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Subject = glycoconjugate;
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Displaying Results 1 - 6 of 6 on page 1 of 1
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A systems biology frame work for integrating and analysing the functional role of glycosylation on immune response
(2019)
Oommen, Anup
A systems biology frame work for integrating and analysing the functional role of glycosylation on immune response
(2019)
Oommen, Anup
Abstract:
Reproducing the systems biology efforts established across areas of cell biology such as integrating biological networks with omic datasets and subjecting it to modelling analysis for studying the functional involvement of glycosylation has the potential to generate greater understanding of the complex biological mechanisms responsible for altered immune response and tolerance. In this regard, presented within this thesis is a systems biology framework, named GlycoGAIT, a database currently limited to human species which captures the mammalian glycosylation machinery in a machine readable format. GlycoGAIT captures the diverse glycan structures expressed on immune cells as well as the enzymatic reactions which leads to the synthesis of these diverse structures. GlycoGAIT, has been released as an open database, accessed freely, aiming to help researchers both within the field of glycobiology and those from related fields, to quickly identify the dysregulated glycosylation genes and ...
http://hdl.handle.net/10379/15142
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Inhibition of Burkholderia Multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides
(2012)
Wight, Ciara; Leyden, Rosaria; Murphy, Paul V; Callaghan, Máire; Velasco-Torrijos, Trin...
Inhibition of Burkholderia Multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides
(2012)
Wight, Ciara; Leyden, Rosaria; Murphy, Paul V; Callaghan, Máire; Velasco-Torrijos, Trinidad; McClean, Siobhan
Abstract:
Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in cystic fibrosis patients which is inherently resistant to antimicrobial agents. The mechanisms of attachment and pathogenesis of Bcc, a group of 17 species, are poorly understood. The most commonly identified Bcc species in newly colonised patients, Burkholderia multivorans, continues to be acquired from the environment. Development of therapies which can prevent or reduce the risk of colonization on exposure to Bcc in the environment would be a better alternative to antimicrobial agents. Previously, it has been shown that Bcc strains bound to many glycolipid receptors on lung epithelia. Using a real-time PCR method to quantify the levels of binding of B. multivorans to the lung epithelial cells, we have examined glycoconjugate derivatives for their potential to inhibit host cell attachment. Bivalent lactosides previously shown to inhibit galectin binding significantly reduced the attachment of B. multivorans to CF l...
https://arrow.dit.ie/ittsciart/1
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Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides
(2014)
Leyden, Rosaria; Murphy, Paul V.
Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides
(2014)
Leyden, Rosaria; Murphy, Paul V.
Abstract:
Journal article (open access)
Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in cystic fibrosis patients which is inherently resistant to antimicrobial agents. The mechanisms of attachment and pathogenesis of Bcc, a group of 17 species, are poorly understood. The most commonly identified Bcc species in newly colonised patients, Burkholderia multivorans, continues to be acquired from the environment. Development of therapies which can prevent or reduce the risk of colonization on exposure to Bcc in the environment would be a better alternative to antimicrobial agents. Previously, it has been shown that Bcc strains bound to many glycolipid receptors on lung epithelia. Using a real-time PCR method to quantify the levels of binding of B. multivorans to the lung epithelial cells, we have examined glycoconjugate derivatives for their potential to inhibit host cell attachment. Bivalent lactosides previously shown to inhibit galectin binding significantly reduced the at...
http://hdl.handle.net/10379/4362
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Inhibition of burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides
(2018)
Wright, Ciara; Leyden, Rosaria; Murphy, Paul V.; Callaghan, Máire; Velasco-Torrijos, Tr...
Inhibition of burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides
(2018)
Wright, Ciara; Leyden, Rosaria; Murphy, Paul V.; Callaghan, Máire; Velasco-Torrijos, Trinidad; McClean, Siobhán
Abstract:
Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in cystic fibrosis patients which is inherently resistant to antimicrobial agents. The mechanisms of attachment and pathogenesis of Bcc, a group of 17 species, are poorly understood. The most commonly identified Bcc species in newly colonised patients, Burkholderia multivorans, continues to be acquired from the environment. Development of therapies which can prevent or reduce the risk of colonization on exposure to Bcc in the environment would be a better alternative to antimicrobial agents. Previously, it has been shown that Bcc strains bound to many glycolipid receptors on lung epithelia. Using a real-time PCR method to quantify the levels of binding of B. multivorans to the lung epithelial cells, we have examined glycoconjugate derivatives for their potential to inhibit host cell attachment. Bivalent lactosides previously shown to inhibit galectin binding significantly reduced the attachment of B. multivorans to CF l...
http://hdl.handle.net/10379/14455
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Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis?
(2019)
Pettenuzzo, Andrea
Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis?
(2019)
Pettenuzzo, Andrea
Abstract:
Rapidly dividing tumour cells require higher amounts of nutrients and energy for their fast proliferation, and glucose is no exception (the so-called “Warburg effect”). Consequently, such increased demand of glucose by cancer cells makes it very attractive to selectively target tumour sites. In particular, tailored glucose-like substrates can be conjugated to chemotherapeutics (including metal-containing anticancer agents) to attain the site-specific delivery of drugs into the affected tissues. Accordingly, we have been focusing on the design of metal-dithiocarbamato glycoconjugates which can combine the antitumor properties and the favourable toxicological profile of the metal-dithiocarbamato scaffold, along with an improved selectivity and cellular uptake provided by the glucose-containing ligands coordinated to the metal center, through the exploitation of the glucose-mediated cellular internalization facilitated by glucose transporters (GLUTs). In this thesis, the generation of ...
http://hdl.handle.net/10379/15012
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Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform
(2019)
Kaltner, Herbert; Manning, Joachim C.; García Caballero, Gabriel; Di Salvo, Claudia; Ga...
Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform
(2019)
Kaltner, Herbert; Manning, Joachim C.; García Caballero, Gabriel; Di Salvo, Claudia; Gabba, Adele; Romero-Hernández, Laura L.; Knospe, Clemens; Wu, Dan; Daly, Harrison C.; O'Shea, Donal F.; Gabius, Hans-Joachim; Murphy, Paul V.
Abstract:
The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by high-avidity/specificity blocking reagents. Synthetic glycoclusters are proving to have potential for becoming such inhibitors but the commonly used assays have their drawbacks to predict in vivo efficacy. They do not represent the natural complexity of (i) cell types and (ii) spatial and structural complexity of glycoconjugate representation. Moreover, testing lectins in mixtures, as present in situ, remains a major challenge, giving direction to this work. Using a toolbox with four lectins and six bi- to tetravalent glycoclusters bearing the cognate sugar in a model study, we here document the efficient and versatile application of tissue sections (from murine jejunum as the model) as a platform for routine and systematic glycocluster testing without commonly encountered limitations. The nature of glycocluster structure, espe...
http://hdl.handle.net/10379/15194
Displaying Results 1 - 6 of 6 on page 1 of 1
Bibtex
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Institution
Dublin Institute of Technology (1)
NUI Galway (5)
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Doctoral thesis (2)
Journal article (3)
Other (1)
Peer Review Status
Peer-reviewed (2)
Unknown (4)
Year
2019 (3)
2018 (1)
2014 (1)
2012 (1)
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