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Subject = Microbiome-gut-brain axis;
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Comparative compositional analysis of the gut microbiome in animal models of addiction and stress
(2018)
Peterson, Veronica L.
Comparative compositional analysis of the gut microbiome in animal models of addiction and stress
(2018)
Peterson, Veronica L.
Abstract:
Intro: The microbiome-gut-brain axis (MGBA) has been shown to be instrumental to brain and behaviour, including psychological disorders affecting stress, depression, and anxiety. Many of the aforementioned disorders are comorbid with substance abuse disorders, and on a larger scale with addiction. In this body of work, we seek to characterize addiction-related phenotypes in the microbiome and correlate with measures of addiction-related behaviours, along with changes in the virome following chronic social stress. Aims: We first examined if vapor administration of ethanol is capable of altering the microbiome and to assess if substances of abuse, such as ethanol, can alter the microbiome outside of oral/gastrointestinal administration. To characterize addictive phenotypes behavioural measures of impulsivity, reward learning, and dopaminergic response to novelty were used. Methods: All studies were carried out in rodents. Following behavioural testing, gut microbiota samples were anal...
http://hdl.handle.net/10468/7941
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