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Mark

Hemodynamic profile, compensation deficit, and ambulatory blood pressure (2018)

Ottaviani, Cristina; Shapiro, David; Goldstein, Iris B.; James, Jack E.; Weiss, Robert

Mark

Prediction of breast cancer risk based on profiling with common genetic variants (2018)

Mavaddat, Nasim; Pharoah, Paul D. P.; Michailidou, Kyriaki; Tyrer, Jonathan; Brook, Mar...

Prediction of breast cancer risk based on profiling with common genetic variants (2018)

Mavaddat, Nasim; Pharoah, Paul D. P.; Michailidou, Kyriaki; Tyrer, Jonathan; Brook, Mark N.; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Dunning, Alison M.; Shah, Mitul; Luben, Robert; Brown, Judith; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Peto, Julian

Abstract:

Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic risk stratification is lacking. Methods: We investigated the value of using 77 breast cancer-associated single nucleotide polymorphisms (SNPs) for risk stratification, in a study of 33 673 breast cancer cases and 33 381 control women of European origin. We tested all possible pair-wise multiplicative interactions and constructed a 77-SNP polygenic risk score (PRS) for breast cancer overall and by estrogen receptor (ER) status. Absolute risks of breast cancer by PRS were derived from relative risk estimates and UK incidence and mortality rates. Results: There was no strong evidence for departure from a multiplicative model for any SNP pair. Women in the highest 1% of the PRS had a three-fold increased risk of developing brea...

http://hdl.handle.net/10379/12688

Mark

The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer (2014)

Kerin, Michael J.; McVeigh, Terri; Dorairaj, Jemima J.; Heneghan, Helen M.; Miller, Nicola

Mark

The kras-variant is associated with risk of developing double primary breast and ovarian cancer (2018)

Pilarski, Robert; Patel, Divya A.; Weitzel, Jeffrey; McVeigh, Terri; Dorairaj, Jemima J...

The kras-variant is associated with risk of developing double primary breast and ovarian cancer (2018)

Pilarski, Robert; Patel, Divya A.; Weitzel, Jeffrey; McVeigh, Terri; Dorairaj, Jemima J.; Heneghan, Helen M.; Miller, Nicola; Weidhaas, Joanne B.; Kerin, Michael J.; McKenna, Megan; Wu, Xifeng; Hildebrandt, Michelle; Zelterman, Daniel; Sand, Sharon; Shulman, Lee P.

Abstract:

Purpose: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian cancer risk in patients from hereditary breast and ovarian families (HBOC), and with the risk of premenopausal triple negative breast cancer, we evaluated the association of the KRAS-variant with women with personal histories of both breast and ovarian cancer, referred to as double primary patients. Experimental Design: Germline DNA from double primary patients was tested for the KRAS-variant (n = 232). Confirmation of pathologic diagnoses, age of diagnoses, interval between ovarian cancer diagnosis and sample collection, additional cancer diagnoses, and family history were obtained when available. All patients were tested for deleterious BRCA mutations. Results: The KRAS-variant was significantly enriched in uninformative (BRCA negative) double primary patients, ...

http://hdl.handle.net/10379/13480

Displaying Results 1 - 4 of 4 on page 1 of 1