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Subject = Next Generation Medical Devices;
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Displaying Results 126 - 150 of 239 on page 6 of 10
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Introduction of a Bayesian Network Builder Algorithm: Personalized Infectious Disease Risk Prediction
(2018)
VINARTI, RETNO AULIA; HEDERMAN, LUCY
Introduction of a Bayesian Network Builder Algorithm: Personalized Infectious Disease Risk Prediction
(2018)
VINARTI, RETNO AULIA; HEDERMAN, LUCY
http://hdl.handle.net/2262/82489
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Non-Invasive and Temporally Resolved Measurement of Ischaemic Tissue Damage in Acute Stroke Using Quantitative 23Na Magnetic Resonance Microscopy at 7 T
(2010)
WETTERLING, FRIEDRICH; FAGAN, ANDREW
Non-Invasive and Temporally Resolved Measurement of Ischaemic Tissue Damage in Acute Stroke Using Quantitative 23Na Magnetic Resonance Microscopy at 7 T
(2010)
WETTERLING, FRIEDRICH; FAGAN, ANDREW
Abstract:
The aim of this study was to define a quantifiable parameter which would allow for the classification of still-viable penumbra and irreversibly damaged (ischaemic core) tissue after Middle Cerebral Artery Occlusion (MCAO) in a rat stroke model. Differences in Tissue Sodium Concentration (TSC) levels [1] and the rate of TSC increase over time [2] have previously been reported in animal models of ischemic stroke, with the expressed aim of trying to differentiate between penumbra and ischaemic core. In the current study, quantitative 23Na Magnetic Resonance Microscopy (qNa-MRM) was used to measure the time course of TSC with high spatio-temporal resolution, in order to investigate regional variations in TSC behavior in the acute phase in a rodent stroke model.
http://hdl.handle.net/2262/50651
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A Logic Based Implementation of Head-Driven Phrase Structure Grammar
(1991)
VOGEL, CARL
A Logic Based Implementation of Head-Driven Phrase Structure Grammar
(1991)
VOGEL, CARL
Abstract:
Head-Driven Phrase Structure Grammar (HPSG), a unification-based formal language for describing linguistic phenomena, has a declarative semantics which makes it amenable to specification as a logic program. The HPSG formalism has undergone significant modification, becoming more declarative and incorporating greater lexicalization, since Proudian and Pollard first introduced a LISP-based HPSG chart parser in 1985. These theoretical developments have led us to the Prolog implementation of an HPSG interpreter which is described in this paper. We provide a brief introduction to the HPSG formalism, and then illustrate how a natural language grammar based on this formalism can be stated in a declarative notation that is directly interpretable by a Prolog chart-parser. This process leads us to refinements in both the specification of the formalism and the interpretation methodology.
http://hdl.handle.net/2262/32289
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Lived Experience, Stakeholder Evaluation and the Participatory Design of Assisted Living Technology
(2017)
CAHILL, JOAN
Lived Experience, Stakeholder Evaluation and the Participatory Design of Assisted Living Technology
(2017)
CAHILL, JOAN
http://hdl.handle.net/2262/81898
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New technologies supporting patient re-enablement, relationship centred care, patient safety and wellness monitoring.
(2018)
CAHILL, JOAN
New technologies supporting patient re-enablement, relationship centred care, patient safety and wellness monitoring.
(2018)
CAHILL, JOAN
http://hdl.handle.net/2262/82869
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Investigating the effect of solubility and density gradients on local hydrodynamics and drug dissolution in the USP 4 dissolution apparatus
(2011)
CORRIGAN, OWEN; D'ARCY, DEIRDRE; LIU, BO
Investigating the effect of solubility and density gradients on local hydrodynamics and drug dissolution in the USP 4 dissolution apparatus
(2011)
CORRIGAN, OWEN; D'ARCY, DEIRDRE; LIU, BO
Abstract:
The aim of this investigation was to evaluate the effect of solubility and related solution density gradients, on hydrodynamics and dissolution rate in a low velocity pulsing flow, in the USP 4 flow-through dissolution apparatus. The paddle apparatus, flow-through apparatus and a free convection system were used in dissolution testing, using Benzoic Acid (BA) and Lactose Monohydrate (LM), representing slightly and freely soluble model compounds, respectively. A flow rate of 8 ml min?1 (22.6 mm diameter cell) was used in the flow-through apparatus. Computational fluid dynamics (CFD) simulations were used to analyze the effect of the dissolved compounds on local hydrodynamics. A higher dissolution rate of both BA and LM was obtained in the free convection system compared to the flow-through apparatus, with highest dissolution rate from both compounds in the paddle apparatus. The effect of downward flow arising from natural convection had a significant effect for the more soluble compo...
