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Subject = Next Generation Medical Devices;
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Displaying Results 1 - 25 of 239 on page 1 of 10
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The Quantification of Tissue Sodium Concentration using 23Na-Magnetic Resonance Microscopy at 7 T: Probing the Acute Stroke Phase
(2010)
WETTERLING, FRIEDRICH; FAGAN, ANDREW
The Quantification of Tissue Sodium Concentration using 23Na-Magnetic Resonance Microscopy at 7 T: Probing the Acute Stroke Phase
(2010)
WETTERLING, FRIEDRICH; FAGAN, ANDREW
Abstract:
Accurate identification of the potentially salvageable ischaemic penumbra is critical in identifying stroke patients who will benefit from thrombolysis and in designing future clinical trials of potential neuroprotectants. The perfusion/diffusion mismatch technique, currently used to detect penumbra is an indirect measure, lacking precision. The ability to accurately quantify TSC in vivo could allow developing of a direct bio-marker for tissue viability in stroke [1]. However, quantitative 23Na-Magnetic Resonance Microscopy (qNa-MRM) of the rat brain is challenging due to the low SNR measured in the MRM images, which results from the 23Na nucleus?s low in vivo concentration, low gyromagnetic ratio, fast transversal signal decay, and the required small voxel size (< 4 ?l).
http://hdl.handle.net/2262/50649
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A Double-Tuned 1H/23Na Two Element Phased Array System for In Vivo 23Na Magnetic Resonance Microscopy at 7 T
(2010)
WETTERLING, FRIEDRICH; FAGAN, ANDREW
A Double-Tuned 1H/23Na Two Element Phased Array System for In Vivo 23Na Magnetic Resonance Microscopy at 7 T
(2010)
WETTERLING, FRIEDRICH; FAGAN, ANDREW
Abstract:
Accurate identification of the potentially salvageable ischaemic penumbra is critical in identifying stroke patients who will benefit from thrombolysis and in designing future clinical trials of potential neuroprotectants. The perfusion/diffusion mismatch technique, currently used to detect penumbra is an indirect measure, lacking precision. The ability to accurately quantify TSC in vivo could allow developing of a direct bio-marker for tissue viability in stroke [1]. However, quantitative 23Na-Magnetic Resonance Microscopy (qNa-MRM) of the rat brain is challenging due to the low SNR measured in the MRM images, which results from the 23Na nucleus?s low in vivo concentration, low gyromagnetic ratio, fast transversal signal decay, and the required small voxel size (< 4 ?l).
http://hdl.handle.net/2262/50650
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Non-enzymatic glucose oxidation at electrocatalytic metal oxide films
(2013)
LYONS, MICHAEL
Non-enzymatic glucose oxidation at electrocatalytic metal oxide films
(2013)
LYONS, MICHAEL
Abstract:
The electro-oxidation of glucose at nickel hydroxide films is discussed. These films can be electrodeposited using a simple potential multi-cycling procedure. The resulting films exhibit a nanostructured surface morphology. Cyclic voltammetry, rotating- disk electrode voltammetry and electrochemical impedance spectroscopy have been used to elucidate the kinetics and mechanism of the oxidation of glucose. NiOOH is shown to be the active form of the nickel hydroxide layer and the impedance data indicates significant surface adsorption at these sites. Furthermore, mass-transport-corrected Tafel slopes of ca. 40 and 60 mV/dec were observed at low and high potentials respectively identifying a change in rate-control with increasing potential. Finally, we show using amperometric techniques that this simple modified electrode possesses excellent sensitivity for the oxidation of glucose, displaying current increases of ca. 3.7 mA mM?1 cm?2 with a limit of detection of the o...
http://hdl.handle.net/2262/67563
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23. Lessons of ALS imaging: Pitfalls and future directions - A critical review.
(2014)
HARDIMAN, ORLA; BEDE, PETER
23. Lessons of ALS imaging: Pitfalls and future directions - A critical review.
(2014)
HARDIMAN, ORLA; BEDE, PETER
Abstract:
Stereotypical shortcomings can be identified in ALS neuroimaging studies. ? A systematic discussion of ALS study limitations is particularly timely. ? Individual patient data meta-analyses and multicentre studies are urgently required. ? The gaps identified in ALS imaging indicate exciting research opportunities.
