rian.ie - Browse - Results

A A A

Limited By:	Subject = cartilage;

Displaying Results 1 - 25 of 33 on page 1 of 2

Mark

Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase i dose-escalation trial (2018)

Pers, Yves-Marie; Rackwitz, Lars; Ferreira, Rosanna; Pullig, Oliver; Delfour, Christoph...

Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase i dose-escalation trial (2018)

Pers, Yves-Marie; Rackwitz, Lars; Ferreira, Rosanna; Pullig, Oliver; Delfour, Christophe; Barry, Frank; Sensebe, Luc; Casteilla, Louis; Fleury, Sandrine; Bourin, Philippe; Noël, Danièle; Canovas, François; Cyteval, Catherine; Lisignoli, Gina; Schrauth, Joachim; Haddad, Daniel; Domergue, Sophie; Noeth, Ulrich; Jorgensen, Christian; ,

Abstract:

Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study aimed at evaluating the safety of a dose-escalation protocol of intra-articular injected adipose-derived stromal cells (ASCs) in patients with knee OA, as well as clinical efficacy as secondary endpoint. A bicentric, uncontrolled, open phase I clinical trial was conducted in France and Germany with regulatory agency approval for ASC expansion procedure in both countries. From April 2012 to December 2013, 18 consecutive patients with symptomatic and severe knee OA were treated with a single intra-articular injection of autologous ASCs. The study design consisted of three consecutive cohorts (six patients each) with dose escalation: low dose (2 x 10(6) cells), medium dose (10 x 10(6)), and high dose (50 x 10(6)). The primary outcome parameter was safety evaluated by...

Full-text link

http://hdl.handle.net/10379/13455

NUI Galway

Journal article

unknown

Mark

Allogeneic cell therapy for osteoarthritis (2016)

Lohan, Paul

NUI Galway

Doctoral thesis

unknown

Mark

Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints (2018)

Levingstone, Tanya J.; Ramesh, Ashwanth; Brady, Robert T.; Brama, Pieter A.J.; Kearney,...

NUI Galway

Journal article

unknown

Mark

Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints. (2016)

Levingstone, Tanya J; Ramesh, Ashwanth; Brady, Robert T; Brama, Pieter AJ; Kearney, Clo...

Royal College of Surgeons in Ireland

Journal article

peer-reviewed

Mark

Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad (2011)

KELLY, DANIEL; BUCKLEY, CONOR; VINARDELL, TATIANA

Trinity College Dublin

Journal article

peer-reviewed

Mark

Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading (2016)

Dowling, Enda P.; Ronan, William; McGarry, J. Patrick

NUI Galway

Journal article

peer-reviewed

Mark

Effect of a degraded core on the mechanical behaviour of tissue-engineered cartilage constructs: a poro-elastic finite element analysis (2004)

KELLY, DANIEL; PRENDERGAST, PATRICK JOHN

Trinity College Dublin

Journal article

peer-reviewed

Mark

Feasibility of mesenchmyal stem cells as modulators of inflammation and as a cellular model to study cartilage damage in osteoarthritis (2020)

Raman, Swarna

NUI Galway

Doctoral thesis

unknown

Mark

Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering (2019)

Buckley, Conor; Dunne, Aisling; Kelly, Daniel

Trinity College Dublin

Journal article

peer-reviewed

Mark

Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state (2018)

Fahy, N.; de Vries-van Melle, M.L.; Lehmann, J.; Wei, W.; Grotenhuis, N.; Farrell, E.; ...

NUI Galway

Journal article

unknown

Mark

Hypoxia activates the PTHrP – Zfp521 – MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage (2016)

Browe, David

NUI Galway

Doctoral thesis

unknown

Mark

Immunomodulation by interleukin-10 overexpressing mesenchymal stem cells for cartilage repair in osteoarthritis (2015)

Fahy, Niamh

NUI Galway

Doctoral thesis

unknown

Mark

Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury (2018)

Mohd Isa, Isma Liza; Abbah, Sunny A.; Kilcoyne, Michelle; Sakai, Daisuke; Dockery, Pete...

NUI Galway

Journal article

unknown

Mark

Integrating non-viral gene therapy and 3D bioprinting for bone, cartilage and osteochondral tissue engineering (2018)

GONZALEZ FERNANDEZ, TOMAS

Trinity College Dublin

Doctoral thesis

peer-reviewed

Mark

Intra-extrafibrillar mixture formulation of soft charged tissues (1999)

Huyghe, Jacques M.

University of Limerick

Journal article

peer-reviewed

Mark

Isolation and phenotypic characterisation of stem cells from late stage osteoarthritic mesenchymal tissues (2018)

Labusca, Luminita; Zugun-Eloae, Florin; Shaw, Georgina; Botez, Paul; Barry, Frank; Mash...

NUI Galway

Journal article

unknown

Mark

Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits. (2016)

Levingstone, Tanya J; Thompson, Emmet; Matsiko, Amos; Schepens, Alexander; Gleeson, Joh...

Royal College of Surgeons in Ireland

Journal article

peer-reviewed

Mark

Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete. (2016)

Stack, J David; Levingstone, Tanya J; Lalor, William; Sanders, Ruth; Kearney, Clodagh; ...

Royal College of Surgeons in Ireland

Journal article

peer-reviewed

Mark

Scaffold-based delivery of nucleic acid therapeutics for enhanced bone and cartilage repair (2019)

Kelly, Domhnall C.; Raftery, Rosanne M.; Curtin, Caroline M.; O'Driscoll, Caitríon...

University College Cork

Journal article

peer-reviewed

Science Foundation Ireland

Mark

Strategies for Articular Cartilage Repair; Mesenchymal Stem Cell-Based Targeting of the Joint Niche (2015)

Ansboro, Sharon

NUI Galway

Doctoral thesis

unknown

Mark

Strategies for improved targeting of therapeutic cells: implications for tissue repair (2018)

Ansboro, S; ,; Greiser, U; Barry, F; Murphy, M

NUI Galway

Journal article

unknown

Mark

The anatomical basis for a novel classification of osteoarthritis and allied disorders (2018)

McGonagle, Dennis; Tan, Ai Lyn; Carey, John; Benjamin, Michael

NUI Galway

Journal article

unknown

Mark

The benefits and limitations of animal models for translational research in cartilage repair. (2016)

Moran, Conor J; Ramesh, Ashwanth; Brama, Pieter AJ; O'Byrne, John M; O'Brien,...

Royal College of Surgeons in Ireland

Journal article

peer-reviewed

Mark

The development of novel collagen-glycosaminoglycan scaffold for in vitro mesenchymal stem cell chondrogenesis (2012)

Matsiko, Amos

Royal College of Surgeons in Ireland

Doctoral thesis

non-peer-reviewed

Mark

The Effect of Group Composition and Mineral Supplementation during Rearing on Measures of Cartilage Condition and Bone Mineral Density in Replacement Gilts (2020)

Hartnett, Phoebe; Boyle, Laura; Younge, Bridget; O'Driscoll, Keelin

Teagasc

Other

peer-reviewed

Displaying Results 1 - 25 of 33 on page 1 of 2

NUI Galway

Dublin City University

University College Cork

Maynooth University

University College Dublin

University of Limerick

Trinity College Dublin

Mary Immaculate College

Dublin Institute of Technology

Lenus

Dundalk Institute of Technology

Marine Institute

Teagasc

All Ireland Public Health Repository

Royal College of Surgeons in Ireland

IUA

HEA

Legal Information | Copyright Information

built by Enovation Solutions