http://hdl.handle.net/2262/59853
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Investigation of Collagen Fibre Orientation in Bovine Pericardium
(2017)
WHELAN, ALISON; LALLY, CAITRIONA; GAUL, ROBERT
Investigation of Collagen Fibre Orientation in Bovine Pericardium
(2017)
WHELAN, ALISON; LALLY, CAITRIONA; GAUL, ROBERT
http://hdl.handle.net/2262/80027
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Living Cell Factories- Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery
(2016)
Buckley, Conor
Living Cell Factories- Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery
(2016)
Buckley, Conor
http://hdl.handle.net/2262/80197
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Living Cell Factories- Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery
(2015)
BUCKLEY, CONOR
Living Cell Factories- Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery
(2015)
BUCKLEY, CONOR
http://hdl.handle.net/2262/80184
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Load induced changes in collagen fibre architecture in arteries characterised by small angle light scattering
(2016)
GAUL, ROBERT
Load induced changes in collagen fibre architecture in arteries characterised by small angle light scattering
(2016)
GAUL, ROBERT
http://hdl.handle.net/2262/80030
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Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis.
(2010)
O'BRIEN, FERGAL
Local and regional mechanical characterisation of a collagen-glycosaminoglycan scaffold using high-resolution finite element analysis.
(2010)
O'BRIEN, FERGAL
Abstract:
Artificial tissue growth requires cells to proliferate and differentiate within the host scaffold. As cell function is governed by mechano-sensitive selection, tissue type is influenced by the microscopic forces exposed to the cells, which is a product of macroscopically straining the scaffold. Accordingly, the microscopic strain environment within a CG scaffold is offered here. Using ?CT to characterise CG scaffold architecture, two high-resolution 3D FE models were used to predict the deformation mechanics. While also providing an analysis of region-specific features, such as relative density, pore diameters and microstructural elastic stability, the deformation patterns afforded strains to be inferred for seeded cells. The results indicate a regional dependence, in terms of architectural and mechanical properties. Specifically, the peripheral regions demonstrated the lowest volume fraction, the highest stress concentrations and the greatest potential for elastic instability. Conv...
http://hdl.handle.net/2262/40218
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Low oxygen tension is a more potent promoter of chondrogenic
(2010)
KELLY, DANIEL; BUCKLEY, CONOR
Low oxygen tension is a more potent promoter of chondrogenic
(2010)
KELLY, DANIEL; BUCKLEY, CONOR
Abstract:
During fracture healing and microfracture treatment of cartilage defects mesenchymal stem cells (MSCs) infiltrate the wound site, proliferate extensively and differentiate along a cartilaginous or an osteogenic lineage in response to local environmental cues. MSCs may be able to directly sense their mechanical environment or alternatively, the mechanical environment could act indirectly to regulate MSC differentiation by inhibiting angiogenesis and diminishing the supply of oxygen and other regulatory factors. Dynamic compression has been shown to regulate chondrogenesis of MSCs. In addition, previous studies have shown that a low oxygen environment promotes in vitro chondrogenesis of MSCs. The hypothesis of this study is that a low oxygen environment is a more potent promoter of chondrogenic differentiation of MSCs embedded in agarose hydrogels compared to dynamic compression. In MSC-seeded constructs supplemented with TGF-?3, GAG and collagen accumulation was higher in low oxygen ...
http://hdl.handle.net/2262/41079
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Luminescence anion sensing via modulation of MLCT emission from a naphthalimide-Ru(II)-polypyridyl complex
(2010)
GUNNLAUGSSON, THORFINNUR; ELMES, ROBERT
Luminescence anion sensing via modulation of MLCT emission from a naphthalimide-Ru(II)-polypyridyl complex
(2010)
GUNNLAUGSSON, THORFINNUR; ELMES, ROBERT
Abstract:
The selective sensing of fluoride (F?; an important breakdown product of some chemical warfare agents such as sarin) was achieved by observing quenching in the Metal to Ligand Charge Transfer (MLCT) emission of the 1,8-naphthalimide ruthenium conjugate Ru-Nap-NH2, which occurs at long wavelengths in CH3CN, using steady state fluorescence spectroscopy. The F? recognition was also visible to the naked eye, with a clear colour change from yellow to red. The sensing mechanism is most likely initially via hydrogen bonding, between the anion and the amine, which at higher concentrations, gives rise to deprotonation of the acidic 4-amino-1,8-naphthalimide moiety. However, counter ion effects may also be contributing to the overall emission changes. Other anions such as acetate, phosphate and chloride also give rise to quenching in the fluorescence emission with only minor changes in the UV-Vis absorption spectra of Ru-Nap-NH2. Moreover, phosphate also gave rise to shifts in the ?max in the...
