley, Brendan; Griffith, Darren M
Au(III) and Pt(II) Complexes of a Novel and Versatile 1,4-Disubstituted 1,2,3-Triazole-Based Ligand Possessing Diverse Secondary and Tertiary Coordinating Groups.
(2018)
Kitteringham, Eolann; Zhou, Zehao; Twamley, Brendan; Griffith, Darren M
Abstract:
<p>“This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Inorganic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work see <a href="https://pubs.acs.org/doi/10.1021/acs.inorgchem.8b01994">https://pubs.acs.org/doi/10.1021/acs.inorgchem.8b01994</a></p>
<p>A novel 1,4-disubstituted 1,2,3-triazole-based ligand, 2-(4-(pyridin-2-yl)-1 H-1,2,3-triazol-1-yl)propane-1,3-diamine (ptpd), which possesses pyridyl and diamino secondary and tertiary coordinating groups was synthesized in excellent yield. The reactivity of 2-(1-phenyl-1 H-1,2,3-triazol-4-yl)pyridine (ptp), di- tert-butyl (2-azidopropane-1,3-diyl)dicarbamate (Boc</p>
https://epubs.rcsi.ie/pmcart/27
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Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects.
(2008)
Köhler, Barbara; Anguissola, Sergio; Concannon, Caoimhín G; Rehm, Markus; Kögel, Donat;...
Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects.
(2008)
Köhler, Barbara; Anguissola, Sergio; Concannon, Caoimhín G; Rehm, Markus; Kögel, Donat; Prehn, Jochen HM
Abstract:
<p>The original article is available at <a href="http://www.plosone.org">www.plosone.org</a></p>
<p>BACKGROUND: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors. Bid has also been reported to be cleaved by other proteases.</p> <p>METHODOLOGY/PRINCIPAL FINDINGS: To test the hypothesis that Bid is a central mediator of stress-induced apoptosis, we investigated the effects of a small molecule Bid inhibitor on stress-induced apoptosis, and generated HeLa cells deficient for Bid. Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and TRAIL-induced caspase activation and apoptosis, and significantly increased clonogenic survival. While Bid-deficient cells were equally sensitive to ER stress-induced apoptosis, they showed moderate, bu...
https://epubs.rcsi.ie/physiolart/63
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Chelating C4-bound imidazolylidene complexes via oxidative addition of imidazolium salts to palladium(0)
(2012)
Krüger, Anneke; Kluser, Evelyne; Müller-Bunz, Helge; Neels, Antonia; Albrecht, Martin
Chelating C4-bound imidazolylidene complexes via oxidative addition of imidazolium salts to palladium(0)
(2012)
Krüger, Anneke; Kluser, Evelyne; Müller-Bunz, Helge; Neels, Antonia; Albrecht, Martin
Abstract:
Oxidative addition of donor-functionalised 4-iodoimidazolium salts to palladium(0) provides a selective route for the preparation of chelating abnormal N-heterocylic carbene complexes and enables the introduction of a variety of donor groups. The activation of the C4 position does not necessitate the imidazolium C2 position to be protected, leaving this site available for further modification. While metallation of the unsubstituted C2 position of the N-heterocyclic carbene ligand was unsuccessful when palladium was bound to the C4 carbon, sequential metallation of first the C2 position via transmetallation followed by C4–I oxidative addition afforded a dimetallic complex comprising two palladium centres bridged by a single NHC ligand.
Science Foundation Ireland
European Research Council
Swiss National Science Foundation
ti, sp, ke, ab, jo, vo, is, li - TS 15.05.12
http://hdl.handle.net/10197/3630
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Cleaving carboxyls: understanding thermally triggered hierarchical pores in the metal-organic framework MIL-121
(2019)
Chen, Shoushun; Mukherjee, Soumya; Lucier, Bryan E.G.; Guo, Ying; Tung, Ying; Wong, Ang...
