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Displaying Results 1 - 25 of 62 on page 1 of 3
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A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation
(2018)
A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation
(2018)
Abstract:
Background: Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis as a broad syndrome rather than within specific diagnostic categories. Methods: 1239 cases with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder; 857 of their unaffected relatives, and 2739 healthy controls were genotyped with the Affymetrix 6.0 single nucleotide polymorphism (SNP) array. Analyses of 695,193 SNPs were conducted using UNPHASED, which combines information across families and unrelated individuals. We attempted to replicate signals found in 23 genomic regions using existing data on nonoverlapping samples from the Psychiatric GWAS Consortium and Schizophrenia-GENE-plus cohorts (10,352 schizophrenia patients and 24,474 controls). Results: No individual SNP showed compelling evidence for association with psychosis in our data. However, we observed a trend for association with same risk...
http://hdl.handle.net/10379/10505
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A meta-analytic perspective on the valid use of subjective human judgement to make medical school admission decisions.
(2018)
Kreiter, Clare; O'Shea, Marie; Bruen, Catherine; Murphy, Paul J; Pawlikowska, Teresa
A meta-analytic perspective on the valid use of subjective human judgement to make medical school admission decisions.
(2018)
Kreiter, Clare; O'Shea, Marie; Bruen, Catherine; Murphy, Paul J; Pawlikowska, Teresa
Abstract:
<p>The original article is available at <a href="https://www.tandfonline.com">www.tandfonline.com</a></p>
<p>While medical educators appear to believe that admission to the medical school should be governed, at least in part, by human judgement, there has been no systematic presentation of evidence suggesting it improves selection. From a fair testing perspective, legal, ethical, and psychometric considerations, all dictate that the scientific evidence regarding human judgement in selection should be given consideration. To investigate the validity of using human judgements in admissions, multi-disciplinary meta-analytic research evidence from the wider literature is combined with studies from within medical education to provide evidence regarding the fairness and validity of using interviews and holistic review in medical school admissions. Fourteen studies, 6 of which are meta-analytic studies that summarized 292 individual studies, were...
https://epubs.rcsi.ie/mededart/12
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A new measure of multimorbid illness and treatment representations: the example of diabetes and depression
(2016)
McSharry, Jennifer
A new measure of multimorbid illness and treatment representations: the example of diabetes and depression
(2016)
McSharry, Jennifer
Abstract:
Journal article
Background: Depression is two to three times more common in people with diabetes than in the general population. Although multimorbid diabetes and depression is associated with poor health outcome, existing research has focused on patients' understanding and management of each condition in isolation. This study describes the development and validation of the Diabetes and Depression Representation and Management Questionnaire (DDRMQ), a measure of understanding, management and medication beliefs in people with diabetes and depression.Methods: In Study 1, DDRMQ items were developed through further analysis of an earlier qualitative study and refined through 18 cognitive interviews. In Study 2, 334 adults with diabetes and depression from general practices, diabetes clinics and support groups completed the DDRMQ demographic questions and validating measures.Results: Factor analysis of the DDRMQ using principal axis factoring resulted in a 35 item scale organise...
http://hdl.handle.net/10379/5879
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A simplified approach to the pooled analysis of calibration of clinical prediction rules for systematic reviews of validation studies.
(2015)
Dimitrov, Borislav D; Motterlini, Nicola; Fahey, Tom
A simplified approach to the pooled analysis of calibration of clinical prediction rules for systematic reviews of validation studies.
(2015)
Dimitrov, Borislav D; Motterlini, Nicola; Fahey, Tom
Abstract:
<p>The original article is available at <a href="http://www.dovepress.com">www.dovepress.com</a></p>
<p>OBJECTIVE: Estimating calibration performance of clinical prediction rules (CPRs) in systematic reviews of validation studies is not possible when predicted values are neither published nor accessible or sufficient or no individual participant or patient data are available. Our aims were to describe a simplified approach for outcomes prediction and calibration assessment and evaluate its functionality and validity.</p> <p>STUDY DESIGN AND METHODS: Methodological study of systematic reviews of validation studies of CPRs: a) ABCD(2) rule for prediction of 7 day stroke; and b) CRB-65 rule for prediction of 30 day mortality. Predicted outcomes in a sample validation study were computed by CPR distribution patterns ("derivation model"). As confirmation, a logistic regression model (with derivation study coefficients) was...
