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Displaying Results 1 - 20 of 20 on page 1 of 1
Marked
Mark
A comparison of stride length and lower extremity kinematics during barefoot and shod running in well trained distance runners
(2016)
Francis, Peter; Ledingham, James; Clarke, Sarah; Collins, Daniel J.; Jakeman, Philip M.
A comparison of stride length and lower extremity kinematics during barefoot and shod running in well trained distance runners
(2016)
Francis, Peter; Ledingham, James; Clarke, Sarah; Collins, Daniel J.; Jakeman, Philip M.
Abstract:
Stride length, hip, knee and ankle angles were compared during barefoot and shod running on a treadmill at two speeds. Nine well-trained (1500m time: 3min:59.80s ± 14.7 s) male (22 ±3 years; 73 ±9 kg; 1.79 ±0.4 m) middle distance (800 m - 5,000 m) runners performed 2 minutes of running at 3.05 m·s-1 and 4.72 m·s-1 on an treadmill. This approach allowed continuous measurement of lower extremity kinematic data and calculation of stride length. Statistical analysis using a 2X2 factorial ANOVA revealed speed to have a main effect on stride length and hip angle and footwear to have a main effect on hip angle. There was a significant speed*footwear interaction for knee and ankle angles. Compared to shod running at the lower speed (3.05 m·s-1), well trained runners have greater hip, knee and ankle angles when running barefoot. Runners undertake a high volume (~75%) of training at lower intensities and therefore knowledge of how barefoot running alters running kinematics at low and high spe...
http://hdl.handle.net/10344/5471
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Automatic Classification of Knee Rehabilitation Exercises Using a Single Inertial Sensor: a Case Study
(2019)
Bevilacqua, Antonio; Huang, Bingquan; Argent, Rob; Caulfield, Brian; Kechadi, Tahar
Automatic Classification of Knee Rehabilitation Exercises Using a Single Inertial Sensor: a Case Study
(2019)
Bevilacqua, Antonio; Huang, Bingquan; Argent, Rob; Caulfield, Brian; Kechadi, Tahar
Abstract:
IEEE 15th International Conference on Wearable and Implantable Body Sensor Networks (BSN), 4-7 March 2018, Las Vegas, Nevada, USA
Inertial measurement units have the ability to accurately record the acceleration and angular velocity of human limb segments during discrete joint movements. These movements are commonly used in exercise rehabilitation programmes following orthopaedic surgery such as total knee replacement. This provides the potential for a biofeedback system with data mining technique for patients undertaking exercises at home without physician supervision. We propose to use machine learning techniques to automatically analyse inertial measurement unit data collected during these exercises, and then assess whether each repetition of the exercise was executed correctly or not. Our approach consists of two main phases: signal segmentation, and segment classification. Accurate pre-processing and feature extraction are paramount topics in order for the technique to work...
http://hdl.handle.net/10197/9947
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Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints
(2018)
Levingstone, Tanya J.; Ramesh, Ashwanth; Brady, Robert T.; Brama, Pieter A.J.; Kearney,...
Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints
(2018)
Levingstone, Tanya J.; Ramesh, Ashwanth; Brady, Robert T.; Brama, Pieter A.J.; Kearney, Clodagh; Gleeson, John P.; O'Brien, Fergal J.
http://hdl.handle.net/10379/12433
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Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: a retrospective cohort study
(2015)
McGoldrick, Niall P; O'Connor, Eabhann M; Davarinos, Nikos; Galvin, Rose; Quinlan,...
Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: a retrospective cohort study
(2015)
McGoldrick, Niall P; O'Connor, Eabhann M; Davarinos, Nikos; Galvin, Rose; Quinlan, John F
Abstract:
AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid (TXA) in lower limb arthroplasty. METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients (control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients (TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 +/- 13 years. There were no significant differences between groups in terms of gender (P = 0.47), proportion of total hip replacement to total knee replacement (P = 0.25) or pre-operative haemoglobin (P = 0.43). In the control group, the transfusion rate was 22%...
http://hdl.handle.net/10344/4994
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Dynamic knee joint mechanics after anterior cruciate ligament reconstruction
(2015)
Breen, Sarah; Kenny, Ian C.; Harrison, Andrew J.
