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Displaying Results 1 - 25 of 29 on page 1 of 2
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A process evaluation of a cluster randomised trial to reduce potentially inappropriate prescribing in older people in primary care (OPTI-SCRIPT study).
(2016)
Clyne, Barbara; Cooper, Janine A; Hughes, Carmel M; Fahey, Tom; Smith, Susan M; OPTI-SC...
A process evaluation of a cluster randomised trial to reduce potentially inappropriate prescribing in older people in primary care (OPTI-SCRIPT study).
(2016)
Clyne, Barbara; Cooper, Janine A; Hughes, Carmel M; Fahey, Tom; Smith, Susan M; OPTI-SCRIPT study team
Abstract:
<p>The original article is available at www.biomedcentral.com</p>
<p>BACKGROUND: The OPTI-SCRIPT cluster randomised controlled trial (RCT) found that a three-phase multifaceted intervention including academic detailing with a pharmacist, GP-led medicines reviews, supported by web-based pharmaceutical treatment algorithms, and tailored patient information leaflets, was effective in reducing potentially inappropriate prescribing (PIP) in Irish primary care. We report a process evaluation exploring the implementation of the intervention, the experiences of those participating in the study and lessons for future implementation.</p> <p>METHODS: The OPTI-SCRIPT trial included 21 GP practices and 196 patients. The process evaluation used mixed methods. Quantitative data were collected from all GP practices and semi-structured interviews were conducted with GPs from intervention and control groups, and a purposive sample of patients from the intervention gr...
https://epubs.rcsi.ie/gpart/98
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A prospective observational pilot study of adverse drug reactions contributing to hospitalisation in a cohort of middle-aged adults aged 45- 64 years.
(2020)
Grimes, Tamasine; Terence, Smeaton; McElwaine, Paul; Cullen, John; Santos-Martinez, Mar...
A prospective observational pilot study of adverse drug reactions contributing to hospitalisation in a cohort of middle-aged adults aged 45- 64 years.
(2020)
Grimes, Tamasine; Terence, Smeaton; McElwaine, Paul; Cullen, John; Santos-Martinez, Maria Jose; Deasy, Evelyn; Widdowson, Matthew
Abstract:
Purpose: Determine the prevalence, severity and preventability of adverse drug reactions (ADRs), ADRs causing or contributing to hospitalisation (cADRs) and preventable ADRs (pADRs) in middle-aged patients aged 45-64 years presenting acutely to hospital. Methods: Prospective observational pilot study. The sampling frame was middle-aged patients in the Acute Medical Unit of an Irish university teaching hospital. 100 patients using ?3 medicines were screened for ADRs present at hospitalisation. Potential ADRs were assessed for causality, preventability, severity and relationship to hospitalisation using validated tools and clinician assessment. The associations between ADRs and potentially inappropriate prescribing (PIP) and polypharmacy (?5 medicines) were investigated using the Pearson?s chi-squared test. Multi-variate logistic regression analyses examined association between ADRs and sex, age, polypharmacy, co-morbidity and PIP. Results: Twenty-one of 100 patients experienced 23...
http://hdl.handle.net/2262/91265
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Addressing potentially inappropriate prescribing in older patients: development and pilot study of an intervention in primary care (the OPTI-SCRIPT study).
(2013)
Clyne, Barbara; Bradley, Marie C; Hughes, Carmel M; Clear, Daniel; McDonnell, Ronan; Wi...
Addressing potentially inappropriate prescribing in older patients: development and pilot study of an intervention in primary care (the OPTI-SCRIPT study).
(2013)
Clyne, Barbara; Bradley, Marie C; Hughes, Carmel M; Clear, Daniel; McDonnell, Ronan; Williams, David; Fahey, Tom; Smith, Susan M; OPTI-SCRIPT study team
Abstract:
<p>The original article is available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND: Potentially inappropriate prescribing (PIP) in older people is common in primary care and can result in increased morbidity, adverse drug events, hospitalizations and mortality. The prevalence of PIP in Ireland is estimated at 36% with an associated expenditure of over €45 million in 2007. The aim of this paper is to describe the application of the Medical Research Council (MRC) framework to the development of an intervention to decrease PIP in Irish primary care.</p> <p>METHODS: The MRC framework for the design and evaluation of complex interventions guided the development of the study intervention. In the development stage, literature was reviewed and combined with information obtained from experts in the field using a consensus based methodology and patient cases to define the main components of the int...
