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Limited By:	Subject = Selenoprotein P;

Displaying Results 1 - 4 of 4 on page 1 of 1

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Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status (2019)

Fedirko, Veronika; Jenab, Mazda; Méplan, Catherine; Hughes, David J.; et al.

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Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements (2016)

Wu, Sen; Mariotti, Marco; Santesmasses, Didac; Hill, Kristina E.; Baclaocos, Janinah; A...

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements (2016)

Wu, Sen; Mariotti, Marco; Santesmasses, Didac; Hill, Kristina E.; Baclaocos, Janinah; Aparicio-Prat, Estel; Li, Shuping; Mackrill, John; Wu, Yuanyuan; Howard, Michael T.; Capecchi, Mario; Guigó, Roderic; Burk, Raymond F.; Atkins, John F.

Abstract:

Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3′ UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously known human Sepp1 mRNA poly(A) addition site just 3′ of SECIS 2, two further sites were identified with one resulting in 10–25% of the mRNA lacking SECIS 2. To address function, mutant mice were generated with either SECIS 1 or SECIS 2 deleted or with the first UGA substituted with a serine codon. They were fed on either high or selenium-deficient diets. The mutants had very different effects on the proportions of shorter and longer product Sepp1 protein isoforms isolated from plasma, and on viability. Spatially and functionally distinctive effects of the two SECIS elements on UGA decoding were inferred. We also bioinformatically identify two selenoprotein S mRNAs with different 5′ sequences predicted to yield products with differen...

http://hdl.handle.net/10468/5714

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Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P (2017)

Mariotti, Marco; Shetty, Sumangala; Baird, Lisa; Wu, Sen; Loughran, Gary; Copeland, Pau...

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Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort (2014)

Hughes, David J; Fedirko, Veronika; Jenab, Mazda; Schomburg, Lutz; Meplan, Catherine; F...

Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort (2014)

Hughes, David J; Fedirko, Veronika; Jenab, Mazda; Schomburg, Lutz; Meplan, Catherine; Freisling, Heinz; Bueno-de-Mesquita, H B; Hybsier, Sandra; Becker, Niels-Peter; Czuban, Magdalena; Tjonneland, Anne; Outzen, Malene; Boutron-Ruault, Marie-Christine; Racine, Antoine; Bastide, Nadia; Kuhn, Tilman; Kaaks, Rudolf; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Lagiou, Pagona

Abstract:

<p>This is the pre-peer reviewed version of the following article: Hughes DJ, Fedirki V, Jenab M, Schomburg L, Meplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjonneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kuhn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters P, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sanchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quiros JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE. Selenium Status is Associated with Colorectal Cancer risk in the European Prospective Investigation of Cancer and Nutrition Cohort. International Journal of Cancer. Article first published online: 21 JUL 2014, which has been published in final form at <a href="http://onlinelibrary.wiley.com/doi/10.1002/ijc.29071/pdf">http://onlinelibrary.wiley.com/doi/10.1002/ijc.29071/pdf&...

https://epubs.rcsi.ie/physiolart/50

Displaying Results 1 - 4 of 4 on page 1 of 1