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A hot-cold cognitive model of depression: Integrating the neuropsychological approach into the cognitive theory framework (2019)

Ahern, Elayne; Bockting, Claudi L.H; Semkovska, Maria

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Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder (2018)

Najt, Pablo; Hausmann, Markus

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Cortical abnormalities in bipolar disorder: an mri analysis of 6503 individuals from the enigma bipolar disorder working group (2018)

Hibar, D P; Westlye, L T; Doan, N T; Jahanshad, N; Cheung, J W; Ching, C R K; Versace, ...

Cortical abnormalities in bipolar disorder: an mri analysis of 6503 individuals from the enigma bipolar disorder working group (2018)

Hibar, D P; Westlye, L T; Doan, N T; Jahanshad, N; Cheung, J W; Ching, C R K; Versace, A; Bilderbeck, A C; Uhlmann, A; Mwangi, B; Krämer, B; Overs, B; Hartberg, C B; Abé, C; Dima, D; Grotegerd, D; Sprooten, E; Bøen, E; Jimenez, E; Howells, F M

Abstract:

Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen's d =-0.293; P = 1.71 x 10(-21)), left fusiform gyrus (d =-0.288; P = 8.25 x 10(-21)) and left rostral middle frontal cortex (d =-0.276; P = 2.99 x 1...