Cleaving carboxyls: understanding thermally triggered hierarchical pores in the metal-organic framework MIL-121
(2019)
Chen, Shoushun; Mukherjee, Soumya; Lucier, Bryan E.G.; Guo, Ying; Tung, Ying; Wong, Angel; Terskikh, Victor V.; Zaworotko, Michael J.; Huang, Yining
Abstract:
Carboxylic acid linker ligands are known to form strong metalcarboxylate bonds to afford many different variations of permanently microporous metal-organic frameworks (MOFs). A controlled approach to decarboxylation of the ligands in carboxylate-based MOFs could result in structural modifications, offering scope to improve existing properties or to unlock entirely new properties. In this work, we demonstrate that the microporous MOF MIL-121 is transformed to a hierarchically porous MOF via thermally triggered decarboxylation of its linker. Decarboxylation and the introduction of hierarchical porosity increases the surface area of this material from 13 m2/g to 908 m2/g, and enhances gas adsorption uptake for industrially relevant gases (i.e., CO2, C2H2, C2H4 and CH4). For example, CO2 uptake in hierarchically porous MIL-121 is improved 8.5 times over MIL-121, reaching 215.7 cm3/g at 195 K and 1 bar; CH4 uptake is 132.3 cm3/g at 298 K and 80 bar in hierarchically porous MIL-121 versus...
http://hdl.handle.net/10344/8078
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Correction: Enantioselective copper catalysed intramolecular C–H insertion reactions of α-diazo-β-keto sulfones, α-diazo-β-keto phosphine oxides and 2-diazo-1,3-diketones; the influence of the carbene substituent
(2019)
Shiely, Amy E.; Slattery, Catherine N.; Ford, Alan; Eccles, Kevin S.; Lawrence, Simon E...
Correction: Enantioselective copper catalysed intramolecular C–H insertion reactions of α-diazo-β-keto sulfones, α-diazo-β-keto phosphine oxides and 2-diazo-1,3-diketones; the influence of the carbene substituent
(2019)
Shiely, Amy E.; Slattery, Catherine N.; Ford, Alan; Eccles, Kevin S.; Lawrence, Simon E.; Maguire, Anita R.
http://hdl.handle.net/10468/7345
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Decomposition of metal alkylamides, alkyls, and halides at reducible oxide surfaces: mechanism of 'clean-up' during atomic layer deposition of dielectrics onto III-V substrates
(2014)
Klejna, Sylwia; Elliott, Simon D.
Decomposition of metal alkylamides, alkyls, and halides at reducible oxide surfaces: mechanism of 'clean-up' during atomic layer deposition of dielectrics onto III-V substrates
(2014)
Klejna, Sylwia; Elliott, Simon D.
Abstract:
The pairing of high-k dielectric materials with high electron mobility semiconductors for transistors is facilitated when atomic layer deposition (ALD) is used to deposit the dielectric film. An interfacial cleaning mechanism (‘clean-up’) that results in consumption of semiconductor native oxides and in practically sharp dielectric/semiconductor interfaces has been observed during ALD of Al2O3, HfO2, TiO2, and Ta2O5 with various degrees of success. We undertake a comprehensive study using density functional theory (DFT) to explain differences in the performance of various classes of precursor chemicals in removing native oxide from III-V substrates. The study covers the metals Ta(V), Ti(IV), Zr(IV), Hf(IV), Al(III), Mg(II) combined with methyl, amide, and chloride ligands. Of these, we show that clean-up is most effective when depositing MgO. Clean-up with metal alkylamides has a similar mechanism to clean-up with metal methyls insofar as oxygen is scavenged by the metal. The differ...
http://hdl.handle.net/10468/2421
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Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells
(2015)
Cloonan, Suzanne M.; Elmes, Robert B.P.; Erby, Marialuisa; Bright, Sandra A.; Poynton, ...
Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells
(2015)
Cloonan, Suzanne M.; Elmes, Robert B.P.; Erby, Marialuisa; Bright, Sandra A.; Poynton, Fergus E.; Nolan, Derek E.; Quinn, Susan J.; Gunnlaugsson, Thorfinnur; Williams, D. Clive
Abstract:
Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT) agents. However, a lack of detailed understanding of their mode of action in cells poses a challenge to their development. We have designed a new Ru(II) PDT candidate that efficiently enters cells by incorporation of the lipophilic aromatic pdppz ([2,3-h]dipyrido[3,2-a:2′,3′-c]phenazine) ligand and exhibits photoactivity through incorporation of 1,4,5,8-tetraazaphenanthrene ancillary ligands. Its photoreactivity toward biomolecules was studied in vitro, where light activation caused DNA cleavage. Cellular internalization occurred via an energy dependent mechanism. Confocal and transmission electron microscopy revealed that the complex localizes in various organelles, including the mitochondria. The complex is nontoxic in the dark, with cellular clearance within 96 h; however, upon visible light activation it induces caspase-dependent and reactive-oxygen-species-dependent apoptosis, with low micromol...
http://mural.maynoothuniversity.ie/12534/
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DNA binding, cleavage and cytotoxicity of a novel dimetallic Fe(III) triaza-cyclononane complex
(2017)
Araujo, Thaylan Pinheiro; Gandin, Valentina; Kavanagh, Paul; Braude, Jeremy Phillip; No...
DNA binding, cleavage and cytotoxicity of a novel dimetallic Fe(III) triaza-cyclononane complex
(2017)
Araujo, Thaylan Pinheiro; Gandin, Valentina; Kavanagh, Paul; Braude, Jeremy Phillip; Nodari, Luca; Montagner, Diego; Erxleben, Andrea
Abstract:
A novel bimetallic Fe(III) complex with the bis(triaza-cyclononane) ligand 2,6-bis(1,4,7-triazacyclonon-1-ylmethyl)-4-methylphenol (bcmp) is reported. [Fe-2(bcmp(-H))(mu-OH)Cl-2]Cl-2 (2) contains two octahedral Fe(III) centers bound to the two triaza-cyclononane rings of bcmp. The coordination sphere is completed by one chlorine, one bridging phenolate oxygen and one bridging hydroxide group. The complex has been characterized by elemental analysis, Mossbauer spectroscopy, UV-Vis spectroscopy, pH potentiometric titration, ESI mass spectrometry and cyclic voltammetry. The complex hydrolyzes the DNA model bis (2,4-dinitrophenyl) phosphate (BDNPP) with a maximum activity a pH 7. Michaelis-Menten behavior is observed with k(cat) = 3.56 x 10(-4)s(-1) and K-m = 0.56 mM (pH 7.0, 40 degrees C). The interaction of 2 with CT DNA was studied by electronic absorption spectroscopy and gel electrophoresis. Notably, the complex relaxes supercoiled pUC19 DNA into the nicked form at low micromolar c...
http://hdl.handle.net/10379/6534
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DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex
(2017)
Montagner, Diego; Gandin, Valentina; Marzano, Cristina; Erxleben, Andrea
DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex
(2017)
Montagner, Diego; Gandin, Valentina; Marzano, Cristina; Erxleben, Andrea
Abstract:
The dinuclear copper(II) complex [Cu-2{bcmp(-H)}(mu-OH)](NO3)(2)center dot H2O (1, bcmp = 2,6-bis(1,4,7-triazacyclonon-1-ylmethyl)-4-methylphenol) has been synthesized and characterized by electrospray ionization mass spectrometry, potentiometric titration and cyclovoltammetry. The X-ray structure of the analogous perchlorate salt [Cu-2{bcmp(-H)}(mu-OH)](ClO4)(2)center dot 2.5H(2)O (2) was determined. Cytotoxicity studies showed very promising activity of 1 against various pancreatic tumor cell lines with IC50 values comparable or even lower than those of cisplatin. The Cu complex displayed low toxicity against a human non-tumor cell line (HEM 293) demonstrating selectivity for cancer cells. 1 converts supercoiled pUC19 plasmid DNA into the nicked form at micromolar concentrations in the absence of added reductants. A detailed kinetic study on the hydrolysis of the DNA model bis(2,4-dinitrophenyl) phosphate (BDNPP) has been performed. 1 hydrolyses BDNPP with a second order rate cons...
http://hdl.handle.net/10379/6540
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Dna damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex
(2018)
Montagner, Diego; Gandin, Valentina; Marzano, Cristina; Erxleben, Andrea
Dna damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex
(2018)
Montagner, Diego; Gandin, Valentina; Marzano, Cristina; Erxleben, Andrea
http://hdl.handle.net/10379/12950
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Doped colloidal InAs nanocrystals in the single ionized dopant limit
(2019)
Biaye, Moussa; Amit, Yorai; Gradkowski, Kamil; Turek, Natalia; Godey, Sylvie; Makoudi, ...
