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A cenp-s/x complex assembles at the centromere in s and g2 phases of the human cell cycle (2018)

Dornblut, C.; Quinn, N.; Monajambashi, S.; Prendergast, L.; van Vuuren, C.; Munch, S.; ...

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A fluorescence anisotropy method for measuring protein concentration in complex cell culture media (2014)

Groza, RC,Calvet, A,Ryder, AG; Groza, Radu Constantin; Calvet, Amandine; Ryder, Alan G.

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A fluorescence anisotropy method for measuring protein concentration in complex cell culture media (2018)

Groza, Radu Constantin; Calvet, Amandine; Ryder, Alan G.

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A high through-put screen for small molecules modulating mcm2 phosphorylation identifies ryuvidine as an inducer of the dna damage response (2018)

FitzGerald, Jennifer; Murillo, Laura S.; O'Brien, Gemma; O'Connell, Enda; O&#...

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A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation (2010)

Ivanov, Ivaylo P.; Atkins, John F.; Michael, Antony J.

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A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining (2018)

Moureau, Sylvie; Luessing, Janna; Harte, Emma Christina; Voisin, Muriel; Lowndes, Noel ...

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Abnormal centrosomal structure and duplication in cep135-deficient vertebrate cells (2018)

Inanc, B.; Putz, M.; Lalor, P.; Dockery, P.; Kuriyama, R.; Gergely, F.; Morrison, C. G.

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Adolescent Risperidone treatment alters protein expression associated with protein trafficking and cellular metabolism in the adult rat prefrontal cortex. (2014)

Farrelly, Lorna; Dicker, Patrick; Wynne, Kieran; English, Jane A; Cagney, Gerard; Föcki...

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Alternative uses for co-products: Harnessing the potential of valuable compounds from meat processing chains (2017)

Mullen, Anne Maria; Álvarez García, Carlos; Zeugolis, Dimitrios; Henchion, Maeve; O...

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Alternative uses for co-products: harnessing the potential of valuable compounds from meat processing chains (2018)

Mullen, Anne Maria; Álvarez, Carlos; Zeugolis, Dimitrios I.; Henchion, Maeve; O'Ne...

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Analysis of gene expression in the bovine corpus luteum through generation and characterisation of 960 ests (2018)

Casey, Orla M.; Fitzpatrick, Richard; McInerney, James O.; Morris, Dermot G.; Powell, R...

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Analysis of stress-induced hepatic gene expression in rainbow trout (Oncorhynchus mykiss) selected for high- and low-responsiveness to stress (2016)

Pemmasani, Jhansi K.; Pottinger, Tom G.; Cairns, Michael T.

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Anisotropy resolved multidimensional emission spectroscopy (ARMES) for the analysis and resolution of insulin oligomer emission (2019)

Casamayou-Boucau, Yannick

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Anisotropy resolved multidimensional emission spectroscopy (ARMES): A new tool for protein analysis (2016)

Groza, Radu Constantin; Ryder, Alan G.; Li, Boyan

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Antinociceptive effects of the GPR55 Antagonist CID16020046 injected into the rat anterior cingulate cortex (2020)

Okine, Bright N.; Mc Laughlin, Gemma; Gaspar, Jessica C.; Harhen, Brendan; Roche, Miche...

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Association analysis identifies 65 new breast cancer risk loci (2018)

Michailidou, Kyriaki; Lindström, Sara; Dennis, Joe; Beesley, Jonathan; Hui, Shirley; Ka...

Association analysis identifies 65 new breast cancer risk loci (2018)

Michailidou, Kyriaki; Lindström, Sara; Dennis, Joe; Beesley, Jonathan; Hui, Shirley; Kar, Siddhartha; Lemaçon, Audrey; Soucy, Penny; Glubb, Dylan; Rostamianfar, Asha; Bolla, Manjeet K.; Wang, Qin; Tyrer, Jonathan; Dicks, Ed; Lee, Andrew; Wang, Zhaoming; Allen, Jamie; Keeman, Renske; Eilber, Ursula; French, Juliet D.

Abstract:

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry(1). We identified 65 new loci that are associated with overall breast cancer risk at P &lt; 5 x 10(-8). The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the geno...