Dynamic knee joint mechanics after anterior cruciate ligament reconstruction
(2015)
Breen, Sarah; Kenny, Ian C.; Harrison, Andrew J.
Abstract:
Purpose: There is a scarcity of information on the long term adaptations in lower limb biomechanics during game specific movements after an anterior cruciate ligament (ACL) reconstruction. Particularly, variables such as knee abduction moments and transverse plane knee motion have not been studied during a game specific landing and cutting task after ACL reconstruction. The purpose of this study was to compare the hip and knee mechanics between the ACL reconstructed (ACLr) group and a healthy control group. Methods: 38 athletes (18 ACLr, 18 control) participated in the study. Three dimensional hip, knee and ankle angles were calculated during a maximal drop jump land from a 0.30 m box and unanticipated cutting task at 45°. Results: During the landing phase ACLr participants had increased hip flexion (p <0.003) and transverse plane knee range of motion (p = 0.027). During the cutting phase, ACLr participant’s previously injured limb had increased internal knee abduction moment com...
http://hdl.handle.net/10344/5046
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Dynamic knee joint mechanics after anterior cruciate ligament reconstruction
(2014)
Breen, Sarah; Kenny, Ian C.; Harrison, Andrew J.
Dynamic knee joint mechanics after anterior cruciate ligament reconstruction
(2014)
Breen, Sarah; Kenny, Ian C.; Harrison, Andrew J.
Abstract:
Purpose: There is a scarcity of information on the long term adaptations in lower limb biomechanics during game specific movements after an anterior cruciate ligament (ACL) reconstruction. Particularly, variables such as knee abduction moments and transverse plane knee motion have not been studied during a game specific landing and cutting task after ACL reconstruction. The purpose of this study was to compare the hip and knee mechanics between the ACL reconstructed (ACLr) group and a healthy control group. Methods: 38 athletes (18 ACLr, 18 control) participated in the study. Three dimensional hip, knee and ankle angles were calculated during a maximal drop jump land from a 0.30 m box and unanticipated cutting task at 45°. Results: During the landing phase ACLr participants had increased hip flexion (p <0.003) and transverse plane knee range of motion (p = 0.027). During the cutting phase, ACLr participant’s previously injured limb had increased internal knee abduction moment com...
http://hdl.handle.net/10344/5249
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Effects of resistance training and neuromuscular electrical stimulation in knee osteoarthritis : a randomised control trial.
(2011)
Bruce-Brand, Robert A
Effects of resistance training and neuromuscular electrical stimulation in knee osteoarthritis : a randomised control trial.
(2011)
Bruce-Brand, Robert A
Abstract:
<p>This study compared the effects of 6-week home-based resistance training (RT) and neuromuscular electrical stimulation (NMES) programs on self-reported disability, functional capacity, quadriceps strength and cross-sectional area (CSA), and expression of myosin heavy chain (MHC) isoforms and ubiquitin-protein ligases in older persons with moderate to severe knee osteoarthritis (OA).</p> <p>A total of 41 patients aged 55 to 75 years with arthroscopically or radiographically confirmed moderate to severe knee OA were randomised to a 6-week home RT program, a 6-week NMES program or a control group receiving standard care. The RT group performed quadriceps femoris strengthening exercises 3 times per week, while the NMES group used a portable garment stimulator for 20 minutes 5 times per week at the maximum intensity comfortably tolerated.</p> <p>Outcomes were assessed at baseline, post-intervention and 6 weeks post-intervention. The primary outcome measur...
https://epubs.rcsi.ie/mchrestheses/9
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High Power, Low Frequency Ultrasound: Meniscal Tissue Interaction and Ablation Characteristics
(2011)
O'Daly, Brendan; Morris, Edmund; Gavin, Graham; Keane, Conor; O Byrne, John; McGui...
