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Subject = Next Generation Medical Devices;
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Displaying Results 176 - 200 of 239 on page 8 of 10
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System for performance measures of predictive grip in a dynamic haptic environment
(2004)
WITNEY, ALICE
System for performance measures of predictive grip in a dynamic haptic environment
(2004)
WITNEY, ALICE
Abstract:
Virtual environments provide a powerful means of experimentally examining object manipulation. In object manipulation a key issue is the coor- dination of grip force used to stabilize the object in the presence of load force variation, such as those due to inertia during object movement5. Here we de- scribe the engineering of an application in which the SensAble PHANToM is used to robotically control a hand held object and provide temporally modu- lated force fields that can be varied on a trial-by-trial basis.. Visual display is synchronized with haptic display and the recording of the robotic endeffector?s position. Analog data from two load cells mounted on the endeffector capture the forces and torques generated during interaction with the varying force fields. The system is cuurently being used to study the learning of novel load force functions during object manipulation.
http://hdl.handle.net/2262/29506
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Temporal water mobility and sodium intensity measurements in penumbra and core tissue during acute stroke
(2011)
Temporal water mobility and sodium intensity measurements in penumbra and core tissue during acute stroke
(2011)
Abstract:
The perfusion-diffusion mismatch is a commonly used approach to distinguish between still-viable penumbra and irreversibly damaged core tissue in human stroke patients. However, in recent years it has become clear that the diffusion lesion does not accurately identify infarcted tissue, casting doubt on the validity of the perfusion-diffusion mismatch approach. Sodium-MRI (Na-MRI) can offer an alternative approach to identifying tissue at risk of infarction. The aim of this study was to investigate the hypothesis that an increase in 23Na signal above normal levels indicates tissue destined for infarction [1]. To do this, the timecourse evolution of Apparent Diffusion Coefficient (ADC) and 23Na signal changes during the acute phase of a rodent stroke model was measured, differentiating between penumbral and core tissue through the use of both the perfusion deficit measured immediately before the animals were sacrificed (~5hrs after stroke) and the subsequent histologically-determined ...
http://hdl.handle.net/2262/63765
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Strain mediated enzyme degradation of arterial tissue characterised by small angle light scattering
(2017)
GAUL, ROBERT
Strain mediated enzyme degradation of arterial tissue characterised by small angle light scattering
(2017)
GAUL, ROBERT
http://hdl.handle.net/2262/80031
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Strain Mediated Arterial Degradation is Critically Influenced by Matrix Content and Collagen Crimp
(2018)
GAUL, ROBERT; NOLAN, DAVID
Strain Mediated Arterial Degradation is Critically Influenced by Matrix Content and Collagen Crimp
(2018)
GAUL, ROBERT; NOLAN, DAVID
http://hdl.handle.net/2262/82714
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Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach
(2010)
PRENDERGAST, PATRICK; CHECA ESTEBAN, SARA
Simulation of angiogenesis and cell differentiation in a CaP scaffold subjected to compressive strains using a lattice modeling approach
(2010)
PRENDERGAST, PATRICK; CHECA ESTEBAN, SARA
Abstract:
Mechanical stimuli are one of the factors that influence tissue differentiation. In the development of biomaterials for bone tissue engineering, mechanical stimuli and formation of a vascular network that transport oxygen to cells within the pores of the scaffolds are essential. Angiogenesis and cell differentiation have been simulated in scaffolds of regular porosity; however, the dynamics of differentiation can be different when the porosity is not uniform. The objective of this study was to investigate the effect of the mechanical stimuli and the capillary network formation on cell differentiation within a scaffold of irregular morphology. A porous scaffold of calcium phosphate based glass was used. The pores and the solid phase were discretized using micro computed tomography images. Cell activity was simulated within the interconnected pore domain of the scaffold using a lattice modeling approach. Compressive strains of 0.5 and 1% of total deformation were applied and two cases...
http://hdl.handle.net/2262/40660
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Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency.
(2011)
O'BRIEN, FERGAL
Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency.