https://epubs.rcsi.ie/gpart/39
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An exploration of deprescribing barriers and facilitators for older patients in primary care in Ireland – the potential role of the pharmacist
(2019)
Hansen, Christina Raae
An exploration of deprescribing barriers and facilitators for older patients in primary care in Ireland – the potential role of the pharmacist
(2019)
Hansen, Christina Raae
Abstract:
Introduction: The older population, often defined as people aged ≥ 65 years is growing. With older age, the risk of multimorbidity (commonly defined as the presence of ≥ 2 chronic conditions) increases together with the use of a high number of daily medicines or polypharmacy (≥ 5 daily medicines). These are two risk factors of poor health outcomes in older people, putting them at greater risk of experiencing potentially inappropriate prescribing (PIP), adverse drug events (ADEs) and poor quality of life (QoL). To reduce polypharmacy and the associated risk, the number of medications used per patient needs to be reduced by means of carefully considered deprescribing when appropriate. Deprescribing is the process of discontinuing inappropriate medications with the goal of optimising pharmacotherapy and improving health outcomes. Existing research is limited to support the effective and practical implementation of deprescribing. Pharmacists are trained to evaluate PIP and their knowled...
http://hdl.handle.net/10468/9544
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Benzodiazepine and Z-drug prescribing in Ireland: analysis of national prescribing trends from 2005-2015
(2018)
Cadogan, Cathal A.; Ryan, Cristín; Cahir, Caitriona; Bradley, Colin P.; Bennett, Kathleen
Benzodiazepine and Z-drug prescribing in Ireland: analysis of national prescribing trends from 2005-2015
(2018)
Cadogan, Cathal A.; Ryan, Cristín; Cahir, Caitriona; Bradley, Colin P.; Bennett, Kathleen
Abstract:
Aims: To examine prescribing trends for benzodiazepines and Z-drugs to General Medical Services (GMS) patients in Ireland. Methods: A repeated cross-sectional analysis of the national pharmacy claims database was conducted for GMS patients aged =16 years from 2005-2015. Prescribing rates per 1000 eligible GMS population were calculated with 95% confidence intervals (CIs). Negative binomial regression was used to determine longitudinal trends and compare prescribing rates across years, gender and age groups. Duration of supply and rates of concomitant benzodiazepine and Z-drug prescribing were determined. Age (16-44, 45-64, =65 years) and gender trends were investigated. Results: Benzodiazepine prescribing rates significantly decreased from 225.92/1000 population (95% CI 224.94-226.89) in 2005 to 166.07/1000 population (95% CI 165.38-166.75) in 2015 (p90 days) for either benzodiazepines or Z-drugs. The proportion of those receiving >1 benzodiazepine and/or Z-drug concomitantly inc...
http://hdl.handle.net/10468/5674
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Challenges in deprescribing for young chronic benzodiazepine patients
(2017)
Murphy, Kevin D.; Lambert, Sharon; McCarthy, Suzanne; Byrne, Stephen; Sahm, Laura J.
Challenges in deprescribing for young chronic benzodiazepine patients
(2017)
Murphy, Kevin D.; Lambert, Sharon; McCarthy, Suzanne; Byrne, Stephen; Sahm, Laura J.
http://hdl.handle.net/10468/5886
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Characterizing Potentially Inappropriate Prescribing of Proton Pump Inhibitors in Older People in Primary Care in Ireland from 1997 to 2012.
(2016)
Moriarty, Frank; Bennett, Kathleen; Cahir, Caitriona; Fahey, Tom
Characterizing Potentially Inappropriate Prescribing of Proton Pump Inhibitors in Older People in Primary Care in Ireland from 1997 to 2012.
(2016)
Moriarty, Frank; Bennett, Kathleen; Cahir, Caitriona; Fahey, Tom
Abstract:
<p>This is the peer reviewed version of the following article: Moriarty, F., Bennett, K., Cahir, C., and Fahey, T. Characterizing Potentially Inappropriate Prescribing of Proton Pump Inhibitors in Older People in Primary Care in Ireland from 1997 to 2012. J Am Geriatr Soc. 2016; 64(12): e291-e296, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/jgs.14528/abstract. This article may be used for noncommercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.</p>
<p>OBJECTIVES: To characterize prescribing of proton pump inhibitors (PPIs) and medicines that increase gastrointestinal bleeding risk (ulcerogenic) in older people from 1997 to 2012 and assess factors associated with maximal-dose prescribing in long-term PPI users.</p> <p>DESIGN: Repeated cross-sectional study of pharmacy claims data.</p> <p>SETTING: Eastern Health Board region of Ireland.</p> <p>PARTICIPANTS...
https://epubs.rcsi.ie/gpart/105
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Effectiveness of medicines review with web-based pharmaceutical treatment algorithms in reducing potentially inappropriate prescribing in older people in primary care: a cluster randomized trial (OPTI-SCRIPT study protocol).
