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Limited By:	Subject = articular cartilage;

Displaying Results 1 - 15 of 15 on page 1 of 1

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3D bioprinting of cartilage-mimetic implants for biological joint resurfacing (2020)

SCHIPANI, ROSSANA

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Advanced Strategies for Articular Cartilage Defect Repair (2013)

Matsiko, Amos; Levingstone, Tanya J; O'Brien, Fergal

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Controlled release of transforming growth factor-?3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells. (2014)

KELLY, DANIEL; O'BRIEN, FERGAL; CUNNIFFE, GR?INNE

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Coupling Freshly Isolated CD44(+) Infrapatellar Fat Pad-Derived Stromal Cells with a TGF-β3 Eluting Cartilage ECM-Derived Scaffold as a Single-Stage Strategy for Promoting Chondrogenesis. (2015)

Almeida, Henrique V; Cunniffe, Gráinne M; Vinardell, Tatiana; Buckley, Conor T; O'...

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Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect (2016)

Barron, Valerie; Merghani, Khalid; Shaw, Georgina; Coleman, Cynthia; Hayes, Jessica; An...

Evaluation of cartilage repair by mesenchymal stem cells seeded on a PEOT/PBT scaffold in an osteochondral defect (2016)

Barron, Valerie; Merghani, Khalid; Shaw, Georgina; Coleman, Cynthia; Hayes, Jessica; Ansboro, Sharon; Manian, Abi; O'Malley, Grace; Connolly, Emma; Nandakumar, Ananda; Van Blitterswijk, Clemen; Habibovic, Pamela; Moroni, Lorenzo; Shannon, Fintan; Barry, Frank; Murphy, Mary

Abstract:

The main objective of this study was to evaluate the effectiveness of a mesenchymal stem cell (MSC)-seeded polyethylene-oxide-terephthalate/polybutylene-terephthalate (PEOT/PBT) scaffold for cartilage tissue repair in an osteochondral defect using a rabbit model. Material characterisation using scanning electron microscopy indicated that the scaffold had a 3D architecture characteristic of the additive manufacturing fabrication method, with a strut diameter of 296 +/- A 52 mu m and a pore size of 512 +/- A 22 mu m x 476 +/- A 25 mu m x 180 +/- A 30 mu m. In vitro optimisation revealed that the scaffold did not generate an adverse cell response, optimal cell loading conditions were achieved using 50 mu g/ml fibronectin and a cell seeding density of 25 x 10(6) cells/ml and glycosaminoglycan (GAG) accumulation after 28 days culture in the presence of TGF beta 3 indicated positive chondrogenesis. Cell-seeded scaffolds were implanted in osteochondral defects for 12 weeks, with cell-free ...

http://hdl.handle.net/10379/5868

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Evaluation of the early in vivo response of a functionally graded macroporous scaffold in an osteochondral defect in a rabbit model (2016)

Barron, Valerie; Neary, Martin; Mohamed, Khalid Merghani Salid; Ansboro, Sharon; Shaw, ...

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Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential. (2015)

Matsiko, Amos; Levingstone, Tanya J; Gleeson, John P; O'Brien, Fergal

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Mechanical Regulation of Skeletal Development (2013)

MURPHY, PAULA; ROLFE, REBECCA; Roddy, Karen

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Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold (2019)

Schiavi, Jessica; Reppel, Loïc; Charif, Naceur; de Isla, Natalia; Mainard, Didier; Benk...

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Mechanisms of osteocyte stimulation in osteoporosis (2016)

Verbruggen, Stefaan W.; Vaughan, Ted J.; McNamara, Laoise M.

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Modulating Gradients in Regulatory Signals within Mesenchymal Stem Cell Seeded Hydrogels: A Novel Strategy to Engineer Zonal Articular Cartilage. (2013)

KELLY, DANIEL JOHN

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Reinforcing interpenetrating network hydrogels with 3D printed polymer networks to engineer cartilage mimetic composites (2020)

Kelly, Daniel

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The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture. (2013)

KELLY, DANIEL

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The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation (2016)

Dowling, Enda P.; Ronan, William; Ofek, Gidon; Deshpande, Vikram S.; McMeeking, Robert ...

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Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues (2019)

Kelly, Daniel; Dunne, Aisling; Cunniffe, Gr?inne M.; D?az-Payno, Pedro J.; Sheehy, Eamo...

Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues (2019)

Kelly, Daniel; Dunne, Aisling; Cunniffe, Gr?inne M.; D?az-Payno, Pedro J.; Sheehy, Eamon J.; Critchley, Susan E.; Almeida, Henrique V.; Pitacco, Pierluca; Carroll, Simon F.; Mahon, Olwyn R.; Levingstone, Tanya J.; Moran, Conor J.; Brady, Robert T.; O'Brien, Fergal J.; Brama, Pieter A.J.

Abstract:

Biological scaffolds generated from tissue-derived extracellular matrix (ECM) are commonly used clinically for soft tissue regeneration. Such biomaterials can enhance tissue-specific differentiation of adult stem cells, suggesting that structuring different ECMs into multi-layered scaffolds can form the basis of new strategies for regenerating damaged interfacial tissues such as the osteochondral unit. In this study, mass spectrometry is used to demonstrate that growth plate (GP) and articular cartilage (AC) ECMs contain a unique array of regulatory proteins that may be particularly suited to bone and cartilage repair respectively. Applying a novel iterative freeze-drying method, porous bi-phasic scaffolds composed of GP ECM overlaid by AC ECM are fabricated, which are capable of spatially directing stem cell differentiation in vitro, promoting the development of graded tissues transitioning from calcified cartilage to hyaline-like cartilage. Evaluating repair 12-months post-implant...

http://hdl.handle.net/2262/91220

Displaying Results 1 - 15 of 15 on page 1 of 1

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