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Subject = Model-based design;
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Displaying Results 1 - 1 of 1 on page 1 of 1
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Positron emission tomography-based assessment of metabolic gradient and other prognostic features in sarcoma
(2018)
Wolsztynski, Eric; O'Sullivan, Finbarr; Keyes, Eimear; O'Sullivan, Janet; Ear...
Positron emission tomography-based assessment of metabolic gradient and other prognostic features in sarcoma
(2018)
Wolsztynski, Eric; O'Sullivan, Finbarr; Keyes, Eimear; O'Sullivan, Janet; Eary, Janet F.
Abstract:
Intratumoral heterogeneity biomarkers derived from positron emission tomography (PET) imaging with fluorodeoxyglucose (FDG) are of interest for a number of cancers, including sarcoma. A range of radiomic texture variables, adapted from general methodologies for image analysis, has shown promise in the setting. In the context of sarcoma, our group introduced an alternative model-based approach to the measurement of heterogeneity. In this approach, the heterogeneity of a tumor is characterized by the extent to which the 3-D FDG uptake pattern deviates from a simple elliptically contoured structure. By using a nonparametric analysis of the uptake profile obtained from this spatial model, a variable assessing the metabolic gradient of the tumor is developed. The work explores the prognostic potential of this new variable in the context of FDG-PET imaging of sarcoma. A mature clinical series involving 197 patients, 88 of whom have complete time-to-death information, is used. Texture vari...
http://hdl.handle.net/10468/6883
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