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Limited By:	Subject = MYOCARDIAL INFARCTION;

Displaying Results 1 - 25 of 44 on page 1 of 2

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A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction (2019)

Dolan, Eimear B.; Hofmann, Björn; de Vaal, M. Hamman; Bellavia, Gabriella; Straino, Ste...

A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction (2019)

Dolan, Eimear B.; Hofmann, Björn; de Vaal, M. Hamman; Bellavia, Gabriella; Straino, Stefania; Kovarova, Lenka; Pravda, Martin; Velebny, Vladimir; Daro, Dorothee; Braun, Nathalie; Monahan, David S.; Levey, Ruth E.; O'Neill, Hugh; Hinderer, Svenja; Greensmith, Robert; Monaghan, Michael G.; Schenke-Layland, Katja; Dockery, Peter; Murphy, Bruce P.; Kelly, Helena M.

Abstract:

The limited regenerative capacity of the heart after a myocardial infarct results in remodeling processes that can progress to congestive heart failure (CHF). Several strategies including mechanical stabilization of the weakened myocardium and regenerative approaches (specifically stem cell technologies) have evolved which aim to prevent CHF. However, their final performance remains limited motivating the need for an advanced strategy with enhanced efficacy and reduced deleterious effects. An epicardial carrier device enabling a targeted application of a biomaterial-based therapy to the infarcted ventricle wall could potentially overcome the therapy and application related issues. Such a device could play a synergistic role in heart regeneration, including the provision of mechanical support to the remodeling heart wall, as well as providing a suitable environment for in situ stem cell delivery potentially promoting heart regeneration. In this study, we have developed a novel, sing...

http://hdl.handle.net/10379/15192

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A comparison of the efficacy of transplantation of bone marrow-derived mesenchymal stem cells and unrestricted somatic stem cells on outcome after acute myocardial infarction (2018)

Flynn, Aidan; Chen, Xizhe; O'Connell, Enda; O'Brien, Timothy

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A virtual reality toolkit for the diagnosis and monitoring of myocardial infarctions (2005)

BELL, CHRISTOPHER; O'SULLIVAN, CAROL ANN

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Adjusted prognostic association of post-myocardial infarction depression withmortality and cardiovascular events: an individual patient data meta-analysis (2013)

Meijer, Anna; Conradi, Henk Jan; Bos, Elske H; Anselmino, Matteo; Carney, Robert M; Den...

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Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels (2019)

Dolan, Eimear B.; Kovarova, Lenka; O'Neill, Hugh; Pravda, Martin; Sulakova, Romana...

Advanced Material Catheter (AMCath), a minimally invasive endocardial catheter for the delivery of fast-gelling covalently cross-linked hyaluronic acid hydrogels (2019)

Dolan, Eimear B.; Kovarova, Lenka; O'Neill, Hugh; Pravda, Martin; Sulakova, Romana; Scigalkova, Ivana; Velebny, Vladimir; Daro, Dorothee; Braun, Nathalie; Cooney, Gerard M .; Bellavia, Gabriella; Straino, Stefania; Cavanagh, Brenton L.; Flanagan, Aiden; Kelly, Helena M.; Duffy, Garry P.; Murphy, Bruce P.

Abstract:

Injectable hydrogels that aim to mechanically stabilise the weakened left ventricle wall to restore cardiac function or to deliver stem cells in cardiac regenerative therapy have shown promising data. However, the clinical translation of hydrogel-based therapies has been limited due to difficulties injecting them through catheters. We have engineered a novel catheter, Advanced Materials Catheter (AMCath), that overcomes translational hurdles associated with delivering fast-gelling covalently cross-linked hyaluronic acid hydrogels to the myocardium. We developed an experimental technique to measure the force required to inject such hydrogels and determined the mechanical/viscoelastic properties of the resulting hydrogels. The preliminary in vivo feasibility of delivering fast-gelling hydrogels through AMCath was demonstrated by accessing the porcine left ventricle and showing that the hydrogel was retained in the myocardium post-injection (three 200 μL injections delivered, 192, 204 ...

http://hdl.handle.net/10379/15190

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Age, job characteristics and coronary health (2012)

McCarthy, Vera J. C.; Perry, Ivan J.; Greiner, Birgit A.

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An injectable collagen scaffold delivering exogenous microRNA as a therapy to modulate extracellular matrix remodelling (2014)

Monaghan, Michael

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Bone marrow-derived mesenchymal stem cells have innate procoagulant activity and cause microvascular obstruction following intracoronary delivery: amelioration by antithrombin therapy (2018)

Gleeson, Birgitta M.; Martin, Kenneth; Ali, Mohammed T.; Kumar, Arun H. S.; Pillai, M. ...

