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Displaying Results 1 - 2 of 2 on page 1 of 1
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A trip upstream to mitigate marine plastic pollution - a perspective focused on the MSFD and WFD
(2019)
Black, Jeffrey E.; Kopke, Kathrin; O'Mahony, Cathal
A trip upstream to mitigate marine plastic pollution - a perspective focused on the MSFD and WFD
(2019)
Black, Jeffrey E.; Kopke, Kathrin; O'Mahony, Cathal
Abstract:
Developing and implementing effective legislation to combat plastic litter in the marine environment has proven a significant challenge. This is in large part due to an incomplete understanding of the sources and transport pathways of plastic litter and is manifested in Europe’s current disjointed legislation that governs the aquatic environment. In this article, the authors present the perspective that marine plastic pollution in European waters cannot be mitigated without increased regional integration between the dominant legislative structures and must provide specific considerations for the role rivers and land-based activities play in the accumulation of plastic litter in the marine environment.
http://hdl.handle.net/10468/9358
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Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5
(2012)
Loughran, Gary; Sachs, Matthew S.; Atkins, John F.; Ivanov, Ivaylo P.
Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5
(2012)
Loughran, Gary; Sachs, Matthew S.; Atkins, John F.; Ivanov, Ivaylo P.
Abstract:
An AUG in an optimal nucleotide context is the preferred translation initiation site in eukaryotic cells. Interactions among translation initiation factors, including eIF1 and eIF5, govern start codon selection. Experiments described here showed that high intracellular eIF5 levels reduced the stringency of start codon selection in human cells. In contrast, high intracellular eIF1 levels increased stringency. High levels of eIF5 induced translation of inhibitory upstream open reading frames (uORFs) in eIF5 mRNA that initiate with AUG codons in conserved poor contexts. This resulted in reduced translation from the downstream eIF5 start codon, indicating that eIF5 autoregulates its own synthesis. As with eIF1, which is also autoregulated through translation initiation, features contributing to eIF5 autoregulation show deep evolutionary conservation. The results obtained provide the basis for a model in which auto- and cross-regulation of eIF5 and eIF1 translation establish a regulatory...
http://hdl.handle.net/10468/5022
Displaying Results 1 - 2 of 2 on page 1 of 1
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