http://hdl.handle.net/2262/73205
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Surface Finish in Micro-drilling of PTFE
(2008)
KELLY, KEVIN; O'DONNELL, GARRET; BUCKLEY, CONOR
Surface Finish in Micro-drilling of PTFE
(2008)
KELLY, KEVIN; O'DONNELL, GARRET; BUCKLEY, CONOR
Abstract:
Surface finish of engineering components pl ays a key role in their functionality, particularly where the size of the geometric feat ures of the component decreases. This paper reports on such an application ? the drilling of micro-holes in PTFE during manufacture of molds for use in the bio-medical field. These mo lds are used for production of silicone scaffolds requiring very large aspect ratios ? typical exam ples being to produce pillars/columns of 300 micron diameter and 15 mm length. The surface fi nish of the holes machined in the PTFE becomes critical in order to facilitate extractio n of the silicone from th e mold without damage. A systematic approach is used to determine th e optimum combination of machining parameters with respect to this goal. Furthermore, a novel approach to surface quality estimation is proposed. Direct methods of surface quality assessment in this a pplication are difficult due to the scale of the holes ? conventional measuremen t method...
http://hdl.handle.net/2262/74309
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A Knowledge-base for a Personalized Infectious Disease Risk Prediction System
(2018)
VINARTI, RETNO AULIA; HEDERMAN, LUCY
A Knowledge-base for a Personalized Infectious Disease Risk Prediction System
(2018)
VINARTI, RETNO AULIA; HEDERMAN, LUCY
http://hdl.handle.net/2262/82488
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3D Printed Sugar-Sensing Hydrogels
(2020)
Florea, Larisa; Bruen, Danielle; Delaney, Colm; Chung, Johnson; Ruberu, Kalani; Wallace...
3D Printed Sugar-Sensing Hydrogels
(2020)
Florea, Larisa; Bruen, Danielle; Delaney, Colm; Chung, Johnson; Ruberu, Kalani; Wallace, Gordon G.; Diamond, Dermot
Abstract:
The ability of boronic acids to reversibly bind diols, such as sugars, has been widely studied in recent years. In solution, through the incorporation of additional fluorophores, this boronic acid-sugar interaction can be monitored by changes in fluorescence. Ultimately, a practical realization of this technology requires a transition from solution-based methodologies. Herein we present the first example of 3D printed sugar-sensing hydrogels, achieved through the incorporation of a boronic acid-fluorophore pair in a gelatin methacrylamide-based matrix. Through optimization of monomeric cocktails, it was possible to use extrusion printing to generate structured porous hydrogels which show a measurable and reproducible linear fluorescence response to glucose and fructose up to 100 mM.
http://hdl.handle.net/2262/92311
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A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes.
(2014)
KELLY, DANIEL; BUCKLEY, CONOR
A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes.
(2014)
KELLY, DANIEL; BUCKLEY, CONOR
Abstract:
Despite an increased interest in the use of hydrogel encapsulation and cellular self-assembly (often termed "self-aggregating" or "scaffold-free" approaches) for tissue-engineering applications, to the best of our knowledge, no study to date has been undertaken to directly compare both approaches for generating functional cartilaginous grafts. The objective of this study was to directly compare self-assembly (SA) and agarose hydrogel encapsulation (AE) as a means to engineer such grafts using passaged chondrocytes. Agarose hydrogels (5?mm diameter ??1.5?mm thick) were seeded with chondrocytes at two cell seeding densities (900,000 cells or 4 million cells in total per hydrogel), while SA constructs were generated by adding the same number of cells to custom-made molds. Constructs were either supplemented with transforming growth factor (TGF)-?3 for 6 weeks, or only supplemented with TGF-?3 for the first 2 weeks of the 6 week culture period. The SA method was only...
http://hdl.handle.net/2262/72875
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A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.
(2007)
PRENDERGAST, PATRICK; CAMPBELL, VERONICA; FARRELL, ERIC; BYRNE, ELAINE
A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.
(2007)
PRENDERGAST, PATRICK; CAMPBELL, VERONICA; FARRELL, ERIC; BYRNE, ELAINE
Abstract:
Adult mesenchymal stem cells (MSCs) have the capability to differentiate along several lineages including those of bone, cartilage, tendon and muscle, thus offering huge potential for the field of tissue engineering. The purpose of this study was to characterise the differentiation capacity of rat MSCs cultured on standard plastic coverslips in 2 dimensions and on a novel collagen glycosaminoglycan scaffold in the presence of a standard combination of osteoinductive factors. Cells were cultured for 3, 7, 14 and 21 days and several markers of osteogenesis were analysed. While the initial response of the cells in 3-D seemed to be faster than cells cultured in 2-D, as evidenced by collagen type I expression, later markers showed that osteogenic differentiation of MSCs took longer in the 3-D environment of the collagen GAG scaffold compared to standard 2-D culture conditions. Furthermore, it was shown that complete scaffold mineralisation could be evoked within a 6 week timeframe. This ...