Doped colloidal InAs nanocrystals in the single ionized dopant limit
(2019)
Biaye, Moussa; Amit, Yorai; Gradkowski, Kamil; Turek, Natalia; Godey, Sylvie; Makoudi, Younes; Deresmes, Dominique; Tadjine, Athmane; Delerue, Christophe; Banin, Uri; Mélin, Thierry
Abstract:
We investigate the electronic properties of individual n-type (Cu) doped and p-type (Ag) doped InAs colloidal nanocrystals (NCs) in the 2–8 nm size range from their charge transfers toward a highly oriented pyrolytic graphite (HOPG) substrate, using ultrahigh vacuum Kelvin probe force microscopy (KPFM) with elementary charge sensitivity at 300 K. The NC active dopant concentration is measured as ND = 8 × 1020 cm–3 and NA > 5 × 1020 cm–3 for n- and p-type doping, respectively. The electrostatic equilibrium between the NC and the HOPG reference substrate is investigated and reveals an enhancement of the Fermi-level mismatch between the NCs and the HOPG substrate at reduced NC sizes, both for n- and p-type doping. It also shows, for n-type doped NCs with smallest sizes (∼2 nm), the existence of a full depletion regime, in which smallest NCs contain single ionized dopants. Results are compared with self-consistent tight-binding calculations of the electronic structure of InAs NCs, in...
http://hdl.handle.net/10468/8402
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Effects of abnormal cannabidiol on oxytocin-induced myometrial contractility
(2018)
Houlihan, D. D; Dennedy, M. C; Morrison, J. J
Effects of abnormal cannabidiol on oxytocin-induced myometrial contractility
(2018)
Houlihan, D. D; Dennedy, M. C; Morrison, J. J
Abstract:
The objective of this study was to investigate the effects of abnormal cannabidiol (abn-cbd) on oxytocin-induced myometrial contractility occurring during pregnancy. Isometric tension recordings were performed in isolated myometrial strips from biopsies obtained at elective cesarean section. The effects of cumulative doses of abn-cbd (10(-9) - 10(-5) M) on oxytocin-induced myometrial contractions alone, and on those following pre-incubation with SR 144528, AM 251, methylene blue, and iberiotoxin were measured, and dose response curves were constructed. The pD(2) (-log EC(50)) values and the maximal inhibitory (MMI) values that were achieved were compared for each tissue type. Abn-cbd exerted a potent relaxant effect on oxytocin-induced myometrial contractions in vitro. Pre-incubation with the guanylate cyclase inhibitor, methylene blue, and the BK(Ca) channel antagonist, iberiotoxin, significantly attenuated this effect (for pD(2), P&lt;0.01; for MMI, P&lt;0.01). Abn...
http://hdl.handle.net/10379/11988
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Ferromagnetic exchange in a twisted, oxime-bridged [mniii2] dimer
(2018)
Houton, Edel; Taylor, Stephanie M.; Beedle, Christopher C.; Cano, Joan; Piligkos, Sterg...
Ferromagnetic exchange in a twisted, oxime-bridged [mniii2] dimer
(2018)
Houton, Edel; Taylor, Stephanie M.; Beedle, Christopher C.; Cano, Joan; Piligkos, Stergios; Hill, Stephen; Ryder, Alan G.; Brechin, Euan K.; Jones, Leigh F.