(2013)
Clyne, Barbara; Bradley, Marie C; Smith, Susan M; Hughes, Carmel M; Motterlini, Nicola;...
Effectiveness of medicines review with web-based pharmaceutical treatment algorithms in reducing potentially inappropriate prescribing in older people in primary care: a cluster randomized trial (OPTI-SCRIPT study protocol).
(2013)
Clyne, Barbara; Bradley, Marie C; Smith, Susan M; Hughes, Carmel M; Motterlini, Nicola; Clear, Daniel; McDonnell, Ronan; Williams, David; Fahey, Tom; study team, OPTI-SCRIPT
Abstract:
<p>This article is also available from <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND: Potentially inappropriate prescribing in older people is common in primary care and can result in increased morbidity, adverse drug events, hospitalizations and mortality. In Ireland, 36% of those aged 70 years or over received at least one potentially inappropriate medication, with an associated expenditure of over €45 million.The main objective of this study is to determine the effectiveness and acceptability of a complex, multifaceted intervention in reducing the level of potentially inappropriate prescribing in primary care.</p> <p>METHODS/DESIGN: This study is a pragmatic cluster randomized controlled trial, conducted in primary care (OPTI-SCRIPT trial), involving 22 practices (clusters) and 220 patients. Practices will be allocated to intervention or control arms using minimization, with intervention ...
https://epubs.rcsi.ie/gpart/34
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Impact of Potentially Inappropriate Prescribing on Adverse Drug Events, Health Related Quality of Life and Emergency Hospital Attendance in Older People Attending General Practice: A Prospective Cohort Study.
(2016)
Wallace, Emma; McDowell, Ronald; Bennett, Kathleen; Fahey, Tom; Smith, Susan M
Impact of Potentially Inappropriate Prescribing on Adverse Drug Events, Health Related Quality of Life and Emergency Hospital Attendance in Older People Attending General Practice: A Prospective Cohort Study.
(2016)
Wallace, Emma; McDowell, Ronald; Bennett, Kathleen; Fahey, Tom; Smith, Susan M
Abstract:
<p>This article is also available at <a href="https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glw140">https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glw140</a></p>
<p>BACKGROUND: Potentially inappropriate prescribing (PIP) describes medications where risk generally outweighs benefit for older people. Cross-sectional studies suggest an association between PIP and poorer health outcomes but there is a paucity of prospective cohort studies. This study investigates the longitudinal association of PIP with adverse drug events (ADEs), health related quality of life, and accident & emergency visits.</p> <p>METHODS: Study design: Two-year (2010-2012) prospective cohort study (n = 904, ≥70 years, community-dwelling) with linked pharmacy dispensing data.</p> <p>EXPOSURE: Baseline PIP: Screening Tool for Older Persons potentially Inappropriate Prescriptions (STOPP)...
https://epubs.rcsi.ie/gpart/108
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Impact of Potentially Inappropriate Prescribing on Adverse Drug Events, Health Related Quality of Life and Emergency Hospital Attendance in Older People Attending General Practice: A Prospective Cohort Study.
(2017)
Wallace, Emma; McDowell, Ronald; Bennett, Kathleen; Fahey, Tom; Smith, Susan M
Impact of Potentially Inappropriate Prescribing on Adverse Drug Events, Health Related Quality of Life and Emergency Hospital Attendance in Older People Attending General Practice: A Prospective Cohort Study.
(2017)
Wallace, Emma; McDowell, Ronald; Bennett, Kathleen; Fahey, Tom; Smith, Susan M
Abstract:
<p>The original article is available at https://academic.oup.com</p>
<p>BACKGROUND: Potentially inappropriate prescribing (PIP) describes medications where risk generally outweighs benefit for older people. Cross-sectional studies suggest an association between PIP and poorer health outcomes but there is a paucity of prospective cohort studies. This study investigates the longitudinal association of PIP with adverse drug events (ADEs), health related quality of life, and accident & emergency visits.</p> <p>METHODS: Study design: Two-year (2010-2012) prospective cohort study (n = 904, ≥70 years, community-dwelling) with linked pharmacy dispensing data.</p> <p>EXPOSURE: Baseline PIP: Screening Tool for Older Persons potentially Inappropriate Prescriptions (STOPP) and Beers 2012 applied 12 months prior.</p> <p>STUDY OUTCOMES: ADEs (patient interview), health related quality of life (EQ-5D-3L: patient questionnaire), and acci...
https://epubs.rcsi.ie/gpart/113
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Inappropriate prescribing in older fallers presenting to an Irish emergency department.