(2011)
O'BRIEN, FERGAL
Abstract:
Although osteoporosis reduces overall bone mass causing bone fragility, recent studies report that the remaining bone tissue is significantly stiffer. Preliminary studies indicate that alterations in bone tissue mineral content might explain these changes, albeit that other studies report conflicting observations. The objective of this study is to quantify whether the distribution of bone tissue mineral is altered during oestrogen deficiency. Individual trabeculae were harvested from the proximal femur of 7 ovariectomised sheep (OVX), sacrificed 12 months post-surgery, and 5 age-matched controls. Mineral content (wt% Ca) was determined using a quantitative backscattered scanning electron microscopy imaging approach. Mineral heterogeneity within individual trabeculae was compared by calculating the full width at half maximum (FWHM) of mineral density distributions. Mean calcium content, the spatial distribution of mineral within trabeculae and the inter-trabecular variation between r...
http://hdl.handle.net/2262/57322
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Sodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset time
(2014)
Sodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset time
(2014)
Abstract:
Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, multinuclear hydrogen-1/sodium-23 magnetic resonance imaging (MRI) was used to measure the changing sodium signal and hydrogen-apparent diffusion coefficient (ADC) in the ischemic core and penumbra after rat middle cerebral artery occlusion (MCAO). Penumbra and core were defined from perfusion imaging and histologically defined irreversibly damaged tissue. The sodium signal in the core increased linearly with time, whereas the ADC rapidly decreased by >30% within 20?minutes of stroke onset, with very little change thereafter (0.5?6?hours after MCAO). Previous reports suggest that the time point at which tissue sodium signal starts to rise above normal (onset of elevated tissue sodium, OETS) represents stroke onset time (SOT). However, extrapolating core data back i...
http://hdl.handle.net/2262/72440
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Sodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset time
(2015)
FAGAN, ANDREW
Sodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset time
(2015)
FAGAN, ANDREW
http://hdl.handle.net/2262/77412
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Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds.
(2015)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds.
(2015)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
Abstract:
Staphylococcus aureus is an important opportunistic pathogen which is a leading cause of biofilm-associated infections on indwelling medical devices. The cell surface-located fibronectin-binding protein A (FnBPA) plays an important role in the accumulation phase of biofilm formation by methicillin-resistant S. aureus (MRSA), but the underlying molecular interactions are not yet established. Here, we use single-cell and single-molecule atomic force microscopy to unravel the mechanism by which FnBPA mediates intercellular adhesion. We show that FnBPA is responsible for specific cell-cell interactions that involve the FnBPA A domain and cause microscale cell aggregation. We demonstrate that the strength of FnBPA-mediated adhesion originates from multiple low-affinity homophilic interactions between FnBPA A domains on neighboring cells. Low-affinity binding by means of FnBPA may be important for biofilm dynamics. These results provide a molecular basis for the ability of FnBPA to promot...
http://hdl.handle.net/2262/78770
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Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation.
(2015)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation.
(2015)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
Abstract:
Staphylococcus aureus biofilms, a leading cause of persistent infections, are highly resistant to immune defenses and antimicrobial therapies. In the present study, we investigated the contribution of fibrin and staphylokinase (Sak) to biofilm formation. In both clinical S. aureus isolates and laboratory strains, high Sak-producing strains formed less biofilm than strains that lacked Sak, suggesting that Sak prevents biofilm formation. In addition, Sak induced detachment of mature biofilms. This effect depended on plasminogen activation by Sak. Host-derived fibrin, the main substrate cleaved by Sak-activated plasminogen, was a major component of biofilm matrix, and dissolution of this fibrin scaffold greatly increased susceptibility of biofilms to antibiotics and neutrophil phagocytosis. Sak also attenuated biofilm-associated catheter infections in mouse models. In conclusion, our results reveal a novel role for Sak-induced plasminogen activation that prevents S. aureus biofilm form...
