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A review of on-farm roadway runoff characterisation and potential management options for Ireland (2021)

Fenton, O.; Tuohy, P.; Daly, K.; Moloney, T.; Rice, P.; Murnane, John G.

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Adenoviral-mediated overexpression of catalase inhibits endothelial cell proliferation (2018)

Zanetti, Michela; Katusic, Zvonimir S.; O'Brien, Timothy

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An evolutionary conserved role of wnt signaling in stem cell fate decision (2018)

Teo, Regina; Möhrlen, Frank; Plickert, Günter; Müller, Werner A.; Frank, Uri

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Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in brassicaceae (2018)

Tohge, Takayuki; Wendenburg, Regina; Ishihara, Hirofumi; Nakabayashi, Ryo; Watanabe, Mu...

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Co-design and user validation of a technology-enabled behaviour change intervention for individuals with cardiovascular disease: Preliminary findings (2016)

Woods, Catherine; Walsh, Deirdre; Duff, Orlaith; Claes, Jomme; Buys, Roselien; Cornelis...

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Dual ire1 rnase functions dictate glioblastoma development (2018)

Lhomond, Stéphanie; Avril, Tony; Dejeans, Nicolas; Voutetakis, Konstantinos; Doultsinos...

Dual ire1 rnase functions dictate glioblastoma development (2018)

Lhomond, Stéphanie; Avril, Tony; Dejeans, Nicolas; Voutetakis, Konstantinos; Doultsinos, Dimitrios; McMahon, Mari; Pineau, Raphaël; Obacz, Joanna; Papadodima, Olga; Jouan, Florence; Bourien, Heloise; Logotheti, Marianthi; Jégou, Gwénaële; Pallares‐Lupon, Néstor; Schmit, Kathleen; Le Reste, Pierre‐Jean; Etcheverry, Amandine; Mosser, Jean; Barroso, Kim; Vauléon, Elodie

Abstract:

Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical role in cancer development. This concept is valid in glioblastoma multiform (GBM), the most lethal primary brain cancer with no effective treatment. We previously demonstrated that the ER stress sensor IRE1 alpha (referred to as IRE1) contributes to GBM progression, through XBP1 mRNA splicing and regulated IRE1-dependent decay (RIDD) of RNA. Here, we first demonstrated IRE1 signaling significance to human GBM and defined specific IRE1-dependent gene expression signatures that were confronted to human GBM transcriptomes. This approach allowed us to demonstrate the antagonistic roles of XBP1 mRNA splicing and RIDD on tumor outcomes, mainly through selective remodeling of the tumor stroma. This study provides the first demonstration of a dual role of IRE1 downstream s...

http://hdl.handle.net/10379/12439

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Endoplasmic reticulum stress: at the crossroads of inflammation and metabolism in hepatocellular carcinoma development (2018)

Maurel, Marion; Samali, Afshin; Chevet, Eric

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Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer (2018)

Switzer, Christopher H; Cheng, Robert Y-S; Ridnour, Lisa A; Glynn, Sharon A; Ambs, Stef...

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Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk (2018)

Stevens, K N; Garcia-Closas, M; Fredericksen, Z; Kosel, M; Pankratz, V S; Hopper, J L; ...

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Functional -aminobutyrate shunt in listeria monocytogenes: role in acid tolerance and succinate biosynthesis (2018)

Feehily, C.; O'Byrne, C. P.; Karatzas, K. A. G.

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Functional studies on the role of notch signaling in hydractinia development (2018)

Gahan, James M.; Schnitzler, Christine E.; DuBuc, Timothy Q.; Doonan, Liam B.; Kanska, ...

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Inhibition of nedd8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia (2018)

Swords, R. T.; Kelly, K. R.; Smith, P. G.; Garnsey, J. J.; Mahalingam, D.; Medina, E.; ...

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Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson's disease. (2019)

Hertel, Johannes; Harms, Amy C.; Heinken, Almut; Baldini, Federico; Thinnes, Cyrille C;...