http://hdl.handle.net/2262/40249
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Many particle magnetic dipole-dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting
(2010)
PRINA MELLO, ADRIELE
Many particle magnetic dipole-dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting
(2010)
PRINA MELLO, ADRIELE
Abstract:
The implant assisted magnetic targeted drug delivery system of Avil?es, Ebner and Ritter is considered both experimentally (in vitro) and theoretically. The results of a 2D mathematical model are compared with 3D experimental results for a magnetizable wire stent. In this experiment a ferromagnetic, coiled wire stent is implanted to aid collection of particles which consist of single domain magnetic nanoparticles (radius ?10 nm). In order to model the agglomeration of particles known to occur in this system, the magnetic dipole-dipole and hydrodynamic interactions for multiple particles are included. Simulations based on this mathematical model were performed using open source C++ code. Different initial positions are considered and the system performance is assessed in terms of collection efficiency. The results of this model show closer agreement with the measured in vitro experimental results and with the literature. The implications in nanotechnology and nanomedicine are based o...
http://hdl.handle.net/2262/36850
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Mechanical characterisation of porcine rectus sheath under uniaxial and biaxial tension
(2014)
SIMMS, CIARAN
Mechanical characterisation of porcine rectus sheath under uniaxial and biaxial tension
(2014)
SIMMS, CIARAN
http://hdl.handle.net/2262/69184
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Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos.
(2011)
PRENDERGAST, PATRICK; MURPHY, PAULA; RODDY, KAREN ANN
Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos.
(2011)
PRENDERGAST, PATRICK; MURPHY, PAULA; RODDY, KAREN ANN
Abstract:
Very little is known about the regulation of morphogenesis in synovial joints. Mechanical forces generated from muscle contractions are required for normal development of several aspects of normal skeletogenesis. Here we show that biophysical stimuli generated by muscle contractions impact multiple events during chick knee joint morphogenesis influencing differential growth of the skeletal rudiment epiphyses and patterning of the emerging tissues in the joint interzone. Immobilisation of chick embryos was achieved through treatment with the neuromuscular blocking agent Decamethonium Bromide. The effects on development of the knee joint were examined using a combination of computational modelling to predict alterations in biophysical stimuli, detailed morphometric analysis of 3D digital representations, cell proliferation assays and in situ hybridisation to examine the expression of a selected panel of genes known to regulate joint development. This work revealed the precise changes ...
http://hdl.handle.net/2262/53205
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Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism.
(2015)
HOEY, DAVID
Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism.
(2015)
HOEY, DAVID
http://hdl.handle.net/2262/78937
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Mechanically induced structural changes during dynamic compression of engineered cartilaginous constructs can potentially explain increases in bulk mechanical properties.
(2012)
KELLY, DANIEL; NAGEL, THOMAS
Mechanically induced structural changes during dynamic compression of engineered cartilaginous constructs can potentially explain increases in bulk mechanical properties.
(2012)
KELLY, DANIEL; NAGEL, THOMAS
Abstract:
Several studies on chondrocyte seeded hydrogels in bioreactor culture report increased mechanical properties of mechanically loaded constructs compared to unloaded free swelling controls despite no significant differences in biochemical composition. One possible explanation is that changes in the collagen architecture of dynamically compressed constructs lead to improved mechanical properties. Collagen molecules are incorporated locally into the extracellular matrix with individual stress-free configurations and orientations. In this study we isolated and computationally investigated possible influences of loading on the collagen architecture in chondrocyte seeded hydrogels and their resulting mechanical properties. Both the collagen orientation and its stress-free configuration were hypothesised to depend on the local mechanical environment. Reorientation of the collagen network alone in response to dynamic compression leads to a prediction of constructs with lower compressive prop...