http://hdl.handle.net/2262/39604
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A double-tuned 1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI
(2010)
FAGAN, ANDREW; WETTERLING, FRIEDRICH
A double-tuned 1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI
(2010)
FAGAN, ANDREW; WETTERLING, FRIEDRICH
Abstract:
A method for quantifying the Tissue Sodium Concentration (TSC) in the rat brain from 23Na-MR images was developed. TSC is known to change in a variety of common human diseases and holds considerable potential to contribute to their study; however, its accurate measurement in small laboratory animals has been hindered by the extremely low signal to noise ratio (SNR) in 23Na images. To address this, the design, construction and characterisation of a double tuned 1H/23Na dual resonator system for 1H-guided quantitative 23Na-MRI is described. This system comprised of an SNR-optimised surface detector coil for 23Na image acquisition, and a volume resonator producing a highly-homogeneous B1 field (<5% inhomogeneity) for the Na channel across the rat head. The resonators incorporated channel independent balanced matching and tuning capabilities with active decoupling circuitry at the 23Na resonance frequency. A quantification accuracy of TSC of < 10mM was achieved in Na-images w...
http://hdl.handle.net/2262/41268
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A high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls.
(2010)
REILLY, RICHARD; KIISKI, HANNI; NOLAN, HUGH; WHELAN, ROBERT
A high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls.
(2010)
REILLY, RICHARD; KIISKI, HANNI; NOLAN, HUGH; WHELAN, ROBERT
Abstract:
Objective. To quantify latency, amplitude and topographical differences in event-related potential (ERP) components between multiple sclerosis (MS) patients and controls and to compare ERP findings with results from the paced auditory serial addition test (PASAT). Methods. Fifty-four subjects (17 relapsing remitting (RRMS) patients, 16 secondary progressive (SPMS) patients, and 21 controls) completed visual and auditory oddball tasks while data were recorded from 134 EEG channels. Latency and amplitude differences, calculated using composite mean amplitude measures, were tested using an ANOVA. Topographical differences were tested using statistical parametric mapping (SPM). Results. In the visual modality, P2, P3 amplitudes and N2 latency were significantly different across groups. In the auditory modality, P2, N2, and P3 latencies and N1 amplitude were significantly different across groups. There were no significant differences between RRMS and SPMS patients on any ERP component. T...
http://hdl.handle.net/2262/41102
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A Mechano-Regulation Model of Fracture Repair in Vertebral Bodies
(2010)
KELLY, DANIEL
A Mechano-Regulation Model of Fracture Repair in Vertebral Bodies
(2010)
KELLY, DANIEL
Abstract:
In this study a multi-scale mechano-regulation model was developed in order to investigate the mechanobiology of trabecular fracture healing in vertebral bodies. A macro-scale finite element model of the spinal segment L3-L4-L5, including a mild wedge fracture in the body of the L4 vertebra, was used to determine the boundary conditions acting on a micro-scale finite element model simulating a portion of fractured trabecular bone. The micro-scale model, in turn, was utilized to predict the local patterns of tissue differentiation within the fracture gap and then how the equivalent mechanical properties of the macro-scale model change with time. The patterns of tissue differentiation predicted by the model appeared consistent with those observed in vivo. Bone formation occurred primarily through endochondral ossification. New woven bone was predicted to occupy the majority of the space within the fracture site approximately 7-8 weeks after the fracture event. Remodeling of cancellous...
http://hdl.handle.net/2262/41080
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A Mechanobiological Framework for the Prediction of In-Stent Restenosis; Insights into the role of load induced damage in restenotic growth
(2016)
NOLAN, DAVID; LALLY, CAITRIONA
A Mechanobiological Framework for the Prediction of In-Stent Restenosis; Insights into the role of load induced damage in restenotic growth
(2016)
NOLAN, DAVID; LALLY, CAITRIONA
http://hdl.handle.net/2262/77591
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A new evaluation of the upper esophageal sphincter using the functional lumen imaging probe: a preliminary report.
(2013)
Mc Mahon, Barry; Regan, Julie
A new evaluation of the upper esophageal sphincter using the functional lumen imaging probe: a preliminary report.