Abstract:
The dimeric complex [Mn-2(III)(Naphth-sao)(2)(Naphth-saoH)(2)(MeOH)(2)]center dot 4MeOH (1.4MeOH), acts as a simple model complex with which to examine the magneto-structural relationship in polymetallic, oxime-bridged Mn-III complexes. Dc magnetic susceptibility studies reveal that ferromagnetic exchange is mediated through the heavily twisted Mn-O-N-Mn moiety (J = + 1.24 cm(-1)) with magnetisation measurements at low temperatures and high fields suggesting significant anisotropy. Simulations of high field, high frequency EPR data reveal a single ion anisotropy, D-(MnIII) = -3.94 cm(-1). Theoretical studies on simplified model complexes of 1 reveal that calculated values of the exchange coupling and the anisotropy are in excellent agreement with experiment, with the weak ferromagnetism resulting from an accidental orthogonality between the Mn-N-O plane of the first MnIII ion and the Jahn-Teller axis of the second Mn-III ion.
http://hdl.handle.net/10379/11992
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First principles static and dynamic calculations for the transition metal hydride series MH4L3 (M = Fe, Ru and Os; L = NH3, PH3 and PF3)
(2015)
Sieffert, Nicolas; Kendrick, Thomas; Tiana, Davide; Morrison, Carole A.
First principles static and dynamic calculations for the transition metal hydride series MH4L3 (M = Fe, Ru and Os; L = NH3, PH3 and PF3)
(2015)
Sieffert, Nicolas; Kendrick, Thomas; Tiana, Davide; Morrison, Carole A.
Abstract:
We present a first principles static and dynamical study of the transition metal hydride series MH4L3 (M = Fe, Ru and Os; L = NH3, PH3 and PF3), with a view to arriving at an understanding of how the variation in the electronic properties of the metal sites and ligands can influence the dynamics of the resulting complexes. A broad range of behaviour was observed, encompassing stable classical minima (M = Os, L = NH3 and M = Ru, L = PH3) to stable eta(2)-H-2 non-classical minima (M = Fe, L = PF3 and M = Ru, L = PH3 or PF3), with the other structures exhibiting dynamical behaviour that spontaneously converted between the classical and non-classical states during the molecular dynamics simulations. The importance of a small L-axial-M-L-axial angle in stabilising the non-classical state is highlighted, as is a short eta(2)-H-2 center dot center dot center dot H-cis distance in non-classical complexes that spontaneously convert to the classical form. We also investigated the changes in t...
http://hdl.handle.net/10468/6413
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Germanium nanowire synthesis from fluorothiolate-capped gold nanoparticles in supercritical carbon dioxide
(2010)
Collins, Gillian; Koleśnik-Gray, Maria M.; Krstić, Vojislav; Holmes, Justin D.
Germanium nanowire synthesis from fluorothiolate-capped gold nanoparticles in supercritical carbon dioxide
(2010)
Collins, Gillian; Koleśnik-Gray, Maria M.; Krstić, Vojislav; Holmes, Justin D.
Abstract:
Ge nanowires seeded from Au nanoparticles capped with fluorothiolate ligands were synthesized in supercritical carbon dioxide (sc-CO2) by the thermal decomposition of diphenylgermane (DPG) at a temperature of 380 °C and a pressure of 25.7 MPa. Both perfluorinated and semifluorinated capped Au nanoparticles acted as effective catalysts for growing Ge nanowires, with mean diameters of 11 nm (σ = 2.8) and 14 nm (σ = 3.5), respectively. The mean diameter of the Ge nanowires grown from the fluorous-capped Au nanoparticles were considerably smaller than those synthesized from dodecanethiol-capped nanoparticles in sc-toluene, under the same reaction conditions, i.e., 28 nm and σ = 10.3. Differences in the ligand conformations on the surface of the Au nanoparticles and phase separation of the fluorocarbon/CO2 and hydrocarbon/toluene systems gave rise to greater steric stabilization of the fluorous-capped Au nanoparticles in CO2, resulting in small diameter nanowires with a relatively narrow...
http://hdl.handle.net/10468/6688
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Identification of putative adhesins and carbohydrate ligands of Lactobacillus paracasei using a combinatorial in silico and glycomics microarray profiling approach
(2020)
Houeix, Benoit; Synowsky, Silvia; Cairns, Michael T.; Kane, Marian; Kilcoyne, Michelle;...