https://epubs.rcsi.ie/gpart/65
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Addressing a Training Gap through Addiction Research Education for Medical Students: Letter to the Editor
(2014)
Klimas, Jan; Cullen, Walter
Addressing a Training Gap through Addiction Research Education for Medical Students: Letter to the Editor
(2014)
Klimas, Jan; Cullen, Walter
Abstract:
Health Research Board
Irish Research Council
Research Incentives Programme at University of Limerick
University of Limerick Graduate Entry Medical School Strategic Research Fund
http://hdl.handle.net/10197/5878
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Addressing cognitive impairment following stroke: systematic review and meta-analysis of non-randomised controlled studies of psychological interventions.
(2019)
Merriman, Niamh A; Sexton, Eithne; McCabe, Grainne; Walsh, Mary E; Rohde, Daniela; Gorm...
Addressing cognitive impairment following stroke: systematic review and meta-analysis of non-randomised controlled studies of psychological interventions.
(2019)
Merriman, Niamh A; Sexton, Eithne; McCabe, Grainne; Walsh, Mary E; Rohde, Daniela; Gorman, Ashleigh; Jeffares, Isabelle; Donnelly, Nora-Ann; Pender, Niall; Williams, David; Horgan, Frances; Doyle, Frank; Wren, Maev-Ann; Bennett, Kathleen; Hickey, Anne
Abstract:
<p>The original article is available at <a href="https://bmjopen.bmj.com/content/9/2/e024429.long">bmjopen.bmj.com</a></p>
<p><strong>OBJECTIVE:</strong> Cognitive impairment is a pervasive outcome of stroke, reported in over half of patients 6 months post-stroke and is associated with increased disability and a poorer quality of life. Despite the prevalence of post-stroke cognitive impairment, the efficacy of existing psychological interventions for the rehabilitation of cognitive impairment following stroke has yet to be established. The aim of this study is to identify psychological interventions from non-randomised studies that intended to improve post-stroke cognitive function and establish their efficacy.</p> <p><strong>DESIGN:</strong> Systematic review and meta-analysis of non-randomised studies of psychological interventions addressing post-stroke cognitive impairment.</p> <p><str...
https://epubs.rcsi.ie/psycholart/128
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Application of Meta-Analysis and Machine Learning Methods to the Prediction of Methane Production from In Vitro Mixed Ruminal Micro-Organism Fermentation
(2020)
Ellis, Jennifer L.; Alaiz-Moretón, Héctor; Navarro-Villa, Alberto; McGeough, Emma J.; P...
Application of Meta-Analysis and Machine Learning Methods to the Prediction of Methane Production from In Vitro Mixed Ruminal Micro-Organism Fermentation
(2020)
Ellis, Jennifer L.; Alaiz-Moretón, Héctor; Navarro-Villa, Alberto; McGeough, Emma J.; Purcell, Peter; Powell, Christopher D.; O’Kiely, Padraig; France, James; López, Secundino
Abstract:
In vitro gas production systems are utilized to screen feed ingredients for inclusion in ruminant diets. However, not all in vitro systems are set up to measure methane (CH4) production, nor do all publications report in vitro CH4. Therefore, the objective of this study was to develop models to predict in vitro CH4 production from total gas and volatile fatty acid (VFA) production data and to identify the major drivers of CH4 production in these systems. Meta-analysis and machine learning (ML) methodologies were applied to a database of 354 data points from 11 studies to predict CH4 production from total gas production, apparent DM digestibility (DMD), final pH, feed type (forage or concentrate), and acetate, propionate, butyrate and valerate production. Model evaluation was performed on an internal dataset of 107 data points. Meta-analysis results indicate that equations containing DMD, total VFA production, propionate, feed type and valerate resulted in best predictability of CH4 ...
http://hdl.handle.net/11019/2190
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Association of blood pressure lowering with incident dementia or cognitive impairment: A systematic review and meta-analysis
(2020)
Hughes, Diarmaid; Judge, Conor; Murphy, Robert; Loughlin, Elaine; Costello, Maria; Whit...