http://hdl.handle.net/2262/66897
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Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair
(2009)
KELLY, DANIEL; NAGEL, THOMAS
Mechano-regulation of mesenchymal stem cell differentiation and collagen organisation during skeletal tissue repair
(2009)
KELLY, DANIEL; NAGEL, THOMAS
Abstract:
A number of mechano-regulation theories have been proposed that relate the differentiation pathway of mesenchymal stem cells (MSCs) to their local biomechanical environment. During spontaneous repair processes in skeletal tissues, the organisation of the extracellular matrix is a key determinant of its mechanical fitness. In this paper, we extend the mechano-regulation theory proposed by Prendergast et al. (J Biomech 30(6):539?548, 1997) to include the role of the mechanical environment on the collagen architecture in regenerating soft tissues. A large strain anisotropic poroelastic material model is used in a simulation of tissue differentiation in a fracture subject to cyclic bending (Cullinane et al. in J Orthop Res 20(3):579?586, 2002). The model predicts non-union with cartilage and fibrous tissue formation in the defect. Predicted collagen fibre angles, as determined by the principal decomposition of strain- and stress-type tensors, are similar to the architecture seen in nati...
http://hdl.handle.net/2262/41228
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Membrane protein crystallization in lipidic mesophases with tailored bilayers.
(2004)
CAFFREY, MARTIN
Membrane protein crystallization in lipidic mesophases with tailored bilayers.
(2004)
CAFFREY, MARTIN
http://hdl.handle.net/2262/82610
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Membrane Protein Crystallization in Lipidic Mesophases. A Mechanism Study Using X-ray Microdiffraction.
(2007)
CAFFREY, MARTIN
Membrane Protein Crystallization in Lipidic Mesophases. A Mechanism Study Using X-ray Microdiffraction.
(2007)
CAFFREY, MARTIN
Abstract:
The membrane structural biologist seeks to understand how membrane proteins function at a molecular level. One of the most direct ways of accomplishing this requires knowing the structure of the protein, ideally at atomic resolution. To date, this can only be done by the method of macromolecular crystallography. Integral to the method is the need for three-dimensional crystals of diffraction quality and their production represents a major rate-limiting step in the overall process of structure determination. The in meso method is a novel approach for crystallizing membrane proteins. It makes use of lipidic mesophases, the cubic phase in particular. A mechanism for how the method works has been proposed. In this study, we set out to test one aspect of the hypothesis which posits that the protein migrates from the bulk mesophase reservoir to the face of the crystal by way of a lamellar conduit. Using a sub-micrometer-sized X-ray beam the interface between a growing membrane protein cry...
http://hdl.handle.net/2262/50464
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Multifactorial determinants that govern nanoparticle uptake by human endothelial cells under flow.
(2012)
GOUNKO, IOURI; PRINA MELLO, ADRIELE; VOLKOV, YURI
Multifactorial determinants that govern nanoparticle uptake by human endothelial cells under flow.
(2012)
GOUNKO, IOURI; PRINA MELLO, ADRIELE; VOLKOV, YURI
http://hdl.handle.net/2262/69243
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Multimodal Agents for Aging and Multicultural Societies
(2018)
Campbell, Nick
Multimodal Agents for Aging and Multicultural Societies
(2018)
Campbell, Nick
http://hdl.handle.net/2262/91213
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Neurostimulation techniques for the modulation of pain
(2018)
Witney, Alice
Neurostimulation techniques for the modulation of pain
(2018)
Witney, Alice
http://hdl.handle.net/2262/85111
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New measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP?.
(2013)
Mc Mahon, Barry; Regan, Julie
New measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP?.
(2013)
Mc Mahon, Barry; Regan, Julie
Abstract:
Background: This paper aims to measure upper esophageal sphincter (UES) distensibility and extent and duration of UES opening during swallowing in healthy subjects using EndoFLIP?. Methods: Fourteen healthy subjects (20?50?years) were recruited. An EndoFLIP? probe was passed trans?orally and the probe balloon was positioned across the UES. Two 20?mL ramp distensions were completed and UES cross?sectional area (CSA) and intra?balloon pressure (IBP) were evaluated. At 12?mL balloon volume, subjects completed dry, 5? and 10?mL liquid swallows and extent (mm) and duration (s) of UES opening and minimum IBP (mmHg) were analyzed across swallows. Key Results: Thirteen subjects completed the study protocol. A significant change in UES CSA (P?<?.001) and IBP (P?<?.000) was observed during 20?mL distension. UES CSA increased up to 10?mL distension (P?<?.001), from which point IBP raised significantly (P?=?0.004). There were significant changes in UES diameter (mm) (P?<?.000) and...
http://hdl.handle.net/2262/90775
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