(2013)
Mc Mahon, Barry; Regan, Julie
Abstract:
Objective and reliable evaluation of upper esophageal sphincter (UES) opening during swallowing based on videofluoroscopy and pharyngeal manometry challenges dysphagia clinicians. The functional lumen imaging probe (FLIP) is a portable tool based on impedance planimetry originally designed to measure esophogastric junction compliance. It is hypothesized that FLIP can evaluate UES distensibility, and can provide UES diameter and pressure measurements at rest, during swallowing, and during voluntary maneuvers. Eleven healthy adult subjects consented to FLIP evaluation. The probe was inserted transorally, and the balloon was positioned across the UES. Two 20?mL ramp distensions were completed. Changes in UES diameter and intraballoon pressure were measured during dry and 5?mL liquid swallows, and during voluntary swallow postures and maneuvers employed in clinical practice. The protocol was completed by 10 of 11 healthy subjects. Mean intraballoon pressure increased throughout 5?mL (5....
http://hdl.handle.net/2262/90773
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A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells.
(2011)
KELLY, DANIEL; HOEY, DAVID
A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells.
(2011)
KELLY, DANIEL; HOEY, DAVID
Abstract:
Bone turnover is a mechanically regulated process, coordinated in part by the network of mechanosensitive osteocytes residing within the tissue. The recruitment and bone forming activity of the mesenchymal derived osteoblast is determined by numerous factors including mechanical loading. It is therefore somewhat surprising that although mechanically regulated signaling between the coordinating osteocytes and mesenchymal stem cells (MSCs) should exist, to date it has not been directly demonstrated. In this study, conditioned media from mechanically stimulated osteocytes (MLO-Y4 cell line) was collected and added to MSCs (C3H10T1/2 cell line). The addition of mechanically stimulated osteocyte conditioned media resulted in a significant upregulation of the osteogenic genes OPN and COX-2 in MSCs compared to statically cultured conditioned media, demonstrating a novel paracrine signaling mechanism between the two cell types. The same mechanically conditioned media did not alter gene expr...
http://hdl.handle.net/2262/59504
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A Structural Model of Passive Skeletal Muscle shows Two Reinforcement Processes in Resisting Deformation
(2013)
Simms, Ciaran
A Structural Model of Passive Skeletal Muscle shows Two Reinforcement Processes in Resisting Deformation
(2013)
Simms, Ciaran
Abstract:
Passive skeletal muscle derives its structural response from the combination of the titin filaments in the muscle fibres, the collagen fibres in the connective tissue and incompressibility due to the high fluid content. Experiments have shown that skeletal muscle tissue presents a highly asymmetrical three-dimensional behaviour when passively loaded in tension or compression, but structural models predicting this are not available. The objective of this paper is to develop a mathematical model to study the internal mechanisms which resist externally applied deformation in skeletal muscle bulk. One cylindrical muscle fibre surrounded by connective tissue was considered. The collagenous fibres of the endomysium and perimysium were grouped and modelled as tension-only oriented wavy helices wrapped around the muscle fibre. The titin filaments are represented as non-linear tension-only springs. The model calculates the force developed by the titin molecules and the collagen network when ...
http://hdl.handle.net/2262/66864
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Modelling the Haemodialysis Machine with?Circus
(2016)
BUTTERFIELD, ANDREW
Modelling the Haemodialysis Machine with?Circus
(2016)
BUTTERFIELD, ANDREW
http://hdl.handle.net/2262/77373
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Adaptive Automation: Diversity, Wellbeing, Uncertainty & The Triple Bottom Line.
(2020)
Cahill, Joan
Adaptive Automation: Diversity, Wellbeing, Uncertainty & The Triple Bottom Line.
(2020)
Cahill, Joan
http://hdl.handle.net/2262/95458
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Addressing issues of need, adaptability, user acceptability and ethics in the participatory design of new technology enabling wellness, independence and dignity for seniors living in residential homes.
(2017)
CAHILL, JOAN
Addressing issues of need, adaptability, user acceptability and ethics in the participatory design of new technology enabling wellness, independence and dignity for seniors living in residential homes.
(2017)
CAHILL, JOAN
http://hdl.handle.net/2262/81897
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Driver Persistence, Safety and Older Adult Self-efficacy: Addressing Driving Challenges Using Innovative Multimodal Communication Concepts
(2020)
Cahill, Joan; Cromie, Samuel; Kay, Alison
Driver Persistence, Safety and Older Adult Self-efficacy: Addressing Driving Challenges Using Innovative Multimodal Communication Concepts
(2020)
Cahill, Joan; Cromie, Samuel; Kay, Alison
Abstract:
New assisted driving technology provides a solution to enabling driver persistence while also addressing older adult fitness to drive issues. The proposed driver assistance system follows a detailed literature review, an analysis of secondary data, and the specification of a solution using human machine interaction (HMI) design methods. Overall, the assisted driving concept follows from a principled/ethical perspective in relation to promoting self-efficacy and enablement for older adults. The system is conceptualized as a supportive friend or ?co-pilot?. It is argued that the use of new car-based sensors, along with machine learning intelligence and novel multimodal HMI communication methods will enable driver persistence while also promoting older adult self-efficacy and positive ageing.