Association of blood pressure lowering with incident dementia or cognitive impairment: A systematic review and meta-analysis
(2020)
Hughes, Diarmaid; Judge, Conor; Murphy, Robert; Loughlin, Elaine; Costello, Maria; Whiteley, William; Bosch, Jackie; O'Donnell, Martin J.; Canavan, Michelle
Abstract:
The benefit of blood pressure lowering for the prevention of dementia or cognitive impairment is unclear. To determine the association of blood pressure lowering with dementia or cognitive impairment. Search of PubMed, EMBASE, and CENTRAL for randomized clinical trials published from database inception through December 31, 2019, that evaluated the association of blood pressure lowering on cognitive outcomes. The control groups consisted of either placebo, alternative antihypertensive agents, or higher blood pressure targets. Data were screened and extracted independently by 2 authors. Random-effects meta-analysis models were used to report pooled treatment effects and CIs. The primary outcome was dementia or cognitive impairment. The secondary outcomes were cognitive decline and changes in cognitive test scores. Fourteen randomized clinical trials were eligible for inclusion (96 158 participants), of which 12 reported the incidence of dementia (or composite of dementia and cognitive...
http://hdl.handle.net/10379/16036
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Attention control comparisons with SLT for people with aphasia following stroke: methodological concerns raised following a systematic review
(2018)
Brady, Marian C.; Godwin, Jon; Kelly, Helen; Enderby, Pam; Elders, Andrew; Campbell, Pa...
Attention control comparisons with SLT for people with aphasia following stroke: methodological concerns raised following a systematic review
(2018)
Brady, Marian C.; Godwin, Jon; Kelly, Helen; Enderby, Pam; Elders, Andrew; Campbell, Pauline
Abstract:
Objective: Attention control comparisons in trials of stroke rehabilitation require care to minimize the risk of comparison choice bias. We compared the similarities and differences in SLT and social support control interventions for people with aphasia. Data sources: Trial data from the 2016 Cochrane systematic review of SLT for aphasia after stroke. Methods: Direct and indirect comparisons between SLT, social support and no therapy controls. We double-data extracted intervention details using the template for intervention description and replication. Standardized mean differences and risk ratios (95% confidence intervals (CIs)) were calculated. Results: Seven trials compared SLT with social support (n = 447). Interventions were matched in format, frequency, intensity, duration and dose. Procedures and materials were often shared across interventions. Social support providers received specialist training and support. Targeted language rehabilitation was only described in therapy ...
http://hdl.handle.net/10468/7337
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Behaviour change techniques targeting both diet and physical activity in type 2 diabetes: A systematic review and meta-analysis
(2017)
Cradock, Kevin A.; Ó Laighin, Gearóid; Finucane, Francis M.; Gainforth, Heather L.; Qui...
Behaviour change techniques targeting both diet and physical activity in type 2 diabetes: A systematic review and meta-analysis
(2017)
Cradock, Kevin A.; Ó Laighin, Gearóid; Finucane, Francis M.; Gainforth, Heather L.; Quinlan, Leo R.; Martin Ginis, Kathleen A.
Abstract:
Background: Changing diet and physical activity behaviour is one of the cornerstones of type 2 diabetes treatment, but changing behaviour is challenging. The objective of this study was to identify behaviour change techniques (BCTs) and intervention features of dietary and physical activity interventions for patients with type 2 diabetes that are associated with changes in HbA1c and body weight. Methods: We performed a systematic review of papers published between 1975–2015 describing randomised controlled trials (RCTs) that focused exclusively on both diet and physical activity. The constituent BCTs, intervention features and methodological rigour of these interventions were evaluated. Changes in HbA1c and body weight were meta-analysed and examined in relation to use of BCTs. Results: Thirteen RCTs were identified. Meta-analyses revealed reductions in HbA1c at 3, 6, 12 and 24 months of -1. 11 % (12 mmol/mol), -0.67 % (7 mmol/mol), -0.28 % (3 mmol/mol) and -0.26 % (2 mmol/mol) with...
http://hdl.handle.net/10379/6422
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Body mass index and risk of surgical site infection following spine surgery: a meta-analysis
(2018)
Abdallah, Dima Y.; Jadaan, Mutaz M.; McCabe, John P.