(2014)
Kenny, Rose; Mc Mahon, Christine
Inappropriate prescribing in older fallers presenting to an Irish emergency department.
(2014)
Kenny, Rose; Mc Mahon, Christine
Abstract:
BACKGROUND: certain medications increase falls risk in older people. OBJECTIVE: to assess if prescribing modification occurs in older falls presenting to an emergency department (ED). DESIGN: before-and-after design: presentation to ED with a fall as the index event. SUBJECTS: over 70's who presented to ED with a fall over a 4-year period. METHODS: dispensed medication in the 12 months pre- and post-fall was identified using a primary care reimbursement services pharmacy claims database. Screening Tool of Older Person's PIP (STOPP) and Beers prescribing criteria were applied to identify potentially inappropriate prescribing (PIP). Polypharmacy was defined as four or more regular medicines. Psychotropic medication was identified using the WHO Anatomical Therapeutic Chemical classification system. Changes in prescribing were compared using McNemar's test (significance P < 0.05). RESULTS: One thousand sixteen patients were eligible for analysis; 53.1% had at lea...
http://hdl.handle.net/2262/69640
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Interventions to address potentially inappropriate prescribing in community-dwelling older adults: a systematic review of randomized controlled trials
(2016)
Clyne, Barbara; Fitzgerald, Ciaran; Quinlan, Aisling; Hardy, Colin; Galvin, Rose; Fahey...
Interventions to address potentially inappropriate prescribing in community-dwelling older adults: a systematic review of randomized controlled trials
(2016)
Clyne, Barbara; Fitzgerald, Ciaran; Quinlan, Aisling; Hardy, Colin; Galvin, Rose; Fahey, Tom; Smith, Susan M.
Abstract:
OBJECTIVES: To perform a systematic review to determine the effectiveness of interventions designed to reduce potentially inappropriate prescribing (PIP) in community-dwelling older adults.DESIGN: Systematic review and narrative synthesis.SETTING: Primary and community care.PARTICIPANTS: Community-dwelling older adults.MEASUREMENTS: The primary outcome was change in PIP measured using implicit or explicit tools. Studies were grouped into organizational, professional, financial, regulatory, and multifaceted interventions.RESULTS: Twelve randomized controlled trials were identified with baseline PIP prevalence of 18% to 100%. Four of six organizational interventions reported a reduction in PIP, particularly through pharmacists conducting medication reviews. Evidence of the effectiveness of multi-disciplinary teams was weak. Both of the two professional (targeting prescriber's directly) interventions were computerized clinical decision support interventions and were effective in d...
http://hdl.handle.net/10344/6094
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Interventions to Address Potentially Inappropriate Prescribing in Community-Dwelling Older Adults: A Systematic Review of Randomized Controlled Trials.
(2016)
Clyne, Barbara; Fitzgerald, Ciaran; Quinlan, Aisling; Hardy, Colin; Galvin, Rose; Fahey...
Interventions to Address Potentially Inappropriate Prescribing in Community-Dwelling Older Adults: A Systematic Review of Randomized Controlled Trials.
(2016)
Clyne, Barbara; Fitzgerald, Ciaran; Quinlan, Aisling; Hardy, Colin; Galvin, Rose; Fahey, Tom; Smith, Susan M
Abstract:
<p>This is the peer reviewed version of the following article: Clyne B, Fitzgerald C, Quinlan A, Hardy C, Galvin R, Fahey T, Smith SM. Interventions to Address Potentially Inappropriate Prescribing in Community-Dwelling Older Adults: A Systematic Review of Randomized Controlled Trials. Journal of the American Geriatrics Society. 2016;64(6):1210-22, which has been published in final form at <a>doi: 10.1111/jgs.14133</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.</p>
<p>OBJECTIVES: To perform a systematic review to determine the effectiveness of interventions designed to reduce potentially inappropriate prescribing (PIP) in community-dwelling older adults.</p> <p>DESIGN: Systematic review and narrative synthesis.</p> <p>SETTING: Primary and community care.</p> <p>PARTICIPANTS: Community-dwelling older adults.</p> <p>MEASUREMENTS...
https://epubs.rcsi.ie/gpart/101
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Longitudinal prevalence of potentially inappropriate medicines and potential prescribing omissions in a cohort of community-dwelling older people.