High Power, Low Frequency Ultrasound: Meniscal Tissue Interaction and Ablation Characteristics
(2011)
O'Daly, Brendan; Morris, Edmund; Gavin, Graham; Keane, Conor; O Byrne, John; McGuinness, Garrett
Abstract:
Abstract—This study evaluates high power low frequency ultrasound transmitted via a flat vibrating probe tip as an alternative technology for meniscal debridement in the bovine knee. An experimental force controlled testing rig was constructed using a 20 kHz ultrasonic probe suspended vertically from a load cell. Effect of variation in amplitude of distal tip displacement (242–494 mm peak-peak) settings and force (2.5–4.5 N) on tissue removal rate (TRR) and penetration rate (PR) for 52 bovine meniscus samples was analyzed. Temperature elevation in residual meniscus was measured by embedded thermocouples and histologic analysis. As amplitude or force increases, there is a linear increase in TRR (Mean: 0.9 to 11.2 mg/s) and PR (Mean: 0.08 to 0.73 mm/s). Maximum mean temperatures of 84.6C and 52.3C were recorded in residual tissue at 2 mm and 4 mm from the ultrasound probe-tissue interface. There is an inverse relationship between both amplitude and force, and temperature elevation, wi...
https://arrow.dit.ie/engschmanart/12
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Joint kinematics of landing in ACL rehabilitated volunteers
(2011)
Breen, Sarah; Harrison, Andrew J.; Kenny, Ian C.
Joint kinematics of landing in ACL rehabilitated volunteers
(2011)
Breen, Sarah; Harrison, Andrew J.; Kenny, Ian C.
Abstract:
The purpose of the present study was to compare the variability of movement and force production in ACL rehabilitated volunteers during landing from a maximal drop jump. Male (n=6) and female (n=7) volunteers with previous ACL reconstruction and rehabilitation performed a maximal drop jump diagonal side cut task (x20 trials). Knee and hip joint kinematics in all three planes were calculated during the landing component of the task. The range of motion (ROM) of the hip and knee joint, showed differences between the legs. The previously injured leg showed smaller ROM in hip and knee abadduction and knee flexion extension. The decreased range of motion in the previously injured leg may be indicative of a less variable landing movement repertoire, which may increase injury risk.
http://hdl.handle.net/10344/2204
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Knee injury and osteoarthritis outcome score (KOOS) responder criteria and minimal detectable change 3–12 years following a youth sport-related knee injury
(2021)
Toomey, Clodagh M.; Whittaker, Jackie L.; Palacios-Derflingher, Luz; Emery, Carolyn A.
Knee injury and osteoarthritis outcome score (KOOS) responder criteria and minimal detectable change 3–12 years following a youth sport-related knee injury
(2021)
Toomey, Clodagh M.; Whittaker, Jackie L.; Palacios-Derflingher, Luz; Emery, Carolyn A.
Abstract:
The applicability of thresholds that constitute an acceptable score or meaningful change on the Knee injury and Osteoarthritis Outcome Score (KOOS) in cohorts ≥ 5 years following knee injury is not well understood. The primary objective of this study was to evaluate the association between intra-articular knee injury type and two different KOOS pain thresholds (patient acceptable symptom state (PASS) and Englund symptomatic knee criteria) in the Alberta Youth Prevention of Osteoarthritis (PrE-OA) cohort, which includes participants 3–12 years following a youth sport-related knee injury and uninjured controls with similar age, sex and sport characteristics. Analyses accounted for sex, time since injury and the interaction between time since injury and injury type. Secondary objectives were to report proportions meeting thresholds for KOOS outcomes and minimal detectable change (MDC) from published test–retest reliability data, over a 1–4-year follow-up. Two hundred and fifty-three (2...
http://hdl.handle.net/10344/9761
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Knee joint mechanics after anterior cruciate ligament reconstruction
(2014)
Kenny, Ian C.; Clarke, Sarah; Harrison, Andrew J.
Knee joint mechanics after anterior cruciate ligament reconstruction
(2014)
Kenny, Ian C.; Clarke, Sarah; Harrison, Andrew J.