Body mass index and risk of surgical site infection following spine surgery: a meta-analysis
(2018)
Abdallah, Dima Y.; Jadaan, Mutaz M.; McCabe, John P.
Abstract:
Inconsistent results have been reported in the literature on the association between obesity, expressed as increased body mass index (BMI), and risk for surgical site infection (SSI) following spine surgery. The objective of this study was to review and quantify the association between increased BMI and risk of spinal SSI in adults. We performed a comprehensive search for relevant studies using PubMed, Embase, and references of published manuscripts. Study-specific risk measures were transformed into slope estimates and combined using the random effects meta-analysis model to establish the risk of SSI associated with every 5-unit increase in BMI. Thirty-four articles underwent full-text review. Variations were noted among these studies in relation to SSI diagnosis criteria and BMI cut-off levels used to define obesity. Data from 12 retrospective studies were included in the analyses. Results showed that BMI was significantly positively associated with the risk of spinal SSI. Unadjus...
http://hdl.handle.net/10379/10064
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Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia.
(2013)
DONOHOE, GARY
Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia.
(2013)
DONOHOE, GARY
Abstract:
Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to be more penetrant at the level of brain structure and function than at the level of behavior. However, to date the relative sensitivity of imaging vs cognitive measures of these variants has not been quantified. We considered effect sizes associated with cognitive and imaging studies of 9 robust SZ risk genes (DAOA, DISC1, DTNBP1, NRG1, RGS4, NRGN, CACNA1C, TCF4, and ZNF804A) published between January 2005-November 2011. Summary data was used to calculate estimates of effect size for each significant finding. The mean effect size for each study was categorized as small, medium, or large and the relative frequency of each category was compared between modalities and across genes. Random effects meta-analysis was used to consider the impact of experimental methodology on effect size. Imaging studies reported mostly medium or large effects, whereas cognitive investigations commonly reported small...
http://hdl.handle.net/2262/71421
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Cognitive coping style and the effectiveness of distraction or sensation-focused instructions in chronic pain patients
(2018)
Fox, Lisa; Walsh, Jane C.; Morrison, Todd G.; O’ Gorman, David; Ruane, Nancy; Mitchell,...
Cognitive coping style and the effectiveness of distraction or sensation-focused instructions in chronic pain patients
(2018)
Fox, Lisa; Walsh, Jane C.; Morrison, Todd G.; O’ Gorman, David; Ruane, Nancy; Mitchell, Caroline; Carey, John J.; Coughlan, Robert; McGuire, Brian E.
Abstract:
Aim This study set out to investigate whether cognitive coping strategies that match participants' preferred coping style effectively reduce pain intensity and situational anxiety in a population of people with chronic pain. Method Chronic pain patients (N = 43) completed questionnaires on coping style, pain intensity, self-efficacy, and situational/trait anxiety. Participants were classified as Monitors (n = 16) or Blunters (n = 19) based on their Miller Behavioural Style Scale score. Participants were then provided with an audiotaped intervention in which they were instructed to focus on pain sensations or to engage in a distraction task and then to rate the pain intensity and their anxiety during and after the attentional focus and distraction conditions. The two interventions were each completed by all participants, having been presented in counterbalanced order. Results Findings revealed that Monitors' level of anxiety decreased following a congruent (i.e., sensation-...
http://hdl.handle.net/10379/11544
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Comparison of outpatient and home-based exercise training programmes for copd: a systematic review and meta-analysis
(2018)
Wuytack, Francesca; Devane, Declan; Stovold, Elizabeth; McDonnell, Melissa; Casey, Mich...