(2015)
Moriarty, Frank; Bennett, Kathleen; Fahey, Tom; Kenny, Rose Anne; Cahir, Caitriona
Longitudinal prevalence of potentially inappropriate medicines and potential prescribing omissions in a cohort of community-dwelling older people.
(2015)
Moriarty, Frank; Bennett, Kathleen; Fahey, Tom; Kenny, Rose Anne; Cahir, Caitriona
Abstract:
<p>The original article is also available at <a href="http://link.springer.com/article/10.1007%2Fs00228-015-1815-1" target="_blank">http://link.springer.com/article/10.1007%2Fs00228-015-1815-1</a></p>
<p>PURPOSE: This study aims to compare the prevalence of potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs) using several screening tools in an Irish community-dwelling older cohort, to assess if the prevalence changes over time and to determine factors associated with any change.</p> <p>METHODS: This is a prospective cohort study of participants aged ≥65 years in The Irish Longitudinal Study on Ageing (TILDA) with linked pharmacy claims data (n = 2051). PIM and PPO prevalence was measured in the year preceding participants' TILDA baseline interviews and in the year preceding their follow-up interviews using the Screening Tool for Older Persons' Prescriptions (STOPP), Beers cr...
https://epubs.rcsi.ie/gpart/66
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Pharmacotherapy optimization in older patients by a structured clinical pharmacist assessment and intervention
(2014)
O'Sullivan, David
Pharmacotherapy optimization in older patients by a structured clinical pharmacist assessment and intervention
(2014)
O'Sullivan, David
Abstract:
Introduction: Older individuals are particularly vulnerable to potentially inappropriate prescribing (PIP), drug related problems (DRPs) and adverse drug reactions (ADRs). A number of different interventions have been proposed to address these issues. However to-date there is a paucity of well-designed trials examining the impact of such interventions. Therefore the aims of this work were to: (i) establish a baseline PIP prevalence both nationally and internationally using the STOPP, Beers and PRISCUS criteria, (ii) identify the most comprehensive method of assessing PIP in older individuals, (iii) develop a structured pharmacist intervention supported by a computer decisions support system (CDSS) and (iv) examine the impact of this intervention on prescribing and incidence of ADRs. Results: This work identified high rates of PIP across all three healthcare settings in Ireland, 84.7% in the long term care, 70.7% in secondary care and 43.3% in primary care being reported. This work i...
http://hdl.handle.net/10468/1900
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PIPc study: development of indicators of potentially inappropriate prescribing in children (PIPc) in primary care using a modified Delphi technique.
(2016)
Barry, Emma; O'Brien, Kirsty; Moriarty, Frank; Cooper, Janine; Redmond, Patrick; H...
PIPc study: development of indicators of potentially inappropriate prescribing in children (PIPc) in primary care using a modified Delphi technique.
(2016)
Barry, Emma; O'Brien, Kirsty; Moriarty, Frank; Cooper, Janine; Redmond, Patrick; Hughes, Carmel M; Bennett, Kathleen; Fahey, Tom; Smith, Susan M
Abstract:
<p>This study is also available at<a href="http://bmjopen.bmj.com/content/bmjopen/6/9/e012079.full.pdf"> http://bmjopen.bmj.com/content/bmjopen/6/9/e012079.full.pdf</a></p>
<p>OBJECTIVE: There is limited evidence regarding the quality of prescribing for children in primary care. Several prescribing criteria (indicators) have been developed to assess the appropriateness of prescribing in older and middle-aged adults but few are relevant to children. The objective of this study was to develop a set of prescribing indicators that can be applied to prescribing or dispensing data sets to determine the prevalence of potentially inappropriate prescribing in children (PIPc) in primary care settings.</p> <p>DESIGN: Two-round modified Delphi consensus method.</p> <p>SETTING: Irish and UK general practice.</p> <p>PARTICIPANTS: A project steering group consisting of academic and clinical general practitioners (GPs) ...
https://epubs.rcsi.ie/gpart/106
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Potentially inappropriate prescribing and its association with health outcomes in middle-Aged people: A prospective cohort study in Ireland
(2017)
KENNY, ROSE; Moriarty, Frank; Cahir, Caitriona; Bennett, Kathleen; Hughes, Carmel M.; F...