Abstract:
Introduction: There is a scarcity of information on the long term adaptations in lower limb biomechanics during game specific movements after an anterior cruciate ligament (ACL) reconstruction. Particularly, variables such as knee abduction moments and transverse plane knee motion have not been studied during a game specific landing and cutting task after ACL reconstruction. The purpose of this study was to compare the hip and knee mechanics between the ACL reconstructed (ACLr) group and a healthy control group. Methods: 38 athletes (18 ACLr, 18 control) participated in the study. Three dimensional hip, knee and ankle angles were calculated during a maximal drop jump land from a 0.30 m box and unanticipated cutting task at 45°. Results: During the landing phase ACLr participants had increased hip flexion (p <0.003) and transverse plane knee range of motion (p = 0.027). During the cutting phase, ACLr participant’s previously injured limb had increased internal knee abduction mom...
http://hdl.handle.net/10344/4137
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Ligament and bone pathologic abnormalities more frequent in neuropathic joint disease in comparison with degenerative arthritis of the foot and ankle: implications for understanding rapidly progressive joint degeneration
(2018)
Halstead, Jill; Bergin, Diane; Keenan, Anne-Maree; Madden, Julie; McGonagle, Dennis
Ligament and bone pathologic abnormalities more frequent in neuropathic joint disease in comparison with degenerative arthritis of the foot and ankle: implications for understanding rapidly progressive joint degeneration
(2018)
Halstead, Jill; Bergin, Diane; Keenan, Anne-Maree; Madden, Julie; McGonagle, Dennis
Abstract:
Objective. The variable disease progression of osteoarthritis (OA) and the basis for rapid joint deterioration in some subgroups of patients are poorly understood. To explore an anatomic basis for rapidly progressive OA, this observational study compared the magnetic resonance imaging (MRI) patterns of disease between patients with neuropathic joint disease (NJD) and patients with degenerative arthritis of the ankle and foot. Methods. MR images of the foot and ankle of patients with early NJD (n = 7) and patients with OA (n = 15) were assessed. The anonomized MR images were dichotomously scored by a musculoskeletal radiologist for the presence of the following abnormalities per bone (of a total of 14 bones): cartilage defects, bone cysts, bone marrow edema, fractures, joint debris, joint effusions, tendinopathy, tendinitis, and ligament tears. Results. Although the degree of cartilage damage and joint cyst formation was comparable between the groups, the degree of ligament tears, or...
http://hdl.handle.net/10379/11801
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Measuring patient satisfaction with exercise therapy for knee osteoarthritis: evaluating the utility of the physiotherapy outpatient survey.
(2010)
French, Helen P; Keogan, F; Gilsenan, Clare; Waldron, L; O'Connell, Paul
Measuring patient satisfaction with exercise therapy for knee osteoarthritis: evaluating the utility of the physiotherapy outpatient survey.
(2010)
French, Helen P; Keogan, F; Gilsenan, Clare; Waldron, L; O'Connell, Paul
Abstract:
<p>This is the pre-peer reviewed version of the following article: French HP, Keogan F, Gilsenan C, Waldron L, O'Connell P. Measuring patient satisfaction with exercise therapy for knee osteoarthritis: evaluating the utility of the physiotherapy outpatient survey. Musculoskeletal Care. 2010;8(2):61-7., which has been published in final form at <a href="http://dx.doi.org/10.1002/msc.166" target="_blank" title="http://dx.doi.org/10.1002/msc.166">doi: 10.1002/msc.166</a>. This article may be used for non-commercial purposes in accordance with <a href="http://olabout.wiley.com/WileyCDA/Section/id-820227.html" target="_blank" title="Wiley Terms and Conditions for Self-Archiving">Wiley Terms and Conditions for Self-Archiving.</a></p>
<p>OBJECTIVES: To assess patient satisfaction with exercise for knee osteoarthritis (OA).</p> <p>METHODS: A convenience sample of 27 pat...
https://epubs.rcsi.ie/sphysioart/19
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Musculoskeletal disorders among irish farmers
(2018)
Osborne, A.; Blake, C.; McNamara, J.; Meredith, D.; Phelan, J.; Cunningham, C.