Comparison of outpatient and home-based exercise training programmes for copd: a systematic review and meta-analysis
(2018)
Wuytack, Francesca; Devane, Declan; Stovold, Elizabeth; McDonnell, Melissa; Casey, Michelle; McDonnell, Timothy J.; Gillespie, Paddy; Raymakers, Adam; Lacasse, Yves; McCarthy, Bernard
Abstract:
Chronic obstructive pulmonary disease is a common, preventable and treatable disease. Exercise training programmes (ETPs) improve symptoms, health-related quality of life (HRQoL) and exercise capacity, but the optimal setting is unknown. In this review, we compared the effects of ETPs in different settings on HRQoL and exercise capacity. We searched (5 July 2016) the Cochrane Airways Group Specialised Register, and World Health Organization trials portal. We selected studies, extracted data and assessed risk of bias with two independent reviewers. We calculated mean differences (MD) with 95% CI. We assessed the quality of evidence using Grades of Recommendation, Assessment, Development and Evaluation. Ten trials (934 participants) were included. Hospital (outpatient) and home-based ETPs (seven trials) were equally effective at improving HRQoL on the Chronic Respiratory Questionnaire (CRQ) (dyspnoea: MD -0.09, 95% CI: -0.28 to 0.10; fatigue: MD -0.00, 95% CI: -0.18 to 0.17; emotional...
http://hdl.handle.net/10379/14459
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Correlates of poor mental health in early pregnancy in obese european women
(2018)
Sattler, Matteo C.; Jelsma, Judith G. M.; Bogaerts, Annick; Simmons, David; Desoye, Ger...
Correlates of poor mental health in early pregnancy in obese european women
(2018)
Sattler, Matteo C.; Jelsma, Judith G. M.; Bogaerts, Annick; Simmons, David; Desoye, Gernot; Corcoy, Rosa; Adelantado, Juan M.; Kautzky-Willer, Alexandra; Harreiter, Jürgen; van Assche, Frans A.; Devlieger, Roland; Jans, Goele; Galjaard, Sander; Hill, David; Damm, Peter; Mathiesen, Elisabeth R.; Wender-Ozegowska, Ewa; Zawiejska, Agnieszka; Blumska, Kinga; Lapolla, Annunziata
Abstract:
Background: Depression during pregnancy is associated with higher maternal morbidity and mortality, and subsequent possible adverse effects on the cognitive, emotional and behavioral development of the child. The aim of the study was to identify maternal characteristics associated with poor mental health, in a group of overweight/obese pregnant women in nine European countries, and thus, to contribute to better recognition and intervention for maternal depression. Methods: In this cross-sectional observational study, baseline data from early pregnancy (&lt; 20 weeks) of the DALI (Vitamin D and Lifestyle Intervention for gestational diabetes mellitus prevention) study were analyzed. Maternal mental health was assessed with the World Health Organization Well-Being Index (WHO-5). Women were classified as having a low (WHO-5 &lt;= 50) or high wellbeing. Results.: A total of 735 pregnant women were included. The prevalence of having a low wellbeing was 27.2%, 95% CI [24.0...
http://hdl.handle.net/10379/13798
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Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
(2018)
Corvin, Aiden
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
(2018)
Corvin, Aiden
Abstract:
Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group. Methods: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11?78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10?87 years; 53% male) assessed with standardized methods at 39 centers worldwide. Results: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen?s d = ?0.530/?0.516) and smaller surface area (left/right hemisphere: Cohen?s d = ?0.251/?0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differen...
http://hdl.handle.net/2262/89882
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Crew resource management training effectiveness: A meta-analysis and some critical needs
(2012)
O'Connor, Paul
Crew resource management training effectiveness: A meta-analysis and some critical needs
(2012)
O'Connor, Paul
Abstract:
http://dx.doi.org/10.1080/10508410802347044
Empirical studies of crew resource management (CRM) training effectiveness were subjected to meta-analysis. Sixteen CRM evaluation studies were found to fulfill the a priori criteria for inclusion in the meta-analysis. The metrics of CRM training effectiveness analyzed were reactions, attitudes, knowledge, and behaviors. CRM-trained participants responded positively to CRM (a mean of 4 on a 5 point Likert scale). The training had large effects on the participants attitudes and behaviors and a medium effect on their knowledge. The findings from the meta-analysis are encouraging for the effectiveness of CRM training. However, there is a need for researchers and reviewers to be more rigorous about the data included in research reporting CRM evaluation to allow effect sizes to be calculated.