Bone marrow-derived mesenchymal stem cells have innate procoagulant activity and cause microvascular obstruction following intracoronary delivery: amelioration by antithrombin therapy (2018)

Gleeson, Birgitta M.; Martin, Kenneth; Ali, Mohammed T.; Kumar, Arun H. S.; Pillai, M. Gopala-Krishnan; Kumar, Sujith P. G.; O'Sullivan, John F.; Whelan, Derek; Stocca, Alessia; Khider, Wisam; Barry, Frank P.; O'Brien, Timothy; Caplice, Noel M.

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Mesenchymal stem cells (MSCs) are currently under investigation as tools to preserve cardiac structure and function following acute myocardial infarction (AMI). However, concerns have emerged regarding safety of acute intracoronary (IC) MSC delivery. This study aimed to characterize innate prothrombotic activity of MSC and identify means of its mitigation toward safe and efficacious therapeutic IC MSC delivery post-AMI. Expression of the initiator of the coagulation cascade tissue factor (TF) on MSC was detected and quantified by immunofluorescence, FACS, and immunoblotting. MSC-derived TF antigen was catalytically active and capable of supporting thrombin generation in vitro. Addition of MSCs to whole citrated blood enhanced platelet thrombus deposition on collagen at arterial shear, an effect abolished by heparin coadministration. In a porcine AMI model, IC infusion of 25 x 10(6) MSC during reperfusion was associated with a decrease in coronary flow reserve but not when coadminist...

http://hdl.handle.net/10379/11660

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CCU 2003: National Survey of the Presentation and Management of Acute Myocardial infarction (AMI) & Other Acute Coronary Syndromes (ACS) in Irish Hospital (2004)

Doyle, Frank; De La Harpe, Davida; McGee, Hannah; Shelly, Emer; Walsh, Michael; Daly, K...

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Clinical experience with regenerative therapy in heart failure (2018)

Bartunek, Jozef; Terzic, Andre; Behfar, Atta; Wijns, William

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Considerable differences exist between prevalent and incident myocardial infarction cohorts derived from the same population (2018)

Buckley, Brian S.; Simpson, Colin R.; McLernon, David J.; Hannaford, Philip C.; Murphy,...

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Delay in seeking medical help following transient ischemic attack (TIA) or "Mini-Stroke": a qualitative study (2016)

Mc Sharry, Jennifer; Baxter, Alison; Wallace, Louise M.; Kenton, Anthony; Turner, Andre...

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Depressive symptoms in persons with acute coronary syndrome: specific symptom scales and prognosis (2010)

Doyle, Frank; Conroy, Ronán; McGee, Hannah; Delaney, Mary

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Elastin-like recombinamers-based hydrogel modulates the post-ischemic remodelling in a clinically-relevant model of myocardial infarction (2019)

Contessotto, Paolo

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Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes. (2004)

Byrne, Connie E; Fitzgerald, Anthony; Cannon, Christopher P; Fitzgerald, Desmond J; Shi...

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Five year prognosis in patients with angina identified in primary care: incident cohort study (2009)

British Medical Journal

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Five year prognosis in patients with angina identified in primary care: incident cohort study (2009)

British Medical Journal

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HeartBeat--improving heart attack care (2011)

Jennings, S; Bennett, K; Cavanagh, B

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High-sensitivity cardiac troponin concentration and risk of first-ever cardiovascular outcomes in 154,052 participants (2017)

Willeit, Peter; Welsh, Paul; Evans, Jonathan D. W.; Tschiderer, Lena; Boachie, Charles;...

High-sensitivity cardiac troponin concentration and risk of first-ever cardiovascular outcomes in 154,052 participants (2017)

Willeit, Peter; Welsh, Paul; Evans, Jonathan D. W.; Tschiderer, Lena; Boachie, Charles; Jukema, J. Wouter; Ford, Ian; Trompet, Stella; Stott, David J.; Kearney, Patricia M.; Mooijaart, Simon P.; Kiechl, Stefan; Di Angelantonio, Emanuele; Sattar, Naveed

Abstract:

BACKGROUND High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-cTnT) in individuals with no clinically manifest myocardial injury. OBJECTIVES The goal of this study was to assess associations of cardiac troponin concentration with cardiovascular disease (CVD) outcomes in primary prevention studies. METHODS A search was conducted of PubMed, Web of Science, and EMBASE for prospective studies published up to September 2016, reporting on associations of cardiac troponin concentration with first-ever CVD outcomes (i.e., coronary heart disease [CHD], stroke, or the combination of both). Study-specific estimates, adjusted for conventional risk factors, were extracted by 2 independent reviewers, supplemented with de novo data from PROSPER (Pravastatin in Elderly Individuals at Risk of Vascular Disease Study), then pooled by using random effects meta-analysis. RESULTS A total of 28 relevant studies were identified involving 154,052 participants. Cardiac troponin was d...

http://hdl.handle.net/10468/4799