Identification of putative adhesins and carbohydrate ligands of Lactobacillus paracasei using a combinatorial in silico and glycomics microarray profiling approach
(2020)
Houeix, Benoit; Synowsky, Silvia; Cairns, Michael T.; Kane, Marian; Kilcoyne, Michelle; Joshi, Lokesh
Abstract:
Commensal bacteria must colonize host mucosal surfaces to exert health-promoting properties, and bind to gastrointestinal tract (GIT) mucins via their cell surface adhesins. Considerable effort has been directed towards discovery of pathogen adhesins and their ligands to develop anti-infective strategies; however, little is known about the lectin-like adhesins and associated carbohydrate ligands in commensals. In this study, an in silico approach was used to detect surface exposed adhesins in the human commensal Lactobacillus paracasei subsp. paracasei, a promising probiotic commonly used in dairy product fermentation that presents anti-microbial activity. Of the 13 adhesin candidates, 3 sortase-dependent pili clusters were identified in this strain and expression of the adhesin candidate genes was confirmed in vitro. Mass spectrometry analysis confirmed the presence of surface adhesin elongation factor Tu and the chaperonin GroEL, but not pili expression. Whole cells were subsequen...
http://hdl.handle.net/10379/15666
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Lanthanide directed self-assembly formations of Tb(iii) and Eu(iii) luminescent complexes from tryptophan based pyridyl amide ligands
(2011)
GUNNLAUGSSON, THORFINNUR; MCCABE, THOMAS
Lanthanide directed self-assembly formations of Tb(iii) and Eu(iii) luminescent complexes from tryptophan based pyridyl amide ligands
(2011)
GUNNLAUGSSON, THORFINNUR; MCCABE, THOMAS
Abstract:
The formation of self-assembly complexes between the ligands 1 (SS) and 2 (RR) and terbium or europium was undertaken and shown (using various spectroscopic titrations) to give rise to the exclusive formation of 2 : 1 (L : Ln) stoichiometry and not the anticipated 3 : 1 stoichiometry.
http://hdl.handle.net/2262/64068
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Localized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurity
(2020)
Flynn, Aaran J.; Ford, Alan; Maguire, Anita R.
Localized partitioning of enantiomers in solid samples of sulfoxides: importance of sampling method in determination of enantiopurity
(2020)
Flynn, Aaran J.; Ford, Alan; Maguire, Anita R.
Abstract:
Localized partitioning of amorphous enantioenriched aryl benzyl sulfoxides in the solid state can lead to substantial variation in enantiopurities, even for sulfoxides which do not show detectable levels of self-disproportionation of enantiomers (SDE) during chromatography on an achiral stationary phase. The importance of preparation of representative samples of enantioenriched sulfoxides for chiral HPLC to enable reproducible results is clear.
http://hdl.handle.net/10468/10542
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Luminescent gold and silver complexes with the monophosphane 1-(PPh2)-2-Me-C2B10H10 and their conversion to gold micro- and superstructured materials
(2014)
Crespo, Olga; Díaz, Carlos; O'Dwyer, Colm; Gimeno, M. Concepción; Laguna, Antonio;...
Luminescent gold and silver complexes with the monophosphane 1-(PPh2)-2-Me-C2B10H10 and their conversion to gold micro- and superstructured materials
(2014)
Crespo, Olga; Díaz, Carlos; O'Dwyer, Colm; Gimeno, M. Concepción; Laguna, Antonio; Ospino, Isaura; Valenzuela, María Luisa
Abstract:
Gold and silver complexes containing the monophosphane 1-PPh2-2-Me-l,2-C2B10H10 with different coordination numbers (2, 3) have been synthesized: [M(7,8-(PPh2)2-C2B9H10)(1-PPh2-2-Me-C2B10H10)] (M = Ag, Au) and [Au2(μ-1,n-C2B10H10)(1-PPh2-2-Me-C2B10H10)2] (n = 2, 12). Solid-state pyrolysis of [AuCl(1-PPh2-2-Me-C2B10H10)] and [Au2(μ-1,12-C2B10H10)(1-PPh2-2-Me-C2B10H10)2] in air and of solutions of [AuCl(1-PPh2-2-Me-C2B10H10)] deposited on silicon and silica at 800 °C results in single-crystal Au, confirmed by diffraction and SEM-EDS. The morphology of the pyrolytic products depends on the thermolytic conditions, and different novel 3-D superstructures or microcrystals are possible. We also propose a mechanism for the thermal conversion of these precursors to structural crystalline and phase pure materials. The presence of the carborane monophosphane seems to originate quenching of the luminescence at room temperature in the complexes [Au2(μ-1,n-C2B10H10)(1-PPh2-2-Me-C2B10H10)2], in co...