http://hdl.handle.net/10379/2575
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Diagnostic accuracy of the STRATIFY clinical prediction rule for falls: a systematic review and meta-analysis
(2012)
Billington, Jennifer; Fahey, Tom; Galvin, Rose
Diagnostic accuracy of the STRATIFY clinical prediction rule for falls: a systematic review and meta-analysis
(2012)
Billington, Jennifer; Fahey, Tom; Galvin, Rose
Abstract:
Background: The STRATIFY score is a clinical prediction rule (CPR) derived to assist clinicians to identify patients at risk of falling. The purpose of this systematic review and meta-analysis is to determine the overall diagnostic accuracy of the STRATIFY rule across a variety of clinical settings. Methods: A literature search was performed to identify all studies that validated the STRATIFY rule. The methodological quality of the studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. A STRATIFY score of ≥2 points was used to identify individuals at higher risk of falling. All included studies were combined using a bivariate random effects model to generate pooled sensitivity and specificity of STRATIFY at ≥2 points. Heterogeneity was assessed using the variance of logit transformed sensitivity and specificity. Results: Seventeen studies were included in our meta-analysis, incorporating 11,378 patients. At a score ≥2 points, the STRATIFY rule is more...
http://hdl.handle.net/10344/4764
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Diagnostic accuracy of the STRATIFY clinical prediction rule for falls: A systematic review and meta-analysis.
(2012)
Billington, Jennifer; Fahey, Tom; Galvin, Rose
Diagnostic accuracy of the STRATIFY clinical prediction rule for falls: A systematic review and meta-analysis.
(2012)
Billington, Jennifer; Fahey, Tom; Galvin, Rose
Abstract:
<p>This article is also available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND: The STRATIFY score is a clinical prediction rule (CPR) derived to assist clinicians to identify patients at risk of falling. The purpose of this systematic review and meta-analysis is to determine the overall diagnostic accuracy of the STRATIFY rule across a variety of clinical settings.</p> <p>METHODS: A literature search was performed to identify all studies that validated the STRATIFY rule. The methodological quality of the studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. A STRATIFY score of ≥2 points was used to identify individuals at higher risk of falling. All included studies were combined using a bivariate random effects model to generate pooled sensitivity and specificity of STRATIFY at ≥2 points. Heterogeneity was assessed using the variance of logit transforme...
https://epubs.rcsi.ie/gpart/28
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Effect of floor type on performance, lying time and dirt scores of finishing beef cattle: A meta-analysis
(2020)
Keane, Michael P.; McGee, Mark; O'Riordan, Edward G.; Kelly, Alan K.; Earley, Bern...
Effect of floor type on performance, lying time and dirt scores of finishing beef cattle: A meta-analysis
(2020)
Keane, Michael P.; McGee, Mark; O'Riordan, Edward G.; Kelly, Alan K.; Earley, Bernadette
Abstract:
Data from individual studies evaluating the effect of housing systems on performance, lying time and dirt scores of finishing beef cattle are conflicting. The objective of this study was to collate the data from previous animal housing studies and quantify, through meta-analysis, the effect of floor type on animal performance, lying time and dirt scores. From 38 peer-reviewed articles, published between 1969 and 2017, 18 were determined to be eligible for meta-analysis. Papers were included in the study if they contained information on the effect of floor surface on animal performance (average daily liveweight gain (ADG), feed conversion ratio (FCR) and carcass weight), lying behaviour or animal cleanliness. There was no difference (P > 0.10) in ADG, FCR or carcass weight between concrete slatted floors (CSF) and CSF overlaid with rubber mats (RM). Using RM had no effect (P > 0.10) on lying duration or dirt scores of cattle. There was no difference (P > 0.10) in the ADG, FC...