http://hdl.handle.net/2262/78769
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Strain mediated Enzymatic Degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp
(2018)
GAUL, ROBERT; Nolan, David; Lally, Caitriona
Strain mediated Enzymatic Degradation of arterial tissue: Insights into the role of the non-collagenous tissue matrix and collagen crimp
(2018)
GAUL, ROBERT; Nolan, David; Lally, Caitriona
http://hdl.handle.net/2262/83431
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Strain Mediated Enzyme Degradation of Arterial Tissue; Implications in Disease and Medical Device Design
(2017)
GAUL, ROBERT
Strain Mediated Enzyme Degradation of Arterial Tissue; Implications in Disease and Medical Device Design
(2017)
GAUL, ROBERT
http://hdl.handle.net/2262/81646
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Stresses in peripheral arteries following stent placement: a finite element analysis
(2009)
PRENDERGAST, PATRICK; KELLY, DANIEL; LALLY, CAITRIONA
Stresses in peripheral arteries following stent placement: a finite element analysis
(2009)
PRENDERGAST, PATRICK; KELLY, DANIEL; LALLY, CAITRIONA
Abstract:
The success of stents to restore blood flow in atherosclerotic peripheral arteries is low relative to coronary arteries. It has been shown that joint flexion induces a mechanical environment that makes stent placement in these arteries highly incompatible, and damage and destruction of stents has been recorded. However, the effect of this environment on the stresses in the arteries is unknown. It is hypothesised that the stresses induced in arteries as a result of this mechanical environment could be sufficient to explain the relatively low success rates. To investigate this hypothesis, a finite element model of the stent-artery interaction was developed. Following stent expansion, bending was simulated by applying a displacement boundary condition to the artery. It is found that high stresses occur at the proximal/distal ends of the stent. As high stress and vascular injury are hypothesised to cause restenosis, the results presented here suggest that the mechanical environment of p...
http://hdl.handle.net/2262/38226
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Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms.
(2013)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms.
(2013)
GEOGHEGAN, JOAN; FOSTER, TIMOTHY
Abstract:
Health care-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) forms biofilm in vitro that is dependent on the surface-located fibronectin binding proteins A and B (FnBPA, FnBPB). Here we provide new insights into the requirements for FnBP-dependent biofilm formation by MRSA. We show that expression of FnBPs is sustained at high levels throughout the growth cycle in the HA-MRSA strain BH1CC in contrast to laboratory strain SH1000, where expression could be detected only in exponential phase. We found that FnBP-mediated biofilm accumulation required Zn(2+), while the removal of Zn(2+) had no effect on the ability of FnBPA to mediate bacterial adherence to fibrinogen. We also investigated the role of FnBPA expressed on the surface of S. aureus in promoting biofilm formation and bacterial adhesion to fibrinogen. The minimum part of FnBPA required for ligand binding has so far been defined only with recombinant proteins. Here we found that the N1 subdomain was not required...
http://hdl.handle.net/2262/72311
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Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen GAG scaffold
(2010)
O'BRIEN, FERGAL
Substrate stiffness and contractile behaviour modulate the functional maturation of osteoblasts on a collagen GAG scaffold
(2010)
O'BRIEN, FERGAL
Abstract:
Anchorage dependent cells respond to mechanical and physical properties of biomaterials. One such cue is a material?s mechanical stiffness. We compared the osteogenic potential of collagen glycosaminoglycan (CG) scaffolds with varying stiffness up to 6 weeks in culture. The mechanical stiffness of CG scaffolds were varied by crosslinking via physical (dehydrothermal [DHT]) and chemical, 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide [EDAC] and glutaraldehyde [GLUT]) methods. Results showed that all CG substrates allowed for cellular attachment, infiltration and osteogenic differentiation. CG scaffolds treated with EDAC and GLUT, were mechanically stiffer, retained their original scaffold structure and resisted cellular contraction. Consequently they facilitated a 2-fold greater cell number probably due to pore architecture being maintained allowing for improved diffusion of nutrients. On the other hand, the less stiff substrates crosslinked with DHT allowed for increased cell-media...
http://hdl.handle.net/2262/40677
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Substrate stiffness and oxygen availability as regulators of mesenchymal stem cell differentiation within a mechanically loaded bone chamber.
(2014)
KELLY, DANIEL
Substrate stiffness and oxygen availability as regulators of mesenchymal stem cell differentiation within a mechanically loaded bone chamber.
(2014)
KELLY, DANIEL
Abstract:
M echanical stimuli such as tissue deformation and fluid flow are often implicated as regulators of mesenchymal stem cell (MSC) differentiation during regenerative events in vivo . However , in vitro studies have identified several other physical and biochemical environmental cues , such as substrate stiffness and oxygen availability, as key regulators of stem cell fate . Hypotheses for how MSC differentiation is regulated in vivo can be either corroborated or rejected based on the ability of in silico models to accurately predic t spatial and temporal patterns of tissue differentiation observed experimentally . The goal of this study was to employ a previously de veloped computational framework to test the hypothesis that substrate stiffness and oxygen availability regulate stem cel l differentiation during t issue regeneration within an implanted bone chamber. To enable a prediction of the oxygen levels within the bone chamber, a lattice model of angiogenesis was implemented where...
http://hdl.handle.net/2262/72872
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Surface neuromuscular electrical stimulation for quadriceps strengthening pre and post total knee replacement.