Musculoskeletal disorders among irish farmers
(2018)
Osborne, A.; Blake, C.; McNamara, J.; Meredith, D.; Phelan, J.; Cunningham, C.
Abstract:
Background Farming is an occupation that predisposes individuals to health problems including musculoskeletal disorders (MSDs). There is limited research regarding MSDs among farmers especially in Ireland. Aims To establish the prevalence of MSDs, identify the most commonly affected body regions and to explore what factors may influence the development of the most common MSDs among farmers in Ireland. Methods A questionnaire survey of Irish farmers was conducted. The study sample comprised 600 farmers (100 farmers from each of the six main farm enterprise systems in Ireland). Results Of the 600 farmers, 56% had experienced a MSD in the previous year. The most commonly experienced MSDs were back pain (37%) and neck/shoulder pain (25%). Other MSDs experienced in the previous year included knee pain (9%), hand-wrist-elbow pain (9%), ankle/foot pain (9%) and hip pain (8%). Overall, MSDs were more common in farmers working longer hours (P &lt; 0.05). Back pain was more prevalent ...
http://hdl.handle.net/10379/13362
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Physical function in patients undergoing arthroscopic meniscus surgery of the knee
(2020)
CARDY, NATHAN
Physical function in patients undergoing arthroscopic meniscus surgery of the knee
(2020)
CARDY, NATHAN
Abstract:
Current evidence does not support the primary use of arthroscopic partial meniscectomy (APM) in the treatment of middle-aged patients with a meniscus tear in a degenerative knee. Findings of these studies are based on Patient Reported Outcome Measures (PROMs). Objective functional performance in patients undergoing APM are poorly reported and research has not been consolidated on this topic. Arthroscopic meniscus surgery continues to be a frequently performed procedure despite recent guidelines; the rationale for surgical treatment in patients with meniscus injuries is not clearly defined. The aim of this thesis was to investigate expectations, functional performance and activity level in a cross sectional population of patients undergoing arthroscopic meniscus surgery of the knee. Two systematic reviews were undertaken to summarise current research on this topic. The first systematic review examined self-reported function and measures of strength in young patients undergoing APM. T...
http://hdl.handle.net/2262/92979
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Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol.
(2017)
Holden, Melanie A; Burke, Danielle L; Runhaar, Jos; van Der Windt, Danielle; Riley, Ric...
Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol.
(2017)
Holden, Melanie A; Burke, Danielle L; Runhaar, Jos; van Der Windt, Danielle; Riley, Richard D; Dziedzic, Krysia; Legha, Amardeep; Evans, Amy L; Abbott, J Haxby; Baker, Kristin; Brown, Jenny; Bennell, Kim L; Bossen, Daniël; Brosseau, Lucie; Chaipinyo, Kanda; Christensen, Robin; Cochrane, Tom; de Rooij, Mariette; Doherty, Michael; French, Helen P
Abstract:
<p>The original article is available at <a href="https://bmjopen.bmj.com/content/7/12/e018971.long">bmjopen.bmj.com</a></p>
<p><strong>INTRODUCTION:</strong> Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify: (1) subgroups of people with knee and hip OA that do/do not respond to therapeutic exercise and to different types of exercise and (2) mediators of the effect of therapeutic exercise for reducing pain and improving physical function. This will enable optimal targeting and refining the content of future exercise intervention...
https://epubs.rcsi.ie/sphysioart/30
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Surface neuromuscular electrical stimulation for quadriceps strengthening pre and post total knee replacement.
(2010)
Monaghan, Brenda
Surface neuromuscular electrical stimulation for quadriceps strengthening pre and post total knee replacement.