Potentially inappropriate prescribing and its association with health outcomes in middle-Aged people: A prospective cohort study in Ireland
(2017)
KENNY, ROSE; Moriarty, Frank; Cahir, Caitriona; Bennett, Kathleen; Hughes, Carmel M.; Fahey, Tom
Abstract:
Objectives: To determine the prevalence of potentially inappropriate prescribing (PIP) in a cohort of community-dwelling middle-aged people and assess the relationship between PIP and emergency department (ED) visits, general practitioner (GP) visits and quality of life (QoL). Design: Prospective cohort study. Setting: The Irish Longitudinal Study on Ageing (TILDA), a nationally representative cohort study of ageing. Participants: Individuals aged 45?64 years recruited to TILDA who were eligible for the means-tested General Medical Services scheme and followed up after 2?years. Exposure: PIP was determined in the 12 months preceding baseline and follow-up TILDA data collection by applying the PRescribing Optimally in Middle-aged People?s Treatments (PROMPT) criteria to participants? medication dispensing data. Outcome measures: At follow-up, the reported rates of ED and GP visits over 12 months (primary outcome) and the CASP-R12 (Control Autonomy Self-realisation Pleasure) meas...
http://hdl.handle.net/2262/91757
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Potentially inappropriate prescribing and its association with health outcomes in middle-aged people: a prospective cohort study in Ireland.
(2017)
Moriarty, Frank; Cahir, Caitriona; Bennett, Kathleen; Hughes, Carmel M; Kenny, Rose Ann...
Potentially inappropriate prescribing and its association with health outcomes in middle-aged people: a prospective cohort study in Ireland.
(2017)
Moriarty, Frank; Cahir, Caitriona; Bennett, Kathleen; Hughes, Carmel M; Kenny, Rose Anne; Fahey, Tom
Abstract:
<p>The original article is available at http://bmjopen.bmj.com</p>
<p><strong>OBJECTIVES:</strong> To determine the prevalence of potentially inappropriate prescribing (PIP) in a cohort of community-dwelling middle-aged people and assess the relationship between PIP and emergency department (ED) visits, general practitioner (GP) visits and quality of life (QoL).</p> <p><strong>DESIGN</strong>: Prospective cohort study.</p> <p><strong>SETTING:</strong> The Irish Longitudinal Study on Ageing (TILDA), a nationally representative cohort study of ageing.</p> <p><strong>PARTICIPANTS:</strong> Individuals aged 45-64 years recruited to TILDA who were eligible for the means-tested General Medical Services scheme and followed up after 2 years.</p> <p><strong>EXPOSURE:</strong> PIP was determined in the 12 months preceding baseline and follow-up TILDA data collectio...
https://epubs.rcsi.ie/gpart/119
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Potentially inappropriate prescribing and vulnerability and hospitalization in older community-dwelling patients.
(2014)
Cahir, Caitriona; Moriarty, Frank; Teljeur, Conor; Fahey, Tom; Bennett, Kathleen
Potentially inappropriate prescribing and vulnerability and hospitalization in older community-dwelling patients.
(2014)
Cahir, Caitriona; Moriarty, Frank; Teljeur, Conor; Fahey, Tom; Bennett, Kathleen
Abstract:
<p>The original article is available at http://journals.sagepub.com</p>
<p><strong>BACKGROUND:</strong> The predictive validity of existing explicit process measures of potentially inappropriate prescribing (PIP) is not established.</p> <p><strong>OBJECTIVE:</strong> To determine the association between PIP, and vulnerability and hospital visits in older community-dwelling patients.</p> <p><strong>METHODS:</strong> This was a retrospective cohort study of 931 community-dwelling patients aged ≥70 years in 15 general practices in Ireland in 2010. PIP was defined by the Beers 2012 criteria and the Screening Tool of Older Person's Potentially Inappropriate Prescriptions (STOPP). Vulnerability was measured by the Vulnerable Elders Survey (score ≥3). The number of hospital visits was measured using patients' medical records and self-report for the previous 6 months. Multilevel logistic and Poisson ...
https://epubs.rcsi.ie/gpart/121
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Potentially inappropriate prescribing in two populations with differing socio-economic profiles: a cross-sectional database study using the PROMPT criteria.