http://hdl.handle.net/11019/2147
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Effect of institutional volume on laparoscopic cholecystectomy outcomes: systematic review and meta-analysis
(2018)
Murray, Muireann
Effect of institutional volume on laparoscopic cholecystectomy outcomes: systematic review and meta-analysis
(2018)
Murray, Muireann
Abstract:
AIM: To determine whether institutional laparoscopy cholecystectomy (LC) volume affects rates of mortality, conversion to open surgery, bile leakage and bile duct injury (BDI). METHODS: Eligible studies were prospective or retrospective cohort studies that provided data on outcomes from consecutive LC procedures in single institutions. Relevant outcomes were mortality, conversion to open surgery, bile leakage and BDI. We performed a Medline search and extracted data. A regression analysis using generalized estimating equations were used to determine the influence of annual institutional LC caseload on outcomes. A sensitivity analysis was performed including only those studies that were published after 1995. RESULTS: Seventy-three cohorts (127404 LC procedures) were included. Average complication rates were 0.06% for mortality, 3.23% for conversion, 0.44% for bile leakage and 0.28% for bile duct injury. Annual institutional caseload did not influence rates of mortality (P = 0.142), b...
http://hdl.handle.net/10379/13055
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ENIGMA-Viewer: interactive visualization strategies for conveying effect sizes in meta-analysis.
(2017)
Zhang, Guohao; Kochunov, Peter; Hong, Elliot; Kelly, Sinead; Whelan, Christopher; Jahan...
ENIGMA-Viewer: interactive visualization strategies for conveying effect sizes in meta-analysis.
(2017)
Zhang, Guohao; Kochunov, Peter; Hong, Elliot; Kelly, Sinead; Whelan, Christopher; Jahanshad, Neda; Thompson, Paul; Chen, Jian
Abstract:
<p>The original article is available at www.biomedcentral.com</p>
<p><strong>Background: </strong>Global scale brain research collaborations such as the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) consortium are beginning to collect data in large quantity and to conduct meta-analyses using uniformed protocols. It becomes strategically important that the results can be communicated among brain scientists effectively. Traditional graphs and charts failed to convey the complex shapes of brain structures which are essential to the understanding of the result statistics from the analyses. These problems could be addressed using interactive visualization strategies that can link those statistics with brain structures in order to provide a better interface to understand brain research results.</p> <p><strong>Results: </strong>We present ENIGMA-Viewer, an interactive web-based visualization tool for brain scienti...
https://epubs.rcsi.ie/mctart/86
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Evaluation of a Susceptibility Gene for Schizophrenia: Genotype Based Meta-Analysis of RGS4 Polymorphisms from Thirteen Independent Samples
(2006)
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL
Evaluation of a Susceptibility Gene for Schizophrenia: Genotype Based Meta-Analysis of RGS4 Polymorphisms from Thirteen Independent Samples
(2006)
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL
http://hdl.handle.net/2262/69359
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Examining the Formation of Human Capital in Entrepreneurship : A Meta-Analysis of Entrepreneurship Education Outcomes
(2013)
Martin, Bruce; McNally, Jeffrey J.; Kay, Michael
Examining the Formation of Human Capital in Entrepreneurship : A Meta-Analysis of Entrepreneurship Education Outcomes
(2013)
Martin, Bruce; McNally, Jeffrey J.; Kay, Michael
Abstract:
Effective human capital formation through the medium of entrepreneurship education and training (EET) is of increasing concern for governments, as EET is growing rapidly across the world. Unfortunately, there is a lack of consistent evidence showing that EET helps to create more or better entrepreneurs. We undertake the first quantitative review of the literature and, in the context of human capital theory, find that there is indeed support for the value of EET. Based on 42 independent samples (N = 16,657), we find a significant relationship between EET and entrepreneurship-related human capital assets (rw = .217) and entrepreneurship outcomes (rw = .159). The relationship between EET and entrepreneurship outcomes is stronger for academic-focused EET interventions (rw = .238) than for training-focused EET interventions (rw = .151). We find evidence of heterogeneity in many of our correlations, and recommend that future studies examine potential moderators to more clearly delineate E...
http://hdl.handle.net/10197/5159
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Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
(2013)
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
(2013)
MORRIS, DEREK; CORVIN, AIDEN; GILL, MICHAEL
http://hdl.handle.net/2262/69361
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