(2010)
Monaghan, Brenda
Abstract:
Background: Total knee replacement has been demonstrated to be one of the most successful procedures in the treatment of osteoarthritis. However quadriceps weakness and reductions in function are commonly reported following surgery. Recently Neuromuscular Electrical Stimulation (NMES) has been used as an adjunct to traditional strengthening programmes. This review considers the effectiveness of NMES as a means of increasing quadriceps strength in patients before and after total knee replacement. Objectives: To assess the effectiveness of NMES as a means of improving quadriceps strength before and after total knee replacement. Search methods: We searched The Cochrane Central Register of Controlled Trials (CENTRAL),MEDLINE (1950 to January week 1 2008), EMBASE (1980 to 2008 week 2), Cumulative Index to Nursing and Allied Health Literature (CINAHL)(1982 to 2007/11), AMED (1985 to Jan 2008), Web of Science, and Pedro (Jan 2008) (http://www.pedro.fhs.usyd.edu.au/index.html) for randomise...
http://hdl.handle.net/2262/95372
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Ten-year follow-up of spa-related oligoarthritis involving the knee: the presence of psoriasis but not hla-b27 or baseline mri bone oedema predicts outcome
(2018)
Bennett, A. N.; Marzo-Ortega, H.; Tan, A. L.; Hensor, E. M. A.; Green, M.; Emery, P.; M...
Ten-year follow-up of spa-related oligoarthritis involving the knee: the presence of psoriasis but not hla-b27 or baseline mri bone oedema predicts outcome
(2018)
Bennett, A. N.; Marzo-Ortega, H.; Tan, A. L.; Hensor, E. M. A.; Green, M.; Emery, P.; McGonagle, D.
Abstract:
Objective. Bone marrow oedema (BMO) and HLA-B27 are poor prognostic factors in axial SpA, and psoriasis is a poor prognostic factor in small-joint polyarthropathy. The aim of this study was to investigate the influence of HLA-B27, MRI BMO and psoriasis on long-term outcomes in early SpA-related knee joint oligoarthritis. Methods. Patients with SpA-related oligoarthritis with knee involvement were recruited. Baseline assessment included ESSG criteria, RF, HLA-B27 and MRI. The degree of MRI BMO was determined on fat-suppression sequences and scored using the whole-organ magnetic resonance imaging score (WORMS) (range 0-45). Patients were treated at the discretion of their rheumatologist and followed up for 10 years. Outcome assessments included joint counts, functional and symptomatic questionnaire, CRP and radiographic assessment for OA. Results. Forty-four patients were recruited [mean age 32 years (range 15-59 years), 70% male] with a mean disease duration at baseline of 9.75 month...
http://hdl.handle.net/10379/10407
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The oarsi histopathology initiative – recommendations for histological assessments of osteoarthritis in sheep and goats
(2018)
Little, C.B.; Smith, M.M.; Cake, M.A.; Read, R.A.; Murphy, M.J.; Barry, F.P.
The oarsi histopathology initiative – recommendations for histological assessments of osteoarthritis in sheep and goats
(2018)
Little, C.B.; Smith, M.M.; Cake, M.A.; Read, R.A.; Murphy, M.J.; Barry, F.P.
http://hdl.handle.net/10379/12467
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Translation of science to surgery: linking emerging concepts in biological cartilage repair to surgical intervention
(2018)
Moran, C. J.; Shannon, F. J.; Barry, F. P.; O'Byrne, J. M.; O'Brien, T.; Curt...
Translation of science to surgery: linking emerging concepts in biological cartilage repair to surgical intervention
(2018)
Moran, C. J.; Shannon, F. J.; Barry, F. P.; O'Byrne, J. M.; O'Brien, T.; Curtin, W.
Abstract:
Orthopaedic surgery is in an exciting transitional period as modern surgical interventions, implants and scientific developments are providing new therapeutic options. As advances in basic science and technology improve our understanding of the pathology and repair of musculoskeletal tissue, traditional operations may be replaced by newer, less invasive procedures which are more appropriately targeted at the underlying pathophysiology. However, evidence-based practice will remain a basic requirement of care. Orthopaedic surgeons can and should remain at the forefront of the development of novel therapeutic interventions and their application. Progression of the potential of bench research into an improved array of orthopaedic treatments in an effective yet safe manner will require the development of a subgroup of specialists with extended training in research to play an important role in bridging the gap between laboratory science and clinical practice. International regulations reg...
http://hdl.handle.net/10379/12967
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