http://hdl.handle.net/2262/93004
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Age-related responses to injury and repair in insect cuticle
(2019)
Taylor, David
Age-related responses to injury and repair in insect cuticle
(2019)
Taylor, David
Abstract:
We evaluated the ability of female adult desert locusts (Schistocercagregaria) to repair injuries to their exoskeletons and restore mechanical strength over the course of their natural life. We discovered that younger insects are more capable of repairing injuries, displaying no significant decreases in failure strength, stiffness or bending moment to failure after 3 weeks of repair. Older insects, in contrast, were only capable of repairing to?70% of their original strength. Both older and younger insects carry out targeted deposition to repair injuries. We also examined different mechanisms of failure, and we discovered that the cuticle of older insects is more susceptible to crack growth due to a large decrease in fracture toughness with age, making them more sensitive to scalpel cuts and punctures. The biological mechanisms that drive these changes are still under investigation.
http://hdl.handle.net/2262/89218
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Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation.
(2014)
BUCKLEY, CONOR; VINARDELL, TATIANA; KELLY, DANIEL
Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation.
(2014)
BUCKLEY, CONOR; VINARDELL, TATIANA; KELLY, DANIEL
Abstract:
Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) can be leveraged to generate bone in vivo by executing an endochondral program, leading to increased interest in the use of such hypertrophic grafts for the regeneration of osseous defects. During normal skeletogenesis, canals within the developing hypertrophic cartilage play a key role in facilitating endochondral ossification. Inspired by this developmental feature, the objective of this study was to promote endochondral ossification of an engineered cartilaginous construct through modification of scaffold architecture. Our hypothesis was that the introduction of channels into MSC-seeded hydrogels would firstly facilitate the in vitro development of scaled-up hypertrophic cartilaginous tissues, and secondly would accelerate vascularisation and mineralisation of the graft in vivo . MSCs were encapsulated into hydrogels containing either an array of micro-channels, or into non-channelled ?solid? controls, and maint...
http://hdl.handle.net/2262/73149
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An acoustic method to automatically detect pressurized metered dose inhaler actuations.
(2014)
REILLY, RICHARD
An acoustic method to automatically detect pressurized metered dose inhaler actuations.
(2014)
REILLY, RICHARD
http://hdl.handle.net/2262/75635
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An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue
(2012)
KELLY, DANIEL; MAHER, EOGHAN JOSEPH; LALLY, CAITRIONA
An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue
(2012)
KELLY, DANIEL; MAHER, EOGHAN JOSEPH; LALLY, CAITRIONA
Abstract:
Inelastic phenomena such as softening and unrecoverable inelastic strains induced by loading have been observed experimentally in soft tissues such as arteries. These phenomena need to be accounted for in constitutive models of arterial tissue so that computational models can accurately predict the outcomes of interventional procedures such as balloon angioplasty and stenting that involve non-physiological loading of the tissue. In this study, a novel constitutive model is described that accounts for inelastic effects such as Mullins-type softening and permanent set in a fibre reinforced tissue. The evolution of inelasticity is governed by a set of internal variables. Softening is introduced through a typical continuum damage mechanics approach, while the inelastic residual strains are introduced through an additive split in the stress tensor. Numerical simulations of aorta and carotid arterial tissue subjected to uniaxial testing in the longitudinal, circumferential and axial direc...
http://hdl.handle.net/2262/63771
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An Experimental Study to Determine the Optimal Access Route for Renal Artery Interventions
(2013)
MURPHY, BRUCE
An Experimental Study to Determine the Optimal Access Route for Renal Artery Interventions
(2013)
MURPHY, BRUCE
Abstract:
Objective The standard approach for endovascular treatment of the renal artery is access via the common femoral artery. However, approximately one in eight patients have a renal artery take-off angle that is less than 50?. In these patients approaching via a femoral access site can be technically challenging. The goal of this study was to design and implement a set of experiments that could empirically determine the critical renal artery take-off angle at which a superior approach would be employed. Methods An experimental model of the abdominal aorta, iliac arteries and the renal arteries was constructed using averaged CT angiography data from 10 patients. A number of guide catheter and guide wire combinations were advanced into this model and the force/displacement response was established. Results Our results demonstrate that a renal artery take-off angle less than 30? has a reduced probability of achieving stable guide wire placement in comparison with the base 90? anatomy (p...
http://hdl.handle.net/2262/72390
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