(2016)
Cooper, Janine A; Moriarty, Frank; Ryan, Cristín; Smith, Susan M; Bennett, Kathleen; Fa...
Potentially inappropriate prescribing in two populations with differing socio-economic profiles: a cross-sectional database study using the PROMPT criteria.
(2016)
Cooper, Janine A; Moriarty, Frank; Ryan, Cristín; Smith, Susan M; Bennett, Kathleen; Fahey, Tom; Wallace, Emma; Cahir, Caitriona; Williams, David; Teeling, Mary; Hughes, Carmel M
Abstract:
<p>This article is available from <a href="http://link.springer.com/article/10.1007%2Fs00228-015-2003-z">http://link.springer.com/article/10.1007%2Fs00228-015-2003-z</a></p>
<p>PURPOSE: The purpose of this study is to establish the prevalence of potentially inappropriate prescribing (PIP) in middle-aged adults (45-64 years) in two populations with differing socio-economic profiles, and to investigate factors associated with PIP, using the PROMPT (PRescribing Optimally in Middle-aged People's Treatments) criteria.</p> <p>METHODS: A retrospective cross-sectional study was conducted using 2012 data from the Enhanced Prescribing Database (EPD), covering the full population in Northern Ireland and the Health Services Executive Primary Care Reimbursement Service (HSE-PCRS) database, covering the most socio-economically deprived third of the population in this age group in the Republic of Ireland. The prevalence for each PROMPT ...
https://epubs.rcsi.ie/gpart/91
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Prescriber variation in potentially inappropriate prescribing in older populations in Ireland.
(2014)
Cahir, Caitriona; Fahey, Tom; Teljeur, Conor; Bennett, Kathleen
Prescriber variation in potentially inappropriate prescribing in older populations in Ireland.
(2014)
Cahir, Caitriona; Fahey, Tom; Teljeur, Conor; Bennett, Kathleen
Abstract:
<p>The original article is available at <a href="http://www.biomedcentral.com">www.biomedcentral.com</a></p>
<p>BACKGROUND: Health care policy-makers look for prescribing indicators at the population level to evaluate the performance of prescribers, improve quality and control drug costs. The aim of this research was to; (i) estimate the level of variation in potentially inappropriate prescribing (PIP) across prescribers in the national Irish older population using the STOPP criteria; (ii) estimate how reliably the criteria could distinguish between prescribers in terms of their proportion of PIP and; (iii) examine how PIP varies between prescribers and by patient and prescriber characteristics in a multilevel regression model.</p> <p>METHODS: 1,938 general practitioners (GPs) with 338,375 registered patients' ≥70 years were extracted from the Health Service Executive Primary Care Reimbursement Service (HSE-PCRS) pharmacy ...
https://epubs.rcsi.ie/gpart/48
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Prevalence of potentially inappropriate prescribing and prescribing omissions in older Irish adults: findings from The Irish LongituDinal Study on Ageing study (TILDA).
(2014)
Galvin, Rose; Moriarty, Frank; Cousins, Grainne; Cahir, Caitriona; Motterlini, Nicola; ...
Prevalence of potentially inappropriate prescribing and prescribing omissions in older Irish adults: findings from The Irish LongituDinal Study on Ageing study (TILDA).
(2014)
Galvin, Rose; Moriarty, Frank; Cousins, Grainne; Cahir, Caitriona; Motterlini, Nicola; Bradley, Marie; Hughes, Carmel M; Bennett, Kathleen; Smith, Susan M; Fahey, Tom; Kenny, Rose-Anne
Abstract:
<p>This original article is available at <a href="http://link.springer.com/article/10.1007%2Fs00228-014-1651-8">http://link.springer.com/article/10.1007%2Fs00228-014-1651-8</a></p>
<p>PURPOSE: We sought to estimate the prevalence of potentially inappropriate prescriptions (PIP) and potential prescribing omissions (PPOs) using a subset of the STOPP/START criteria in a population based sample of Irish adults aged ≥ 65 years using data from The Irish LongituDinal Study on Ageing (TILDA).</p> <p>METHODS: A subset of 26 PIP indicators and 10 PPO indicators from the STOPP/START criteria were applied to the TILDA dataset. PIP/PPO prevalence according to individual STOPP/START criteria and the overall prevalence of PIP/PPO were estimated. The relationship between PIP and PPOs and polypharmacy, age, gender and multimorbidity was examined using logistic regression.</p> <p>RESULTS: The overall prevalence of PIP in the study po...
https://epubs.rcsi.ie/gpart/52
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Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study
(2018)
O'Riordan, David; Elodie Aubert, Carole; Walsh, Kieran A.; Van Dorland, Anette; Ro...
Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study
(2018)
O'Riordan, David; Elodie Aubert, Carole; Walsh, Kieran A.; Van Dorland, Anette; Rodondi, Nicolas; Du Puy, Robert S.; Poortvliet, Rosalinde K E.; Gussekloo, Jacobijn; Sinnott, Carol; Byrne, Stephen; Galvin, Rose; Jukema, J Wouter; Mooijaart, Simon P.; Baumgartner, Christine; McCarthy, Vera J.C.; Walsh, Elaine K.; Collet, Tinh-Hai; Dekkers, Olaf M.; Blum, Manuel R.; Kearney, Patricia M.
Abstract:
Objectives To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among communitydwelling older adults (≥65 years) enrolled to a clinical trial in three European countries. Design A secondary analysis of the Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset. Participants A subset of 48/80 PIP and 22/34 PPOs indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) V2 criteria were applied to prescribed medication data for 532/737 trial participants in Ireland, Switzerland and the Netherlands. Results The overall prevalence of PIP was lower in the Irish participants (8.7%) compared with the Swiss (16.7%) and Dutch (12.5%) participants (P=0.15) and was not statistically significant. The overall prevalence of PPOs was approximately one-quarter in the Swiss (25.3%) and Dutch (24%) participants and lower in the...
http://hdl.handle.net/10344/6698
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Prevalence of potentially inappropriate prescribing in older people in primary care and its association with hospital admission: longitudinal study
(2018)
Perez, Teresa; Moriarty, Frank; Wallace, Emma; McDowell, Ronald; Redmond, Patrick
Prevalence of potentially inappropriate prescribing in older people in primary care and its association with hospital admission: longitudinal study
(2018)
Perez, Teresa; Moriarty, Frank; Wallace, Emma; McDowell, Ronald; Redmond, Patrick
Abstract:
<p>The original article is available at <a href="https://www.bmj.com">www.bmj.com</a></p>
<p id="x-x-x-x-p-2"><strong>Objective</strong> To determine whether hospital admission is associated with potentially inappropriate prescribing among older primary care patients (aged ≥65 years) and whether such prescribing was more likely after hospital admission than before.</p> <p id="x-x-x-x-p-3"><strong>Design</strong> Longitudinal study of retrospectively extracted data from general practice records.</p> <p id="x-x-x-x-p-4"><strong>Setting</strong> 44 general practices in Ireland in 2012-15.</p> <p id="x-x-x-x-p-5"><strong>Participants</strong> Adults aged 65 years or over attending participating practices.</p> <p id="x-x-x-x-p-6"><strong>Exposure</strong> Admission to hospital (any hospita...
https://epubs.rcsi.ie/gpart/127
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Reducing potentially inappropriate prescribing for older people in primary care: cost-effectiveness of the opti-script intervention
(2018)
Gillespie, Paddy; Clyne, Barbara; Raymakers, Adam; Fahey, Tom; Hughes, Carmel M.; Smith...
Reducing potentially inappropriate prescribing for older people in primary care: cost-effectiveness of the opti-script intervention
(2018)
Gillespie, Paddy; Clyne, Barbara; Raymakers, Adam; Fahey, Tom; Hughes, Carmel M.; Smith, Susan M.
Abstract:
Objectives: This study examines the cost-effectiveness of the OPTI-SCRIPT intervention on potentially inappropriate prescribing in primary care. Methods: Economic evaluation, using incremental cost-effectiveness and cost utility analyses, conducted alongside a cluster randomized controlled trial of twenty-one general practices and 196 patients, to compare a multifaceted intervention with usual practice in primary care in Ireland. Potentially inappropriate prescriptions (PIPs) were determined by a pharmacist. Incremental costs, PIPs, and quality-adjusted life-years (QALYs) at 12-month follow-up were estimated using multilevel regression. Uncertainty was explored using cost-effectiveness acceptability curves. Results: The intervention was associated with a nonsignificant mean cost increase of Euro407 (95 percent CIs, -357-1170), a significant mean reduction in PIPs of 0.379 (95 percent CI, 0.092-0.666), and a nonsignificant mean increase in QALYs of 0.013 (95 percent CIs, -0.016-0.042...
http://hdl.handle.net/10379/11644
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