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Limited By:	Subject = glycoconjugate;

Displaying Results 1 - 6 of 6 on page 1 of 1

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A systems biology frame work for integrating and analysing the functional role of glycosylation on immune response (2019)

Oommen, Anup

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Inhibition of Burkholderia Multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides (2012)

Wight, Ciara; Leyden, Rosaria; Murphy, Paul V; Callaghan, Máire; Velasco-Torrijos, Trin...

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Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides (2014)

Leyden, Rosaria; Murphy, Paul V.

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Inhibition of burkholderia multivorans adhesion to lung epithelial cells by bivalent lactosides (2018)

Wright, Ciara; Leyden, Rosaria; Murphy, Paul V.; Callaghan, Máire; Velasco-Torrijos, Tr...

Mark

Metal-based dithiocarbamato glycoconjugates: a suitable strategy to target tumour glycolysis? (2019)

Pettenuzzo, Andrea

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Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform (2019)

Kaltner, Herbert; Manning, Joachim C.; García Caballero, Gabriel; Di Salvo, Claudia; Ga...

Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform (2019)

Kaltner, Herbert; Manning, Joachim C.; García Caballero, Gabriel; Di Salvo, Claudia; Gabba, Adele; Romero-Hernández, Laura L.; Knospe, Clemens; Wu, Dan; Daly, Harrison C.; O'Shea, Donal F.; Gabius, Hans-Joachim; Murphy, Paul V.

Abstract:

The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by high-avidity/specificity blocking reagents. Synthetic glycoclusters are proving to have potential for becoming such inhibitors but the commonly used assays have their drawbacks to predict in vivo efficacy. They do not represent the natural complexity of (i) cell types and (ii) spatial and structural complexity of glycoconjugate representation. Moreover, testing lectins in mixtures, as present in situ, remains a major challenge, giving direction to this work. Using a toolbox with four lectins and six bi- to tetravalent glycoclusters bearing the cognate sugar in a model study, we here document the efficient and versatile application of tissue sections (from murine jejunum as the model) as a platform for routine and systematic glycocluster testing without commonly encountered limitations. The nature of glycocluster structure, espe...

http://hdl.handle.net/10379/15194

Displaying Results 1 - 6 of 6 on page 1 of 1