(2010)
Monaghan, Brenda
Surface neuromuscular electrical stimulation for quadriceps strengthening pre and post total knee replacement.
(2010)
Monaghan, Brenda
Abstract:
Background: Total knee replacement has been demonstrated to be one of the most successful procedures in the treatment of osteoarthritis. However quadriceps weakness and reductions in function are commonly reported following surgery. Recently Neuromuscular Electrical Stimulation (NMES) has been used as an adjunct to traditional strengthening programmes. This review considers the effectiveness of NMES as a means of increasing quadriceps strength in patients before and after total knee replacement. Objectives: To assess the effectiveness of NMES as a means of improving quadriceps strength before and after total knee replacement. Search methods: We searched The Cochrane Central Register of Controlled Trials (CENTRAL),MEDLINE (1950 to January week 1 2008), EMBASE (1980 to 2008 week 2), Cumulative Index to Nursing and Allied Health Literature (CINAHL)(1982 to 2007/11), AMED (1985 to Jan 2008), Web of Science, and Pedro (Jan 2008) (http://www.pedro.fhs.usyd.edu.au/index.html) for randomise...
http://hdl.handle.net/2262/95372
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Temporal discrimination threshold: VBM evidence for an endophenotype in adult onset primary torsion dystonia.
(2009)
Reilly, Richard; Whelan, Robert; Walsh, Richard
Temporal discrimination threshold: VBM evidence for an endophenotype in adult onset primary torsion dystonia.
(2009)
Reilly, Richard; Whelan, Robert; Walsh, Richard
Abstract:
Familial adult-onset primary torsion dystonia is an autosomal dominant disorder with markedly reduced penetrance. Most adult-onset primary torsion dystonia patients are sporadic cases. Disordered sensory processing is found in adult-onset primary torsion dystonia patients; if also present in their unaffected relatives this abnormality may indicate non-manifesting gene carriage. Temporal discrimination thresholds (TDTs) are abnormal in adult-onset primary torsion dystonia, but their utility as a possible endophenotype has not been examined. We examined 35 adult-onset primary torsion dystonia patients (17 familial, 18 sporadic), 42 unaffected first-degree relatives of both familial and sporadic adult-onset primary torsion dystonia patients, 32 unaffected second-degree relatives of familial adult-onset primary torsion dystonia (AOPTD) patients and 43 control subjects. TDT was measured using visual and tactile stimuli. In 33 unaffected relatives, voxel-based morphometry was used to comp...
http://hdl.handle.net/2262/40656
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Temporal discrimination, a cervical dystonia endophenotype penetrance and functional correlates
(2014)
REILLY, RICHARD; WHELAN, ROBERT
Temporal discrimination, a cervical dystonia endophenotype penetrance and functional correlates
(2014)
REILLY, RICHARD; WHELAN, ROBERT
http://hdl.handle.net/2262/75632
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Temporal discrimination, a cervical dystonia endophenotype: Penetrance and functional correlates.
(2014)
WALSH, CATHAL; REILLY, RICHARD
Temporal discrimination, a cervical dystonia endophenotype: Penetrance and functional correlates.
(2014)
WALSH, CATHAL; REILLY, RICHARD
Abstract:
The pathogenesis of adult-onset primary dystonia remains poorly understood. There is variable age-related and gender-related expression of the phenotype, the commonest of which is cervical dystonia. Endophenotypes may provide insight into underlying genetic and pathophysiological mechanisms of dystonia. The temporal discrimination threshold (TDT)-the shortest time interval at which two separate stimuli can be detected as being asynchronous-is abnormal both in patients with cervical dystonia and in their unaffected first-degree relatives. Functional magnetic resonance imaging (fMRI) studies have shown that putaminal activation positively correlates with the ease of temporal discrimination between two stimuli in healthy individuals. We hypothesized that abnormal temporal discrimination would exhibit similar age-related and gender-related penetrance as cervical dystonia and that unaffected relatives with an abnormal TDT would have reduced putaminal activation during a temporal discrimi...
http://hdl.handle.net/2262/75639
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Tensile and compressive properties of fresh human carotid atherosclerotic plaques.
(2009)
KELLY, DANIEL; LALLY, CAITRIONA
Tensile and compressive properties of fresh human carotid atherosclerotic plaques.