http://hdl.handle.net/10468/6087
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Non-classical N-Heterocyclic carbene complexes
(2012)
Krüger, Anneke; Albrecht, Martin
Non-classical N-Heterocyclic carbene complexes
(2012)
Krüger, Anneke; Albrecht, Martin
Abstract:
The expansion of the concept of N-heterocyclic carbenes as ligands for transition metals to mesoionic ligand systems has led to the discovery of a wide range of non-classical carbene-type ligands. These non-classical carbene-type ligands are characterised by a significantly lower heteroatom stabilisation of the (putative) free carbene, a situation that also affects the ligand donor properties and hence the reactivity of the coordinated metal centre. Based on the unique impact of non-classical carbene-type ligands, a number of attractive transition metal-catalysed processes have been disclosed in recent years, predominantly in the area of cross-coupling reactions, hydrogenations, and olefin metathesis
Not applicable
Book published Jan 2011 (12 months embargo doesn't apply)
http://hdl.handle.net/10197/3735
Marked
Mark
Oxidations and Oxidative Couplings Catalyzed by Triazolylidene Ruthenium Complexes
(2015)
Prades, Amparo; Peris, Eduardo; Albrecht, Martin
Oxidations and Oxidative Couplings Catalyzed by Triazolylidene Ruthenium Complexes
(2015)
Prades, Amparo; Peris, Eduardo; Albrecht, Martin
Abstract:
A series of 'RuII(η6-arene)' complexes with 1,2,3-triazolylidene ligands have been prepared and fully characterized. The molecular structure of one of the new complexes has been determined by means of X-ray diffractrometry. The new complexes have been tested in a set of catalytic reactions involving alcohols and amines as substrates, including (i) base-free oxidation of benzylic alcohols to benzaldehydes, (ii) homocoupling of amines to form imines, and (iii) oxidative coupling of amines and alcohols to form amides. The results show the high versatility of the catalysts used and illustrate the application potential of 1,2,3-triazolylidene ligands in the design of effective homogeneous catalysts.
European Research Council
MCINN of Spain
Bancaixa
http://hdl.handle.net/10197/6572
Marked
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PEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensions
(2013)
Rahme, Kamil; Hobbs, Richard G.; Chen, Lan; Morris, Michael A.; O'Driscoll, Caitrí...
PEGylated gold nanoparticles: polymer quantification as a function of PEG lengths and nanoparticle dimensions
(2013)
Rahme, Kamil; Hobbs, Richard G.; Chen, Lan; Morris, Michael A.; O'Driscoll, Caitríona M.; Holmes, Justin D.
Abstract:
Au nanoparticles with diameters ranging between 15 and 170 nm have been synthesised in aqueous solution using a seed-mediated growth method, employing hydroxylamine hydrochloride as a reducing agent. Thiolated polyethylene glycol (mPEG-SH) polymers, with molecular weights ranging from 2100 to 51 000 g mol-1, were used as efficient particle stabilising ligands. Dynamic light scattering and zeta potential measurements confirmed that the overall mean diameter and zeta potential of the capped nanoparticles increased in a non-linear way with increasing molecular weight of the mPEG-SH ligand. Electron microscopy and thermal gravimetric analysis of the polymer-capped nanoparticles, with a mean gold core diameter of 15 nm, revealed that the grafting density of the mPEG-SH ligands decreased from 3.93 to 0.31 PEG nm-2 as the molecular weight of the ligands increased from 2100 to 51 400 g mol-1 respectively, due to increased steric hindrance and polymer conformational entropy with increase in ...
http://hdl.handle.net/10468/2287
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