Integrated analyses of microbiome and longitudinal metabolome data reveal microbial-host interactions on sulfur metabolism in Parkinson's disease. (2019)

Hertel, Johannes; Harms, Amy C.; Heinken, Almut; Baldini, Federico; Thinnes, Cyrille C; Glaab, Enrico; Vasco, Daniel A.; Pietzner, Maik; Stewart, Isobel D.; Wareham, Nicholas J.; Langenberg, Claudia; Trenkwalder, Claudia; Krüger, Rejko; Hankemeier, Thomas; Fleming, Ronan M. T.; Mollenhauer, Brit; Thiele, Ines

Abstract:

Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched controls with constraint-based modeling of gut microbial communities derived from an independent, drug-naive PD cohort, and prospective data from the general population. Our key results are (1) longitudinal trajectory of metabolites associated with the interconversion of methionine and cysteine via cystathionine differed between PD patients and controls; (2) dopaminergic medication showed strong lipidomic signatures; (3) taurine-conjugated bile acids correlated with the severity of motor symptoms, while low levels of sulfated taurolithocholate were associated with PD incidence in the general population; and (4) computational modeling predicted changes in sulfur metabolism, driven by A. muciniphila and B. wadsworthia, which is consistent with the changed metab...

http://hdl.handle.net/10379/15580

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Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model (2018)

Roel, María; Rubiolo, Juan A.; Guerra-Varela, Jorge; Silva, Siguara B. L.; Thomas, Oliv...

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Noxa contributes to the sensitivity of perk-deficient cells to er stress (2018)

Gupta, Sanjeev; Giricz, Zoltan; Natoni, Alessandro; Donnelly, Neysan; Deegan, Shane; Sz...

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Post-transcriptional expression regulation in the yeastsaccharomyces cerevisiaeon a genomic scale (2018)

Beyer, Andreas; Hollunder, Jens; Nasheuer, Heinz-Peter; Wilhelm, Thomas

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Sexual dimorphism, age, and fat mass are key phenotypic drivers of proteomic signatures (2018)

Curran, Aoife M.; Fogarty Draper, Colleen; Scott-Boyer, Marie-Pier; Roche, Helen M.; Ry...

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Targeting the pim kinases in multiple myeloma (2018)

Keane, N A; Reidy, M; Natoni, A; Raab, M S; O'Dwyer, M

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The budding yeast rad9 checkpoint complex: chaperone proteins are required for its function (2018)

Gilbert, Christopher S; van den Bosch, Michael; Green, Catherine M; Vialard, Jorge E; G...

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The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis (2018)

Hargreaves, A.; Anney, R.; O'Dushlaine, C.; Nicodemus, K. K.; Gill, M.; Corvin, A....

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Trail receptor gene editing unveils trail-r1 as a master player of apoptosis induced by trail and er stres (2018)

Florent, Dufour; Thibault, Rattier; Andrei Alexandru, Constantinescu; Luciana, Zischler...

Trail receptor gene editing unveils trail-r1 as a master player of apoptosis induced by trail and er stres (2018)

Florent, Dufour; Thibault, Rattier; Andrei Alexandru, Constantinescu; Luciana, Zischler; Aymeric, Morlé; Hazem, Ben Mabrouk; Etienne, Humblin; Guillaume, Jacquemin; Eva, Szegezdi; Fabien, Delacote; Naziha, Marrakchi; Gilles, Guichard; Catherine, Pellat-Deceunyn; Pierre, Vacher; Patrick, Legembre; Carmen, Garrido; Micheau, Olivier

Abstract:

TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion have solely been described to occur through TRAIL-R2. Using the TALEN gene-editing approach, we show that TRAIL-R1 can also induce apoptosis during unresolved unfolded protein response (UPR). Likewise, TRAIL-R1 was found to co-immunoprecipitate with FADD and caspase-8 during ER stress. Its deficiency conferred resistance to apoptosis induced by thaspigargin, tunicamycin or brefeldin A. Our data also demonstrate that tumor cell motility and invasion-induced by TRAIL-R2 is not cell autonomous but induced in a TRAIL-dependant manner. TRAIL-R1, on the other hand, is unable to trigger cell migration owing to its inability to induce an increase in calcium flux. Importantly, all the isogenic cell lines generated in this study revealed that apoptosis induced TRAIL is prefer...

http://hdl.handle.net/10379/11285