(2009)
KELLY, DANIEL; LALLY, CAITRIONA
http://hdl.handle.net/2262/31946
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Testing the Reliability of an Authorship Identification Method
(2004)
VOGEL, CARL
Testing the Reliability of an Authorship Identification Method
(2004)
VOGEL, CARL
Abstract:
Forensic linguists try to #12;nd irregularities in language use, as irregularities provide 'signature' information that may withstand legal tests of certainty about, for example, authorship identi#12;cation. Irregularities inhere in all levels of language use, but here we focus on textual rather than spoken forms of language. Yet, this research #12;eld is still nascent and a lot of work needs to be done though existing methods give promising results. In this paper we will focus on an authorship identi#12;cation method from the literary (Chaski, 2000) implemented in a suite of computer programs developed by McCombe (2002) which was modi- #12;ed by Medori (2004). Validation tests of the method are reported here, using fabricated corpora as well as real texts. The results for the arti#12;cial and real text data will stress that further research is necessary. Besides the bad results, the program also gives very good results which, especially with regards to the poor results, a...
http://hdl.handle.net/2262/32286
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The anisotropic mechanical behaviour of passive skeletal muscle tissue subjected to large tensile strain
(2013)
SIMMS, CIARAN; TAKAZA, MICHAEL
The anisotropic mechanical behaviour of passive skeletal muscle tissue subjected to large tensile strain
(2013)
SIMMS, CIARAN; TAKAZA, MICHAEL
Abstract:
The passive mechanical properties of muscle tissue are important for many biomechanics applications. However, significant gaps remain in our understanding of the three-dimensional tensile response of passive skeletal muscle tissue to applied loading. In particular, the nature of the anisotropy remains unclear and the response to loading at intermediate fibre directions and the Poisson?s ratios in tension have not been reported. Accordingly, tensile tests were performed along and perpendicular to the muscle fibre direction as well as at 30, 45 and 60 degrees to the muscle fibre direction in samples of Longissimus dorsi muscle taken from freshly slaughtered pigs. Strain was measured using an optical non-contact method. The results show the transverse or cross fibre (TT?) direction is broadly linear and is the stiffest (77kPa stress at a stretch of 1.1), but that failure occurs at low stretches (approximately ? = 1.15). In contrast the longitudinal or fibre direction (L) is nonlinear a...
http://hdl.handle.net/2262/68234
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The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health.
(2013)
Campbell, Veronica
The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health.
(2013)
Campbell, Veronica
Abstract:
Significant loss of bone due to trauma, underlying metabolic disease, or lack of repair due to old age surpasses the body?s endogenous bone repair mechanisms. Mesenchymal stem cells (MSCs) are adult stem cells which may represent an ideal cell type for use in cell-based tissue engineered bone regeneration strategies. The body?s endocannabinoid system has been identified as a central regulator of bone metabolism. The aim of the study was to elucidate the role of the cannabinoid receptor type 1 in the differentiation and survival of MSCs. We show that the cannabinoid receptor type 1 has a prosurvival function during acute cell stress. Additionally, we show that the phytocannabinoid, -Tetrahydrocannabinol, has a negative impact on MSC survival and osteogenesis. Overall, these results show the potential for the modulation of the cannabinoid system in cell-based tissue engineered bone regeneration strategies whilst highlighting cannabis use as a potential cause for concern in the managem...
http://hdl.handle.net/2262/72741
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The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture.
(2013)
KELLY, DANIEL
The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture.
(2013)
KELLY, DANIEL
Abstract:
The biomechanical functionality of articular cartilage is derived from both its biochemical composition and the architecture of the collagen network. Failure to replicate this normal Benninghoff architecture in regenerating articular cartilage may in turn predispose the tissue to failure. In this article, the influence of the maturity (or functionality) of a tissue-engineered construct at the time of implantation into a tibial chondral defect on the likelihood of recapitulating a normal Benninghoff architecture was investigated using a computational model featuring a collagen remodeling algorithm. Such a normal tissue architecture was predicted to form in the intact tibial plateau due to the interplay between the depth-dependent extracellular matrix properties, foremost swelling pressures, and external mechanical loading. In the presence of even small empty defects in the articular surface, the collagen architecture in the surrounding cartilage was predicted to deviate significantly...
http://hdl.handle.net/2262/66929
Displaying Results 176 - 200 of 239 on page 8 of 10
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