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Limited By:	Subject = antibody response;

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Displaying Results 1 - 4 of 4 on page 1 of 1

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Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination (2009)

Gallagher, Stephen; Phillips, Anna C.; Drayson, Mark T.; Carroll, Douglas

Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination (2009)

Gallagher, Stephen; Phillips, Anna C.; Drayson, Mark T.; Carroll, Douglas

Abstract:

Objective: Older spousal caregivers of dementia patients have been found to show a relatively poor antibody response to medical vaccination. The present case control study compared the antibody responses to vaccination of younger parental caregivers of children with developmental disabilities and parents of typically developing children. Methods: At baseline assessment, 32 parents of children with developmental disabilities and 29 parents of typically developing children completed standard measures of perceived stress and child problem behaviours. They also provided a blood sample and were then vaccinated with the thymus-dependent trivalent influenza vaccine. Further blood samples were taken at 1- and 6-month follow-ups. Results: Relative to parents of typically developing children (mean titre = 458, SD = 155.7 at 1-month and mean titre = 265, SD = 483.0 at 6-month followup) caregivers (mean titre = 219, SD = 528.4 at 1-month and 86, SD = 55.0 at 6- month) mounted a poorer antibody ...

http://hdl.handle.net/10344/3072

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Parental caregivers of children with developmental disabilities mount a poor antibody response to pneumococcal vaccination. (2009)

Gallagher, Stephen; Phillips, Anna C.; Drayson, Mark T.; Carroll, Douglas

Parental caregivers of children with developmental disabilities mount a poor antibody response to pneumococcal vaccination. (2009)

Gallagher, Stephen; Phillips, Anna C.; Drayson, Mark T.; Carroll, Douglas

Abstract:

In older populations, caregiving for a spouse with dementia has been associated with a poor antibody response to vaccination. The present study examined whether younger caregivers, specifically the parents of children with developmental disabilities, would also show a diminished antibody response to vaccination. At baseline assessment, 30 parents of children with developmental disabilities and 29 parents of typically developing children completed standard measures of depression, perceived stress, social support, caregiver burden, and child problem behaviours. They also provided a blood sample and were then vaccinated with a pneumococcal polysaccharide vaccine. Further blood samples were taken at 1- and 6-month follow-ups. Caregivers mounted a poorer antibody response to vaccination than control parents at both follow-ups. This effect withstood adjustment for a number of possible confounders and appeared to be, at least in part, mediated by child problem behaviours. The negative impa...

http://hdl.handle.net/10344/4372

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Psychosocial factors are associated with the antibody response to both thymus-dependent and thymus-independent vaccines (2008)

Gallagher, Stephen; Phillips, Anna C.; Ferraro, Alastair J.; Drayson, Mark T.; Carroll,...

Psychosocial factors are associated with the antibody response to both thymus-dependent and thymus-independent vaccines (2008)

Gallagher, Stephen; Phillips, Anna C.; Ferraro, Alastair J.; Drayson, Mark T.; Carroll, Douglas

Abstract:

The present study examined the association between psychological stress, social support and antibody response to both thymus-dependent and thymus-independent vaccinations. Stressful life events in the previous year and customary social support were measured by standard questionnaires at baseline in 75 (41 females) healthy students. Antibody status was assessed at baseline, 4 and 18 weeks following vaccination with formaldehyde inactivated hepatitis A virus and pneumococcal polysaccharides, which induce thymus-dependent and -independent antibody responses respectively. Controlling for baseline antibody status, life event stress was negatively associated with antibody response to the hepatitis A vaccine at the 18-week follow-up; participants reporting a greater number of stressful life events had a poorer antibody response. There was no relationship between psychological stress and antibody response to pneumococcal vaccination. Social support was not associated with the antibody respo...

http://hdl.handle.net/10344/3078

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Social support is positively associated with the immunoglobulin M response to vaccination with pneumococcal polysaccharides (2008)

Gallagher, Stephen; Phillips, Anna C.; Ferraro, Alastair J.; Drayson, Mark T.; Carroll,...

Social support is positively associated with the immunoglobulin M response to vaccination with pneumococcal polysaccharides (2008)

Gallagher, Stephen; Phillips, Anna C.; Ferraro, Alastair J.; Drayson, Mark T.; Carroll, Douglas

Abstract:

Evidence shows that psychosocial factors are associated with immunoglobulin G response to medical vaccinations. As yet, there are no reports of whether the earlier immunoglobulin M response is similarly susceptible. This study examined the association between psychological stress, social support and the immunoglobulin M response to vaccination with pneumococcal capsular polysaccharides. Stressful life events in the previous year and customary social support were measured by standard questionnaires at baseline in 74 healthy students (41 females). The response to five common pneumococcal serotypes was assessed at baseline and five-days following vaccination. Social support, particularly tangible social support, was positively associated with the antibody response to two of five serotypes, after controlling for baseline titre. These associations survived adjustment for demographics and health behaviours. There was no association between life events stress and immunoglobulin M response....

http://hdl.handle.net/10344/3075

Displaying Results 1 - 4 of 4 on page 1 of 1

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2009 (2)
2008 (2)

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